Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

《公主出任務》女力再出擊。傳說中的美人魚公主祈求黑衣公主保護她免受海怪襲擊。但海底世界並不利於黑衣公主行動，美人魚公主必須學習勇敢為自己發聲！There’s trouble under the sea! Can the Princess in Black and her new mermaid friend put a stop to a big blue kraken’s shenanigans?The Princess in Black and her friends are enjoying a day of sun and sea on Princess Sneezewort’s royal boat when a real, live mermaid princess emerges from the waves! Eeeeeee! Princess Posy needs their help protecting her very cute sea goats from being eaten by a very greedy kraken. But the princesses and the Goat Avenger quickly realize that fighting underwater can be tough for land dwellers, and only the mermaid Princess Posy can save the day. Can the masked heroes help her learn that being a princess means more than just being nice―it means speaking up? An ode to using your voice (along with a kelp-tree swing or two), this newest installment in the New York Times best-selling series is a splish-splashing good time.

Take to the trails for a celebration of nature — and a day spent with dad.In the cool and quiet early light of morning, a father and child wake up. Today they’re going on a hike. Follow the duo into t

Who doesn't love a ladybug? Maisy explores these helpful little critters in the seventh adventure of the Maisy's Planet series. Join Maisy as she learns all about ladybugs! This cheerful board book introduces little ones to the colorful insects (look, one has landed on Maisy's nose!) and lightly traces their life cycle and what they need to survive (did you know they eat plant-invading aphids?). Maisy is happy to help the ladybug population along by watering her garden and building a tiny house out of pine cones and sticks for ladybugs to discover and stay safe in during the wintertime. A final fold-out surprise invites readers to join in a ladybug-counting party outside--how many can you see?

Hop along with Maisy as she discovers fascinating facts about frogs and toads in this eighth Maisy's Planet adventure. Frogs are fantastic! Every toddler who has been up close and personal with one of these big-eyed amphibians--as well as those not so sure about the bumpy green guys--will be intrigued by this fun introduction to frogs and toads with Maisy leading the way. Young children can find out about everything from tadpoles to lily-pad-leapfrogging in a gentle learning experience, then open out the final inviting scene as Maisy and friends make a frog-friendly pond in her backyard.

Water, water, everywhere! From rain in the sky to waves under the sea, this colorful board book in the Maisy's Planet series introduces the youngest explorers to a natural resource. We all need water for drinking, washing, growing--and jumping in puddles, like Maisy! But where does it come from, and where does it go? Join the curious mouse as she explores wildlife living in ponds, drops a stick in a stream to watch it float away, and follows a stream all the way to the ocean, where she and her friends can play, swim, and snorkel. There's so much to see under the water! In the Maisy's Planet series, each sturdy board book celebrates a different feature of the natural world, with bold colors, clear language, and a fun spread to open out at the end. Kids love to love our planet with Maisy!

It’s a snow day today―and Maisy and friends are going outside! A First Experiences story celebrates the everyday pleasures of the season.One day Maisy wakes up to a wonderful surprise: it’s snowing! After putting on her coat, scarf, and gloves, she heads outside, where everything looks beautiful covered in snow, even if it’s cold. Brrr! In the park, Eddie and Cyril are catching snowflakes on their tongues, while Charley and Tallulah throw snowballs. Maisy joins in the fun, and soon she and her friends are building a snowman and sledding down a hill. Yippee! When it gets too cold, the whole crew returns inside for hot cocoa and a snuggle. Warm and delightful, this First Experiences book captures the joys of a snowy day spent with friends.

Discover namaste’s many meanings in a simple, lyrical text, paired with a charmingly detailed visual narrative about a little girl’s kindness.Namaste calms your heart when things aren’t going right.Namaste is saying “You matter.”What is namaste? It’s found in a smile, a friendship, a celebration. It exists in silence; it can be said when you’re happy or when you’re feeling low. For one small girl in a bustling city, namaste (“I bow to you”) is all around her as she and her mother navigate a busy marketplace―and when she returns with a little plant and chooses to give it to an elderly neighbor, it can be seen in the caring bond between them. In a sweet, universal text, debut author Suma Subramaniam shines a light on a word with significance far beyond yoga class, while artist Sandhya Prabhat makes the concept of mindfulness come alive in delightful illustrations likely to draw children in again and again.

