Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

THE CAT IN the Hat puts to rest any notion that money grows on trees in this super simple look at numismatics, the study of money and its history. Beginning with the ancient practice of bartering, the

Bestselling author Ava Reid’s YA debut, the haunting stand-alone dark academia fantasy, instant Indie and #1New York TimesbestsellingA Study in Drowning, is now available in a gorgeous package that also includes bonus content written by the author. With intricate foil case design, antique-style endpapers, filigree cover, custom designed edges, and bonus content, it’s a true collector’s edition. Quantities will be limited, so be sure to preorder now!Effy Sayre has always believed in fairy tales. She’s had no choice. Since childhood, she’s been haunted by visions of the Fairy King. She’s found solace only in the pages ofAngharad—author Emrys Myrddin’s beloved epic about a mortal girl who falls in love with the Fairy King and then destroys him. Effy’s tattered, dog-eared copy is all that’s keeping her afloat at Llyr’s prestigious architecture college. So when Myrddin’s family announces a contest to redesign the late author’s estate, Effy feels certain this is her destiny.But Hiraeth Manor

Enjoy the countdown to Christmas! Open a numbered window every day in December until the big day and reveal a seasonal image to help you get in the festive spirit! Featuring a delightful snowy Moomin scene, each window reveals an image from Tove Jansson's beloved Moomin world. Printed on FSC-certified paper.Product detailsCalendar, Foiled cover, 1 pages

At long last Lottie and Daniel are an official couple and everything seems to be going brilliantly (except for Amber being increasingly mean and jealous, but what's new there?).Meanwhile Toby's new year's resolution is to get a dog, and for once Lottie and him see eye to eye. Pot Noodle, the cockapoo, becomes the newest member of the Brooks family. He's VERY cute but also not toilet trained AT ALL.Lottie soon finds having a new boyfriend and a new dog means she has little time for anyone else, leaving her best friends pretty upset. How is Lottie meant to keep everybody happy and stop Pot Noodle from pooing on the carpet?!Readers LOVE Lottie Brooks:My daughter couldn't put it down and read it in 2 days. Read at breakfast, walking downstairs, tea time, in the bath.My 9-year-old daughter devoured it in two nights, and all I could hear from her was giggling and the occasional "Mum! Listen to this! This is SO me!".My 12 year old reluctant reader took this book, read 100 pages in one night a

商務場合常用語句趣味大解析，完整收錄商務人士必懂用語，有些連Google翻譯都翻不出來。以幽默解析與生動典故，讓你除了聽得懂，還能靈活用，跟老闆、同事、客戶溝通時準確回應，不再滿頭問號、一臉尷尬，增進專業度與好感度什麼是FAQ、MO、KISS（絕對不是親親…）？跟信封一點關係都沒有的「Push the envelope」是什麼意思？老闆為什麼叫你「把海水煮沸」(boil the ocean)？同事幹嘛請你「挪一下針頭」(move the needle)？為什麼英文學了十幾年，進了商業世界什麼都聽不懂？本書針對商業情境與職場最常使用的商業詞彙與片語，提供明確定義，並介紹這些用語的來源、歷史與故事，讓你在大笑中了解這些商務行話的真正含意，無論是商務演講或是與同事分享重要訊息，都能正確回應，提升溝通技巧與專業度。★精彩搶先看★ducks in a row──每件事情都安排的有條不紊，準備完全。商務行話定義：總之不能拿來形容鐵達尼號上負責確認救生艇數量是否足夠的那個人。Hardball──用最強硬的方式積極地進行任何遊戲，包括真實人生。商務行話定義：在紐約市上下班尖峰時間，擁擠的地鐵車廂靠站時你必須要採取的態度。hump day──禮拜三商務行話定義：黑洞漩渦般的工作日中，一絲絲微弱的希望之光。left holding the bag──擔起被強加在自己身上的責難或重擔商務行話定義：預定要跟老闆報告案子失敗的當天，其他同事全因為流感倒下。★特別收錄★來自經典電影、貓狗、軍事、賽馬等領域的商務行話「給我錢﹗」（Show me the money﹗）——《征服情海》（Jerry Maguire）這句台詞告訴各位商業合作夥伴，他們能最能夠表達重視你或你的貢獻的最佳方式，就是付錢給你。「我要給他一個無法拒絕的條件。」（I’m gonna make him an offer he can’t refuse.）——《教父》（The Godfather）沒有甚麼比引用黑手黨的話，更能說明你對進行中的商業交易的認真程度。Cat got your tongue一時語塞barking up the wrong tree採取錯誤的行動或選錯人說話【好評推薦】「這本好書不只清楚定義許多企業界使用的商業詞彙與片語，而且也將片語的起源用有趣也具豐富知識性的方式呈現。我覺得這是學習商務行話（與跟著大笑）

