Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Shortlisted for the Irish Novel of the YearShortlisted for the International Dublin Literary AwardLonglisted for the Man Booker Prize'A marvellously engrossing journey, studded with ideas and lyrical treats' The Times______________________________________In 1919, pioneering journalist Emily Ehrlich watches as two young airmen emerge from the carnage of World War One to pilot the very first non-stop transatlantic flight from Newfoundland to the west of Ireland. In 1845 Frederick Douglass, a Black American slave, lands in Ireland to champion ideas of democracy and freedom, only to find a famine unfurling at his feet. And in 1998 Senator George Mitchell criss-crosses the ocean in search of an elusive Irish peace.Stitching these stories intricately together, Colum McCann sets out to explore the fine line between what is real and what is imagined, and the tangled skein of connections that make up our lives.'History comes vividly to life in a majestic work' Sunday Times'Beautifully hypnotic

'A powerful and moving collection' Roddy Doyle___________________A group of British soldiers appear to help a farmer and his daughter free their horse from a stream in a flood. A young boy and his mother, under cover of night, painstakingly prepare for the marching season ahead. And a young woman and her son sit over a game of chess in a Galway caravan, their thoughts elsewhere – in the Derry prison where a young man is slowly succumbing to hunger strike.Everything in this Country Must reveals the reverberations of political tragedy in the most intimate lives of men and women, parents and children – and confirms Colum McCann as a master storyteller.'These are powerful stories – gritty, memorable and ambitious … Goes straight to the heart, both in terms of its theme and its emotional punch' Edna O'Brien'McCann writes with a dazzling blend of menace and heartbreak' New York Times'McCann returns to Ireland with this collection, turning his measured gaze and incisive prose to the country's

Once sidelined in legal discourse, natural law is experiencing a resurgence in the United States. Truth About Natural Law offers an accessible yet critical introduction to its theory, history, and contemporary relevance.

A revelatory look at one of America's most progressive cities--Minneapolis--as journalist Justin Ellis returns to his hometown to grapple with the quiet history of white supremacy in the wake of George Floyd's murder, uncover his family's story of surviving "Minnesota nice," and revisit the city years later as state violence again forces the question of what a real reckoning looks like. It's the "North," they like to say, not the Midwest. It's dif­ferent. Minneapolis is a city for everyone. But in 2020, George Floyd's murder by the city's police left many Americans stunned and wondering, "How could this hap­pen in Minneapolis?" To Ellis, the real question is: What made people think it couldn't?The Minneapolis Justin Ellis grew up in is not the idealistic metropolis it claims to be. The "City of Lakes" was built on discrimination-- in its housing, its schools, its politics--much like all other American cities. Black families were systematically cut out of the prosperous neighbor

WINNER OF THE YOTO CARNEGIE MEDAL FOR WRITING 2023LONGLISTED FOR THE UKLA BOOK AWARDS 2023Dylan was six when The End came. Now he is 14. Since the nuclear disaster that changed everything, Dylan and his mam have survived in their isolated hilltop house above the village of Nebo in north-west Wales, learning new skills, and returning to old ways of living. They trap rabbits, tend the vegetable garden, and trade duties caring for Dylan's little sister, Mona.Dylan does not remember the time before they were alone, before the electricity went off for good, before the 'normal' 21st century world disappeared.His mother, Rowenna, has given him a simple task. To write in a journal - the book now in your hands. When, one night, Dylan asks his Mom to write too - the story of The End, and the life before that he cannot remember - The Blue Book of Nebo is created."We've agreed not to read what the other has written, just in case," Dylan writes. "In case of what, I'm not sure."Together, they take t