Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

In The Trinitarian Testimony of the Spirit, Kyle R. Hughes offers a new approach to the development of early Christian pneumatology by linking the Holy Spirit with testimony to the deity and lordship

The first book to discuss robust aspects of nonlinear regression—with applications using R softwareRobust Nonlinear Regression: with Applications using R covers a variety of theories and applica

9789571467443 小報亭 (精裝本)9781776572991 The Kiosk (精裝本)走吧！今天就抬起你的工作與生活，向天涯海角出發！ ★國際大獎動畫作品改編★★已售出英、德、瑞士與韓國等多國版權，繁體中文版本搶先全球上市★ ★4~8歲親子共讀，8歲以上自行閱讀 ◎無注音 【內容簡介】個性爽朗的奧爾嘉，已經在小報亭工作了很久、很久，事實上，她可能有一點「卡」在裡面了。 奧爾嘉偶爾會因為離不開小報亭而感到悲傷，這時候她會閱讀旅遊雜誌，夢想著遠方。 然而，一連串突如其來的事件，意外開啟了奧爾嘉的旅程…… ◎《小報亭》原作動畫電影：https://vimeo.com/258238541 【心動推薦】Emily│作家／插畫設計師黃大米│暢銷人氣作家螺螄拜恩│暢銷人氣作家（按姓氏筆畫排序） 【本書特色】★親子共讀之外，更是一本獻給大人的童話一本好書，能讓不同年齡的讀者感受到不同的層次。《小報亭》以它繽紛的色彩、搞笑的情節吸引住孩子的目光，然後沉浸在宛如漫畫式的分鏡和無所不在的亮點之中，目不暇給，重讀數遍也不厭倦。對成人讀者來說，本書除了視覺上的饗宴，也許還能對照我們自己的生活，是不是如奧爾嘉一般一成不變？也在心中隱隱盼望能夠在千里之外有另一種人生呢？ ★繪本 VS. 動畫，樂趣大不同先看過動畫短片的讀者，會驚訝於動畫重新創作成靜態插畫時，作者為了適應不同媒體所做的調整。像是頁面的配置，還有精彩情節的放大，故事被精煉成一頁頁的精華；而閱讀完繪本再欣賞動畫的讀者，則能將自己對畫面的原初想像，和活起來的畫面相比較，會有另一番趣味，同時也可以在動畫中享受到許多畫面之外的小細節。 ★打開一扇通往異國的窗「小報亭」這種街邊路旁的小雜貨店，對於便利商店極度密集的臺灣來說相當陌生。藉由繪本《小報亭》，我們可以一窺歐洲，特別是拉脫維亞首都──里加的生活樣貌與城市風情。IBBY Honour List 2020International Jānis Baltvilks Prize in Children’s Literature and Book Art 2019

When Baby speaks, people listen. Could Baby be president? Find out in this leadership-themed addition to the Future Baby series!The president is the leader of our country. Baby was born to lead!Does B

Sassy and Waldo are good dogs in the spotlight when their class puts on a school play!Sassy and Waldo love to have fun!Like when they put on their trench coat and everyone think they're a student name

Meet Rainbow Tinseltail and the unicorns of Sparklegrove Forest, in this magical series from the creator of the bestselling Owl Diaries series!Pick a book. Grow a Reader!This series is part of Scholas

Mac B. and his arch-nemesis are facing off at the Video Game World Championships! But first, Mac B. needs to crack an unbreakable secret code... can he solve it in time to defeat his enemy? Find out i

Blue the SilkWing is content. Life in his Hive is safe; he loves his family; he has enough to eat. And Pantala has been at peace for as long as he can remember -- SilkWings and HiveWings live and work

George's favourite thing in the entire world is DINOSAURS!All George and his friends want to do is play with dinosaurs.So, when Mummy Pig and Miss Rabbit take them to hunt for dinosaur fossils at the

The official art book for the animated movie Spies in Disguise.Super spy Lance Sterling (Will Smith) and scientist Walter Beckett (Tom Holland) are almost exact opposites. Lance is smooth, suave and d

From the legendary civil rights activist and author of the million-copy selling Warriors Don't Cry comes an ardent and profound childhood memoir of growing up while facing adversity in the Jim Crow So

Learning the importance of kindness is as easy as A-B-C with this sweet board book.A is for all of us be everyone’s friend.B is for believing things will turn out well in the end.C is for being caring

Find out about the life of Harriet Tubman and how her brave actions working to “conduct” the Underground Railroad helped the Union Army in the Civil War lead more than 700 slaves to freedom.Learn abou

The Politics of Higher Education: The Imperial University in Northern Song China uses the history of the Imperial University of the Northern Song to show the limits of the Song emperors’ powers. At th

