Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

This is the way we use the potty. Do you know what to do?Are you ready to take your nappy offand try the potty too?Get ready for your little one's next big step with this adorable slider book you can read together before you start potty-training. This rhyming story is perfect for reading aloud together with toddlers, building familiarity and confidence around using the potty, and introducing some fun ideas for all the family to try.Little ones will love to unroll the toilet paper, slide a nappy down and spin a wheel to change clothes after a little accident. For parents and carers, each page features short practical tips to help you and your child, consulted by Early Years expert Lizzie Noble.

Welcome toMiniTouch: On the Go! A gorgeous, giftable touch-and-feel book for little ones from birth upwards. Introduce vehicles and first words, and boost motor skills with sensory touch-and-feel fabrics.The MiniTouch series for babies aged 0–3 is packed full of developmental benefits. Fresh, stylish and playful with gently rhyming text, each book makes a beautiful addition to your child's playspace or bookshelf,forming an eye-catching collection.The content of each book covers core early learning concepts. There are two layers of learning: the first being topic-themed, such as vehicles, and the second being learning-based, such as first words. Theplayful rhyming text is perfect for engaging your childand will help develop their rhythm and rhyme as well as bringing added context to each new word.Each book in the series features a unique range of touch-and-feel areas, which are ideal for developing your child's motor skills as well as aiding sensory development. Fabrics such as corduroy

Trace the trails for search and find finger fun!Discover finger-tracing fun as you trace the trails and follow the shark through the busy under-the-sea pictures. There are peekaboo windows to peep through, and lots of splashing, snapping and swimming sea creatures to spot, too!Bright illustrations feature lots of detail to spot and words to say out loud, andaid development of first wordsand early reading.Perfect forsensory funandinteractive play.Helps to develop bothmotor and literacy skills.

Trace the trails for search and find finger fun!Discover search-and-find finger-tracing fun as you trace the trails and follow the tractor through the busy farmyard pictures!Each scene is full of lots of neighing, oinking, and baaing farm animals to spot, too!Bright illustrations feature lots of detail to spot and words to say out loud, and aid development of first words and early reading.There are tactile trails to follow, bumpy textures to find and feel, plus peep-through windows lead you through the pages as you follow that tractor and find out where it is going!The tactile trails, bumpy textures and peep-through holes are perfect for sensory fun and interactive play.

Trace the trails for search and find finger fun!Discover search-and-find finger-tracing fun as you trace the trails and follow the truck through the busy pictures!Each scene is full of lots of beeping, chugging and rumbling vehicles to spot, too!Bright illustrations feature lots of detail to spot and words to say out loud, and aid development of first words and early reading.There are tactile trails to follow, bumpy textures to find and feel, plus peep-through windows lead you through the pages as you follow that truck and find out where it is going!The tactile trails, bumpy textures and peep-through holes are perfect for sensory fun and interactive play.

Join in this popular nursery rhyme as you slide and play with this interactive board book!Sing along with your baby as you do the actions to Pat-a-Cake with this sturdy book that encourages language development. Use the Stories Aloud QR code to listen to the song and join in the words as you pull the sliders and spin the wheel. The perfect first introduction to this classic nursery rhyme. Other titles in the series: Here We Go Round the Mulberry Bush, Five Little Speckled Frog, Polly Put the Kettle On, Old MacDonald Had a Farm and Twinkle, Twinkle, Little Star, plus many more.

A stompingly good novelty book with hilarious animals and fun sliders!With simple rhyming text, things to push pull and spin, and brilliant illustrations from Guilerhem Karsten, children will love to copy the movements of these animals and join in the jungle fun.A fun way to develop a child's physical development and encourage them to explore the way their bodies move.Look out forAnimal Actions: Snap Like a Crabtoo!

Join the unicorns and their fairy friends as they fly over a rainbow, explore and enchanted forest and splash in a magical pond. Move the chunky sliders to reveal lots of little surprises. The eye-catching illustrations are designed for very young children, and the sliders, cut-outs and fingertrails are brilliant for developing essential early learning skills.