A star-studded cast of authors including Pamela Butchart, Hannah Gold and Adam Kay deliver twelve brand new stories inspired by the great Roald Dahl's incredible characters in this Christmas collection that will delight readers 8-12.Why is Matilda worried about being on the naughty list?What happens when years after the creation of his original marvellous medicine George's granddaughter Gigi decides to make her own potion? And how does Charlie plan to celebrate Christmas at the chocolate factory?A magical and hilarious collection from 13 bestselling, much-loved storytellers. Perfect for Christmas Eve, this collection features 12 brand-new short stories based on their author's favourite Roald Dahl characters.Discover George's Marvellous Medicine as told by bestseller, Adam Kay. Laugh yourself silly with Greg James and Chris Smith's take on The Twits.Dive into Hannah Gold's The Fantastic Mr Fox and celebrate Konnie Huq's Danny the Champion of the World.Plus discover stories from:Nadia Sh

Celebrate twenty years of the modern classic The Gruffalo's Child with this special anniversary edition of the story, featuring a shiny cover and bonus extra material.Join in the birthday fun with this special 20th anniversary edition of The Gruffalo's Child, featuring a shiny cover and special bonus content to enjoy!Adventure back into the deep dark snowy wood, and discover what happens when a curious and brave Gruffalo's Child goes out in search for the Big Bad Mouse! Celebrate the Gruffalo's child's birthday with bonus content to make headbands to look like the characters and sing The Gruffalo's Child Song. The Gruffalo's Child 20th Anniversary Edition is a brilliant addition to the bookshelves of all Julia Donaldson and Axel Scheffler fans.Julia Donaldson and Axel Scheffler's The Gruffalo's Child is an undisputed modern classic and has become a bestselling phenomenon around the world. Just like the Gruffalo, this brilliant rhyming story of a mouse and a monster has found its way in

獾先生Pete正準備享用水果大餐，卻被一隻小小的蒼蠅打擾。接著整片森林的動物都忍無可忍，一起把所有蟲子都趕走！看似安靜清爽，卻換來更大的麻煩……Emily Gravett 再次用詼諧韻文與細膩插圖，帶出自然界中每個生物的角色缺一不可。《Bothered by Bugs》在歡笑中傳遞生態平衡的重要，是一本富含觀察力與環保意識的共讀繪本。Another brilliant Pete the Badger story from the inimitable Emily Gravett: plenty of laughs and an important environmental message.A very funny picture book story in which Pete the Badger, star of Emily Gravett's award-winning books Tidy and Too Much Stuff!, learns valuable lessons about the importance of all creatures, big and small, in maintaining the harmony of nature.In Bothered By Bugs, Pete the Badger is choosing a delicious recipe from his new fruit cookbook when his peace is interrupted by a teeny tiny fly. The fly becomes a swarm and soon all the animals are being bothered by bugs and insects of all kinds – so they help Pete rid the forest of/capture every single one. But . . . disaster! Now nobody's around to clean up the poo, and come autumn, there's not a berry or a cherry to be found. Will Pete and the other

活在當下，才是最積極的態度。從今年開始，念念新生，步步高陞！◆ 量大福大，隨遇而安。◆ 一念之間，平安幸福。2025年法鼓山桌暦《一念》，取景於農禪寺水月道場。天光雲影、晨昏四季，只要用心體會，每一個當下，都是最美的一念、最好的因緣。‧ 收錄聖嚴法師法語精選(中英對照) ‧ 實用標記佛菩薩聖誕、六齋日及農曆‧ 附2025、2026完整年曆【聖嚴法師法語摘錄】1月不管是成功或失敗，過去的已經過去了，從今年開始，是念念新生、步步高陞。Whether there is success or failure, the past is the past. From this year on, let us constantly renew our thinking and make progress with each step we take.3月當一個階段的任務達成後，就要有轉換下一階段跑道的心理準備，如此才能不斷地欣賞到一個接一個的人生好風光。Once the tasks in a phase have been completed, we should mentally prepare ourselves to move onto the next stage. This enables us to continue to appreciate the beautiful scenes of life, one after another.12月很多的人經常期待著貴人相助，但是沒有想到自己就是其他的人的貴人，自己就可以付出溫度和熱度來幫助人！Many people often expect a benefactor to help them, but hardly ever reflect on how they can be a benefactor to others, by giving of their warmth and enthusiasm to help people.