紐伯瑞銀獎《A Wish in the Dark》作者以泰國為原型打造古老、奇異的海上冒險。前途備受矚目的製圖師助理得到遠征繪製地圖的機會，前往傳說中的島嶼。謊稱家世的她其實來自低下階級，秘密會在危機重重的旅途中被揭穿嗎？From Christina Soontornvat, the visionary and versatile author of two 2021 Newbery Honor Books, comes a high-seas adventure set in a Thai-inspired fantasy world.In a fantasy adventure every bit as compelling and confident in its world building as her Newbery Honor Book A Wish in the Dark, Christina Soontornvat explores a young woman’s struggle to unburden herself of the past and chart her own destiny in a world of secrets. As assistant to Mangkon’s most celebrated mapmaker, twelve-year-old Sai plays the part of a well-bred young lady with a glittering future. In reality, her father is a conman―and in a kingdom where the status of one’s ancestors dictates their social position, the truth could ruin her. Sai seizes the chance to join an expedition to chart the southern seas, but she isn’t the only one aboard with secrets. When Sai learns that the ship might be heading for the fa

With a noisy giant crashing around the kingdom, the Princess in Black uses the Sparkle Signal to call ALL her heroic friends together - for the biggest adventure yet.The Princess in Black is ready for

Something smells like trouble! Can five princess heroes and one Goat Avenger pool their talents to vanquish a monstrous stink?The Princess in Black is in a very stinky situation. A foul cloud is plagu

“Captures the ways that war can forever alter a child’s sense of order, morality, and security in the world. Strongly visual scenes…will long resonate in readers’ minds.” — Publishers Weekly (starred

All living creatures have a special place in the world in this extraordinary exploration of the concept of self for very young readers.Only I know how to be me.Only you know how to be you.Trees have l

Amos is counting himself to sleep. It’s a good plan, until the cranky sheep land in his bedroom — and start in with their many demands.It’s bedtime for Amos, who smiles as he closes

Surprises are in store as Stink excavates his backyard in search of a relic from an extinct beast — and Judy lends him a little sleight of hand.Mega-chomp! Stink wants to make the find of the ce

Observe the ways plants and insects interact in a gentle introduction to growing for budding scientists.What’s that wedged in a crack in the ground, small and hard and wrinkly and brown? A bean seed!

A game of hide-and-seek in the forest might lead to unexpected discoveries. Could there be something hidden in the trees?When their dog goes missing, siblings Poppy and Cy decide to play hide-and-seek

Is a lion still a lion if he wears a hat? With whimsical illustrations and a nod to earlier classics, Polly Dunbar celebrates the shrewd mind of a child — and the power of saying no.Is a lion still a lion . . . if he skips down the street singing "Hoobie-doobie-doo"?Dapper in his hat and flourishing a cane, a very large lion invites himself inside, inquires about Auntie Sue, and spins the two children of the house around the room in a silly dance. He doesn’t mind at all if they invite him to lunch, where he gobbles up all his greens and devours the plate, too. When he leans in to ask for dessert, his sharp teeth gleam oh so pearly white, and it seems very possible that he may just bite. . . . Surely it’s time to go-go-go — until, that is, the brave little girl finds her voice in a most satisfying way. The Cat in the Hat meets Pierre meets The Tiger Who Came to Tea in this rollicking story with an exhilarating ending.

It’s an honest-to-jeepers mystery! Agent Judy Drewdy sets out to solve the case of the missing puppy when a canine-cop-in-training vanishes into thin air.Judy Moody is in a mood. A sleuthing, Na

When a visit to Boston spurs Judy's interest in Revolutionary heroes and heroines, she's soon on a quest for more independence in this hilarious new episode from Megan McDonald and Peter H. Reynolds.

The mercurial Judy returns - and she’s in a mood to take on the world! Get ready for the newest installment in the hilarious Judy Moody series. Rare!Judy Moody did not set out to save the world.

