Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Created by a teacher, Bob Books have been helping children learn to read for more than forty years! This set gives children who are just beginning to read practice with their early phonics skills, setting them up for success on their reading journeys!With playful stories, silly illustrations, and a phonics approach based on Science of Reading research, Bob Books keep young readers'' confidence high, leading to continued success and a love of reading. Your child will soon join the millions of happy kids who say, "I read the whole book!"®Science of Reading research proves that mastering phonics is key to a child''s success in learning to read. Like all Stage 1 Bob Books, these 12 storybooks feature simple words with consistent short vowel sounds. Early readers get lots of practice with foundational phonics skills while giggling at the playful stories and pictures!This set is perfect for children who have never read Bob Books, or for children who have read Bob Books Beginning Readers or B

Fox Tails #1-3: An Acorn BookThe Great Bunk Bed Battle: An Acorn Book (Fox Tails #1)The Biggest Roller Coaster: An Acorn Book (Fox Tails #2)The Giant Ice Cream Mess: Acorn Book (Fox Tails #3)Siblings Fritz and Franny have their sights set on the tastiest ice cream treat in this early reader from Geisel Honor winner Tina Kügler!Pick a Book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed at children who are learning to read. With easy-to-read text, a short-story format, plenty of humor, and full-color artwork on every page, these books will boost reading confidence and fluency. Acorn books plant a love of reading and help readers grow!Scoop up this fun-filled early reader series! When competitive fox siblings Fritz and Franny hear the ice cream truck on their street, they both imagine making the sweetest treat with different flavors and toppings. But there's just one problem: Their mom says they can only have one scoop each! Maybe Fritz and Franny need

Mermaid Days #1-3: An Acorn BookThe Sunken Ship: An Acorn Book (Mermaid Days #1)The Sea Monster: An Acorn Book (Mermaid Days #2)A New Friend: An Acorn Book (Mermaid Days #3)Vera and Beaker make a new friend when they meet a mantis shrimp, in this series perfect for beginning readers!Pick a book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed at children who are learning to read. With easy-to-read text, a short-story format, plenty of humor, and full-color artwork on every page, these books will boost reading confidence and fluency. Acorn books plant a love of reading and help readers grow!Swim along with mermaid Vera and octo-kid Beaker! In these three stories, Vera and Beaker make a new friend with a powerful baby mantis shrimp. Together, they explore the town of Tidal Grove. Then they play fun underwater games! Young readers will love discovering Vera and Beaker’s funny adventures and learning nonfiction information about mantis shrimp. Did you know

Now a major motion picture!"I wish I'd had these books as a kid. Hilarious!" -- Dav Pilkey, creator of Captain Underpants and Dog ManThey may look like Bad Guys, but these wannabe heroes are doing good deeds... whether you like it or not in this New York Times bestselling illustrated series.The next installment in the hilarious Bad Guys series!

The Cat Kid Comic Club learns to collaborate in this creative, funny, and insightful graphic novel by Dav Pilkey, the author and illustrator of Dog Man.Excitement and imagination run wild as Naomi, Melvin, Poppy, Gilbert, Curly, and their siblings get back to making comics with originality and laughter. But wait -- have they cleaned their rooms yet?!After their chores, the rambunctious group presents even more amazing mini-comics: a thrilling ride in "Chubbs McSpiderbutt," an action-packed romp in "Frogzilla," reflective haikus in "In the Autumn Pond," a candy-coated mystery in "Mallo Cop," and much, much, more. By working together, the baby frogs discover that small things can have a huge impact.In this innovative graphic novel series, award-winning author and illustrator Dav Pilkey employs a variety of techniques -- including origami, acrylic paints, colored pencils, photography, collage, gouache, watercolors, and more -- to capture the creative and joyful spirit of collaboration. Th

Ten fierce animals battle it out in this exciting bind-up featuring five books in this action-packed animal series!Which dangerous animals would win in a fight? Find out in this awesome bind-up of five books in the popular Who Would Win? series. The collection features a range of mammals, sea creatures, reptiles, and birds to satisfy all kinds of animal fans, including Falcon vs. Hawk, Hyena vs. Honey Badger, Komodo Dragon vs. King Cobra, Tarantula vs. Scorpion, and Whale vs. Giant Squid.Kids will learn about each animal's anatomy, behavior, and more alongside photos, charts, illustrations, and amazing facts.

