Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The world's greatest detective is back in the fifth and final instalment in a brilliantly clever, funny, illustrated murder mystery series. Perfect for fans of Robin Stevens, Beth Lincoln and M.G. Leonard."Knives Out meets Poirot – but for kids!" Radio 4Bonnie Montgomery is at the local theatre group rehearsal when playwright Cynthia Cecil collapses on stage. Natural causes? Perhaps, but the world’s finest detective – and Bonnie's alter-ego Montgomery Bonbon – heard a final, unscripted word with Cynthia's last breath: "Murder!"The cast were either within sight or backstage with rock-solid alibis. As opening night approaches, can Bonbon untangle lines from the truth, and expose a killer clever enough to get away with murder in front of an audience?

THE SEVENTH BOOK IN THE GLOBALLY BESTSELLING CHAPTER-BOOK SERIES ABOUT THE UNICORNIA ACADEMY OF MAGIC – PERFECT FOR FANS OF ISADORA MOON!Magical schools have magical school trips! Welcome to the Campsite in the Clouds.What could be more magical than a camping trip in the sky?! Claudia and Pippa can hardly wait … but something is troubling Sara. Can she overcome her fears in time to help her friends solve a sky-high mystery? Find out in this star-filled, cloud-camping adventure!With colour illustrations, this magical chapter-book series is great for building confidence in newly independent readers.There’s a whole world of Unicornia to read:Unicornia: Learning to Fly – perfect for talking to children who are worried about starting schoolUnicornia: A Magical Birthday – perfect for birthdays and celebrationsUnicornia: The Cupcake Contest – perfect for budding bakers and for talking to children about teamworkUnicornia: The Dance Show – perfect for talking to children about stage fright and

Sasha wants to join in on a playdate, but her shyness keeps getting in the way. A kindhearted, funny, reassuring story for anyone who needs more time warming up in this socially extroverted world.“Models empathy for shyness of all stripes” Kirkus ReviewsSasha has been invited to a playdate at Leo's. Leo bounces up and down as he wants to play cafe, start a band, and fly to the moon. It's all too much for Sasha who wants to go back home. How can Sasha manage her shyness and show Leo that she really does want to make friends?A reassuring story for anyone who has ever felt shy, and for those of us who need more time to warm up socially. In a world that focuses on extroverts, this little wolf cub shows that introverts enjoy company too ... when they're ready to play!A funny, heartwarming picture book that explores shyness with empathy, by the award-winning creator of Pavlo Gets the Grumps.

*NEW YORK TIMES AND SUNDAY TIMES BESTSELLING AUTHOR**HEARTSTOPPER: FASTEST EVER SELLING GRAPHIC NOVEL*Boy meets boy. Boys become friends. Boys fall in love. The final installment in the bestselling LGBTQ+ graphic novel series about life, love, and everything that happens in between.*NEW YORK TIMES AND SUNDAY TIMES BESTSELLING AUTHOR**FASTEST EVER SELLING GRAPHIC NOVEL**Read it before you see it: Heartstopper Forever movie coming soon from Netflix*Boy meets boy. Boys become friends. Boys fall in love. The final installment in the bestselling LGBTQ+ graphic novel series about life, love, and everything that happens in between.Everyone in school knows Nick and Charlie. Everyone knows they're going to be together forever.But Charlie's busy with his bid to become head boy. And while Nick is preparing to leave for uni, he's starting to wonder who he'll be . . . without Charlie.Contains discussions around mental health and eating disorders, underage drinking, and sexual references.'The queer

2025 SLJ Best Young Adult BooksThe start of a daring new dystopian series where humanity has moved to virtual reality to flee their deteriorating world, following two young soldiers who must depend on unlikely allies in their fight for survival.The first in a young adult dystopian trilogy from the author of These Violent Delights.From #1 Sunday Times bestselling author Chloe Gong comes the start of a daring new dystopian series following two young soldiers who must depend on unlikely allies in their fight for survival. This paperback edition features new exclusive bonus content!THE FUTURE IS LOADING . . .A cold war rages between two powerful nations: Medaluo and Atahua. Amid this conflict, Medan orphans in Atahua can either enrol at Nile Military Academy, or be condemned the enemy.Recent graduate Eirale joined NileCorp's private forces readily. But when Atahua's most wanted anarchist frames her for treason, she is forced on the run with him. . . in Medaluo.Academy cadet Lia aspires to

An enchanting novel about a witch who has a second chance to get her magic - and her life - back on track, from the author of The Very Secret Society of Irregular Witches.It's time to get her spark back . . .Once, Sera Swan was one of the most powerful witches in Britain - until she sacrificed most of her magic to resurrect her beloved aunt. Now she runs an enchanted inn in Lancashire, where she deals with her quirky guests' shenanigans and longs for a future that seems entirely lost.Then she meets Luke Larsen, the handsome and icy magical historian who could hold the key to restoring her power. Luke has no interest in the inn's goings-on or letting a certain witch past his walls, so no one is more surprised than he when he agrees to help. Worse, he might actually be thawing.But as the two work together alongside the family Sera has built, she begins to wonder . . . could love be the best magic of all?A witch has a second chance to get her magical powers - and her life back on track in

When everything she wishes for starts coming true, Ayesha discovers what will really make her happy.A book about tween friendships, with a sprinkling of magic, from award-winning journalist and author Radhika Sanghani. Perfect for fans of Lottie Brooks and Dork Diaries.Ayesha can't wait for summer camp, it's going to be the best two weeks ever with her best friend Nikki. But Nikki's changed over the summer and things don't feel the same between them. When Ayesha overhears Nikki telling their roommates she's immature, Ayesha is embarrassed and wishes her life could be different.The next day Ayesha realizes everything she wishes for is coming true. Lie-in in the morning? Tick! Pizza for lunch? Tick! Nikki to be her best friend? Tick! Suddenly Nikki's hanging out with her again, and then Ayesha wishes for Nikki to get a part in the camp's musical, and now she's playing the lead role.But their friendship still isn't the same. Ayesha thinks she needs a part in the musical too, so she makes

Join Poppy and Sam for a noisy day on Apple Tree Farm in this irresistible touchy-feely sound book. Each time you press one of the soft patches, you'll hear one of Poppy and Sam's animal friends... and of course there's a little yellow duck to find in every picture too.

Bring the world of the jungle to life with the three different jigsaws and simple story in this enchanting book. The jigsaws have nine pieces each and are perfect for young children, who will also enjoy reading about the magic of the jungle in the atmospheric story.

This volume presents a selection of eight letters in verse from Ovid's Heroides in Latin with English translations. P. J. Davis's introduction and accompanying commentary discuss the literary themes and historical context of the poems.

Why do your feet age more slowly than your head? Is time travel possible? How did spies use clocks to complete secret missions? What caused the year of confusion? Why don't naked mole rats age? Find the fascinating answers to these questions and many more in this book full of mind-boggling facts about time.Ideal for fact loving readers aged 8+.Each book in this best-selling and award-winning series presents 100 bite-sized topics, with bold, graphic illustrations and clear text. Perfect for dipping in and out of, and for sharing with family and friends.