Since time immemorial, nature has inspired humans to find ways to treat different ail- ments. With
advancements in time and technology, human civilization has encountered new diseases and has even
found ways to deal with them. During the development of a new drug, pre-clinical studies occur in
mammals on the onset of in-vivo studies. Here effort has been made to include in-silico
studies of drugs (transdermal drugs only) before experimentation on any live animal. In this
we briefly introduce the idea of transdermal drug delivery along with its advantages over
other drug delivery methods, concept of skin impedance and electrical models of skin.
The usual methods of drug administrations are oral intake and hypodermic injection. However, in the
history of medical science, it has been observed that people have applied substances on the skin
for therapeutic effects from ancient days. These substances were naturally occurring or locally
available drugs derived from nature. However, with the advancement in time and development of
medical science, various drug formulations have been developed to treat local
indications. This method of drug administration through intact skin is known as transdermal
drug delivery (TDD). Oral drug delivery involved hepatic first-pass effect, where drugs are metabolized pre- maturely by
the liver. This also involves gastrointestinal degradation of drugs, proteins, peptides and hormones by the stomach acids.
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