Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Brave knights, fire-breathing dragons, and underwear—every kid’s favorite things in one book illustrated by #1 New York Times bestselling artist Pete Oswald!Cole’s wish comes true when he becomes an A

在 Max Meow, Cat Crusader 裡，Max 一夕之間從平凡小貓變成拯救城市的超級英雄，起因竟是意外吃下「放射性太空肉丸」！有了超能力，生活似乎變得精彩無比，但 Max 很快就發現，力量之外更重要的是友情與信任。當好友 Mindy 受冷落、城市又面臨大反派 Agent M 與 Big Boss 的威脅時，Max 必須學會如何平衡英雄角色與真誠的友誼。這部漫畫以幽默橋段、熱鬧場景與滿滿「貓態度」吸引讀者，讓孩子在歡笑中感受友情與勇氣的價值。本書亮點：輕鬆搞笑，風格近似 Dog Man 與 InvestiGators主角魅力十足，充滿「貓式幽默」圖文並茂，閱讀門檻低，適合中低年級額外附上繪畫教學，增添互動樂趣A USA TODAY Bestseller!Meet a secret superhero with CAT-ITUDE--Max Meow, Cat Crusader--in this purr-fectly awesome, hiss-sterically funny graphic novel series just right for fans of Dog Man and InvestiGators!Max is just a regular cat in Kittyopolis, trying to make it big as a podcaster UNTIL he accidentally takes a bite of an RADIOACTIVE SPACE MEATBALL at his best friend Mindy's SECRET LAB. Then before you can say MEOWZA, Max becomes...The CAT CRUSADER! Being a super hero is fun--but not if you get so cocky, you forget your best friend! Will Max and Mindy make up? And together, can they save Kittyopolis from the evil Agent M and BIG BOSS?! Find out in this furr-ociously funny s

什麼能讓壞脾氣猴子變不那麼壞脾氣？是一顆球？一根香蕉？一片彩虹？還是一隻戴著毛茸茸假髮的青蛙？不過似乎什麼都不管用，但幸運的是，Jim的好朋友Norman出現了！他可否幫助Jim將那張皺眉的臉翻轉過來呢？Suzanne和Max Lang用簡單的文字和生動傳神的插畫，為幼兒打造了一本幽默又溫馨的讀物，幫助他們學會面對並處理壞心情。In this hilarious original board book for the littlest grumpy monkey, Jim learns that sometimes it's hard to get over a bad case of grumpiness, but having a good friend can help.What can make a grumpy monkey less grumpy? A ball? A banana? A rainbow? How about a frog in a fluffy wig? Nothing seems to work, but fortunately for young readers Jim's frown is finally turned upside down with the help of his good friend Norman.With just a few words and truly expressive artwork Suzanne and Max Lang give toddlers the perfect funny book to help them deal with a grumpy mood.

A shark and a robot are unlikely friends. But in this hilarious young graphic novel series, what makes you different makes for an EPIC friendship.Can a shark and a robot really be friends? What makes

Winner of the 2021 Ezra Jack Keats New Writer Award!In this moving story that celebrates cultural diversity, a shy girl brings her West African grandmother--whose face bears traditional tribal markings--to meet her classmates. This is a perfect read for back to school!It is Grandparents Day at Zura's elementary school, and the students are excited to introduce their grandparents and share what makes them special. Aleja's grandfather is a fisherman. Bisou's grandmother is a dentist. But Zura's Nana, who is her favorite person in the world, looks a little different from other grandmas. Nana Akua was raised in Ghana, and, following an old West African tradition, has tribal markings on her face. Worried that her classmates will be scared of Nana--or worse, make fun of her--Zura is hesitant to bring her to school. Nana Akua knows what to do, though. With a quilt of traditional African symbols and a bit of face paint, Nana Akua is able to explain what makes her special, and to make all of Zu

The first in a hilarious young graphic novel series about Pizza and Taco. Two best friends, lots of toppings…but only one of them can be the BEST, right? Fans of Narwhal and Jelly will eat this book u

An office at night is reimagined as a fantastical kingdom of paper complete with friendly dragons in this own voices picture book.When the babysitter is unable to come, Daniel is woken out of bed and

The #1 bestselling chapter book series of all time celebrates 25 years with new covers and a new, easy-to-use numbering system!When Jack and Annie came back from their adventure in Magic Tree House #1