9780545639149 Rescue on the Oregon Trail (Ranger in Time #1)9780545639170 Danger in Ancient Rome (Ranger in Time #2)9780545639200 Long Road to Freedom (Ranger in Time #3)9780545639255 Race to the South Pole (Ranger in Time #4)9780545909785 Journey through Ash and Smoke (Ranger in Time #5)9780545909839 Escape from the Great Earthquake (Ranger in Time #6)9781338133905 D-Day ─ Battle on the Beach (Ranger in Time #7)9781338133950 Hurricane Katrina Rescue (Ranger in Time #8)9781338133981 Disaster on the Titanic (Ranger in Time #9)9781338134018 Night of Soldiers and Spies (Ranger in Time #10)9781338537949 Escape from the Twin Towers (Ranger in Time #11)9781338537963 Attack on Pearl Harbor (Ranger in Time #12)

When Steve Jobs died in 2011, the world mourned the passing of one of the most influential inventors and business leaders in history. Readers will learn about Jobs' incredible life and get a close loo

這套《Wings of Fire》盒書，完整收錄第1-5集，每冊內頁加收未曾公開的角色素描、專屬作者問答內容；每本都有彩色刷邊，隨書附贈專屬海報。適合書迷收藏，或是想試試Wings of Fire的讀者。A box set that includes the special editions of books #1-5 in the #1 New York Times bestselling Wings of Fire series with colorful stenciled edges and an exclusive poster!Go back to where it all began with the special editions of the first five books in the Wings of Fire series. This set includes all five books in the first Wings of Fire story arc, each with never-before-seen character sketches, an exclusive Q&A with bestselling author Tui T. Sutherland, and stunning stenciled edges.

A Baby-sitters Club graphic novel adapted by New York Times bestselling cartoonist Arley Nopra!Mallory knows she's a good baby-sitter. She's been looking after her seven younger brothers and sisters for years. So when Kristy offers her a steady job baby-sitting for the Arnold twins, Mal thinks it'll be easy money.The twins sure are cute in their matching outfits. But once Mrs. Arnold leaves, Marilyn and Carolyn turn into twin terrors! They trick Mallory so that she can't tell them apart and they act like spoiled brats.Taking care of Marilyn and Carolyn is a baby-sitting nightmare. But Mallory is a responsible member of the Baby-sitters Club and she's not giving up!

Relive your favorite moments from Dav Pilkey's bestselling Dog Man series with this paw-some official sticker book!Dog Man is half man, half dog, and all Supa Cop! You can join Dog Man, Petey, Lil Petey, and all their friends on their action-packed adventures in this interactive sticker book based on the bestselling book series. This book comes with twelve sheets of stickers -- over 200 stickers total! -- that can be used to create sticker scenes and decorate notebooks, water bottles, and more.This sticker book is hours of fun for any Dog Man fan!

The graphic novel adaptations of the #1 New York Times bestselling Wings of Fire series continue to set the world on fire!Peril has been loyal to Queen Scarlet, who used her fatal firescales to kill countless dragons in the SkyWing arena. Now, Peril is loyal to Clay, the only dragonet who has ever been her friend. So when Scarlet threatens Jade Mountain Academy, Peril sets off to find her former queen, stop her, and save the day, no matter what it takes.There's just one problem: a strangely persistent SeaWing, Turtle, insists on coming along, too. Turtle is worried about his friends, who left to search for Scarlet and haven't returned. Peril is worried that she might accidentally burn Turtle -- or burn him on purpose, for being so annoying -- and frustrated that she keeps saying and doing the wrong things. She can't escape her firescales, and she can't escape her reputation as the deadliest dragon in Pyrrhia.So when she's offered a chance to trade everything for a new life, Peril has t

D.I.Y. squishy stickers featuring some of your favorite Pokémon!Color, stack, and squeeze! It's super simple to make 3D puffy stickers with Klutz's nifty, tried-and-true sticker press. Simply layer the sticky back with the foam insert and the artwork. When you press on the handheld sticker maker, the custom plates squish everything into a neatly lined-up sticker. Cut around the outside, and you have a round sticker you can stick and display, or simply store it in your sticker collection to use later. Some of the artwork is already colored in, while the rest is up to you to use colored pencils, markers, and other art supplies from home to fill in the blanks. Preprinted artwork features Pokémon characters including Eevee, Charizard, and of course Pikachu.

