Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

For the first time, the complete stories of the master chronicler of tradition and transformation in the twentieth-century South are available in a deluxe two-volume Library of America boxed set.Born

What kind of choices fatally shape a life? How does the individual withstand the onslaught of circumstance? These are the dark questions that animate Nemeses, the quartet of thematically related short novels that are published here together for the first time in this final volume of The Library of America’s definitive edition of Philip Roth’s collected works. Everyman (2006) is the sparse and affecting story of one man’s lifelong skirmish with mortality. Set against the backdrop of the Korean War, Indignation (2008) is the extraordinary narrative of a young man struggling against the conformity of McCarthy-era America and his father’s overwhelming fear. In The Humbling (2009), aging actor Simon Axler embarks on a risky and aberrant affair in a desperate attempt to recoup his lost artistic gifts. And in Nemesis (2010), Roth offers an exacting portrait of the emotions—fear and anger, bewilderment and grief—bred by a polio epidemic in Newark in the summer of 1944.Philip Roth is the only l

The definitive edition of Cooper’s great epic of the American frontier, now in a dramatic boxed set. Here, presented in their order of composition and in the most authoritative texts available, are a

In celebration of the Tennessee Williams centennial in 2011, The Library of America presents its acclaimed two-volume edition of his plays in a collector's boxed set. Gathering thirty-two works writt

In this, the first of two volumes collecting all his woodcut novels, The Library of America brings together Lynd Ward’s earliest books, published when the artist was still in his twenties.Gods’ Man (1

H. L. Mencken was the most provocative and influential journalist and cultural critic in twentieth-century America. In this volume and a companion, The Library of America presents all six series of Pr

In just two decades—she died in 1965, at the age of 48—Shirley Jackson created a weird and distinctive world of fiction, one in which a grinning death's head lies just behind the smiling mask of so-c

On September 28, 1960-a day that will live forever in the hearts of fans-Red Sox slugger Ted Williams stepped up to the plate for his last at-bat in Fenway Park. Seizing the occasion, he belted a sol

It was as a humorous travel writer, in The Innocents Abroad and Roughing It, that Mark Twain first became widely known, and at the height of his career he returned to the genre in the works collected

"Perhaps the most remarkable book in the American canon. As dense as scripture, crowded with aphorism, Walden is full enough of ideas for a score of ordinary books." -Bill McKibben In 1845 Henry David

Of mixed Greek and Irish parentage, raised under unhappy circumstances in Ireland, England, and France, Lafeadio Hearn came to America in 1869 as a young man forced to fend for himself. Over the next

With over 100,000 copies in print, here, with a new jacket for LincolnA's bicentennial, is the second volume in The Library of AmericaA's acclaimed, comprehensive edition of LincolnA's writings, feat

Americans have had an uneasy fascination with crime since the earliest European settlements in the New World, and right from the start true crime writing became a dominant genre in American writing.

Robert Giroux and Lloyd Schwartz, editors James Merrill described Elizabeth Bishop's poems as "more wryly radiant, more touching, more unaffectedly intelligent than any written in our lifetime" and called her "our greatest national treasure." Robert Lowell said, "I enjoy her poems more than anybody else's." Long before a wider public was aware of Bishop's work, her fellow poets expressed astonished admiration of her formal rigor, fiercely observant eye, emotional intimacy, and sometimes eccentric flights of imagination. Today she is recognized as one of America's great poets of the 20th century. This unprecedented collection offers a full-scale presentation of a writer of startling originality, at once passionate and reticent, adventurous and perfectionist. It presents all the poetry that Bishop published in her lifetime, in such classic volumes as North & South, A Cold Spring, Questions of Travel, and Geography III. In addition it contains an extensive selection of un_published po

The raucous, exuberant, often wildly funny account of a journey through America and Mexico, Jack Kerouac's On the Road instantly defined a generation upon its publication in 1957: it was, in the word

Here, in one volume for the first time, are the most important works of Henry David Thoreau, America's greatest nature writer and a political thinker of worldwide influence. A landmark in American lit

Collects 367 letters written between 1881 and 1919 in a volume that features his correspondences with such individuals as Rudyard Kipling, Upton Sinclair, and FDR and the texts of four key speeches in