Yikes! Eddie's in for the surprise of his life when he discovers that his teddy bear has grown much too big to cuddle! But there's fun in store when Eddie meets up with a real bear who's got just th

Yikes! Eddie's in for the surprise of his life when he discovers that his teddy bear has grown much too big to cuddle! But there's fun in store when Eddie meets up with a real bear who's got just the

Now kids can get a jump start on the Judy Moody and Friends series with this appealing bind-up of three books in one.Here’s what’s included in this trio of tales — no lie!Jessica Finch in Pig TroubleR

Marvel over this exact replica of a miniature book created for Queen Mary’s Dolls’ House by cartoonist Fougasse, in print for the very first time!Written in rhyming text and illustrated in full color,

Real kids make a real difference in their communities in this vibrantly photographed chronicle by George Ancona.George Ancona celebrates the joy of kids giving back. In one after-school program, middl

Aaron Becker, creator of Journey, a Caldecott Honor book, presents the next chapter in his stunning wordless fantasy.A king emerges from a hidden door in a city park, startling two children sheltering

A birthday party sets the scene in this sweet and relatable story for anyone who’s ever been the odd girl out.It’s Ginger’s birthday, and she has to invite all the girls in her class to her party, inc

Look through each eye-catching spy hole to spot a new bird in the sky!Up in the sky there are many colorful birds to spy, each of them different. Look through the spy hole and use the clues to guess w

“[A] fun romp, a child’s fantasy, and a great little easy-to-read comic that everyone can enjoy.” – Publishers WeeklyLuke looks on at the pigeons in Central Park, while Dad is lost in “boring Daddy ta

It’s the best thing since buttered toast — Mercy Watson in paperback! Mercy loves nothing more than a ride in the convertible, with the wind tickling her ears and the sun on her snout. But one day

Out on the playground, kids are skipping rope and making trades. In the library, they’re whispering, fi dgeting, and giggling. In the classroom, they’re learning their lessons....or spinning tales abo

As seen on Nick Jr!A new storybook based on Maisy’s hit TV series is here, just in time for the crazy-for-Maisy preschoolers who have been clamoring for more. In MAISY GOES SHOPPING, Charley and our f

Who doesn't love a butterfly? Set a little one's heart aflutter with this exploration of the beautiful creatures, led by everyone's favorite mouse. Join Maisy as she learns all about gorgeous butterflies! This fifth book in the Maisy's Planet series introduces children to both butterflies and moths, as it investigates everything from caterpillars to cocoons to the insects in flight. Find out about patterns, color, and camouflage, and open out the final scene to marvel at Maisy's butterfly- and moth-friendly garden!

“A wonderful addition to the Hales’ unique series, wherein zany humor and teamwork tells the story that children can be anything they dream of.” —School Library JournalPrincess Magnolia is at the Flower Festival prepping for the evening ball when suddenly she hears a commotion. Oh no! She isn’t prepared to fight a monster or . . . a grumpy emu! To her surprise, a knight in shining armor comes to the rescue, but not before the princess’s prized decorations are stomped on and destroyed. Luckily, the gallant Prince Valerian has his own secret identity—the Prince in Pink—and has been yearning for a chance to show off his special skills, with the help of some twinkle-twinkle and major glam. Glitter has been restored, but then the angry emu returns—with friends! Can the party heroes step up to save the day again? Expect the unexpected as this sparkling new entry in the New York Times best-selling series takes the floor with a flourish.

In this exciting launch of the Maisy's Planet series, everyone's favorite mouse learns all about the bees in her garden--and why they're so important to our natural world. Did you know that bees use their tongues to eat sweet nectar from flowers, then carry dusty pollen on their bodies to spread it from flower to flower? Or that they need lots of flowers, water, and a dry place to live? Through Lucy Cousins's familiar bold, inviting artwork and cheery narration, the youngest children can join Maisy as she tends to her growing garden and discovers some fun and informative things about the bees that live there. Open the final gatefold to see how Maisy is helping the amazing bees!

