Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Few public places in the early nineteenth century offered men and women from different regions of the United States the opportunity to socialize with each other. At the resorts of Virginia's western m

Who else but Whole Foods Market could create a cookbook so fresh, so appealing, so full of valuable information, and so perfect for the way we are all cooking and eating today? Bursting with winning r

A Carnegie Corporation Initiative: Summarizing a Decade of Progress in Early Education"As a mother of three, I am acutely aware of how much a baby learns during the earliest years and how much that af

A dramatic and moving tribute to the military’s unsung heroes, American Patriots tells the story of the black servicemen and women who defended American ideals on the battlefield, even as they faced r

S-T-R-E-T-C-H, STRENGTHEN, AND MEDITATE—WITH YOUR BABYPracticing yoga with your baby—as you hold your baby, have your baby next to you, or have your baby leaning against your thighs or atop your belly

With sharp and soulful insight, T. R. Luhrmann examines the world of psychiatry, a profession which today is facing some of its greatest challenges from within and without, as it continues to offer ho

First published in 1792, A Vindication of the Rights of Woman was an instant success, turning its thirty-three-year-old author into a minor celebrity. A pioneering work of early feminism that extends

The author of Fear Itself and Singing Yet presents a new selection of poetry that explores the essence of the human spirit with works on feelings, mortality, grief, nature, marriage, myth, and love. R

Being a short Introduction to the fine Art of Execution, containing much useful Information on Neck-breaking, Throttling, Strangling, Asphyxiation, Decapitation, and Electrocution; Data and Wrinkles o

One of the great cornerstones in the history of Christian philosophy, The City of God provides an insightful interpretation of the development of modern Western society and the origin of most Western

When an individual labeled as schizophrenic comes to Bruce Scott for counseling, Scott discovers that only when he drops his external image as a skilled therapist—when he opens his heart and becomes r

Using a computer doesn't have to hurt. Prevent or reverse repetitive stress injuries Cure carpal tunnel syndrome End chronic wrist, shoulder, and neck pain Ease eyestrain Avoid surgery, drugs, and wri

An investigation into the lost city of Atlantis traces the legend's development from the literature of the ancients to the popular culture of contemporary America

The first definitive guide to using the wisdom of the enneagram for spiritual and psychological growthThe ancient symbol of the Enneagram has become one of today's most popular systems for self-unders

"My father tried to kill my mother one Sunday in June, in the early afternoon."Shame begins as the story of a twelve-year-old girl, but it is also about the storyteller, a mature woman, the author her

Tells the story of how the best college basketball players of the early 1950s adjusted the outcome of the games they played in exchange for money from gamblers and, in doing so, became part of a natio

Here is a liberating vision of love that offers couples powerful new ways of using words and touch to create levels of intimacy they have never reached before. Barbara De Angelis, Ph.D., reveals how p

Looks at origins and attitudes of the eugenics movement of the late 19th and early 20th centuries, examining the interests it served, why it fell into disrepute, and whether it has survived in other g

Kohn Pedersen Fox, one of America's premier architectural firms, has distinguished itself through dedicated attention to the development of the most characteristic and significant American building ty

Represents a significant stage in the development of Macmurray's philosophy of the personal. His suggestions about the nature of freedom and the conditions under which we may hope to enjoy it should b

As homeopathic medicine becomes more available, increasing numbers of clinicians, families and patients are learning how to use these natural medicines to treat common ailments. Using homeopathic medi

Presenting the first in-depth study of Thomas Moran's early western landscapes, Joni Louise Kinsey describes how the artist created three monumental paintings—The Grand Canon of the Yellowstone (1872)

"This collection of essays on aesthetics is the first set of Dufrenne's shorter pieces to appear in English. It is arranged thematically and includes works from as early as 1948 to as late as 1974. ..

Studies the development of paraphilias and traces their roots to psychological, family, social, and cultural factors

In the mid-nineteenth century Mill turned his sharp analytic eye toward the issues raised by social critics such as Robert Owen, Saint-Simon, and others. These early socialists sought to reform, if no

Throughout the history of Western Civilization many powerful works, penned by some of the greatest minds in philosophy, have influenced the development and evolution of political theory, but none has

Traces the development of the stereotyped images of the American Indian and the misconceptions that have sustained a regrettable lack of understanding

In an economic future centered on artificially-intelligent platforms, how can their power be balanced to ensure a broad prosperity for everyone?Our world is dominated by a handful of tech platforms. They provide great conveniences and entertainment, but also stand as some of the most effective instruments of wealth extraction ever created, seizing immense amounts of money, data, and attention from all of us.An economy driven by digital platforms and AI influence offers the potential to enrish us, but also threatens to marginalize entire industries, widen the wealth gap, and foster a two-class nation.Tim Wu—the preeminent scholar and former White House official who coined the phrase “net neutrality”—explores the rise of platform power and details the risks and rewards of working within such systems.The Age of Extractiontells the story of an Internet that promised widespread wealth and democracy in the 1990s and 2000s, only to create new economic classes and aid the spread of autocracy i