Here, in the most comprehensive collection of George S. Kaufman's plays ever assembled, are nine classics: his "backstage" play The Royal Family (1927, written with Edna Ferber); the Marx Brothers-in

Democracy in America (1835-40) is arguably the most perceptive and influential book ever written about American politics and society. This volume presents Alexis de Tocqueville's masterpiece in an entirely new translation, the first to capture fully the precision and grace of his style while providing a rigorous and faithful rendering of his profound ideas and observations.In Democracy in America he vividly describes the unprecedented "equality of conditions" found in the United States and explores its implications for European society in the emerging modern era. His book provides enduring insight into the political consequences of widespread property ownership, the potential dangers to liberty inherent in majority rule, the importance of civil institutions in an individualistic culture dominated by the pursuit of material self-interest, the influence of the press and the judiciary in American politics, and the vital role of religion in American life, while prophetically examining the

From A. Philip Randolph's defiant call in 1941 for African Americans to march on Washington to Alice Walker in 1973, Reporting Civil Rights presents firsthand accounts of the revolutionary events tha

"Against the assault of laughter nothing can stand," Mark Twain once wrote. In this sixth volume in The Library of America's authoritative collection of his writings-the final volume of his fiction-A

Gathers stories and essays prominent in the career of the nineteenth-century American writer.

The second in a two-volume set furnishes Stein's later literary masterpieces, including Stanzas in Meditation, Lectures in America, and The Geographical History of America, and details her relationshi

The first in a two-volume set of works combines fiction with the author's personal experiences in Paris and includes the play Four Saints in Three Acts and Lifting Belly, in which she documents her wo

A collection of stories penned by one of the greatest African-American writers of the postwar era includes such works as Go Tell It on the Mountain, Giovanni's Room, Another Country, and Going to Mee

This second volume in The Library of America's authoritative edition of John Steinbeck features his acknowledged masterpiece, The Grapes of Wrath. Written in an incredibly compressed five-month period

The 21 stories in Complete Stories 1892-1898 represent James at the peak of his storytelling powers. Among them are "The Turn of the Screw," one of his most popular works, a terrifying exercise in ps

"I know not whether any man in the world," wrote John Adams in 1805, "has had more influence on its inhabitants or affairs for the last thirty years than Tom Paine." The impassioned democratic voice

Ralph Waldo redivivus. How long is it since you read your Emerson: "Tax not my sloth that I/Fold my arms beside the brook;/Each cloud that floated in the sky/Writes a letter in my book." Essential for

The stories of a free-spirited American woman in Paris, an unhappy marriage, small town mores, a lovers' triangle, and life in New York are accompanied by the author's autobiography

LIBRARY OF AMERICA is an independent nonprofit cultural organization founded in 1979 to preserve our nation’s literary heritage by publishing, and keeping permanently in print, America’s best and most

The five novels in The Leatherstocking Tales (collected in two Library of America volumes), Cooper's great saga of the American wilderness, form a pageant of the American frontier. Cooper's hero, Natt

Gathers all of Poe's poetry, tales, short stories, and general essays in chronological order

Together for the first time: two masterworks on the undercurrents of the American mind by one of our greatest historiansRichard Hofstadter’s Anti-Intellectualism in American Life and The Paranoid Styl

Thomas Mallon and Library of America invite readers to rediscover the Pulitzer Prize-winning novels of a classic American writer on the 150th anniversary of his birthMuch in need of rediscovery today,

The American Revolution comes to vivid life in two dramatic tales of espionage, intrigue, and romance from the author of The Last of MohicansWith his second novel, The Spy:A Tale of the Neutral Ground

The Civil War's greatest general as you've never seen him before, in a revealing collection of letters to his wife Julia introduced by Ron Chernow.Ulysses S. Grant is justly celebrated as the author o

At last in a deluxe collector's edition boxed set, the most complete and authoritative anthology of 19th century American poetry ever publishedFrom the lyrics of Walt Whitman and Emily Dickinson to fo

From the street game to March Madness to Jordan and LeBron, the greatest writing about the grit, grace, and glory of basketballMade in America, basketball is a sport that stirs a national passion, rea

Four Mailer classics in one volume for the first time, books that crackle with the creative energy and raw passions of America's most turbulent decadeNo writer plunged more wholeheartedly into the cha