Latcripin-7A, derivative of Lentinula edodes C91-3, induces apoptosis

Gastric cancer (GC) is considered the 3rd most lethal cancer among cancer, followed by lung and colorectal cancer. The GC cases are increasing gradually, with an escalation rate of 5.7% approximately documented only in 2019. According to the record of 2015, the majority of the new cases, nearly 50% of patients were diagnosed in South and Central America, Eastern Europe, and East Asia. In comparison, North America, Africa, South Asia, Australia, and New Zealand found significantly fewer cases. Mushrooms have a long history to be used as a medicine and food source, believed a delicious and healthy food source. Lentinula edodes, also known as shiitake mushrooms, have the potential for anti-tumor activity. Recent studies showed Lentinula edodes have potential and significant effects on cell apoptosis and its well-intentioned source to decrease the antagonistic reactions of chemotherapy. Peptides acquired from Lentinula edodes (LP-1, LP-13) provided substantial results on various cancer types, increasing apoptosis. LP-1 is also reported to inhibit migration, and invasion of GC cells by arresting cell growth at the S phase via the phosphatidylinositol-3-kinase (PI3K)/Akt pathways.