Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

This collection offers a cross-disciplinary exploration of the ways in which multilingual practices were embedded in early modern European literary culture, opening up a dynamic dialogue between contemporary multilingual practices and scholarly work on early modern history and literature.The eleven chapters draw on translation studies, literary history, transnational literatures, and contemporary sociolinguistic research to explore how multilingual practices manifested themselves across different social, cultural and institutional spaces. The exploration of a diverse range of contexts allows for the opportunity to engage with questions around how individual practices shape national and transnational language practices and literatures, the impact of multilingual practices on identity formation, and their implications for creative innovations in bilingual and multilingual texts. Taken as a whole, the collection paves the way for future conversations on what early modern literary studies

Is art created with computers really art? This book answers 'yes.' Computers can generate visual art with unique aesthetic effects based on innovations in computer technology and a Postmodern naturalization of technology wherein technology becomes something we live in as well as use. The present study establishes these claims by looking at digital art's historical emergence from the 1960s to the start of the present century. Paul Crowther, using a philosophical approach to art history, considers the first steps towards digital graphics, their development in terms of three-dimensional abstraction and figuration, and then the complexities of their interactive formats.

This book provides an introduction into social science pedagogy in India. It delves into the interrelationships between society, social relationships, education and learning.Social science education in schools help build critical understanding of social processes and institutions. This book critically examines school spaces and approaches to social science teaching and pedagogy in modern Indian schools. It outlines distinguishing features, differences, and similarities in pedagogical models and also explains how these varied approaches can be applied in the teaching process. The book also addresses the challenges and possibilities of using technology and the experiences of using technology-based resources during the COVID-19 pandemic. Part of the series, 'Principles of Adaptive-based Teaching', this book will be of interest to students and teachers of education and sociology. It will also be of interest to teachers, educators, curriculum designers and social science course developers,

This collection reflects on the state-of-the-art of research into the use of translation technologies in the translation of creative texts, encompassing literary texts but also extending beyond to cultural texts, and charts their development and paths for further research.Bringing together perspectives from scholars across the discipline, the book considers recent trends and developments in technology that have spurred growing interest in the use of computer-aided translation (CAT) and machine translation (MT) tools in literary translation. Chapters examine the relationships between translators and these tools - the extent to which they already use such technologies, the challenges they face, and prevailing attitudes towards these tools - as well as the ethical implications of such technologies in translation practice. The volume lends special focus to drawing on examples with and beyond traditional literary genres to look to these technologies' use in working with the larger group of

John Locke is widely perceived as a foundational figure within the liberal tradition. This book investigates the competing purposes that informed Locke's political philosophy, not all of which resulted in outcomes consistent with what we today understand as "liberal" ideals. Locke himself was unaware that he belonged to a "liberal" tradition. Traditions only acquire meaning in retrospect. But many have perceived the development of Locke's political philosophy as involving a smooth evolution from "authoritarian" origins to "liberal" conclusions, beginning with Locke's Two Tracts on Government (1660-62) and culminating in his later political works, the Two Treatises of Government (1689) and A Letter Concerning Toleration (1689). This book advances an interpretation of this development which reveals how, by the time of his mature political writings, Locke sought to advance three competing imperatives within his political philosophy, only two of which were consistent with ideals of individ

This volume offers a systematic philosophical analysis of the normative challenges facing European refugee policy, focusing on whether the response to it can be based on European values. By considering the refugee policy through the lens of European values, cosmopolitan norms, and universal human rights, the contributions expose the weaknesses and limitations of existing regulations and make proposals on how to improve them. The EU is often seen as a cosmopolitan project. Europe is supposed to be a community of states that aspires to be guided by cosmopolitan norms. However, the idea of a cosmopolitan Europe has never been unanimously shared, and in recent years, it has come under increasing scrutiny, particularly with regards to the EU's refugee policy. The guiding idea of this book is that a deeper philosophical understanding of the normative issues at stake can foster greater conceptual clarity and enrich political debates on the future of European refugee policy. The first part of