A new board book for the youngest fans of Leo Lionni--inspired by his bestselling classics!Discover a world full of color in this delightful board book inspired by the works of legendary children's bo

A new board book for the youngest fans of Leo Lionni--inspired by his bestselling books and perfect for baby showers and anyone looking for an alphabet book to help teach the little ones in their live

An all-new storybook about the LEGO(R) City firefighters--plus 30 brick-tastic stickers!Children 3 to 7 will love to read about their favorite LEGO(R) City firefighters as they learn what it means to be everyday heroes as they practice new skills and try out new equipment in this full-color storybook--plus 30 brick-tastic stickers!LEGO City delivers reality-based role-play and building fun. LEGO City is all about REAL action, REAL fun, and REAL heroes. It can be seen on Nickelodeon, Netflix, and Amazon.

Celebrate a birthday in LEGO(R) City with this Step 3 Step into Reading leveled reader--with more than 30 stickers!It's a birthday celebration in LEGO(R) City! Handyman Harl Hubbs helps people every day, and now everyone wants to thank him by making his birthday extra-special! Children 5 to 8 will love read this Step 3 Step into Reading leveled reader--with over 30 brick-tastic stickers to add to the fun! Step 3 readers feature engaging characters in easy-to-follow plots about popular topics. For children who are ready to read on their own.LEGO City delivers reality-based role-play and building fun. LEGO City is all about REAL action, REAL fun, and REAL heroes. It can be seen on Nickelodeon, Netflix, and Amazon.

Quirky questions exercise imaginations in this Bright & Early Board Book adaptation of a Dr. Seuss classic!Written in simple rhyme, this board book edition of Would You Rather Be a Bullfrog? is fu

An over-the-top celebration of pink, as told by a small girl with a BIG imagination!In this charming Beginner Book by New York Times best-selling author Diane Muldrow, a spunky young girl encourages r

The Positive Power early reader series introduces self-esteem and empathy to budding young readers. I am Smart is a fun and encouraging early reader about making good choices! Now a part of the premier early reading line, Step into Reading!When a young boy's teacher announces that there will be a science fair in a few weeks, he is worried. He doesn't like science. But by doing research, asking his friends for help instead of going out to play soccer, and not giving up, he learns that making smart choices leads to success. In this installment of the Positive Power series, kids will learn the affirmation "I am smart" through a relatable story of dedication and perseverence.Through simple text and joyful illustrations, this installment in the Positive Power series inspires kids to make smart choices while giving them the confidence they need to transform from little to BIG readers. Step 2 Readers use basic vocabulary and short sentences to tell simple stories, for children who recogn

Track the facts about snow leopards and other amazing wild cats in this nonfiction companion to the bestselling Magic Tree House series!When Jack and Annie came back from their adventure in Magic Tree House #36: Sunlight on the Snow Leopard, they had lots of questions. Where do snow leopards live? Why are they endangered? Which wild cat has the longest fangs? How do lions hunt? Find out the answers to these questions and more as Jack and Annie track the facts about snow leopards and wild cats from all over the world.Filled with up-to-date information, photographs, illustrations, and fun tidbits from Jack and Annie, the Fact Trackers are the perfect way for kids to find out more about the topics they discover in their favorite Magic Tree House adventures.Did you know that there’s a Magic Tree House book for every kid?Magic Tree House: Adventures with Jack and Annie, perfect for readers who are just beginning chapter booksMerlin Missions: More challenging adventures for the experienced r

Budding cat fanciers will love hunting down the TRUTH about their favorite animals in this innovative early reader.Cats were domesticated before dogs, right? That’s a LIE! The TRUTH is, dogs were living with people for 10,000 years before cats ever were! Though this engaging early reader is 100% fun, 25% of it is FALSE! In a unique Q&A format, proficient readers are quizzed about cats to see if they can separate facts from “lies.” The book’s mascot—the Truth Sleuth—guides readers through this funny and fact-packed book, which features photos and illustrations of a wide variety of felines.Step 3 Readers feature easy-to-follow plots about popular topics, for children who are ready to read on their own.