My Very First Britannica Encyclopedia 是一本為學齡前孩子設計的第一本百科全書。從地球到音樂、數字到食物，以最貼近孩子視角的方式，呈現世界的多樣與驚奇。語言簡潔、節奏感強，適合朗讀，圖像溫暖生動，幫助幼兒建立語彙與認知概念，是親子共讀、日常探索的最佳起點。The first-ever Britannica Encyclopedia for children under three, in a beautifully illustrated, large-format board book.My Very First Britannica Encyclopedia explores big ideas through a little one’s eyes. This huge board book covers an enthralling spectrum of topics: Earth, Animals, Plants, Food, Machines, Art, Music, Numbers and Shapes. The simple, clear and lyrical text includes plenty of sound words for an enjoyable reading-aloud experience, and is paired with gorgeous illustrations by Hanako Clulow. Reviewed by early-years specialist Dr Amanda Gummer, as well as a host of Britannica subject experts, this is the perfect book to inspire little brainiacs!Quotes/Reviews"Rocket fuel for cognitive development."-Wall Street JournalSelected for Waterstones Best Children's Books in October 2022 List"Just the right amount of information is included

Follow Little Bee as she buzzes from garden to greenhouse to desert, visiting all kinds of different blooms, each one as beautiful and fascinating as the next.Little Bee leaves her hive and flies out to discover the many beautiful and strange plants and flowers that bring color to the world. Buzz by dazzling tulips and floating water lilies but watch out for the snapping Venus flytraps!Packed with bright illustrations and creative wordplay, this chunky board book is designed to instill a love of nature from an early age, great for reading aloud yet perfect for bedtime, finishing with a peaceful nighttime scene. Written by an expert baby-book writer, using sound effects and simple phrases to engage babies with the pictures on the page, this series of board books has broad appeal to both Zommer fans and gift givers alike.

Find your baby’s face in this delightful new lift-the-flap book with a mirror on every page!One thing is for sure – babies love mirrors! This series of board books aims to enhance early mirror play as very young children will enjoy finding their own face on every page. Featuring large card flaps with friendly animals which are easy for even the littlest hands to grab, babies will enjoy reaching for these books again and again.Scan the QR code on the back cover to join in with the playful rhyming song based on the classic ‘Finger Family’ rhyme!Other books in the series include: Little Bear, Little Dog, Little Owl, Little Tiger, Little Lamb, Little Lion and Little Mouse

Sing along with Bluey and Bingo!Bluey and Bingo love to sing! They even make up fun songs for their games. Join them and sing along to The Wheels on the Bus, Ten Green Bottles and Poor Little Bug on the Wall, and other Bluey and Bingo tunes.Follow the tabs in this musical board book and start singing!More Bluey fun:Bluey: Love From BlueyBluey: PerfectBluey: What Games Should We Play?Bluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

Find your baby's face in this delightful new lift-the-flap book with a mirror on every page! One thing is for sure - babies love mirrors! This series of board books aims to enhance early mirror play as very young children will enjoy finding their own face on every page. Featuring large card flaps with friendly animals which are easy for even the littlest hands to grab, babies will enjoy reaching for these books again and again. Scan the QR code on the back cover to join in with the playful rhyming song based on the classic 'Finger Family' rhyme! Other books in the series include: Little Bear, Little Dog, Little Owl, Little Tiger, Little Lamb and Little Lion

An exciting new collection of board books for early years fun!A new collection of board books introducing early concepts and the world of Dr. Seuss, perfect for babies and toddlers!Flip the flap – what can you see? Full of Dr. Seuss’s craziest characters and wittiest rhymes, this collection of eight lift-the-flap board books is perfect for introducing early concepts to young readers.Bright, vibrant and with interactive flaps throughout, these books are brilliantly designed for babies and toddlers and offer a perfect first step into the wonderfully wacky world of Dr. Seuss.Includes:Silly OppositesAmazing AnimalsWacky WeatherDizzy DaysSpecial ShapesSuper SensesCrazy ColoursNutty Numbers