With his vibrant, stylish art and spot-on visual storytelling, Chris Haughton turns to Antarctica for an irresistible ode to family bonds and awesome moms.“She’ll be back soon, won’t she?”“She sure will,” says Daddy Penguin.The sky may be dark over icy waters, but Mommy Penguin is off to catch some fish for dinner. As Daddy and Little Penguin watch in suspense, Mommy swims, jumps, and climbs up a slippery slope, barely avoiding a plunge back into the sea. Well done! There's just one more hurdle to overcome, past some grumpy, just-awakened seals, before she returns to her anxiously waiting family. With a nod to the fascinating nature of penguin parenting, this boldly illustrated adventure from the creator of Little Owl Lost and Oh No, George! will have little ones happily on the edge of their seats as they root for Mommy Penguin.

Thai American creators portray the inspirational and barrier-breaking life of Senator Tammy Duckworth in a picture-book tribute to an extraordinary woman. Given Tammy Duckworth's personal heroism as an Army veteran, her stunning recovery from injuries sustained in the line of duty, and her subsequent career as an influential US senator, it's easy to see why Joe Biden earmarked her as a possible running mate during his Democratic presidential campaign. Senator Duckworth has logged a long list of firsts during her tenure as the first Thai American member of Congress, including being the first woman with a disability to serve in the House and Senate. But it is her tireless determination to keep going against staggering odds that will rivet readers of all ages. Christina Soontornvat's narrative biography of this groundbreaking military veteran and rising political star will inspire readers to dream and achieve. Evoking Senator Duckworth's spirited nature with sensitivity and joy, this dram

The #1 New York Times bestseller! Big trucks may brag and roar, but small and steadfast wins the day in this cheerful story with timeless appeal. On the Mighty Mountain Road Crew, the trucks come in one size: BIG. That is, until the little snowplow joins the crew. None of the other trucks think that the little snowplow can handle the big storms, but he knows that he can do it--and just to be sure, he trains hard, pushing loads of gravel, pulling blocks of concrete, and doing plow lifts to get ready. But when a blizzard arrives, will the little snowplow's training be enough to clear the streets and handle unexpected trouble? Taking its place beside classics such as The Little Engine That Could and Mike Mulligan and His Steam Shovel, this tale of a plucky little plow will find a clear path to readers' hearts.

David Almond、Marta Altes合作與青少年讀者一起反思何為人性。新來的男生善於足球、喜歡零食，與其他同學沒什麼不同。但他其實是誕生自某個實驗的機器人，而現在學校的新朋友們要他不被邪惡之人消滅。An inventive tale by a beloved Hans Christian Andersen Award winner celebrates our differences─and the joys of inclusion─through the lens of artificial intelligence.From the boundless imagination of David Almond comes a thought-provoking question, packaged in a lively illustrated chapter book: what if a robot went to school? When a new boy joins their class, everyone thinks he’s…odd. George doesn’t behave like other kids. He doesn’t think like other kids. But he’s great at football and snacking, and that’s what matters to Dan and Maxie and friends, who resolve to make George feel welcome. Over time, they learn that he’s just like them, in most ways, except one: George is a robot, part of an ambitious new experiment, with sinister people bent on destroying him. When his lab pulls him out of school, can George’s new friends recover him─and set him free? Told in David Almond’s signatur

WWNDD? What Would Nancy Drew Do? Judy and her new friend, Mighty Fantaskey, take cues from their favorite sleuth as they search for a lost mood ring in a spooky attic.Judy Moody is freaky for Nancy Drew, the famous girl detective from the book series. Nancy Drew is an ace at solving mysteries with brains, bravery, and bobby pins, and Judy is determined to solve mysteries too. So when Judy bumps into Mighty Fantaskey, she is excited to meet another Nancy Drew fan and to make a new friend. Excited, that is, until she visits Mighty’s house: it’s big and old and creaky and definitely haunted. It even turns Judy’s mood ring the color of fear! On Judy’s first visit, she hightails it out of there, leaving Mighty in the dust. But where is Judy’s favorite ring? Jeepers! Can Judy pluck up enough courage to go back and find it―and solve the real-life mystery waiting in Mighty’s attic?