Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Fairies, dragons, wizards, and more await Geronimo on every magical Kingdom of Fantasy adventure!Geronimo's sixteenth adventure in the Kingdom of Fantasy!I, Geronimo Stilton, have been called to the Kingdom of Fantasy so many times. Each visit is more of an adventure than the last!This time there was big trouble! Queen Imaginaria has been kidnapped. The evil witch is using her wand to take treasures from the kingdom. Can I help stop the evil witch before all the treasures are gone?

潛入深海，看頂尖掠食者一較高下！這本合輯收錄四場海洋動物精彩對戰，帶領讀者認識雙髻鯊、虎鯨、大白鯊等強者的生態祕密。透過生動圖解與豐富資料，培養孩子的觀察力！Dive into underwater animal battles in this exciting bind-up featuring four favorite action-packed Who Would Win? books!Which underwater animals would win in a head-to-head battle? Find out in this awesome bind-up of four books in the popular Who Would Win? series. The collection features a range of ocean battles to satisfy all kinds of animal fans, including Hammerhead vs. Bull Shark, Whale vs. Giant Squid, Lobster vs. Crab, and Killer Whale vs.Great White Shark.Kids will learn about each animal's anatomy, behavior, and more alongside photos, charts, illustrations, and amazing facts.

From three-time Newbery honor-winning author Christina Soontornvat comes a compelling and immersive young middle grade fantasy series for readers who love stories about animals, magic, and kids like them embracing their power to change the world.Plum's adventure continues in the fourth installment of the Legends of Lotus Island series. Lotus Island is in grave danger, and the powers of the Guardians are weakening. Plum must gather all her strength in order fulfill her destiny and save her friends.

Eight monstrous mammals battle it out in this exciting bind-up featuring four Who Would Win? books in this action-packed animal series!Which dangerous animals would win in a fight? Find out in this awesome bind-up of four books in the popular Who Would Win? series. The collection features a range of mammal battles to satisfy all kinds of animal fans, including Coyote vs. Dingo, Lion vs. Tiger, Rhino vs. Hippo, and Walrus vs. Elephant Seal. Kids will learn about each animal's anatomy, behavior, and more alongside photos, charts, illustrations, and amazing facts.

Pass the magic on! This enchanting multi-author series is like American Girl with magic.In this book, written by bestselling author Sarah Mlynowski and three-time Newbery Honor recipient Christina Soontornvat, the magic bracelet comes to a girl in Texas, who ends up in a Groundhog Day-style time loop.Lucy Usathorn of Fort Worth, Texas is super excited for her class trip to the Natural History Museum, where her dad works. Sure, Ms. Brock, the strict school librarian who happens to be dating Lucy's dad (awkward) is chaperoning, but it'll still be the best day ever, right?Wrong! Lucy has to watch in shock and humiliation as her dad proposes to Ms. Brock. Lucy is distraught. If only she could do this whole day over from scratch...Enter the magic bracelet. It arrives in the mail, with a long letter from Addie, a girl in Columbus, Ohio, who had the bracelet last time. The bracelet grants wishes, and Lucy knows just what to wish for: a do-over day, where she'll fix everything and most importa

Learning to spell really can be fun, especially when you have an amazing Spelling Machine, a 2-book series for preschoolers ages 4-6 to learn spelling and start to read. Within each scene there are five objects to find and learn to spell. Flip out your magical spelling machine contained inside the book, dial in the letters of each word and lift the flap to check your answer!※無音檔英文學習遊戲書有了spelling machine的神奇轉盤，拼單字，也可以變得超級有趣！全新包裝，內容再升級知名親子叢書作家廖彩杏推薦：“ Spelling Machine：Make Spelling Fun！”是一本寓教於樂的遊戲書，讓孩子從小小的拼字遊戲，得到樂趣。本套書以「度假」為主題，分6大場景，共收錄30個常用英文單字。在不同場景，小朋友要先動手動眼，找一找不同物件在哪裡？並學會認識這些物件的英文，學會認字後，用前方的轉盤練習拼字。剛開始認字、學習自然發音的小讀者，都能從遊戲中開心學習！ 【玩法說明】1.第一步，先把紅圈順時針轉到「start」處。2.假設今天要讓孩子熟悉crab的拼法，就先大聲念出crab，讓孩子聽聽看，這個單字，是由哪些字母所組成的。3.現在要拼出crab，就把第一個字母c，順時針轉到start處。4.再把第二個字母r，撥到start處，接下來的字母以此類推。5.最後.恭喜，完成了！請孩子打開翻頁機關確認答案，看到「crab」了嗎？ 是不是好像變魔術一樣，好神奇呢？拼字，也可以這麼有趣！