重返奈落學院，進入《星期三》影集第一季的詭異與精彩世界！本書由暢銷作家改編Netflix熱門影集，以小說形式重新詮釋這段充滿懸疑與超自然的故事。擁有通靈能力的星期三・亞當絲不情願地來到專為局外人設立的奈落學院，立下三大禁令：不交朋友、不接受心理治療、不輸給怪物。但一場同學死亡的異象，將她捲入一樁塵封25年的恐怖謎案。充滿哥德風格與黑色幽默，這部小說帶你進入星期三的陰鬱世界，探索陰影下的真相──如果你敢的話。Return to the hallowed halls of Nevermore Academy in this spooky and spectacular novel reimagining season one of the hit Netflix show, Wednesday!Emerging psychic Wednesday Addams begrudgingly arrives at Nevermore Academy, a school for outcasts, with just a few things on her do-not list:Do not make new friendsDo not attend court-ordered therapyDo not lose to the monsterSoon after enrolling, unexpected visions of a classmate’s very real death has her on the case of solving a 25-year-old mystery involving a supernatural terror. So get ready to plunge into the curious mind of Wednesday in [bestselling and award winning author]’s dark and twisted retelling of the Netflix phenomenon’s first season . . . if you dare.

From New York Times bestselling author Elin Hilderbrand, comes a novel about the many ways family can fill our lives with love...if they don't kill us first. *New York Times bestseller*It's Nantucket wedding season, also known as summer-the sight of a bride racing down Main Street is as common as the sun setting at Madaket Beach. The Otis-Winbury wedding promises to be an event to remember: the groom's wealthy parents have spared no expense to host a lavish ceremony at their oceanfront estate.But it's going to be memorable for all the wrong reasons after tragedy strikes: a body is discovered in Nantucket Harbor just hours before the ceremony-and everyone in the wedding party is suddenly a suspect. As Chief of Police Ed Kapenash interviews the bride, the groom, the groom's famous mystery-novelist mother, and even a member of his own family, he discovers that every wedding is a minefield-and no couple is perfect. Featuring beloved characters from The Castaways, Beautiful Day, and A Summe

Getting the kids to school on time can be filled with hurdles – Rebecca Cobb perfectly captures the epic adventure it can be in A Wild Walk to School, a witty story full of imagination!From the Waterstones prize-winner and best-selling illustrator of The Paper Dolls by Julia Donaldson. It's time to walk to school and mum wants the children to get there on time. But what Mum doesn't realise is that the hill is in fact the tummy of a sleeping giant and it's important to tread carefully when the floor turns to lava! It's just as well Mum has these two Brave Explorers with her .. . A charming, relatable and beautifully illustrated story that's full of fun: recognisable to children and their grown-ups everywhere!

《另一個山谷》是一部融合文學與科幻元素的小說，故事發生在一個與自己過去與未來相鄰的小鎮。16歲的奧蒂是一位安靜、內向的女孩，努力爭取進入決策委員會，負責審核誰能穿越邊界。這座山谷的東邊是二十年後，西邊則是二十年前。當她意外發現一對來自未來的訪客是她朋友艾德梅的父母，並得知艾德梅即將死亡後，她被迫在守護時序與真摯情感之間做出選擇。這是一部關於命運、選擇與時間的細膩小說，溫柔動人，令人深思。For fans of David Mitchell, Ruth Ozeki, and Kazuo Ishiguro, an elegant and exhilarating literary speculative novel about an isolated town neighbored by its own past and future, and a young girl who spots two elderly visitors from across the border: the grieving parents of the boy she loves. Sixteen-year-old Odile is an awkward, quiet girl vying for a coveted seat on the Conseil. If she earns the position, she'll decide who may cross her town's heavily guarded borders. On the other side, it's the same valley, the same town. Except to the east, the town is twenty years ahead in time. To the west, it's twenty years behind. The towns repeat in an endless sequence across the wilderness. When Odile recognizes two visitors she wasn't supposed to see, she realizes that the parents of her friend Edme ha

本書原題A Chinese Text in Central Asian Brahmi Script，副標題New Evidence for the Pronunciation of Late Middle Chinese and Khotanese，是由兩位著名學者──中古伊朗語專家恩莫瑞克和漢學家蒲立本發揮各自學術專長，共同撰寫的一部學術專著。本書的研究對象是兩片敦煌遺書殘卷（Ch.00120和P.5597，此二殘卷可以綴合）上的中亞婆羅米文字，其內容是以晚期于闐語音寫的鳩摩羅什譯漢文《金剛經》。兩位作者通過對婆羅米文與相應漢文的考察，歸納了不少晚期中古漢語和于闐語中的語音現象，提出了許多富有參考價值的推論。總而言之，本書是研究漢語音韻學和晚期于闐語的重要參考資料。（印度學與印度研究．譯叢Ⅲ）

From the New York Times bestselling author of The Power of Habit, an investigation of what makes conversations work, and how we can all learn to be supercommunicators at work and in our livesThe right conversation, at the right moment, can change everything.We all know people who seem capable of connecting with anyone. They are the ones we turn to for advice, who ask the best questions—but who are also able to hear what goes unsaid, what we are really trying to say.Why are these people so good at connecting? And what can they tell us about how communication works?Supercommunicators, Charles Duhigg argues, understand—some by intuition, some by hard-won experience—that there is a science to how human beings connect. They understand that every time we speak to someone, we’re actually engaging in one of three conversations: What is this really about? How do we feel? And, Who are we? They know the importance of identifying what kind of conversation we’re having, and then matching it, so tha

