TABLE OF CONTENTS
Chapter 1 The Science of Genetics
The Personal Genome
An Invitation
Three Great Milestones in Genetics
DNA as the Genetic Material
Genetics and Evolution
Levels of Genetic analysis
Genetics in the World: applications of Genetics to human Endeavors
Chapter 2 Cellular Reproduction
Cells and Chromosomes
Mitosis
Meiosis
Life Cycles of Some Model Genetic Organisms
Chapter 3 Mendelism The Basic Principles of Inheritance
Mendel’s Study of heredity
Applications of Mendel’s principles
Testing Genetic hypotheses
Mendelian principles in human Genetics
Chapter 4 Extensions of Mendelism
Allelic Variation and Gene Function
Gene Action: From Genotype to Phenotype
Inbreeding: Another Look at Pedigrees
Chapter 5 The Chromosomal Basis of Mendelism
Chromosomes
The Chromosome Theory of Heredity
Sex-Linked Genes in Humans
Sex Chromosomes and Sex Determination
Dosage Compensation of X-Linked Genes
Chapter 6 Variation in Chromosome Number and Structure
Cytological Techniques
Polyploidy
Aneuploidy
Rearrangements of Chromosome Structure
Chapter 7 Linkage, Crossing Over, and Chromosome Mapping in Eukaryotes
Linkage, Recombination, and Crossing Over
Chromosome Mapping
Cytogenetic Mapping
Linkage Analysis in Humans
Recombination and Evolution
Chapter 8 The Genetics of Bacteria and Their Viruses
Viruses and Bacteria in Genetics
The Genetics of Viruses
The Genetics of Bacteria
Mechanisms of Genetic Exchange in Bacteria
Chapter 9 DNA and the Molecular Structure of Chromosomes
Proof That Genetic Information Is Stored in DNA and RNA
The Structures of DNA and RNA
Chromosome Structure in Viruses and Prokaryotes
Chromosome Structure in Eukaryotes
Special Features of Eukaryotic Chromosomes
Chapter 10 Replication of DNA and Chromosomes
Basic Features of DNA Replication In Vivo
DNA Replication in Prokaryotes
Unique Aspects of Eukaryotic Chromosome Replication
Chapter 11 Transcription and RNA Processing
Transfer of Genetic Information: The Central Dogma
The Process of Gene Expression
Transcription in Prokaryotes
Transcription and RNA Processing in Eukaryotes
Interrupted Genes in Eukaryotes: Exons and Introns
Removal of Intron Sequences by RNA Splicing
Chapter 12 Translation and the Genetic Code
Protein Structure
Genes Encode Polypeptides
The Components of Polypeptide Synthesis
The Process of Polypeptide Synthesis
The Genetic Code
Codon-tRNA Interactions
Chapter 13 Mutation, DNA Repair, and Recombination
Mutation
The Molecular Basis of Mutation
Mutagenesis
Complementation Test
DNA Repair Mechanisms
DNA Recombination Mechanisms
Chapter 14 The Techniques of Molecular Genetics
Basic Techniques Used to Identify, Amplify, and Clone Genes
DNA CLONING: AN OVERVIEW
Construction and Screening of DNA Libraries
The Molecular Analysis of DNA, RNA, and Protein
The Molecular Analysis of Genes and Chromosomes
Chapter 15 Genomics
Genomics: An Overview
Correlated Genetic, Cytological, and Physical Maps of Chromosomes
The Human Genome Project
RNA and Protein Assays of Genome Functions
Genome Diversity and Evolution
Chapter 16 Applications of Molecular Genetics
Use of Recombinant DNA Technology to Identify Human Genes and Diagnose Genetic Diseases
Human Gene Therapy
DNA Profiling
Production of Eukaryotic Proteins in Bacteria
Transgenic Animals and Plants
Processes by Inhibiting Gene Expression
Genome Engineering
Chapter 17 Regulation of Gene Expression in Prokaryotes
Strategies for Regulating Genes in Prokaryotes
Constitutive, Inducible, and Repressible Gene Expression
Positive and Negative Control of Gene Expression
Operons: Coordinately Regulated Units of Gene Expression
The lactose operon in E. coli: Induction and Catabolite Repression
The Tryptophan Operon in E. coli: Repression and Attenuation
Posttranscriptional Regulation of Gene Expression in Prokaryotes
Chapter 18 Regulation of Gene Expression in Eukaryotes
Ways of Regulating Eukaryotic Gene Expression: An Overview
Environmental and Biological Factors
Molecular Control of Transcription in Eukaryotes
Gene Expression and Chromatin Organization
Activation and Inactivation of Whole Chromosomes
Chapter 19 Inheritance of Complex Traits
Complex Traits
Statistics of Quantitative Genetics
Statistical Analysis of Quantitative Traits
Molecular Analysis of Complex Traits
Correlations between Relatives
Quantitative Genetics of Human Behavioral Traits
Chapter 20 Population Genetics
The Theory of Allele Frequencies
Natural Selection
Random Genetic Drift
Populations in Genetic Equilibrium
Chapter 21 (Online) Transposable Genetic Elements
Transposable Elements: An Overview
Transposable Elements in Bacteria
Cut-and-Paste Transposons in Eukaryotes
Transposon Activity in Maize
Retroviruses and Retrotransposons
Transposable Elements in Humans
The Genetic and Evolutionary Significance of Transposable Elements
Chapter 22 (Online) The Genetic Control of Animal Development
A Genetic Perspective on Development
Maternal Gene Activity in Development
Zygotic Gene Activity in Development
Genetic Analysis of Development in Vertebrates
Chapter 23 (Online) The Genetic Basis of Cancer
Cancer: A Genetic Disease
Oncogenes
Tumor Suppressor Genes
Genetic Pathways to Cancer
Chapter 24 (Online) Evolutionary Genetics
The Emergence of Evolutionary Theory
Genetic Variation in Natural Populations
Molecular Evolution
Speciation
Human Evolution
Appendices
Appendix A: The Rules of Probability
Appendix B: Binomial Probabilities
Appendix C: Evolutionary Rates
Answers to Odd-Numbered Questions and Problems
Glossary
Index
