Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

New York City, 1972—A dabbler in mathematics and chess, Catherine Velis is also a computer expert for a Big Eight accounting firm. Before heading off to a new assignment in Algeria, Cat has her palm r

An unconventional vicar must exorcise the dark past of a remote village haunted by death and disappearances in this explosive and unsettling thriller from the acclaimed author of The Chalk Man. "Hypnotic and horrifying . . . Without doubt Tudor's best yet, The Burning Girls left me sleeping with the lights on."--Chris Whitaker, New York Times bestselling author of We Begin at the End A dark history lingers in Chapel Croft. Five hundred years ago, Protestant martyrs were betrayed--then burned. Thirty years ago, two teenage girls disappeared without a trace. And a few weeks ago, the vicar of the local parish hanged himself in the nave of the church. Reverend Jack Brooks, a single parent with a fourteen-year-old daughter and a heavy conscience, arrives in the village hoping for a fresh start. Instead, Jack finds a town rife with conspiracies and secrets, and is greeted with a strange welcome package: an exorcism kit and a note that warns, "But there is nothing covered up that will not be

★ 《紐約時報》暢銷作家Jennette McCurdy，萬眾矚目首部長篇小說！★ 席捲 2026 歐美文壇，最具爭議、最赤裸的「少女慾望」剖析。主角Waldo是一名17歲的少女。她飢渴、衝動、孤獨、充滿憤怒，卻也無比敏銳。她最渴望的目標，是她的寫作老師—柯基先生 (Mr. Korgy)。柯基先生是一個有妻小、有貸款、夢想早已萎縮、挺著小腹的中年男人。沃多不知道自己為何想要他。是因為他的熱情？人生經驗？還是因為他懂那些她不懂的書與電影？或者更單純：在所有人都無視她的世界裡，柯基先生是唯一「看見」她的人。如果你也曾在愛中迷失，如果你也曾為了被看見而付出昂貴代價，這本書寫給每一個受過傷、卻依然渴望著什麼的靈魂。From the #1 New York Times bestselling author of I'm Glad My Mom Died comes a sad, funny, thrilling novel about sex, consumerism, class, desire, loneliness, the internet, rage, intimacy, power, and the (oftentimes misguided) lengths we'll go to in order to get what we want.Waldo is ravenous. Horny. Blunt. Naive. Wise. Impulsive. Lonely. Angry. Forceful. Hurting. Perceptive. Endlessly wanting. And the thing she wants most of all: Mr. Korgy, her creative writing teacher with the wife and the kid and the mortgage and the growing paunch. She doesn't know why she wants him. Is it his passion? His life experience? The fact that he knows books and films and things that she doesn't? Or is it

The first book of the blockbuster trilogy is the basis for the buzzed-about Fox TV series, The Passage, set to premiere in January 2019.An epic and gripping tale of catastrophe and survival, The Passa

#1 NEW YORK TIMES BESTSELLER • “A thrilling finale to a trilogy that will stand as one of the great achievements in American fantasy fiction.”—Stephen King You followed The Passage. You faced The Twel

這是一部動人心弦、關於失去與重生的小說。約翰・哈丁原本擁有成功的事業、摯愛的妻子與可愛的兒子，卻在一連串打擊後失去一切，帶著絕望回到新罕布夏州的故鄉，甚至徘徊在自我毀滅的邊緣。就在此時，一位老朋友請他接手一支名為「天使隊」的小聯盟棒球隊。起初勉強答應的約翰，卻在與一名資質平平、卻神似亡子的孩子相處過程中，慢慢被觸動。透過球場上的陪伴、指導與信任，他重新面對傷痛，也重新理解愛與責任的意義。這段跨越創傷的友誼，為他帶來重生的力量，讓他再次看見生命值得堅持的理由。"A very special story about life and love and courage."MERLIN OLSEN, SPORTSCASTERJohn Harding had a high-powered career, a loving wife, and a beautiful son. He's lost it all and has returned to his home town of Boland, New Hampshire, teetering on the brink of suicide. But an old friend asks John to manage his old Little League team, the Angels. Reluctantly, he agrees, and meets a hopeless player who bears a striking resemblance to his dead son--and through their extroardinary relationship, John finds the wisdom in living that he thought had slipped beyond his grasp forever....An Alternate Selection of the Literary Guild