STAEDTLER─Made in Germany 施德樓─對品質的堅持座落於Nuremberg 的企業總部，我們很驕傲的說，我們仍堅持在德國製造，那種對品質堅守承諾的傳統。相較於全世界各大品牌，紛紛以成本考量，寧願犧牲品質的現實考量，作為德國紐倫堡施德樓基金會的公司─"Made in Germany"是一種象徵著品質的使命與榮耀，我們有75％的產品，仍堅持著由這裡生產來發送全世界。品名：施德樓

“Will keep readers on edge from start to finish.” —Kirkus ReviewsTell the truth. Or face the consequences.Clue meets Riverdale in this page-turning thriller that exposes the lies five teens tell about

The mystery continues in book two of New York Times bestselling author Maureen Johnson’s Truly Devious series, as the young detective Stevie Bell races to discover the truth behind the Ellingham Acade

The second book in New York Times bestselling author and National Book Award finalist Eliot Schrefer’s Lost Rainforest series will thrill fans of Warriors and Spirit Animals with action and humor as t

全書包含35,000個單字與片語，新增110個新詞，並以3,000幅彩色插圖與清晰圖表提升理解力。字典內文設有色彩分明的字母索引，翻閱簡單；每個詞條皆提供定義、拼字提示與例句，協助孩子在寫作與口語表達上更準確。新版特別更新世界地圖、國旗與相關資訊，適合搭配課堂作業或自學使用，是一部兼顧內容廣度與學習樂趣的工具書。亮點：收錄35,000詞條，含新詞更新3,000張全彩插圖，圖文並茂提供拼字、標點與例句說明參考資料區含最新地圖與資訊ABOUT MERRIAM-WEBSTER CHILDREN’S DICTIONARY, NEW EDITIONWith more than 35,000 words–including 110 new words–and 3,000 full-color illustrations specially created by DK’s celebrated design team and Merriam-Webster’s renowned language experts.Updated for 2019, 20 years after it was first published, DK’s Merriam-Webster Children’s Dictionary remains a must-have project companion for use at home and in school. This book combines color-coded page borders for each letter of the alphabet with modern photography and crystal-clear diagrams to enhance the learning experience.Entries include a clear definition, notes on spelling and punctuation, and examples on how to use the word in a sentence. In the reference section, maps have been updated to include new countries, cities, borders,

This comprehensive book by renowned scholars Paul Nation and Rob Waring accessibly covers all aspects of extensive reading in second and foreign language contexts. The book serves as a major update to

Featuring in-depth discussions on tensile and compressive properties, shear properties, strength, hardness, environmental effects, and creep crack growth, "Mechanical Properties of Engineered Material

第50期 No. 50【卷首語】鄭政恆◆不可言說的言說【Special Feature 專輯：International Poetry Nights in Hong Kong 香港國際詩歌之夜】【本地創作】鄭潔明◆盧卓倫◆吳予文◆鄭詠詩◆千雲◆吳耀宗◆今文◆彭顯舜◆莊元生◆區聞海◆冬莉◆曾繁裕◆水盈◆吳見英◆劉安廉◆村正◆黃凱怡◆邱嘉榮◆曾魂◆麥敬暉◆洛楓◆蕭欣浩◆嚴瀚欽◆賴泓豪◆伍慧儀◆張朴◆夏

This groundbreaking volume critically examines how writers in Japanese-occupied northeast China negotiated political and artistic freedom while engaging their craft amidst an increasing atmosphere of

This is the first sea slug identification book specifically on Taiwan that has been published in English. It describes more than 400 species of sea slugs—from distinct orders such as Cephala^pidea, 9；

The Scythians were nomadic tribes and masters of mounted warfare, who flourished between 900 and 200 BCBarry Cunliffe here marshals this vast array of evidence - both archaeological and textual - in a

Mia goes up against a mighty robot in this sixth adventure of the Mia Mayhem chapter book series!Mia’s best friend, Eddie, has built an awesome robot that’s supposed to be a mighty cleaning machine! A

It’s 1978 in San Francisco, and the city is filled with music and art and protests for social justice – and the Gay Freedom Day Parade needs a new symbol. What happens when a group of friends take up

Many think of the United States Marine Corps as a second land army, and while it has been employed in that capacity, it is foremost a naval expeditionary force able to seize, secure, and defend advanc

I feel more attractive.Honestly, you are.It’s the star damage.I CRAVE STAR DAMAGE.Straight from the mind of New York Times bestselling author Nathan W. Pyle comes an adorable and profound universe in