哈利波特精裝插畫版《鳳凰會的密令》全新出版！面對黑魔王的回歸，秘密地下組織「鳳凰會」再次集結…全彩、大開本、緞帶書籤、全新繪製的精美插畫圖，哈利波特迷不可錯過的完美收藏。The fifth book in the beloved, bestselling Harry Potter series, now illustrated in brilliant full color.There is a door at the end of a silent corridor. And it's haunting Harry Potter's dreams. Why else would he be waking in the middle of the night, screaming in terror? It's not just the upcoming O.W.L. exams; a new teacher with a personality like poisoned honey; a venomous, disgruntled house-elf; or even the growing threat of He-Who-Must-Not-Be-Named. Now Harry Potter is faced with the unreliability of the very government of the magical world and the impotence of the authorities at Hogwarts. Despite this (or perhaps because of it), he finds depth and strength in his friends, beyond what even he knew; boundless loyalty; and unbearable sacrifice.This stunning illustrated edition brings together the talents of award-winning artists Jim Kay and Neil Packer in a visual feast, featuring iconic scenes and mu

The Thea Sisters are on a magical adventure!The Thea Sisters were are needed in Starlight Kingdomthe Kingdom of Starlight. All of the stars in the sky of the kingdom's sky have been losing their shine

Which dangerous animals would win in a fight? Find out in this awesome bind-up of five books in the popular Who Would Win? series! The collection features a range of mammals, sea creatures, reptiles,

New Mouse City is in danger! There is only one way to bring harmony back to the island. Geronimo and friends must travel back in time to retrieve King Solomon's Ring. Along the way Geronimo visits Nap

Everyone's favorite penguin--and the star of two best-selling readers in clubs and fairs--is back in another adorable adventure!Tony Baloney is excited. It's Pen Pal Month at school. Tony hopes he and

The adventure continues in this fifth book in the New York Times bestselling series.The sun is shining in the Hundred Isles, and yet the path forward seems crowded with shadows. Conor, Abeke, Meilin,

Calling Harry Potter fans! Read all about Albus Dumbledore in the POCKET POTTERS series, the completely collectible, fully illustrated, must-have official guides to all your favorite characters from the wizarding world.Why is Dumbledore such a brilliant headmaster? What's on his Chocolate Frog Card and which is his favorite Quidditch team? Find out all this and much more! Join Professor Albus Dumbledore in the Great Hall for the start-of-term feast, climb the enchanted spiral staircase to the headmaster's office, and learn all about Fawkes the phoenix. Get set for wise words, grand wizardry, and some scrumptious magical sweets...Joyfully illustrated, boisterously brilliant, the POCKET POTTERS are collectible, must-have official guides to the Harry Potter books. Whether you are just starting your magical reading journey or you already know your Fizzing Whizbees from your Acid Pops, each of the POCKET POTTERS is perfect for sharing together or reading independently.