Five fabulous early readers featuring Uni--everyone's favorite unicorn--available in a gifty boxed set!Uni the unicorn is a model of kindness, creativity, generosity, and determination. New readers will relate to Uni while the stories work to bolster confidence in this new skill.Perfect for independent or guided reading at home or in the classroom! Titles chosen especially for your Step 2 reader are:Uni Brings SpringUni's First SleepoverUni Goes to SchoolUni Bakes a CakeUni and the Perfect PresentFrom helping a bear cub to supporting a friend to believing in unicorn magic, Uni is a perfect role model!Step 2 readers use basic vocabulary and short sentences to tell simple stories. They are perfect for children who recognize familiar words and can sound out new words with help.

Corduroy was first introduced to readers in 1968 and soon became a classic character. Everybody's favorite department store bear is having further adventures in a story about using your voice. Now available in Step into Reading, the premier reader line!When Lisa wants to contact a movie theater owner about a problem, she thinks he's too important and won't respond. Can Corduroy help his friend with her good deed? He shows her how powerful a letter can be, and that speaking up about a problem can make a change! Step 2 Readers use basic vocabulary and short sentences to tell simple stories, for children who recognize familiar words and can sound out new words with help. Rhyme and rhythmic text paired with picture clues help children decode the story.

An awesome Batman (TM) activity book packed with over 500 stickers!Swing into the crime-fighting world of Batman with this awesome full-color activity book that features over 500 stickers of Batman, R

Just in time for Halloween comes a spooky, funny early reader starring Big Shark and Little Shark!Big Shark is scared! The cave looks far too dark and spooky to swim into. But Little Shark isn’t scare

Budding inventors and science fair nerds will love hunting down the TRUTH about some groundbreaking inventions—past and present—and the people behind them in this innovative early reader.The computer

You've heard of the Gingerbread boy, but what about his pup? This fun Step 3 early reader puts a great spin on the classic fairytale.Evalina desperately wants a dog, so she bakes one out of gingerbread and he springs to life! But the gingerbread pup gets into mischief all over town and Evalina must find a way to catch him if she can! This is the latest enchanting fractured fairy tale from the author of early readers Pupunzel, Dogerella, and, The Fairy Dogmother.Step 3 Readers feature engaging characters in easy-to-follow plots about popular topics. For children who are ready to read on their own.

Inspired by the work of Dr. Seuss, the 5 books in this collection feature simple reading and math activities that make early learning FUN--and FUNNY! With over 100 stickers, it's the perfect way for c

A brand-new train-shaped Thomas board book!This sturdy train-shaped board book lets train-loving boys and girls ages 0 to 3 learn all about their favorite blue engine, Thomas!In the early 1940s, a lov

Encourage someone to speak up for their beliefs with this small, hardcover giftbook featuring art by Dr. Seuss! An ideal choice instead of a greeting card, it includes unrhymed lines about using your

Five classic Little Golden Books have been adapted as early readers in this Step into Reading collection!With five Step into Reading stories featuring some of the most beloved Little Golden Book chara

It’s Thanksgiving Day, and there’s a lot to be done before turkey time!I Am Thankfulfollows a young boy through his busy holiday adventures, from running in the turkey trot to helping his family bake pies. Even though the weather might ruin the annual family football game, the jam-packed day proves there’s never a shortage of things to be thankful for. In this first installment of the Positive Power series, kids will learn the affirmation “I am thankful” through a delightful story of food, family, and fun.About the Positive Power Series:Short on words and long on empowerment, the Positive Power early reader series teaches kids and parents alike the power of positive affirmations and how to incorporate them into their daily lives.

Science is a blast, when you work together with Grandma! Follow the volcano fun in this silly Step 2 early reader story from the New York Times bestselling creators of How to Babysit a Grandpa.Once you've learned how to make a volacano at home, it's time to teach Grandma what to do! But what happens when you don't remember the right ingredients? Work together with Grandma to create the best at-home volacno ever, with a few tips and tricks from the experts -- kids!This Step into Reading story features a sweet Grandma and grandchild relationship and all the silly, sticky moments that come with creating an at-home experiment. Perfect for children who are ready to read on their own!Step 2 readers use basic vocabulary and short sentences to tell simple stories. They are perfect for children who recognize familiar words and can sound out new words with help.