Alex Honnold is one of the world''s best ‘free solo’ climbers. He scales impossible rock faces without ropes, pitons or any support of any kind. In Alone on the Wall, he takes you with him.‘Riveting’ - Jon Krakauer, bestselling author of Into the WildThis edition includes the account of Alex''s El Capitan climb, subject of the Oscar and BAFTA-winning documentary, Free Solo.Exhilarating, brilliant and dangerous, there is a purity to Alex''s climbs that is easy to comprehend, but also impossible to fathom. In the last forty years, only a handful of climbers have pushed themselves as far, ‘free soloing’ to the absolute limit of human capabilities.Half of them are dead.From Yosemite''s famous Half Dome to the terrifying heights of El Sendero Luminoso in Mexico, Alone on the Wall explores Alex''s seven most extraordinary climbing achievements so far. These are tales to make your palms sweat and your feet curl with vertigo. Together, they get to the heart of how – and why – Alex does what he

Peppa and George are in their very own frosty fairy tale!Once upon a time, it was a snowy day and Granny and Grandpa Pig had a surprise for Peppa and George - they were all going to Frosty Kingdom!The

嘉年華即將登場，Hotel Flamingo也準備加入這場繽紛盛會。安娜一邊迎接形形色色的動物旅客，一邊秘密接待超紅樂團「夜行動物」。風雨突襲、計畫失控，安娜能否同時守住音樂、友情與夢想？'Truly heartwarming and uplifting. I'd love to book a room there myself' Philip Ardagh'Hotel Flamingo is bursting with charm, friendship and fabulous characters!' Laura Ellen AndersonIt's the last of the autumn days before winter sets in, which means it's time for CARNIVAL! And Hotel Flamingo, the sunniest hotel in town, is all set to join the party. Animal Boulevard is a riot of colour, and every establishment is preparing a float for the annual procession. Anna is determined to win the prize for Hotel Flamingo for the best display, despite rival hotel the Glitz having won it every year since the Carnival began.Meanwhile Hotel Flamingo is welcoming its usual array of eclectic guests. Wilbur the sheepdog, who has no home, and needs a place to stay and someone to give him a chance at a new start. Mr and Mrs Kunkworth, a pair of skunks, who are rather anxious, and Mac Macaw the parrot, who is qu

From the mind of basketball legend, Academy Award–winning, and New York Times–bestselling storyteller Kobe Bryant comes a new tale of finding your strength against all odds.Set in an alternate classic

本書由知名藝術家兼教師 Sarah Simblet 編寫，透過實用的步驟教學與經典名作示範，帶領讀者從基本筆觸開始，練習形體、明暗與透視，進而觀察與描繪生活中的人事物。不論你是初學者，還是想重新拾起畫筆的愛好者，都能在書中找到靈感，慢慢建立屬於自己的繪畫節奏與視角。Develop your drawing skills and rediscover the world around you with this innovative and beautifully illustrated book.In Drawing for the Artist, acclaimed artist and teacher Sarah Simblet teaches you how to draw by combining practical lessons with examples of both her own work and some of the world's greatest drawings. She introduces all the key drawing materials, then shows you how to master the basic elements of drawing in a series of step-by-step drawing classes, covering topics ranging from simple mark-making to establishing form, creating tone, and conveying perspective.You will learn how to explore a wide variety of subjects, from still life, plants, and animals to portraits, the human body, landscapes, and buildings, all introduced with outstanding drawings by famous artists. The bestselling author of Anatomy for the Artist and Botany for the Artis

Pet is here to hunt a monster.Are you brave enough to look?There are no more monsters anymore, or so the children in the city of Lucille are taught. With doting parents and a best friend named Redempt

Maisy is throwing a Christmas party, and all her friends are invited. Open the envelopes to join in the festive fun with cards, an advent calendar, a gingerbread recipe and more! Maisy is throwing a Christmas party! When her friends R.S.V.P., they send other Christmas surprises including an advent calendar, decorations, a gingerbread recipe and more. Happy Christmas, everyone! This story includes six real envelopes containing Christmas cards, gifts, decorations and a special letter from Maisy to personalise.

Winner of the 2018 Caldecott MedalA girl is lost in a snowstorm. A wolf cub is lost, too. How will they find their way home?Pictures rich with feeling tell this satisfying story of friendship and trus

【得獎記錄】★榮獲芬蘭年度最美圖書獎The Most Beautiful Book of the Year in Finland★入選義大利波隆那國際童書插畫展The Bologna Illustrators Exhibition★入選芬蘭Grafia設計大賽．插畫組決選名單很久很久以前，世界上只有一個聖誕老公公......聖誕老公公會在聖誕夜那晚，親手把禮物送給每個小朋友，但是日子一天一天過去，

All's fair in love and anarchy...The epic conclusion to Marissa Meyer's thrilling Renegades Trilogy finds Nova and Adrian struggling to keep their secret identities concealed while the battle rages on

Soon to be a major Netflix film starring Alicia Vikander and Riley Keough, a haunting psychological thriller set in Tokyo probing deep into the mind of a murder suspectThe grisly headline leaves nothi