本書延續 Dav Pilkey 一貫的幽默節奏，讓 Dog Man 與夥伴們再度踏上一場既混亂又溫暖的冒險。故事從城市突然改變開始，主角們必須依靠彼此找回真相，也重新思考「相信」的力量。Power up with Dog Man: Big Jim Believes from the global #1 bestselling author and award-winning artist Dav Pilkey. Join the journey as our heroes discover the influence of belief and find truth from within. With threads of self-awareness, confidence, and integrity, Dav Pilkey masterfully crafts a humorous and heartfelt adventure, weaving together the importance of truth, goodness, and believing in yourself.The celebration comes to a halt for our heroes in Dog Man: Big Jim Believes when the mischievous Space Cuties From Space return. Our caped crusaders -- Dog Man (aka Scarlet Shedder), Commander Cupcake, and Sprinkles -- along with Mecha Molly discover that the city has changed, and nothing is how it should be. Can Big Jim's positivity and innocence help our heroes? Will Dog Man, Big Jim, Grampa, and Molly have the courage to trust each other and save the day? How does the past help shape the f

The brand new feel-good, laugh-out-loud Tom Gates story featuring LOADS of doodles, three parties and some pesky pets. From Liz Pichon, the multi-million copy bestselling author and illustrator. Norman's told the whole school that DogZombies have a NEW SONG and a NEW LOOK for the BIG end of term party.But the problem is... they don't. How can they be the best band when they will be up against Oakfield Manor school? Will Tom make it to Leroy's party on time? Is dressing as a dolphin with a blue face a good idea? And will Mum and Dad ever do a fun run again? These questions and SO much more answered in this hilarious extra special story.Written in diary form Every page STUFFED full of laughs, stories, doodles and creative FUN The Brilliant World of Tom Gates was the winner of the 2011 Roald Dahl Funny Prize! Perfect gifts for boys & girls who love to laugh themselves silly The first series of The Brilliant World of Tom Gates won the Scottish BAFTA for Entertainment! REVIEWS OF TOM GA

A fabulous new felt-flap addition to the NYT bestselling Leaf Thief series. That pesky leaf thief has stolen Squirrel's favourite leaves! Can you help him find them? Little ones will love searching for the Leaf Thief in this chunky board book with bright coloured felt flaps, perfect for little hands. The Leaf Thief has been a NYT bestseller and has been translated into over twenty languages Other books in the series include That's MY Flower and The Snow Thief Explore numbers and colours The Leaf Thief - Colours and The Leaf Thief - Numbers , two chunky board books with card flaps

Tom has created brand new comic *Ants In Pants* to make everyone laugh. Inspiration is everywhere! There's Mr Keen's unicycle mishap and their NEW supply teacher Miss Jam (whose first name is NOT Strawberry or Traffic). BUT when Tom's comic falls into the wrong hands, everything starts to go wrong. HOW will he get himself out of this MESS? The top-of-the-class, extra special 22nd book from bestselling author and illustrator Liz Pichon.A feel-good, laugh-out-loud, packed-with-pictures Tom Gates story!The brand new Tom Gates bestseller from multi-million selling writer and illustrator Liz Pichon.Tom Gates is Ha! Ha! HILARIOUS! He's created brand new comic *Ants In Pants* to make everyone (even Delia) laugh. Inspiration for his new comic is everywhere! There's Mr Keen's unicycle mishap and their NEW supply teacher Miss Jam (whose first name is NOT Strawberry or Traffic - but it should be). Class 5F LOVE Miss Jam's lessons. Mr Fullerman, not so much. BUT when Tom's comic falls into th

《飢餓遊戲》豪華典藏版套書——粉絲必收！完整收錄全四部小說！包含 《飢餓遊戲》三部曲 + 前傳《鳴鳥與毒蛇之歌》，搭配 Freya Betts 全新封面設計，打造絕美收藏版！ 「這本書讓我徹底著迷！」——Stephenie Meyer，《暮光之城》作者「我無法停下來閱讀。」——Stephen King**「生存唯一的規則：殺，或被殺。」** 在殘酷的帕納姆國，每年 12 個區都要派出 **一男一女** 參加 **飢餓遊戲**，在電視直播下進行殊死戰……This beautiful hardcover box set includes all three books in Suzanne Collins's internationally bestselling Hunger Games trilogy together with The Ballad of Songbirds and Snakes. You can step into the world of Panem with the 10th annual Hunger Games, and continue all the way to the electrifying conclusion. This beautiful deluxe hardcover box set includes all three books in Suzanne Collins's internationally bestselling Hunger Games trilogy together with The Ballad of Songbirds and Snakes.With brand new artwork by Freya Betts: this is a must-have collection for all fans of this groundbreaking, phenomenally bestselling series."I was so obsessed with this book. . . . The Hunger Games is amazing." Stephenie Meyer, author of the Twilight saga"I couldn'