She was a beautiful doelike child, with an intense, graceful fragility. In her first year, she picked up words, smiled and laughed, and learned to walk. But then Anne-Marie began to turn inward. And w

Anatole Broyard，長年擔任《紐約時報》書評人、書評版編輯與隨筆作家，渴望被記住——而他確實做到了。這本隨筆集收錄多篇不羈、幽默又犀利的文章，書寫生命與死亡的種種考驗，其中許多篇章完成於他與癌症對抗、並於 1990 年辭世之前的歲月。本書收錄他晚年完成的隨筆，文字優雅、清醒而不煽情，被譽為直面生命極限的經典之作，是一部關於如何活著、也如何告別的深刻書寫。獲《紐約時報》年度注目好書Anatole Broyard, long-time book critic, book review editor, and essayist for the New York Times, wants to be remembered. He will be, with this collection of irreverent, humorous essays he wrote concerning the ordeals of life and death—many of which were written during the battle with cancer that led to his death in 1990. A New York Times Notable Book of the Year “A heartbreakingly eloquent and unsentimental meditation on mortality . . . Some writing is so rich and well-spoken that commentary is superfluous, even presumptuous. . . . Read this book, and celebrate a cultured spirit made fine, it seems, by the coldest of touches.”—Los Angeles Times“Succeeds brilliantly . . . Anatole Broyard has joined his father but not before leaving behind a legacy rich in wisdom about the written word and the

"Extraordinary. A brilliant, painful, and important book."THE NEW YORK TIMESIf there was any one man who articulated the anger, the struggle, and the beliefs of African Americans in the 1960s, that ma

THREE BOOKS IN ONE MEANS THREE TIMES THE FUN!Get ready for a triple dose of laughs with the world's funniest fat cat.Garfield's back in all his gut-busting glory: catching his tongue in the electric m

A TRIPLE DOSE OF LAUGHTER--COMPLIMENTS OF GARFIELD!Imagine three GARFIELD classic collections in one plump volume and you've got a veritable War and Pizza of feline fun. But what do you expect from th

The Dallas police chief who inspired a nation with his response to the killing of five of his officers shares his personal story and his faith in America’s potential to unite communities through

For fans of Craig Johnson and James Lee Burke—False Positive follows up the powerful punch of Andrew Grant’s novelRUN with a staggering second dose of thrills and suspense that is just as smart, atmos

In 1995, after receiving a tip from an informant that a new drug called Ecstasy was being pushed in Manhattan’s nightclubs, DEA agent Robert Gagne embarked on a mission to unravel one of the

CAN A LOVE BE LOST THAT WAS MEANT TO BE??A rising star in the modeling world, Margot Radcliffe hasn’t forgotten the hurt that sent her running from Rosewood, the beautiful Virginia horse farm where sh

Four women—friends, family, rivals—turn to online dating for companionship, only to find themselves in the crosshairs of a tech-savvy killer using an app to target his victims in this harr

NEW YORK TIMES BESTSELLER • In this sexy paranormal romance novel set in the world of the Black Dagger Brotherhood, #1 New York Times bestselling author J. R. Ward tells the story of two couples&

In #1 New York Times bestselling author J. R. Ward’s thrilling finale to her Bourbon Kings series, the Bradford family dynasty teeters on the edge of collapse after the murder of their patriarch

NEW YORK TIMES BESTSELLER • A scorching forbidden love threatens to tear a rift through the Black Dagger Brotherhood in J. R. Ward’s newest novel in the #1 New York Times bestselling series

In #1 New York Times bestselling author J. R. Ward’s thrilling finale of the Bourbon Kings series, the Bradford family dynasty teeters on the edge of collapse after the murder of their patriarch—and a

The Dallas police chief who inspired a nation with his compassionate, community-focused response to the killing of five of his officers shares his uplifting personal story and a blueprint for the futu

#1 New York Times bestselling author J. R. Ward returns with an all-new tale of paranormal passion in the world of the Black Dagger Brotherhood. The Black Dagger Brotherhood continues to train the b

A scorching, forbidden love threatens to tear a rift through the Black Dagger Brotherhood in this highly anticipated installment of J. R. Ward’s New York Times bestselling series.