Explore colors with cute Pokemon--and use the water pen to reveal images on every page!What color is Pikachu? What color fruit does Dedenne like to eat? Explore colors with the cute Pokemon of monpoke island!Fill the pen with water and reveal hidden colors, objects, and Pokemon on every page. When the pages dry, refill the pen and do it all over again--the perfect mess-free activity for fun at home or on the go!Illustrated in a soft, sweet style, this adorable Water Wonder board book is sure to appeal to moms and dads eager to introduce their children to the world of Pokemon.

I Survived the Sinking of the Titanic, 1912: A Graphic Novel (I Survived Graphic Novel #1) (平裝本)I Survived the Shark Attacks of 1916: A Graphic Novel (I Survived Graphic Novel #2)(平裝本)I Survived the Nazi Invasion, 1944: A Graphic Novel (I Survived Graphic Novel #3)(平裝本)I Survived the Attacks of September 11, 2001: A Graphic Novel (I Survived Graphic Novel #4)(平裝本)I Survived the Attack of the Grizzlies, 1967: A Graphic Novel (I Survived Graphic Novel #5)I Survived Hurricane Katrina, 2005: A Graphic Novel (I Survived Graphic Novel #6)I Survived the Great Chicago Fire, 1871 (I Survived Graphic Novel #7)I Survived the American Revolution, 1776 (I Survived Graphic Novel #8)The Battle of D-Day, 1944 (I Survived Graphic Novel #9)I Survived the Destruction of Pompeii, AD 79 (I Survived Graphic Novel #10)Lauren Tarshis's New York Times bestselling I Survived series comes to vivid life in graphic novel editions. Perfect for readers who prefer the graphic novel format, or for existing fans of the

Magic Pickle battles Square Root and his pungent, garlicky sidekick in this action-packed, pun-filled graphic novel.New enemies have taken root! Evil tuber Square Root, along with his sidekick Herb Cloverson, a smelly clove of garlic, plans to squash Magic Pickle's powers and rule the world! But Square Root hasn't reckoned with Magic Pickle's own sidekick, Jo Jo, a human girl who's full of daring and smarts. Can Magic Pickle and Jo Jo dish out some Dill Justice? Or will Square Root's rotten plot prevail?

The #1 New York Times and USA Today bestselling series is hotter than ever, and this thrilling conclusion to the Lost Continent Prophecy arc is a must-read!With talons united...Luna has always wanted to change the world -- to fix it, to free it -- even if she’s never actually known how. Now that all of dragon- and humankind are in mortal danger, Luna is flying back home to Pantala with a team of dragons on a rescue mission, determined to be brave and useful.But saving a continent isn’t as easy as a prophecy makes it sound, and "facing a great evil" definitely requires more than the fiery silk that Luna is uniquely able to create.As she fights her way to the abyss that hides the dark roots poisoning Pantala, Luna must uncover a long-buried secret and unite her friends, her enemies, and her own powers. If she doesn’t, she won’t get to change the world. She’ll have to say goodbye to it -- forever.

The magic of the New York Times and PW bestselling Whatever After series comes to life in this brand-new graphic novel adaptation that will appeal to fans of the BSC and Wings of Fire alike! Fractured fairy tales have never been this fun.Once upon a time, Abby and her little brother, Jonah, were ordinary kids. The next minute? The mirror in their basement slurped them up and magically transported them into the fairy tale of Snow White.Yes, really!When Abby and Jonah stop Snow from eating the poison apple, they think they're heroes. But wait! If Snow doesn't die, she won't meet her prince and get her happy ending. Oops.Now it's up to Abby and Jonah-- with some help from Snow and the seven dwarfs--to outwit the witch and save the famous fairy tale in time.But what if Snow's REAL happy ending is something else entirely?Bestselling author Sarah Mlynowski and award-winning illustrator Anu Chouhan join forces to bring us this vibrant, action-packed, enchanting graphic novel adventure that wi