A gorgeous board book collection of much-loved nursery rhymes illustrated by Axel Scheffler, the bestselling team of The Gruffalo and Zog. Climb up the waterspout with Incy Wincy, help the king's men try to put Humpty Dumpty back together again, dance along with the cat playing his fiddle and so much more! Brought to life with Axel Scheffler's stunning illustrations, this collection of beloved nursery rhymes such as Twinkle Twinkle and Mary Had a Little Lamb, is the perfect bedtime read for the whole family to enjoy. A collection of children's nursery rhymes illustrated by the one and only award-winning superstar, Axel Scheffler This lovely board book format is perfect for little hands to turn pages without tearing them Part of the new series of fairy tale and traditional stories illustrated by Axel Scheffler, published by Scholastic - check out Puss in Boots, Hare and the Hedgehog, Goldilocks and the Three Bears and The Three Little Pigs and the Big Bad Wolf in lovely gifty hardbacks.

The classic, much-loved story of Puss in Boots, masterfully brought to life by Axel Scheffler, illustrator of The Gruffalo and Zog. When a young miller's son is given a cat by his father, he doesn't understand what use the cat will be to him except as a pair of furry gloves... But when Puss starts to talk, the miller's son soon learns that his fortune is about to change.With clever Puss in Boots by his side, the pair move up in the world ... but will they be able to outwit a wicked magician and save a kingdom together? A well-known children's fairy tale story illustrated by the one and only award-winning superstar, Axel Scheffler Hardback pocket-size format is perfect for little hands Part of a new series of fairy tale stories illustrated by Axel Scheffler, published by Scholastic - Goldilocks and the Three Bears and The Three Little Pigs are also out now! Watch out for The Hare and The Hedgehog, which publishes simultaneously Translated by Alison Green, author of bestselling picture b

2024 Caldecott Medal Honor2025 RICBA NomineesThe remarkable true story of Jovita Valdovinos, a Mexican revolutionary who disguised herself as a man to fight for her rights, told by her great niece, award-winning author, Aida Salazar!Jovita dreamed of wearing pants like her brothers, Ram鏮 and Luciano.She hated the way the big skirts that Abuela made her wear tangled around her legs as she scaled the tallest mesquite tree in Rancho Palos Blancos. She wanted to ride her horse Morongo and feel the wind curl her face into a smile.When her father and brothers joined the Cristeros War to fight for the right to practice religion freely, she wanted to help. Though she wasn't allowed to fight, that didn't stop her from learning the terrain and observing how her father strategized. Then tragedy struck, compelling Jovita to cut her hair, put on pants, and continue the fight. Disguised as a man, she commanded a battalion who followed her without question.Jovita Wore Pants is the story of a trailbla

Have a top-of-the-class count down to Christmas with this advent calendar collection of twenty-four mini activity and story books, PERFECT for every Tom Gates superfan! Enjoy a book every day packed with how-to-doodles, mega make-and-do activities and stories to share, starring all your favourite characters, including Rooster, Marcus, Delia and Amy. 'Tom Gates is as moreish as a caramel wafer' The Sunday Times 'High octane and highly entertaining' Guardian A sturdy hardback with pockets for each book and a ribbon tie to keep everything safe Over 5 million copies of the Tom Gates series sold in the UK Leave boredom behind with a book each day, and pockets to colour in The perfect advent calendar for creative kids. ABOUT THE SERIES: Each Tom Gates book is written in diary form Full of Tom's doodles and pictures and his amazing sense of humour The Brilliant World of Tom Gates was the winner of the Roald Dahl Funny Prize! Perfect gifts for boys and girls who love to laugh themselves silly

Discover tons of exciting pranks, jokes, and hijinks from the films of Harry Potter in this hilarious and interactive book with a paintbrush that reveals hidden messages.Ever wanted to tell a joke lik

A diverse cast of characters-Kamala Khan (Ms Marvel), Miles Morales (Spider-Man) and Doreen Green (Squirrel Girl)-team up in their first-ever illustrated middle-grade series about ordinary kids with e

Professor Volt's first time machine somehow made it to the present and must be escorted back in time as soon as possible, before it alters the course of history!