The Routledge History of Loneliness takes a multidisciplinary approach to the history of a modern emotion, exploring its form and development across cultures from the seventeenth century to the present.Bringing together thirty scholars from disciplines including history, anthropology, philosophy, literature and art history, the volume considers how loneliness was represented in art and literature, conceptualised by philosophers and writers, and described by people in their personal narratives. It considers loneliness as a feeling so often defined in contrast to sociability and affective connections, particularly attending to loneliness in relation to the family, household and community. Acknowledging that loneliness is a relatively novel term in English, the book explores its precedents in ideas about solitude, melancholy and nostalgia, as well as how it might be considered in cross-cultural perspectives.With wide appeal to students and researchers in a variety of subjects including th

Originally published as a collection in 2006, this volume covers the Atlantic slave trade from its origins to 1600, the selection of essays here look at the reasons for the causes of slavery and serfdom; slavery in Africa; the development of the slave trade; the demographic situation in Latin America; and European attitudes to slavery as an institution. The volume also has an introduction by the editor commenting on the contribution each essay makes.

This book analyses the phenomenon of digitally mediated property and considers how it problematises the boundary between human and nonhuman actors. The book addresses the increasingly porous border between personhood and property in digitized settings and considers how the increased commodification of knowledge makes visible a rupture in the liberal concept of the property owning, free, person. Engaging with the latest work in posthumanist and new materialist theory, it shows, how property as a concept as well as a means for control, changes fundamentally under advanced capitalism.Such change is exemplified by the way in which data, as an object of commodification, is extracted from human activities yet is also directly used to affectively control - or nudge - humans. Taking up a range of human engagements with digital platforms and coded architectures, as well as the circulation of affects through practices of artificial intelligence that are employed to shape behaviour, the book argu

This book examines teaching practices in international education, focusing on two significant meanings of the notion of 'practice' the concrete activities used by university lecturers and the role of education as a platform for transferring particular skills or approaches. In addition to discussing techniques involved in programme design, curricular development, course activities, multicultural teamwork and examination, the author explores the idea of the lecturer as an actor communicating practices, considering the role and responsibility of academic staff in the development of successful international education. With attention to the importance of the context of internationalisation, the book draws on research from two major research projects, presenting extensive interview material with teaching staff engaged in international education and projects of internationalisation. Combining the approaches of 'pragmatism' and practice theory, as developed by Bourdieu and Schatzki, among othe

This accessible book explores the development of play skills and schemas to support children with learning differences and physical disabilities in learning to play.Each chapter looks at an aspect of play - from play therapy and sensory play, to LEGO, role play and digital play - and discusses how the approach can meet the needs of children in specialist settings, from those with sensory needs, to children with physical disabilities. The book introduces a myriad of different ways to use play and shares both evidence and anecdotes of the benefits to physical and mental health, as well as learning. Rich examples are given from special schools who have intentionally designed their schools to meet the play needs of their children and a range of adaptable resources are also provided, including policy documents and risk assessments ready to be taken away and used. Learning Through Play in Special Education will be essential reading for teachers working with children with additional needs and

Aimed firmly at the student reader, this handbook offers an overview of the full range of the history of France, from the origins of the concept of post-Roman 'Francia', through the emergence of a consolidated French monarchy, and the development of both nation-state and global empire into the modern era, forward to the current complexities of a modern Republic, integrated into the European Usnion and struggling with the global legacies of its past.Short, incisive contributions by a wide range of expert scholars offer both a spine of chronological overviews, and a diverse spectrum of up-to-date insights into areas of key interest to historians today. From the ravages of the Vikings to the role of gastronomy in the definition of French culture, from Caribbean slavery to the place of Algerians in present-day France, from the role of French queens in medieval diplomacy to the youth-culture explosion of the 1960s, and the explosions of France's nuclear-weapons programme, this handbook prov

