Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Designed as a textbook for a one or two-term introduction to mathematical statistics for students training to become data scientists, Foundations of Statistics for Data Scientists: With R and Python is an in-depth presentation of the topics in statistical science with which any data scientist should be familiar, including probability distributions, descriptive and inferential statistical methods, and linear modelling. The book assumes knowledge of basic calculus, so the presentation can focus on 'why it works' as well as 'how to do it.' Compared to traditional "mathematical statistics" textbooks, however, the book has less emphasis on probability theory and more emphasis on using software to implement statistical methods and to conduct simulations to illustrate key concepts. All statistical analyses in the book use R software, with an appendix showing the same analyses with Python.The book also introduces modern topics that do not normally appear in mathematical statistics texts but ar

The COVID-19 pandemic has affected the entire world in an unprecedented way and this book provides an overview of the historical facts as well as ongoing approaches to tackle the COVID-19 pandemic. Experts of the respective domains provide details on anti-SARS-COV-2 drug strategies, including repurposing drugs used for other indications and development of novel drugs looking at different approaches to target virus entry and replication. COVID-19 vaccine development based on inactivated and attenuated live virus, protein subunit and peptide-based vaccines and utilization of vaccine candidates based on viral vectors, DNA and RNA are presented for both preclinical studies and clinical trials.Key Features* Explains the background of the COVID-19 pandemic, the current progress in the development of treatments and prevention of COVID-19 including future aspects of dealing with pandemics. * Serves as a timely repository of knowledge on COVID-19 for researchers and medical professionals engage

Jazz Improvisation Using Simple Melodic Embellishment teaches fundamental concepts of jazz improvisation, highlighting the development of performance skills through embellishment techniques. Written with the college-level course in mind, this introductory textbook is both practical and comprehensive, ideal for the aspiring improviser, focused not on scales and chords but melodic embellishment. It assumes some basic theoretical knowledge and level of musicianship while introducing multiple techniques, mindful that improvisation is a learned skill as dependent on hard work and organized practice as it is on innate talent.This jargon-free textbook can be used in both self-guided study and as a course book, fortified by an array of interactive exercises and activities:musical examplesperformance exerciseswritten assignmentspractice gridsresources for advanced studyand more!Nearly all musical exercises-presented throughout the text in concert pitch and transposed in the appendices for E-fla

Surfactant research explores the forces responsible for surfactant assembly and the critical industrial, medical, and personal applications, including viscosity control, microelectronics, drug stabilization, drug delivery, cosmetics, enhanced oil recovery, and foods. Surfactant Science and Technology: Retrospects and Prospects, "a Festschrift in honor of Dr. Kash Mittal," provides a broad perspective with chapters contributed by leaders in the fields of surfactant-based physical, organic, and materials chemistries.Many of the authors participated in a special symposium in Melbourne, Australia, honoring Kash Mittal's 100th edited book at the 18th Surfactants in Solution (SIS) meeting. Each chapter provides an overview of a specific research area, with discussions on past, present, and future directions. The book is divided into six parts.Part I reviews the evolution of theoretical models for surfactant self-assembly, and introduces a model for interpreting ion-specific effects on aggreg

This book provides a significant contribution to the increasing conversation concerning the place of big data in education. Offering a multidisciplinary approach with a diversity of perspectives from international scholars and industry experts, chapter authors engage in both research- and industry-informed discussions and analyses on the place of big data in education, particularly as it pertains to large-scale and ongoing assessment practices moving into the digital space. This volume offers an innovative, practical, and international view of the future of current opportunities and challenges in education and the place of assessment in this context.

Sixty years after its birth, Synthetic Aperture Radar (SAR) evolved as a key player of earth observation, and it is continually upgraded by enhanced hardware functionality and improved overall performance in response to user requirements. The basic information gained by SAR includes the backscattering coefficient of targets, their phases (the truncated distance between SAR and its targets), and their polarization dependence. The spatiotemporal combination of the multiple data operated on the satellite or aircraft significantly increases its sensitivity to detect changes on earth, including temporal variations of the planet in amplitude and the interferometric change for monitoring disasters; deformations caused by earthquakes, volcanic activity, and landslides; environmental changes; ship detection; and so on.Earth-orbiting satellites with the appropriate sensors can detect environmental changes because of their large spatial coverage and availability. Imaging from Spaceborne and Airbo

This book is a comprehensive treatise on infective and inflammatory pathologies of the cornea with corresponding clinical images and diagrammatic illustrations. Corneal infections and inflammations are a major cause of ocular morbidity and visual impairment. Early diagnosis and treatment can lead to improved visual outcome and quality of life.Both infectious (bacterial, fungal, viral and protozoan) and non-infectious keratitis that cause corneal vascularisation, scarring and vision loss are covered extensively. The illustrated clinical findings presented in the form of diagrams, photographs, cases and videos aim to serve as a practical teaching tool for fellows, trainees and practising ophthalmologists. KEY FEATURESFocuses on clinically relevant parts of corneal diseases, using illustrations with arrows indicating different pathologies and signsServes as a ready clinical compendium for trainees, fellows and ophthalmologistsExplores various corneal pathologies through a wealth of accomp

Interoperability in IoT for Smart Systems discusses the different facets of interoperability issues among the IoT devices and their solutions, the scalability issues in an IoT network, and provides solutions for plug-n-play of new devices with the existing IoT system. It also addresses the possible usage of interoperable and plug-n-play IoT networks in different systems to make them smarter. Aimed at researchers and graduate students in computer science, computer engineering, computer networks, electronics engineering, this bookExclusively covers interoperability of IoT systems in parallel with their use towards the development of smart systems Discusses the requirements of interoperability in smart IoT systems and their solutions Reviews IoT applications in different smart and intelligent systems Explores dealing with interoperability of heterogeneous participating devices Provides different case studies and open problems related to interoperability in IoT systems

Recognised by the UN's Sustainable Development Goals as a measure to make cities inclusive, safe and resilient, conservation of natural and cultural heritage has become an increasingly important issue across the globe. The equity principle of sustainable development necessitates that citizens hold the right to participate in the cultural economy of a place, requiring that inhabitants and other stakeholders are consulted on processes of continuity or transformation. However, aspirations of cultural exchange do not translate in practice.Equity in Heritage Conservation takes the UNESCO World Heritage City of Ahmedabad, India, as the foundational investigation into the realities of cultural heritage conservation and management. It contextualises the question of heritage by citing places, projects and initiatives from other cities around the world to identify issues, processes and improvements. Through illustrated chapters it discusses the understanding of heritage in relation to the sustai