I, Geronimo Stilton, was called to the Kingdom of Fantasy for the tenth time! A fairy princess had called me there. She needed my help: The most powerful and dangerous wizard in the realm wanted to capture her -- and conquer the entire kingdom!The wizard was hunting for special magical objects to increase his powers -- fairy dust to make him fly, the precious gold of the gnomes, the dazzling egg of fire, and more. It was up to me to foil his plans, with the help of magical friends new and old. Could we save the Kingdom of Fantasy?

In the still before dawn, while the rest of the world is sleeping, a boy and his dog leave the comfort of their warm bed to deliver newspapers. As the boy pedals his bike along a route he knows by hea

In a sequel to her bestselling When Sophie Gets Angry..., Caldecott Honor Illustrator Molly Bang asks: What hurts your feelings, and what do you do about it?Everyone's feelings get hurt, and it's espe

Everyone needs UNDERPANTS! The perfect gift for Captain Underpants fans and newcomers to the series: a boxed collection of the first three books in hardcover and full color!Meet George and Harold, two

Blood Will Spill, Hearts Will Break: With a fierce rivalry raging between two warring families, falling in love is the deadliest thing Sophie could do. An epic debut set outside modern-day Chicago.For

A bedtime book in the vein of Everywhere Babies, Harold and Purple Crayon, and In the Night Kitchen, THE NIGHT PARADE is a dreamworthy story.Have you ever wondered what happens at nightwhile mothers and fathers lie sleeping?Children wake up. They climb out of their bedssome crawling, some running, some leaping.As the moon shines down they escape into townTo the Night Parade they go sneaking...THE NIGHT PARADE is a goodnight book filled with the whimsical wilderness of children's imaginations just before they fall asleep. Written by first time author, Lily Roscoe, and illustrated by bestselling illustrator, David Walker, THE NIGHT PARADE is a truly dreamworthy read-aloud.

The "Monster Mash" was a graveyard smash--and now it's a picture book by David Catrow!The "Monster Mash" gets Wolf Man, zombies, and other monsters to dance and party in this catchy, classic song. Dra

David finds that school can be great fun after he takes control of his own activities, but the teachers don't think his kind of entertainment is amusing and so try to stay one step ahead of him in ord

The third book in Scholastic's exciting Carry and Learn series teaches toddlers early learning concepts using multi-sensory novelties for maximum activity, play, and discovery!Shapes are all around us

The perfect back-to-school reference book for the early elementary set!From Scholastic, the most trusted name in learning (R), comes this picture dictionary featuring America's favorite big red dog, C

Embrace your bright side with a daily dose of positivity from the sweetest fruits and the cutest vegetables. You deserve happiness and love. Nothing can stand in your way.You are strong and full of courage. Packed with positive affirmations from lovable lemons, adorable apples, peppy peppers and more, A Little Bit of Positivity gives you just the boost you need with encouraging words and optimism on every page. It's the perfect way to put a smile on your face every day.Filled with adorable illustrations by Jason Cox Guaranteed to give a daily dose of positivity A wonderful gift for loved ones.

Princess Truly is not afraid of anything, in these rhyming stories perfect for early readers!Pick a book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed at children

Travel to a magical moonlit party with fairy friends Ruby, Iris, and Pip in this wondrous early reader series!Pick a Book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, a

Take to the sky with Ruby, Iris, and Pip -- the Fairylight Friends -- in this sparkly early reader series!Pick a Book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed

Bo grants the goblin princess a wish in this magical early chapter book from the USA Today bestselling author of Owl Diaries!Pick a book. Grow a Reader!This series is part of Scholastic's early chapte