Find your baby's face in this delightful new lift-the-flap book with a mirror on every page! One thing is for sure - babies love mirrors! This series of board books aims to enhance early mirror play as very young children will enjoy finding their own face on every page. Featuring large card flaps with friendly animals which are easy for even the littlest hands to grab, babies will enjoy reaching for these books again and again. Scan the QR code on the back cover to join in with the playful rhyming song based on the classic 'Finger Family' rhyme! Other books in the series include: Little Bear, Little Dog, Little Owl, Little Tiger and Little Lamb

Learn why it rains with the help of The Very Hungry Caterpillar!In this nonfiction story, young readers can discover what rain is and why it falls. The miracles of nature come to life in this early-learning series centered around weather, featuring simple text and Eric Carle's classic illustrations!

Find your baby's face in this delightful new lift-the-flap book with a mirror on every page! One thing is for sure - babies love mirrors! This brand new series of board books aims to enhance early mirror play as very young children will enjoy finding their own face on every page. Featuring large card flaps with friendly animals which are easy for even the littlest hands to grab, babies will enjoy reaching for these books again and again. Scan the QR code on the back cover to join in with the playful rhyming song based on the classic 'Finger Family' rhyme! Other books in the series include: Little Bear, Little Dog, Little Tiger and Little Owl

Find your baby's face in this delightfully festive new title, the latest book in a lift-the-flap book series with a mirror on every page!One thing is for certain - babies love mirrors! This series of board books aims to enhance early mirror play as very young children will enjoy finding their own face in the five mirrors found inside. Each of the mirrors is hidden behind a large card flap, which is easy for even the littlest hands to grab and lift up. Will baby be behind little snowman, little elf, little Santa, little reindeer? Lift the flap to find out! Scan the QR code on the back cover to join in with the playful rhyming song based on the classic 'Finger Family' rhyme! Other books in the series include: Little Bear, Little Dog, Little Owl, Little Tiger, Little Lamb, Little Lion and Little Penguin.

Press the soft patches to hear the skeleton and its friends come to life in this hilarious Halloween treat.You'd better not tickle the skeleton... because it might just rattle if you do!Babies and toddlers just won't be able to resist tickling the touchy-feely patches to hear each creature make a sound in this hilarious novelty book. At the end, readers will find all the characters gathered together for a spooktastic Halloween dance. An exciting series for babies and toddlers, from the creators of That's not my...Withover 20 books to discover in this award-winning series, there is a book to excite every baby and toddler; including dinosaurs, bears, tigers, unicorns and lots more - giggles are guaranteed!Every DON'T TICKLE book supports sensory development with:- Engaging characters to encourage playfulness- Furry patches for developing motor skills- Playful music to inspire movement- Holes to peep through, sparking curiosity- Rhythmic text for developing language

Get ready for bed in this big board format with three games to play on every page!Pip and Posy are going to bed. They need to have a snack, brush their teeth and have a wash before it's time to read a bedtime story. This chunky board book is the perfect way to make the bedtime routine fun, with 36 sliders and three games to play but none of the mess of a card game!Designed to aid a chil'd's memory and language development, with simple labels to build vocabulary and lots of things to spot.Other titles to collect: The Super Seasons

This is the way we brush our teeth.Do you know what to do?First open up the cupboard.Now which brush belongs to you?Get ready to brush your teeth in this adorable slider book, full of gentle messages to help little ones with their daily routines.This rhyming story is perfect for reading aloud together with toddlers, building familiarity and confidence about tooth-brushing, and introducing some fun ideas for all the family to try. Little ones will love to slide the toothbrush from side to side, turn the wheel to make water come out of the tap and lift a flap to see teddy brush his teeth.For parents and carers, each page features short practical tips to help you and your child, consulted by Early Years expert Lizzie Noble.

