Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Cameron Boxer, king of the slackers, has found something worth his time. By playing video games online in front of an audience he can find both fame AND fortune -- especially with Elvis (a beaver who

A beautifully-illustrated story about a girl who longs for magic in her life and learns that, on the inside, she already is what she wishes she could be. Reminiscent of Studio Ghibli, this lushly-draw

《A Million Dots》從一棵樹、一顆點開始，每頁翻倍，直到滿頁的點點達成百萬之數。作者以圖像演繹數學概念，讓抽象的「倍數」變得具象而美麗。書頁間的變化不只是數字的增長，更是孩子對數與圖像關聯的直觀理解。這本書不需要艱深的公式，只需要一雙好奇的眼睛，就能體會數學的樂趣與壯觀，非常適合數學啟蒙與跨領域創作使用。Double the numbers from 1 to 1,000,000 in 40 pages. A stunning visualization of numbers big and small.Winner of the New York Times Top 10 Best Illustrated Children's Books of 2019.A book to promote interest in numbers and wonder at the scale they can represent, with lots to interrogate and talk about. -- School Library AssociationPotential goldmine of teaching ideas. -- School Reading ListDouble the numbers to go from 1 to 1,000,000 in 40 pages. A stunning visualization of numbers big and small.We start with a single tree; 1. As we turn the page, we are presented with a sum doubling the number on the page before it: 1+1 = 2; 2+2 = 4; 4+4 = 8. In this way, we reach a million (actually 1,048,576) within 44 pages.Each sum is brought to life with a simple graphic illustration in the distinctive style of Sven Völker. The dots form the

The story of The Hundreds and the precepts that made it an iconic streetwear brand by Bobby Hundreds himselfStreetwear exists in that rarefied space where genuine “cool” coexists with big business; wh

Elise Gravel wants to write a totally drab book; her characters want to let loose. Who’s gonna win?Don’t take the title as a metaphor: it really is the worst book ever. The winner of the Governor General Literary Award and children’s book author and illustrator Elise Gravel takes readers on an unexpected journey through the world’s most boring book in The Worst Book Ever. The characters and omniscient readers alike quickly become annoyed by the author’s bland imagination and rebel against her tired tropes and stale choices, spouting sass in an attempt to get her attention and steer the narrative in a more interesting direction. After all, you don’t even have to buy the book, but the characters? They’re stuck in there for an eternity, and they’re going to do their best to make the most of it, or at least have a little fun when they can.As the charming and bizarre true nature of the characters overpowers the dry attributes given to them by the author, this once blasé story quickly picks

"A true story of the woods, of the fae, and of the heart. Deep and green and wonderful.”—New York Times bestselling author Naomi NovikThere is a Wild Man who lives in the deep quiet of Greenhollow, an

In 2017, Myanmar’s military launched a campaign of violence against the Rohingya minority that UN experts later said amounted to a genocide. More than seven hundred thousand civilians fled to Banglade

* Which strategies and tactics are needed to develop and implement a Digital Business?* How do we work out where to put our investment?* What are the things that have to happen in an organisation to m

Whoever opens this book will unearth an amazing hoard of fun things to do outdoors, throughout summer - and the other seasons too. Whether you're in a garden or at the park, up a hill or by the sea, w

A fun, magical story, ideal for children practising their reading at home or in school. Manju wants to get a present for her Mum's birthday but Cumin her cat isn't sure about the toy elephant or robot

A delightful story based on the popular fairytale, ideal for children practising their reading at home or in school. Princess Imelda has come up with a way to escape from the boring old palace and see

Little children will love pressing the pages and hearing the zoo come to life with the ten realistic sounds in this charmingly illustrated book. From lions and elephants to monkeys and exotic birds, t

The English edition of Liu Lihong’s milestone work is a sublime beacon for the profession of Chinese medicine in the 21st century. Classical Chinese Medicine delivers a straightforward critique of the

夏日炎炎，火Hotel Flamingo迎來企鵝國王一家投宿皇家套房。女孩安娜和動物夥伴們齊心協力，卻面臨冰塊短缺的危機。她能否讓賓客滿意、飯店重拾光彩？'A total joy' PIERS TORDAY'Truly heartwarming and uplifting' PHILIP ARDAGH'Bursting with charm, friendship and fabulous characters!' LAURA ELLEN ANDERSONAn enchanting four-book series featuring the adventures of Anna and her array of animal friendsThe temperature is rising, which can only mean one thing: it's summer! Bookings are up at Hotel Flamingo and the hotel is getting busy. Anna is excited to receive word from King Penguin royalty asking to holiday in their Royal Suite. But there's a lot to get done, and it's not easy to manage the needs of the penguins when there's a heatwave on and a huge ice shortage. Help! Can Anna get Hotel Flamingo back to its usual shining self and have happy guests all round?