好想成為轉學生那樣的酷壞小子啊！新來的培根生菜番茄三明治連上學都戴著墨鏡，上課遲到，老是把「隨便啦」掛在嘴邊。披薩與塔可這對哥倆好決定向他看齊，但這會讓他們惹上什麼麻煩呢？New backpacks? Check! Besties Pizza and Taco are ready to head back to school, but are they ready to meet the cool new kid?B.L.T. wears sunglasses―even in school! He’s not even worried about being late to class. SO COOL! I mean, “whatever.” Pizza and Taco quickly pick up on what’s cool―and what’s not―by watching B.L.T.’s every move. Will that spell t-r-o-u-b-l-e for Pizza and Taco with their teacher, Mr. Apple? This hilarious young graphic novel―with chapters―will tickle the funny bones of kids ages 5-8 and bolster their reading confidence. Young graphic chapter books are a great step on the way to graphic novels and longer chapter books.Readers will also love the first three books in the series:Pizza and Taco: Who’s the Best?Pizza and Taco: Best Party Ever!Pizza and Taco: Super-Awesome Comic!Series Overview: 1. PIZZA AND TACO: WHO’S THE BEST? (Summer ’20)2. PIZZA AND TACO: THE BEST PARTY EVER! (Summe

Sail into the critically-acclaimed world of New York Times bestselling author Rachel Hartman's Southlands in this sea-faring masterpiece that is part fantasy, part reckoning.Tess Dombegh has a mission from her Queen: sail across the oceans to the Archipelagos at the bottom of the world and keep a stealthy record of war-like aggressions. Tess has never been a spy, but she’s well practiced in the art of keeping secrets. Which is why no one knows that Tess is using this mission as an excuse to search for the last World Serpent—a once-mythical creature with magical abilities—and the last hope for Tess to save her best friend Pathka. But when a villain from Tess's past makes a surprise return, old wounds are cracked open, throwing her mission—both the Queen's and Tess's secret agenda—into complete disarray. What's more, Tess's personal pain is intertwined with the colonial history of the Archipelagos and the mending of her heart threatens the delicate balance of the entire Southlands. She i

The Batman(TM) The Deluxe Junior Novel--Special Edition combines fast-paced prequel story with exciting events from the all-new motion picture The Batman, which swings into theaters in theaters on March 4, 2022! Warner Bros.'s The Batman releases in theaters March 4, 2022, bringing with it all the adventure and action of one of the most popular Super Heroes in the world. We all know that billionaire Bruce Wayne is secretly Gotham City's vigilante detective and protector, The Batman--but what road led him there? Find out in The Batman: The Deluxe Junior Novel--Special Edition, which includes the exciting prequel story of Bruce Wayne's early adventures on his way to becoming The Batman, as well how those events come to an exciting conclusion in the new action-packed feature film, starring Robert Pattinson as Batman and Zo?Kravitz as Catwoman. This novel features an eight-page full-color insert and a pull-out poster!

Kids are learning to read with Rocket! The beloved puppy from Tad Hills’s New York Times bestselling picture books returns in an easy-to-read book that proves every egg has a nest.Rocket and his friend Bella find an egg! The birds in the meadow don’t know whose it is. The egg is too small, too colorless, or too round to be theirs! Will the friends return the egg to its nest? With its simple words, lots of repetition, and bright, colorful illustrations, young readers will love this Step 1 leveled reader about Rocket, which they can ready all by themselves!Step 1 Readers feature big type and easy words. Rhymes and rhythmic text paired with picture clues help children decode the story. Perfect for early readers of Rocket the Brave and Drop it, Rocket! and children who know the alphabet and are eager to begin reading

Kids are learning to read with Rocket! The beloved puppy from Tad Hills’s New York Times bestselling picture books returns in an easy-to-read book that proves every egg has a nest.Rocket and his friend Bella find an egg! The birds in the meadow don’t know whose it is. The egg is too small, too colorless, or too round to be theirs! Will the friends return the egg to its nest? With its simple words, lots of repetition, and bright, colorful illustrations, young readers will love this Step 1 leveled reader about Rocket, which they can ready all by themselves!Step 1 Readers feature big type and easy words. Rhymes and rhythmic text paired with picture clues help children decode the story. Perfect for early readers of Rocket the Brave and Drop it, Rocket! and children who know the alphabet and are eager to begin reading