You'd better not tickle the dolphin... because it might just squeak if you do!Babies and toddlers just won't be able to resist tickling the touchy-feely patches to hear each sea animal make a sound in this hilarious novelty book. At the end, readers will find all the sea creatures being noisy at once in a musical finale guaranteed to get little ones dancing along.An exciting new series for babies and toddlers, from the creators of That's not my... With over 20 books to discover in this award-winning series, there is a book to excite every baby and toddler; including dinosaurs, bears, tigers, unicorns and lots more - giggles are guaranteed! Every DON'T TICKLE book supports sensory development with:- Engaging characters to encourage playfulness - Furry patches for developing motor skills- Playful music to inspire movement- Holes to peep through, sparking curiosity - Rhythmic text for developing language

A BIG book for sharing with a little person, introducing things that go, first words, colours, numbers and more – with felt flaps and a mirror!With bright, stylish artwork from Ingela P Arrhenius, illustrator of the internationally bestselling Felt Flaps and Peekaboo series, this BIG vehicle-themed playbook is perfect for sharing with older babies and toddlers. How many cars can you count? What colour is the fire engine? What noise does the train make? And finally, where are you?A brilliant large-format board book introducing early-learning first concepts and encouraging interactive play, with 10 soft felt flaps, tactile die-cuts on every page and a surprise mirror ending.Other titles available in the series:My BIG PlaybookMy BIG Playbook: FarmMy BIG Playbook: Nature

Follow Little Robin on a flight from the city to the jungle, visiting ten different kinds of birds from around the world.Little Robin wakes up early and flies away from the nest on an adventure, meeting over ten species of birds from all over the world, from garden sparrows to city magpies, soaring bald eagles to flightless kiwis. Little Robin’s Book of Birds is a delightful, colorful treat, ending with a quiet nighttime scene perfect for winding down at bedtime.This reimagining of the author’s bestselling The Big Book of Birds is designed to instill an early love and curiosity for the natural world and its wonderous wildlife. Packed with sound effects and simple phrases to engage babies with Yuval Zommer’s gorgeous illustrations, this chunky board book is perfect for Zommer fans and any child who loves the sound of birdsong.

和小貓一起出發環遊世界，猜猜牠會去哪裡旅行呢？這本可重複使用的魔法水畫書，操作簡單，只要加水就能讓隱藏的圖案和色彩一一浮現。書中有七幅生動場景，畫面乾了還能再玩，適合孩子透過輕鬆的塗畫體驗，發現旅行的驚喜與樂趣。Help Cat get ready for a holiday adventure in this 100% reusable and 100% fun magic water painting book!Join Cat on a holiday adventure around the world. But which countries does Cat visit? Simply pick up the brush pen, paint the magical pages with water, and find out!To bring the seven adorable pictures to life, just add water to the magic painting pen and paint over the white spaces on each right-hand page. You'll gaze with wonder as colour magically appears with each brush of the pen and hidden pictures are revealed.With pictures to discover in every scene, children can colour in the pictures with the magic painting pen included in this book. Using the book is super-simple. Just unscrew the pen tip, add water, then screw back on, and your pen is ready to use! The book is 100% reusable too, with specially designed pages that can be used again and again.Once the water dries on eac

A funny flip-the-flap book from the classic world of Dr. Seuss, perfect for babies and young children!An introduction to a variety of shapes and the world of Dr. Seuss, perfect for babies and toddlers!Flip the flap – what can you see? Full of Dr. Seuss’s craziest characters and wittiest rhymes, this brilliant board book explores a variety of shapes.Bright, vibrant and with interactive flaps throughout, the Flip-the-Flap books are brilliantly designed for introducing early concepts to babies and toddlers and offer a perfect first step into the wonderfully wacky world of Dr. Seuss.

