Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

WINNER OF THE NATIONAL BOOK AWARDWinner of the Dublin Impac International PrizeWinner of Best Foreign Novel Award Weshanhu AwardWinner of the Grinzane AwardWinner of the Prix DeauvilleWinner of the Ambassador Book AwardWinner of the Medici Book Club PrizeWinner of the Aspen Literary Prize'A wow of a novel – rich, humane, brilliantly written and as deep as it is wide' The Times____________________________________New York, August 1974: a man is walking in the sky. Between the newly built Twin Towers, the man twirls through the air. Far below, the lives of complete strangers spin towards each other: Corrigan, a radical Irish monk working in the Bronx; Claire, a delicate Upper East Side housewife reeling from the death of her son; Lara, a drug-addled young artist; Gloria, solid and proud despite decades of hardship; Tillie, a hooker who used to dream of a better life; and Jazzlyn, her beautiful daughter raised on promises that reach beyond the skyline of New York.In the shadow of one reckl

Shortlisted for the Irish Novel of the YearShortlisted for the International Dublin Literary AwardLonglisted for the Man Booker Prize'A marvellously engrossing journey, studded with ideas and lyrical treats' The Times______________________________________In 1919, pioneering journalist Emily Ehrlich watches as two young airmen emerge from the carnage of World War One to pilot the very first non-stop transatlantic flight from Newfoundland to the west of Ireland. In 1845 Frederick Douglass, a Black American slave, lands in Ireland to champion ideas of democracy and freedom, only to find a famine unfurling at his feet. And in 1998 Senator George Mitchell criss-crosses the ocean in search of an elusive Irish peace.Stitching these stories intricately together, Colum McCann sets out to explore the fine line between what is real and what is imagined, and the tangled skein of connections that make up our lives.'History comes vividly to life in a majestic work' Sunday Times'Beautifully hypnotic

'A powerful and moving collection' Roddy Doyle___________________A group of British soldiers appear to help a farmer and his daughter free their horse from a stream in a flood. A young boy and his mother, under cover of night, painstakingly prepare for the marching season ahead. And a young woman and her son sit over a game of chess in a Galway caravan, their thoughts elsewhere – in the Derry prison where a young man is slowly succumbing to hunger strike.Everything in this Country Must reveals the reverberations of political tragedy in the most intimate lives of men and women, parents and children – and confirms Colum McCann as a master storyteller.'These are powerful stories – gritty, memorable and ambitious … Goes straight to the heart, both in terms of its theme and its emotional punch' Edna O'Brien'McCann writes with a dazzling blend of menace and heartbreak' New York Times'McCann returns to Ireland with this collection, turning his measured gaze and incisive prose to the country's

'A gifted and determined stylist, Colum McCann seems to have taken a vow never to write a dull line' New York Times Book Review'Orwell would have been proud to journey with a writer as good as Colum McCann' Irish Sunday Independent______________________An ageing nun is tracked to ground by her sister; a garrulous beautician must lay out the corpse of a loved one.These are eloquent tales of exile and displacement, of characters always in search of a way back home or of a way to leave it. Mischievous, assured and versatile, Colum McCann's collection of short stories marks him out as one of our best contemporary writers.

'A great book and a marvellously crafted story' Roddy Doyle____________________________________Zoli Novotna is a poet by accident as much as desire. As Fascism spreads over Czechoslovakia, she and her grandfather flee an unspeakable loss to join a clan of fellow Romani harpists. As Zoli shapes the ancient songs to her times, she finds her gift embraced – by her own people, and, for the first time, by the world outside their circle.But Zoli has become an instrument herself – wielded by the hands of the powerful. And her greatness in her art will see her severed and exiled from the people and tradition she loves, setting her on a path she must tread alone…'A hymn to specificity, a clamour against homogenisation … With each voice McCann performs an astonishing feat' Richard Eyre, Guardian'A writer of large and driving vision … Zoli contains passages of stunning lyricism and sharp ironic force' New York Times'Poetic and beautifully observed' Daily Telegraph

A propulsive novel of rupture and repair in the digital age, delving into a hidden world deep under the ocean—from the New York Times bestselling author of Apeirogon and Let the Great World Spin“The spirit of Joseph Conrad hovers over the text, but here the heart of darkness lies at the bottom of the ocean.”—Salman Rushdie"Everything gets fixed, and we all stay broken."Anthony Fennell, an Irish journalist and playwright, is assigned to cover the underwater cables that carry the world’s information. The sum of human existence—words, images, transactions, memes, voices, viruses—travels through the tiny fiber-optic tubes. But sometimes the tubes break, at an unfathomable depth.Fennell’s journey brings him to the west coast of Africa, where he uncovers a story about the raw human labor behind the dazzling veneer of the technological world. He meets a fellow Irishman, John Conway, the chief of mission on a cable repair ship. The mysterious Conway is a skilled engineer and a freediver capabl

Anthony Fennell, a journalist, is in pursuit of a story buried at the bottom of the sea: the network of tiny fibre-optic tubes that carry the world’s information across the ocean floor - and what happens when they break.So he has travelled to Cape Town to board the George Lecointe, a cable repair vessel captained by Chief of Mission John Conway. Conway is a talented engineer and fearless freediver - and Fennell is quickly captivated by this mysterious, unnerving man and his beautiful partner, Zanele.As the boat embarks along the west coast of Africa, Fennell learns the rhythms of life at sea. But as the mission falters, tensions simmer - and Conway is thrown into crisis by a terrible, violent tragedy unfolding in the life he has left behind on land.Then Conway disappears; and Fennell must set out to find him.As taut and propulsive as a thriller, and a timeless exploration of narrative and truth, Twist is the work of a master storyteller at the height of his powers.