With lots to see in Busy Tractor, children can help out on the farm, pulling and turning the tabs. See the big tyres turn, drive the tractor through fields and harvest a crop of tasty vegetables!Child

Timothée de Fombelle and Isabelle Arsenault capture the heart-wrenching cost of war for one small girl in a delicately drawn, expertly told tale.While her father is at war, five-year-old Rosalie is a

From the Booker Prize-winning and Women's Prize-shortlisted author of The Silence of the Girls The first novel in Pat Barker's acclaimed 'Life Class' trilogy - an unforgettable story of art and war, f

A bestseller and winner of the IMPAC Dublin Literary Award, now in paperback from Graywolf Press for the first timeWe were going out stealing horses. That was what he said, standing at the door to the

With Fire and Fury, Michael Wolff defined the first phase of the Trump administration; now, in Siege, he has written an equally essential and explosive book about a presidency that is under fire from

Goku and friends battle intergalactic evil in the greatest action-adventure-fantasy-comedy-fighting series ever!Son Goku is the greatest hero on Earth. Five years after defeating the demon king Piccol

Frankie Sparks uses her inventing skills to help her friend overcome stage fright in this second chapter book in the STEM inspired Frankie Sparks, Third-Grade Inventor series.It’s time for the annual school talent show, and Frankie is excited to audition with her magic act! She wants to be just like her idol, Adelaide Herrmann, Queen of Magic. But on the day of the audition, Frankie’s best friend and Magician’s Assistant, Maya, gets a big, scary case of stage fright! How can Maya be Frankie’s helper on stage if she can’t bring herself to speak in front of their audience? It’s up to Frankie Sparks to invent just the perfect thing to help her best friend cope with the spotlight!

Drew Brockington, creator of the CatStronauts series, makes his picture book debut with a send-up of Godzilla movies that also tackles a relatable toddler topic: the crankiness that comes from an empty stomach! When a young lizard monster gets a hankering for his favorite hot dog spot, he takes the train all the way to the city--only to find that the place is closed for vacation. But when this little monster gets too hungry, he starts to get angry. And when he gets hangry, this poor city is at risk of a full-scale monster attack. As his rage swells, so does he, until he's the size of a skyscraper, and it falls to the citizens to find him some food--and fast! In a hilarious story about a hunger-induced tantrum, Drew Brockington uses speech bubbles and sight gags to bring a smile to the face of any little monster.

Book Two in the Magnificent Dune Chronicles—the Bestselling Science Fiction Adventure of All TimeDune Messiah continues the story of Paul Atreides, better known—and feared—as the man christened Muad’D

Book Four in the Magnificent Dune Chronicles—the Bestselling Science Fiction Adventure of All TimeMillennia have passed on Arrakis, and the once-desert planet is green with life. Leto Atreides, the so

Book Three in the Magnificent Dune Chronicles—the Bestselling Science Fiction Adventure of All TimeThe Children of Dune are twin siblings Leto and Ghanima Atreides, whose father, the Emperor Paul Muad

Part of the best-selling Little People, BIG DREAMS series, Wilma Rudolph tells the inspiring story of this remarkable sprinter.New in the critically acclaimed Little People, BIG DREAMS series, discove

Frank Herbert's Final Novel in the Magnificent Dune Chronicles—the Bestselling Science Fiction Adventure of All TimeThe desert planet Arrakis, called Dune, has been destroyed. The remnants of the Old

專為「基礎文法」沒學好、文法觀念薄弱的多益考生所設計。打好文法基礎，才能蓋起英文的萬丈高樓！對於多益目標600分但卻頻頻卡關的考生來說，有時最關鍵的一步是文法觀念薄弱不紮實，在PART 5「單句填空」沒有拿到該有的分數。市面上相關書籍多半偏難或只針對單一文法問題解說，頭痛醫頭，腳痛醫腳，考生讀起來成效有限，更難建立起完整全面的觀念。作者富岡惠老師在日本出版十餘本多益工具書，在《TOEIC L&am

Geronimo's adventures in a collectible slipcase!Join Geronimo as he embarks on a treasure hung, learns the secret of the Seven Wonders of the Ancient World, deals with an evil doppelganger, rescues his cousin from Transratarnia and more!本套書包含以下10本9780545835541 #61: Mouse House Hunter (Geronimo Stilton)9780545872515 #62: Mouse Overboard! (Geronimo Stilton)9780545872522 #63: The Cheese Experiment (Geronimo Stilton)9781338032871 #64: Magical Mission (Geronimo Stilton)9781338087758 #65: Bollywood Burglary (Geronimo Stilton)9781338087826 #66: Operation Secret Recipe (Geronimo Stilton)9781338159158 #67: The Chocolate Chase (Geronimo Stilton)9781338215199 #68: Cyber-thief Showdown (Geronimo Stilton)9781338215243 #69: Hug a Tree, Geronimo (Geronimo Stilton)9781338268539 #70: The Phantom Bandit (Geronimo Stilton)