A funny flip-the-flap book from the classic world of Dr. Seuss, perfect for babies and young children!An introduction to crazy colours and the world of Dr. Seuss, perfect for babies and toddlers!Flip the flap – what can you see? Full of Dr. Seuss’s craziest characters and wittiest rhymes, this brilliant board book explores a range of colours.Bright, vibrant and with interactive flaps throughout, the Flip-the-Flap books are brilliantly designed for introducing early concepts to babies and toddlers and offer a perfect first step into the wonderfully wacky world of Dr. Seuss.

A funny flip-the-flap book from the classic world of Dr. Seuss, perfect for babies and young children!An introduction to numbers and the world of Dr. Seuss, perfect for babies and toddlers!Flip the flap – what can you see? Full of Dr. Seuss’s craziest characters and wittiest rhymes, this brilliant board book explores numbers from 1 to 10!Bright, vibrant and with interactive flaps throughout, the Flip-the-Flap books are brilliantly designed for introducing early concepts to babies and toddlers and offer a perfect first step into the wonderfully wacky world of Dr. Seuss.

A funny flip-the-flap book for babies and young children, from the world of classic Dr. Seuss!An introduction to a variety of senses and the world of Dr. Seuss, perfect for babies and toddlers!Flip the flap – what can you see? Full of Dr. Seuss’s craziest characters and wittiest rhymes, this brilliant board book explores the world of the senses.Bright, vibrant and with interactive flaps throughout, the Flip-the-Flap books are brilliantly designed for introducing early concepts to babies and toddlers and offer a perfect first step into the wonderfully wacky world of Dr. Seuss.

A BIG nature book for sharing with a little person, introducing first words, colours, numbers, shapes, opposites and more - with felt flaps and a mirror!With bright, stylish artwork from Ingela P Arrhenius, illustrator of the internationally bestselling Felt Flaps and Peekaboo series, this BIG nature-themed playbook is perfect for sharing with older babies and toddlers. How many acorns can you count? What colour is the ladybird? What noise do the birds make? And finally, where are you?A brilliant large-format board book introducing early-learning first concepts and encouraging interactive play, with 10 soft felt flaps, tactile die-cuts on every page and a surprise mirror ending. Other titles available in the series: My BIG Playbook, My BIG Playbook: Farm

A BIG book for sharing with a little person, introducing first words, colours, numbers, farm animals and more - with felt flaps and a mirror!With bright, stylish artwork from Ingela P Arrhenius, illustrator of the internationally bestselling Felt Flaps and Peekaboo series, this BIG farm-themed playbook is perfect for sharing with older babies and toddlers. How many sheep can you count? What colour are the tomatoes? What noise do the farm animals make? And finally, where are you?A brilliant large-format board book introducing early-learning first concepts and encouraging interactive play, with 10 soft felt flaps, tactile die-cuts on every page and a surprise mirror ending. Other titles available in the series: My BIG Playbook

A beautifully illustrated series that grows with your baby.Baby's First Stories presents a unique blend of read-aloud stories and high-contrast visuals, featuring an adorable elephant, panda, whale and bunny. Each story has been created in consultation with Early Years Expert Lizzie Noble, to perfectly suit your baby's needs at every stage in their first year.9-12 months prompts older babies to interact with the book, tickling panda's tummy and looking for details in the artwork to reflect your baby's ability to spot fine details and respond to basic questions. Jane Foster's black-and-white artwork features bold pops of blue, red and yellow, including hidden details - reflecting your baby's sharpening eyesight.Neither too long, nor too short, each story will easily fit into baby's day, to make reading together a regular activity. Beautifully illustrated by award-winning textile designer Jane Foster, and written by picture book rising-star, Lily Murray.