Show yourself who's in charge using the original art of persuasion, backed by contemporary pop culture examples that make transforming your habits and achieving goals easy, even fun—from theNew York Timesbestselling author ofThank You for ArguingRhetoric once sat at the center of elite education.Alexander the Great, Shakespeare, and Martin Luther King, Jr., used it to build empires, write deathless literature, and inspire democracies. Now it will help you to take leadership over yourself; not through pop psychology or empty inspiration, but with persuasive tools that have been tested for more than three thousand years. InAristotle's Guide to Self-Persuasion,Heinrichs helps readers persuade their most difficult audiences—themselves—by usingtechniques invented by the likes of Aristotle and Cicero and deployed by our culture’s most persuasive characters. With their help, rhetoric can convert the most negative situations into positive ones.Heinrichs brings in examples from history and pop

An exclusive thriller writer's retreat hosted on a private island turns lethal when one of the authors is found murdered in this twisty locked room mystery.When renowned anonymous author J. R. Alastor hires former aspiring writer Mila del Angél to host a writing retreat at his private manor off the coast of Maine, she jumps at the chance—particularly since she has an ax to grind with one of the invitees. The guest list? Six thriller authors, all masters of deceit, misdirection, and mayhem.Confess the crimes, survive the tropes.Alastor and Mila have masterminded a week of games, trope-fueled riddles, and maybe a jump scare or two—the perfect cover for Mila to plot a murder of her own. But when a guest turns up dead—and it’s not the murder she planned—Mila finds herself trapped in a different narrative altogether.One by one, you'll lose your turn.With a storm cutting off the island, and the body count rising, Mila must outwit a killer who knows literally every trick in the book.Until onl

A myth-busting, science-based guidethat addresses the timeless question of how to manage your emotional life using tools you already possess—from the bestselling author ofChatter.Whether it’s anxiety about going to the doctor, boiling rage when we’re stuck in traffic, or devastation after a painful break-up, our lives are filled with situations that send us spiraling. But as difficult as our emotions can be, they are also a superpower. Far from being “good” or “bad,” emotions are information. When they’re activated in the right ways and at the right time, they function like an immune system, alerting us to our surroundings, telling us how to react to a situation, and helping us make the right choices.But how do we make our emotions work for us rather than against us? Acclaimed psychologist Dr. Ethan Kross has devoted his scientific career to answering this question. InShift, he dispels commonmyths—for instance, that avoidance is always toxic or that we should always strive to live in t

From Pulitzer Prize–winning, #1 New York Times bestselling author Elizabeth Strout comes a poignant, pitch-perfect novel about a former couple in lockdown together―and the love, loss, despair, and hope that animate us even as the world seems to be falling apart.With her trademark spare, crystalline prose―a voice infused with “intimate, fragile, desperate humanness” (The Washington Post)―Elizabeth Strout once again turns her exquisitely-tuned eye to the inner workings of the human heart, this time following the indomitable heroine of My Name Is Lucy Barton and Oh William! through the early days of the pandemic. As a panicked world goes into lockdown, Lucy Barton is uprooted from her life in Manhattan and bundled away to a small town in Maine by her ex-husband and longtime friend, William. For the next several months, it’s just Lucy, William, and their complex past together in a little house nestled against the moody, swirling sea. They will not emerge unscathed. Rich with empathy and em

A young poet tells the unforgettable story of his harrowing migration from El Salvador to the United States at the age of nine in this moving, page-turning memoir hailed as "the mythic journey of our era" (Sandra Cisneros)Trip. My parents started using that word about a year ago―“one day, you’ll take a trip to be with us. Like an adventure.” Javier’s adventure is a three-thousand-mile journey from his small town in El Salvador, through Guatemala and Mexico, and across the U.S. border. He will leave behind his beloved aunt and grandparents to reunite with a mother who left four years ago and a father he barely remembers. Traveling alone except for a group of strangers and a "coyote" hired to lead them to safety, Javier’s trip is supposed to last two short weeks.At nine years old, all Javier can imagine is rushing into his parents’ arms, snuggling in bed between them, and living under the same roof again. He cannot foresee the perilous boat trips, relentless desert treks, pointed guns,

An intimate, deeply reported account of the women who made a shocking decision: to leave their comfortable lives behind and join the Islamic State.In early 2014, the Islamic State clinched its control

A down-to-earth and deeply intimate portrait of Pope Francis and his faith, based on interviews with the men and women who knew him simply as Jorge Mario Bergoglio Early on the evening of March 13, 20

A baby's first year is filled with an endless stream of new experiences, contributing profoundly to their physical, mental, and emotional development. Typically at the age of one-year an infant has th

Bitcoin, the digital currency, was introduced in 2009 with little fanfare; five years later, shocking the world, it was worth $14 billion. This book explores the cyber currency by focusing on the rema

Let the weather take the lead and never be bored again! Paint in the rain, send kites soaring in the wind, build ice orbs, and become a snowflake scientist—let the wonders of nature inspire your next

From the acclaimed author of the international best seller Einstein’s Dreams,here is a stunning, lyrical memoir of Memphis from the 1930s through the 1960s that includes the early days of the movies a

In the follow-up to his National Translation Award-winning collection The Undiscovered Chekhov, translator and scholar Peter Constantine brings us more little-known work from the legendary author's ea