“Do you remember that first time we met? It was in the old studio in Brunson Road. How much did we miss, love, by not being together?”?In the early 1960s, Maureen Griffiths, married with children, acc

In the fall of 1966, at a university in the Northeast, 350 students signed up for a psychological survey on personal development and happiness. In 1977, Susan Krauss Whitbourne, then a young psycholog

SUGAR BUSTERS!R forever changed the way Americans eat, offering a delicious new approach to diet and health. The SUGAR BUSTERS!R Shopper’s Guide soon followed–and made finding SUGAR BUSTERS!R-friendly

Do you ever really know your mother, your daughter, the people in your family? In this rich and rewarding new novel by the beloved bestselling author of Talk Before Sleep and The Pull of the Moon, a r

When the first Superman movie came out I was frequently asked 'What is a hero?'??I remember the glib response I repeated so many times.??My answer was that a hero is someone who commits a courageous a

"A MUST READ . . . This book [is] one of the best on that war in Korea. . . . A wonderful account of common, decent men in desperate action."--LeatherneckDuring the early, uncertain days of the Korean

New York City, 1972—A dabbler in mathematics and chess, Catherine Velis is also a computer expert for a Big Eight accounting firm. Before heading off to a new assignment in Algeria, Cat has her palm r

IT'S HARD TO BE HUMBLEWHEN YOU'RE SERVING WITH THE VERY BESTFor UDT/SEAL team member Gary R. Smith, just being part of an elite military organization wasn't enough--he had to be in the thick of the ac

"Hunter S. Thompson is to drug-addled, stream-of-consciousness, psycho-political black humor what Forrest Gump is to idiot savants."--The Philadelphia InquirerSince his 1972 trailblazing opus, Fear an

A woman trying to outrun her past is drawn to a coastal village in Maineand to a string of unsolved murdersin this novel of romance and psychological suspense from New York Times bestselling author Tess Gerritsen.';Suspenseful, sexy, and soulful.'J. R. Ward, bestselling author of the Black Dagger Brotherhood seriesAfter an unspeakable tragedy in Boston, Ava Collette flees to a remote village in Maine, where she rents an old house named Brodie's Watch.In that isolated seaside mansion, Ava finally feels at peace .. . until she glimpses the long-dead sea captain who still resides there.Rumor has it that Captain Jeremiah Brodie has haunted the house for more than a century.One night, Ava confronts the apparition, who feels all too real, and who welcomes her into his worldand into his arms. Even as Ava questions her own sanity, she eagerly looks forward to the captain's ghostly visits. But she soon learns that the house she loves comes with a terrible secret, a secret that those in the vill

The bestselling author of Dream Team tells the interconnected stories of the NBA champion Golden State Warriors and the early-1970s Los Angeles Lakers, two extraordinary teams playing in extraordinary

Open Wide . . . and Laugh! “Eat early and often”—that’s the credo of the furry fatso. Garfield fans who are gluttons for fun will want to indulge themselves in this meat

Mel, Sara, Annie, and Lola have traveled diverse paths since their years together at a small Southern liberal arts college during the early 1980s. Mel, a mystery writer living in New York, is grapplin

Early on an April morning, eighteen-year-old Billy Frank Gilley, Jr., killed his sleeping parents. Surprised in the act by his younger sister, Becky, he turned on her as well. Billy then climbed the s

In today’s uncertain economy, if using a little buying savvy can get you small- or even big-ticket items at a cheaper price, can you afford not to do it? Now, with this handy, accessible guide, Rick D

“Fans of the early Anita Blake books will love this series.”–Deborah Smith, New York Times bestselling author of A Gentle RainJack McShane: lover, killer, seducer, family man, and vampire. In the shad

“Terrifically intelligent, moving, and entertaining.”–The New York Sun“With snappy dialogue [and] intelligent prose . . . Begley paints a memorable portrait of lasting friendship and of the strength r