Get Ready Books teach valuable life lessons with your favorite Nickelodeon characters--and they include over 30 stickers!Marshall learns that even heroic pups get scared. Luckily, Nickelodeon's PAW Patrol is there to support him and help him deal with his fears. Boys and girls ages 3 to 7 will enjoy this storybook that shows children how they can cope with nervousness and worries. Featuring popular Nickelodeon characters and fun-filled stories, Get Ready Books teach important social-emotional lessons. Look for the second book in the series, SpongeBob Goes to the Doctor. Follow Nickelodeon's PAW Patrol! Chase, Marshall, Rubble, Skye, and the rest of the puppy heroes are on missions to save their friends and protect the community of Adventure Bay using paw-some vehicles, tools, and teamwork.

The curious crew from Netflix’s Ask the StoryBots star in an all-new storybook about recycling that includes over 30 stickers! Bing, Bo, and the rest of Netflix’s StoryBots want to know where garbage goes. Join them on an adventure that takes them from the landfill to the recycling plant. Children ages 3 to 7 who love Ask the StoryBots will thrill to this fun and fascinating storybook that includes over 30 stickers. The stars of Netflix’s Ask the StoryBots are curious little robots who bring a world of learning and fun to kids ages 2 to 7 across a broad range of subjects with their animated series. All of the award-winning StoryBots content is developed by teachers and early-education experts.

Uni the Unicorn for early readers! Another exciting Step 2 Uni adventure that children will love in the Step into Reading series!Uni has a new friend, a butterfly! First, Uni finds its cocoon and cares for it. It’s incredible to watch nature’s magic as the cocoon develops into and emerges as a butterfly. But Uni notices that the butterfly seems sad while other butterflies that are flying free seem really happy. So, it’s time to say goodbye and allow the butterfly the freedom it deserves. That is what true friendship is all about!Fans of the picture books, as well as new Uni fans, will be excited to join this bighearted unicorn and friends on a new adventure of learning about caring for another and friendship. Look for all the Uni stories, including Uni the Unicorn Bakes a Cake, Uni the Unicorn Goes to School, Uni’s First Sleepover and more!Step 2 readers use basic vocabulary and short sentences to tell simple stories. They are perfect for children who recognize familiar words and can s

Uni the Unicorn for early readers! Another exciting Uni adventure that children will love in the Step into Reading series!Uni is generous, and plans to give Silkie a special present for his birthday. Oh no! Uni loses the present on the way to the party! Is the gift lost for good? What can Uni give instead? And what will Uni discover along the way? Uni the unicorn is a charming and relatable character! Fans of the picture books, as well as new Uni fans, will be excited to join this bighearted unicorn and friends on a new adventure of learning about disappointment and gratitude. Look for all the Uni readers: Uni the Unicorn Bakes a Cake Uni the Unicorn Goes to School Uni's First Sleepover Step 2 readers use basic vocabulary and short sentences to tell simple stories. They are perfect for children who recognize familiar words and can sound out new words with help.

Join Otis and his farmyard friends for all kinds of fun. Now available in Step into Reading, the premier early reader line. Otis is a very busy tractor. He loves working on the farm and playing with his friends. But at the end of a long day, Otis is happy to go home and rest! This is the perfect complement to Loren Long's New York Times bestselling picture books featuring Otis, and a great book with which to learn to read! Step 1 Readers feature big type and easy words for children who know the alphabet and are eager to begin reading. Rhyme and rhythmic text paired picture clues help children decode the story.

Preschool boys and girls will learn lessons about growing up with Thomas & Friends in this all-new hardcover storybook collection Train-loving boys and girls ages 2-5 will love to learn important lessons about growing up with Thomas the Tank Engine in this 96-page beautifully illustrated hardcover collection featuring four stories about feelings, being kind, respecting rules, and making friends. In the early 1940s, a loving father crafted a small blue wooden train engine for his son, Christopher. The stories that this father, the Reverend W Awdry, made up to accompany the wonderful toy were first published in 1945 and became the basis for the Railway Series, a collection of books about Thomas the Tank Engine and his friends--and the rest is history. Thomas & Friends(TM) are now a big extended family of engines and others on the Island of Sodor. They appear not only in books but also in television shows and movies, and as a wide variety of beautifully made toys. The adventures o