一個世界已然毀滅，全新的世界正在誕生， 至於我，則是知曉這個世界結局的唯一讀者── 懷著絕不放棄任何伙伴的信念， 我踏上了擁有拯救劉尚雅方法的轉生者之島， 同時，我也將在此完成我的「唯一神話」的轉之篇章。 然而當傳送到任務地區的我再次睜眼， 整個世界，已然面目全非。 克服了一個又一個星星直播的惡意考驗， 我與伙伴終於抵達神魔大戰的戰場， 非善非惡的金獨子集團， 卻立刻成了雙方陣營競相剷除的首要目標。 眼見無法調和的善惡矛盾越演越烈， 沉睡在地獄最深處的絕望，悄悄伸出了獠牙…… -- ※網書通路特裝版內含：  全知讀者視角09  全知讀者視角10  2024三角象牙桌曆｜Season’s Greetings ◇規格：14.8 × 18.5cm╱白雙鐵線圈╱220G象牙卡+水性光 ◇韓國知名繪者 BLACKBOX & 臺灣人氣繪者 老大 繪製  壓克力萬年曆｜偉大的謀略 ◇規格：14.5 × 20.5cm（整板）╱3mm壓克力╱雙面開版全彩+局部白墨 ◇韓國知名繪者 HABAN、몽몽 繪製  地鐵便條組｜首爾地鐵3號線 ◇規格：10.5 × 7.5cm（底卡）╱6款便條╱特殊軋型 ◇韓國知名繪者 Kim ZERO 繪製  珠光造型貼紙組｜Meme in the house ◇規格：6.5 × 6.5cm╱珠光貼紙+霧P+特殊軋型 ◇人氣繪者 大小喵 繪製  微薰香氛小卡組｜屬於你的氣息 ◇規格：7 × 7cm╱雙面彩印+精選香氛╱圓角 ◇韓國知名繪者 달리 繪製  角色臺詞收藏卡組｜三位角色經典臺詞 ◇規格：7 × 12cm╱350P銅西+燙金╱圓角 ◇韓國知名繪者HABAN繪製  質感包裝盒｜質感霧面厚磅包裝盒 ◇規格：23.6 × 33 × 6cm╱厚磅瓦楞+霧P ◇韓國知名繪者HABAN繪製  網書通路特典｜懲罰者（網書通路限定） ◇規格：21 × 14.8cm╱220P萊妮紙 ◇日本知名繪者 西 繪製 ◆《全知讀者視角》同名漫畫LINE WEBTOON熱血連載中！ ◆ 韓國讀者票選最佳網路小說第1名 ◆ 榮登TWITTER全球熱搜TOP 10 ◆ MUNPIA正式授權繁體中文版 ◆〈與神同行〉出品方電影改編預定 ◆ 遊戲＆電視劇＆動畫改編預定

'An acerbic, compelling and always accessible account of how opium corrupted the world' TLS'The writing is sublime, the research thorough, the eye for story superb' Sunday TelegraphWhen Amitav Ghosh began the research for his monumental cycle of novels the Ibis Trilogy, he was startled to find how the lives of the 19th century sailors and soldiers he wrote of were dictated not only by the currents of the Indian Ocean, but also by the precious commodity carried in enormous quantities on those currents: opium. Most surprising of all, however, was the discovery that his own identity and family history was swept up in the story.Smoke and Ashes is at once a travelogue, memoir and a history, drawing on decades of archival research. In it, Ghosh traces the transformative effect the opium trade had on Britain, India, and China, as well as the world at large.The trade was engineered by the British Empire, which exported Indian opium to sell to China and redress their great trade imbalance, and

Discover the natural and physical world, how our body works, the galaxies surrounding our planet, and the periodic table in this compact science box set.Pocket Genius Science Collection combines four visually striking titles: Science, Human Body, Space, and Elements, in one exquisite slipcase that takes kids aged 9-12 through the fascinating world of all things science! This boxset contains: Pocket Genius ScienceCovering the basic principles of science, including matter and materials, energy and forces, and the living world, what things are made of, how things move, and how life works. Pocket Genius Human BodyFocusing on bones and joints, blood and the heart, lungs and breathing, the digestive system, brain, nerves, senses, and the life cycle, this is a head-to-toe look at our body and how it works. Pocket Genius SpaceExploring the Big Dipper, Little Dipper and other constellations, as well as in-depth looks at Mercury, Venus, Earth, Mars, Saturn, Uranus, and Neptune and to the moons o