Wilfred 和 Neville 是班上唯一不是小海豹的學生，格格不入的感覺讓他們彼此也不對盤。直到 Betty 白鯨加入，這位機靈又自信的新同學讓他們重新看見自己的價值。《Wilfred and Neville》是一則讓孩子理解差異與接納的溫暖故事，情節輕快，情感真摯，無論孩子是否覺得自己「特別」，這本書都能陪伴他們找到自信與友誼。This charming tale neatly tackles a number of situations that young readers will recognise and relate to. -- Ibby UKThis empowering, super-cute read is a must for all children, whether they feel like the odd-one-out or not. -- BookTrustThe story of a walrus and a narwhal, who, with the help of a beluga, discover that being different can be cool! Wilfred Walrus and Neville Narwhal are the only kids in Miss Blubber’s class who are not seals. Life is tough being the odd ones out - lunchtimes and football matches and school photos all present challenges to the two outliers. And they don’t even like each other very much!When Betty Beluga joins the class, everything changes. Betty is smart and independent and amazing at football. As a friendship forms, Betty helps the two boys to recognise that being different isn’t always a

The Second book in the OFFICIAL Minecraft fiction series for readers age 7+Morgan, Ash and friends are back for another adventure.Woodsword Middle has been infested by bats, bringing chaos and disorde

Sassy and Waldo are back! When Ms. Twohey announces that her class is going on a trip to the History Museum, Stewart is worried he's in for another long day of facts and learning. But nothing can be b

Shark lovers will enjoy hunting down the TRUTH about their favorite ocean predators in this innovative new Science Reader series.Baby sharks are toothless at first, right? That's a LIE! The TRUTH is,

車子怎麼跑起來的？油門踩下去後，裡面發生了什麼事？讀者將穿越汽車的發展歷史，從蒸汽車、內燃機，到電動車的崛起，一探汽車如何改變世界！這本圖像科普漫畫不僅拆解汽車構造，也揭開動力來源的祕密，像是汽油如何燃燒驅動活塞，或電池怎麼轉換成能量驅動馬達。知識點豐富，畫風生動，滿足讀者的好奇心！Every volume of Science Comics offers a complete introduction to a particular topic—dinosaurs, the solar system, robots, and more. Whether you're a fourth grader doing a natural science unit at school or a thirty year old with a secret passion for airplanes, these books are for you!In this Science Comics: Cars, you'll learn where cars came from and how they work. When you pop the hood, what are you looking at? How does gasoline—or electric batteries, or even steam—make a car move? Rev up your motor and take look at the combustible history of the automobile and its explosive effects on our modern lives.

What with his friend Bear’s snoring, and a BANG! BANG! BANG! noise from up in the tree, Rabbit knows that Something Simply Has To Be Done. But high in the branches, perhaps Bear can show Rabbit how to see the world from a different perspective. A story of friendship, wisdom, and how to be REALLY NOISY, this delightful and hilarious illustrated chapter book is another fun read for Rabbit & Bear fans.

The clothes don't make the bunny in this new picture book from New York Times-bestselling author Deborah Underwood, illustrated by T. L. McBeth.When Ogilvy moves to a new town, the possibilities feel

A definitive guide to the dress, weapons and accruements of the infantry elements of the most famous formation of the Napoleonic Wars.From its origins as the Consular Guard of the French Republic, and as Napoleon’s personal bodyguard, the Imperial Guard developed into a force of all arms numbering almost 100,000 men. Used by Napoleon as his principal tactical reserve, the Guard was engaged only sparingly, being deployed at the crucial moment of battle to turn the tide of victory in favor of the Emperor of the French.Naturally, the Imperial Guard has been the subject of numerous books over many decades, yet there has never been a publication that has investigated the uniforms and equipment of the infantry of the Imperial Guard in such detail and with such precision. The author has collected copies of almost all the surviving documents relating to the Guard, which includes a vast amount of material regarding the issuing of dress items, in some instances down to company level.This informa

WHY DO WE FIND SEXUALITY SO, WELL ... SCARY?Comedian Mae Martin investigates in this hilarious and intelligent guide to 21st century sexuality. Covering everything from the pros and cons of labels, to

A new board book for the youngest fans of Leo Lionni--inspired by his bestselling classics!Discover a world full of color in this delightful board book inspired by the works of legendary children's bo

When her mami meets someone new, Juana worries that everything will change in a humorous, heartwarming follow-up to the Pura Belpré Award–winning Juana & Lucas.Juana’s life is j