Neuroimmunology: Multiple Sclerosis, Autoimmune Neurology and Related Diseases

Part 1 Immunology, Pathophysiology and ImmunotherapyIntroduction to Immunology and Overview of the Immune System (BBB, Lymphatics, innate and adaptive immune system)Immunology of Multiple sclerosis (Role of B, T and innate immune system)Pathology of Multiple sclerosisAntibody pathogenesis and detection method for neuronal autoantibodies (Testing methods IFA, CBA, ELISA etc., (Synaptic vs intracellular antibodies in autoimmune/paraneoplastic disease)Mechanisms and Principles of Immunotherapy
Part 2 Multiple SclerosisNatural history of MS (relapses/progressive MS)Evolution of the diagnostic criteria in MS (MRI, CSF, OCT/VER)Epidemiology/Demographics/Environmental effects of MSPediatric MSTreatment of MS Trial design (ARR/MRI metrics/biomarkers)Disease modifying treatmentsTreatment selection and Treatment discontinuation
Part 3 Autoimmune NeurologyAutoimmune EncephalitisAutoimmune Myelitis and MyelopathyAutoimmune EpilepsyAutoimmune Movement DisordersAutoimmune Demyelinating disease: NMOSD and anti-MOGAutoimmune Ophthalmologic diseaseAutoimmune Neurology in Pediatrics (might need to include discussion on ADEM in this chapter)Treatment Approaches in Autoimmune Neurology (Overall lack of clinical trials and barriers, Current treatment approach)
Part 4 Other CNS inflammatory diseases NeurorheumatologyNeurosarcoidosisVasculitisHypertrophic Pachymeningitis (To include a discussion on IgG-RD)Role of infection and immunodeficiency in inflammatory diseaseRole of Oncological disease in inflammatory disease (to include lymphoma, CLIPPERS, Erdheim Chester)