Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Experts explore the maturation of nonlinear brain dynamics from a developmental perspective and consider the relationship of neurodevelopmental disorders to early disruption in dynamic coordination.Th

The first full-length biography of a brilliant, self-taught inventor whose innovations in information and energy technology continue to shape our world. The Economist called Stanford R. Ovshinsky (192

Imagining a future in which humans fundamentally reshape the natural world using nanotechnology, synthetic biology, de-extinction, and climate engineering.We have all heard that there are no longer an

The emergence of the international oil corporation as a political actor in the twentieth century, seen in BP's infrastructure and information arrangements in Iran.In the early twentieth century, inter

How Britain lost its early dominance in computing by systematically discriminating against its most qualified workers: women.In 1944, Britain led the world in electronic computing. By 1974, the Britis

Experts from MIT explore recent advances in cybersecurity, bringing together management, technical, and sociological perspectives. Ongoing cyberattacks, hacks, data breaches, and privacy concerns demo

A rigorous analysis of the role played by globalization in key episodes in the development of the Israeli economy, from hyperinflation crisis to high-tech surge.Anti-globalization sentiments are risin

Advances in medicine often depend on the effective collection, storage, research use, and sharing of human biological specimens and associated data. But what about the sources of such specimens? When

In 1969, ten years after the discovery of the perceptron -- which showed that a machine could be taught to perform certain tasks using examples -- Marvin Minsky and Seymour Papert published Perceptro

Information is power. It drives commerce, protects nations, and forms the backbone of systems that range from health care to high finance. Yet despite the avalanche of data available in today's inform

In the 1980s, there was a revolution with far-reaching consequences -- a revolution to restore software freedom. In the early 1980s, after decades of making source code available with programs, most p

A detailed examination of the UN's Sustainable Development Goals and the shift in governance strategy they represent. In September 2015, the United Nations General Assembly adopted the Sustainable D

The practice of development economics has undergone something of a revolution as many economists have adopted new methods to answer perennial questions about the effectiv

This textbook presents a wide range of subjects in neuroscience from a computational perspective. It offers a comprehensive, integrated introduction to core topics, using

This anthology provides the first art-historical reassessment of information-based art in relation to data structures and exhibition curation. It examines such landmark e

We may imagine the digital cloud as placeless, mute, ethereal, and unmediated. Yet the reality of the cloud is embodied in thousands of massive data centers, any one of w

Focusing on early social media in the arts and humanities and on the core role of creative computer scientists, artists, and scholars in shaping the pre-Web social media

This book examines the wide range of scientific and social arenas in which the concept of inheritance gained relevance in the late nineteenth and early twentieth centurie

New Tendencies, a nonaligned modernist art movement, emerged in the early 1960s in the former Yugoslavia, a nonaligned country. It represented a new sensibility, rejecting both Abstract Expressionism and socialist realism in an attempt to formulate an art adequate to the age of advanced mass production. In this book, Armin Medosch examines the development of New Tendencies aa a major international art movement in the context of social, political, and technological history. Doing so, he traces concurrent paradigm shifts: the change from Fordism (the political economy of mass production and consumption) to the information society, and the change from postwar modernism to dematerialized postmodern art practices.Medosch explains that New Tendencies, rather than opposing the forces of technology as most artists and intellectuals of the time did, imagined the rapid advance of technology to be a springboard into a future beyond alienation and oppression. Works by New Tendencies cast the viewe

The public sector has grown substantially in the last fifty years. In the euro area, for example, total government expenditures have been around fifty percent of GDP since the early 2000s, resulting i

In the late 2000s, ordinary citizens in Jamaica and Mexico demanded that government put a stop to lucrative but environmentally harmful economic development activities -- bauxite mining in Jamaica and

In the late 2000s, ordinary citizens in Jamaica and Mexico demanded that government put a stop to lucrative but environmentally harmful economic development activities -- bauxite mining in Jamaica and

Most of us have gone online to search for information about health. What are the symptoms of a migraine? How effective is this drug? Where can I find more resources for cancer patients? Could I have a

In Becoming Human, Jennifer Greenwood proposes a novel theory of the development of human emotionality. In doing so, she makes important contributions to the nature-nurture debate in emotion theory an

Dolphin researchers have collected an impressive amount of data over the last twenty years, thanks to advances in technology for monitoring, recording, and analyzing dolphin behavior as well as increa

Yayoi Kusama is the most famous artist to emerge from Japan in the period following World War II. Part of a burgeoning international art scene in the early 1960s, she exhibited in New York with Andy W

We may imagine the digital cloud as placeless, mute, ethereal, and unmediated. Yet the reality of the cloud is embodied in thousands of massive data centers, any one of which can use as much electrici

Developmental robotics is a collaborative and interdisciplinary approach to roboticsthat is directly inspired by the developmental principles and mechanisms observed in children'scognitive development

Since Malthus, an East--West dichotomy has been used to characterize marriagebehavior in Asia and Europe. Marriages in Asia were said to be early and universal, in Europe lateand non-universal. In Eur

In Voice and v, Julie Anne Legate investigates the syntacticstructure of voice, using Acehnese as the empirical starting point. A central claim is that voice isencoded in a functional projection, Voic

In Voice and v, Julie Anne Legate investigates the syntacticstructure of voice, using Acehnese as the empirical starting point. A central claim is that voice isencoded in a functional projection, Voic

In this wide-ranging book, Frances Dyson examines the role of sound in thedevelopment of economic and ecological systems that are today in crisis. Connecting early theoriesof harmony, cosmology, and t

The emergence of open networked models made possible by digital technology has thepotential to transform international development. Open network structures allow people to cometogether to share inform

Although there is scientific consensus that genetic factors play a substantial rolein an individual's vulnerability to drug or alcohol addiction, specific genetic variables linked torisk or resilience

Vision is one of the most active areas in biomedical research, and visualpsychophysical techniques are a foundational methodology for this research enterprise. Visualpsychophysics, which studies the r

Luc Tuymans is one of the most influential figurative painters working today.Born in1958 and based in Antwerp, he has exhibited since 1985, emerginginternationally in the early 1990sas an artist who h

For as long has humans have lived in communities, storytelling has bound people toeach other and to their environments. In recent times, scholars have noted how social networks arisearound issues of r

For as long has humans have lived in communities, storytelling has bound people toeach other and to their environments. In recent times, scholars have noted how social networks arisearound issues of r

"This fascinating and accessible text describes Townsend's field research efforts in Thailand that span over 15 years, making it perhaps the longest running, high-frequency panel data set in a develop

Investors and analysts often need to look into a firm's operations more deeply than traditional financial statements and models allow. This book describes newly developed tools for using operations me