The fourth edition of the Handbook of Educational Psychology, sponsored by Division 15 of the American Psychological Association, addresses new developments in educational psychology theory and research methods while honoring the legacy of the field's past. Comprised of thirty-one chapters written by a diverse group of recognized Educational Psychologist and/or Learning and Motivational Scientist (EDP/LMS) scholars, this volume provides integrative reviews and critical syntheses of inquiry across a variety of foundational and new areas. Key constructs like motivation, development, beliefs, literacy, and emotions are given substantive updates, while entire new chapters in touch on trends that have materialized since the publication of the third edition, such as inquiry world views, Critical Race Theory, cognitive neuroscience, and emerging technologies in education. Throughout this new edition, chapter authors coalesce on issues of social justice, situated approaches to inquiry, and pro

This book traces the development of audio description (AD), a form of audiovisual translation delivered orally or consumed aurally that makes visual elements accessible primarily to people who are visually impaired, and in particular, art AD as an emergent sub-genre.Perego reflects on the static arts and the role of modern museums as key sites for art AD and multisensory environments that create memorable experiences for visitors. Based on professional, pre-recorded British and American English AD scripts, this book outlines the textual and linguistic features of art AD and its most relevant textual patterns. It explores diverse AD practices across different contexts, including stand-alone ADs for specific paintings and sculptures that can be consumed independently to enhance the appeal and accessibility of cultural environments. Moreover, the book investigates AD tours, which provide descriptions of a selection of interconnected artworks while also assisting, through focused instructi

This collection bridges the voices of international scholars and adopted persons to share knowledge about clinical practice with adopted people in adolescence and early adulthood. Coming at a time when countries are beginning to focus on adoption reform, this handbook is the first to address not only the external, systemic contributions to their developmental complexities, but also the underlying, internal meanings of being adopted as children become adolescents and mature into adulthood. It explains how adopted clients differ from those not adopted and emphasizes the need for clinical research on adopted people in this older age group. Exploring how clinicians can understand their client's clinical needs, it offers specific protocols and frameworks for assessment and necessary modifications in language and treatment. With a foreword from Miriam Steele, chapters examine the legal and sociopolitical cultures, policies, and practices in which adoption is embedded, calling for broad syste

This book explores routes of interaction and exchange in the Southern Maya Area, a zone that had both short and long-distance trade and whose natural resources were exploited by merchants and rulers, colonists and entrepreneurs during Olmec, Teotihuacan, Maya, Aztec, colonial and modern times. The book presents the research of both archaeologists and art historians to identify routes of interconnection, to demonstrate the strategic importance of settlements and ritual locations, and assess the significance of modes and mediums of exchange. The contributors employ innovative approaches, making use of state-of-the art technologies to reproduce and analyze the archaeological landscape (e.g. LiDAR, GIS, and Least Cost Path Analysis) and to source and characterize archaeological materials (e.g. Neutron Activation Analysis (NAA), X-Ray Fluorescence analysis [XRF] and Strontium analysis). The book combines these innovative approaches with earlier data sources and past analyses to develop a ne

This timely book will explain, via a number of thematic and case studies, that international economics is not an independent terrain of economic activity reproducing itself throughout history, but a complex articulation of social, political and culturally determined actions that are inextricably linked. Chapters will address the role of dominant global powers in the making of global industrial and monetary relations, and, in particular, ways in which, and the degrees to which dominant economic and military powers, such as the USA, tend to shape the domestic economic environments of lesser powers after their own image. Supplementing the chapters will be a comprehensive A - Z glossary section, which will include key International Political Economy terms, e.g. international debt, European free trade area, International Bank for Reconstruction and Development, IMF, GATT-WTO, Foreign exchange, fixed exchange rates, floating exchange rates, reserve currency, gold-dollar parity, multinational