Stretch your wings--and your knowledge--with this bird-themed addition to the bestselling Abrams Block Book series From the tiny bee hummingbird to the giant condor and every-wing in between, no fowl is left behind in this fabulous addition to the acclaimed Abrams Block Book series! In this small but sturdy block-shaped board book, young readers are introduced to an incredible array of birds. Follow our young protagonists and their avian-expert grandfather as they explore what makes birds amazing--from the nests of bald eagles to the swift running speed of an ostrich. Around 96 million people in the United States--more than a third of the population--are avid birdwatchers. This book will be a hit with the youngest readers who have jumped on the birding bandwagon! Like other books in the Block Book series, Birdblock features die-cut pages to peek through as well as durable, interactive gatefolds perfect for curious hands. Illustrated in Peski Studio's bright, graphic style, this is a mu

Who doesn't love a ladybug? Maisy explores these helpful little critters in the seventh adventure of the Maisy's Planet series. Join Maisy as she learns all about ladybugs! This cheerful board book introduces little ones to the colorful insects (look, one has landed on Maisy's nose!) and lightly traces their life cycle and what they need to survive (did you know they eat plant-invading aphids?). Maisy is happy to help the ladybug population along by watering her garden and building a tiny house out of pine cones and sticks for ladybugs to discover and stay safe in during the wintertime. A final fold-out surprise invites readers to join in a ladybug-counting party outside--how many can you see?

Hop along with Maisy as she discovers fascinating facts about frogs and toads in this eighth Maisy's Planet adventure. Frogs are fantastic! Every toddler who has been up close and personal with one of these big-eyed amphibians--as well as those not so sure about the bumpy green guys--will be intrigued by this fun introduction to frogs and toads with Maisy leading the way. Young children can find out about everything from tadpoles to lily-pad-leapfrogging in a gentle learning experience, then open out the final inviting scene as Maisy and friends make a frog-friendly pond in her backyard.

The Ancient Roman world is brought to life with carefully researched and meticulously illustrated scenes. Flaps animate the action and reveal fascinating hidden details. Simply turn the pages to visit the Roman Forum, stroll the streets of Ancient Rome, attend a party in a villa, spend a day at the Roman baths, watch gladiators in action at the Colosseum, and so much more.

A fascinating flap book about the biggest, fastest, strongest, deadliest, brightest, loudest and scariest animals in the worldThe ultimate gift for animal-obsessed kids who want to know, definitively, which creatures are THE most extreme in all sorts of categories. What's the fastest and slowest animal? How about the fastest and slowest on land, or at sea, or in the air? What has the brightest glow, or the most powerful bite? What do they look like, and what else can these amazing animals do? Lift flaps to find all the answers.

在 The Pigeon Won’t Count to 10! 中，Pigeon 又一次展現了牠的倔強與幽默：牠不想數數，因為理由很多──不想、已經做過、還有其他更重要的事！Mo Willems 以輕鬆的文字和充滿表情的插圖，創造出孩子熟悉又爆笑的情境。這本硬頁繪本不只是故事，還在頁面中加入觸摸與描線數字的設計，讓孩子在互動中認識 1 到 10。書的形式簡單卻巧妙，把概念學習和閱讀樂趣結合。這是 Pigeon 系列的新篇章，也是一部非常適合親子共讀的數數入門書。A counting adventure you WON'T want to miss, from bestselling and award-winning author Mo Willems. The Pigeon won't count to ten, and here's why: Reasonably reasonable reason #1: He doesn't want to! Practically perfect reason #2: He already did a bunch of counting yesterday! And perfectly obvious reason #3: He has THINGS to do! Also, counting is for the birds! Do YOU think The Pigeon will count to ten? (Don't count on it!) From #1 New York Times bestselling author Mo Willems comes this funny and engaging numbers and counting early-learning concept board book with touch and trace numbers and art throughout. The Pigeon Won't Count to 10! is the first in a collection of original Pigeon board books and is a perfect addition for babies and toddlers to The Pigeon

A wonderful interactive insight into castle life.Visit a stunning stone castle and be transported back in time in this carefully curated flap book. With highly detailed illustrations, entertaining, informative text and over 50 flaps to lift, readers can lower the drawbridge, explore the keep, indulge in a feast, compete in a joust and witness a castle siege.

Mouse needs to catch Gorilla - and quick! - in this zany story that's perfect for car-crazy babies and toddlers. Follow Mouse on an epic mission to find Gorilla in this interactive adventure full of