The newest graphic novel in the #1 bestselling series by Dav Pilkey, the author and illustrator of Dog Man!The Cat Kid Comic Club is in crisis! After learning that one of their comics will be published, the baby frogs are filled with anxiety and doubt. How will they get their creative groove back? Will Naomi or Melvin emerge as a leader? Will Flippy convince them to finally straighten up and fly right?The story is hysterical, thought-provoking, and full of action-packed mini-comics: "Frogzilla vs. Mechafrogzilla," "I Am Dr. Fredric Wertham," "Two Birds," and "RoboChubbs." Bestselling author-illustrator Dav Pilkey shows the reader that the best way to influence people is to be open, gentle, and kind. The variety of art styles, paired with Pilkey's trademark storytelling and humor, inspires imagination and innovation for readers of all ages.For more hilarity and heart, dive into the newest graphic novel in the Dog Man series: Dog Man: Twenty Thousand Fleas Under the Sea. And don't forget

This gripping story, set in the world of the award-winning Show Me a Sign and Set Me Free, completes an unforgettable trilogy centering the d/Deaf experience."Thrilling, important, and profoundly moving. A true gift." -- Brian Selznick, creator of the New York Times bestsellers Big Tree and The Invention of Hugo Cabret, winner of the Caldecott MedalAs a young teacher on Martha's Vineyard, Mary Lambert feels restless and adrift. So when a league of missionaries invite her to travel abroad, she knows it's a once-in-a-lifetime opportunity. Paris is home to a pioneering deaf school where she could meet its visionary instructors Jean Massieu and Laurent Clerc--and bring back their methods to America!But the endeavor comes at a cost: The missionaries' plan to "save" deaf children is questionable at best--and requires Mary's support. What's more, the missionaries' work threatens the Wampanoag and other Native peoples' freedom and safety. Is pursuing Mary's own goals worth the price of betrayi

《紐約時報》暢銷作家 Joanna Ho 與插畫家 Catia Chien 聯手，帶來這本關於藝術家暨行動主義者 艾未未（Ai Weiwei） 生命與創作的動人繪本。本書以 Joanna Ho 抒情的筆調，講述了艾未未如何將難民困境化為震撼世界的藝術。他在希臘萊斯沃斯島看見成堆廢棄的橙色救生衣後，獲得靈感，將其變成了柏林音樂廳裡醒目的裝置藝術——《救生衣》，藉此引起全球對難民危機的關注。Catia Chien 大師級的插畫採用木刻版畫風格，並特別強調救生衣的橙色，象徵希望與力量。本書精彩呈現艾未未的藝術家之路，證明了藝術在人類社會中的強大影響力。這是向孩子介紹艾未未，以及送給年輕藝術愛好者的完美禮物。2024 Bank Street Children’s Book Committee Best Books of the Year2023 IA Iowa City Public Library Best Books of the Year2023 CA Eureka! Nonfiction Children’s Book Award Silver Medal2024 NCTE Orbis Pictus Award Recommended TitleStarred Review from Kirkus ReviewsStarred Review from Publishers WeeklyStarred Review from School Library JournalStarred Review from BooklistFrom New York Times bestselling author of Eyes That Kiss in the Corners, Joanna Ho, and critically acclaimed illustrator, Catia Chien comes a moving, powerful picture book about the life and work of activist and artist, Ai Weiwei. He [Ai Weiwei] felt the life jackets and an idea curled and crested through his fingertips. The w

Rocks and minerals come alive in the next Animated Science book, an outstanding comic series illustrated by Shiho Pate!From gemstones to fossils and beyond, Animated Science: Rocks and Minerals is the definitive guide to rocks and minerals for grade school readers. In this book, readers will explore the substances that make up our Earth through comic illustrations and hilarious characters.With a narrative nonfiction text, kid-friendly information, and Shiho Pate's engaging illustrations, Animated Science: Rocks and Minerals is a perfect introduction and ready reference, appealing and laugh-out-loud funny. Easily accessible for readers just learning, with more interesting facts and details for older kids honing their knowledge.Great for all ages!

The Spy Ninjas are going viral in their first original graphic novel!The Spy Ninjas finally have the upper hand! Chad and Vy have discovered a super secret project Zorgo base. It's filled with gadgets, gizmos and some serious technology. Chad and Vy just have to show some of this to the other Spy Ninjas. They bring a VR headset home with them, but it's more than meets the eye. Chad and Vy try on the headset and get sucked into a virtual world! This can't be good. Complete with digital bosses, exploding food, and wacky characters, will the Spy Ninjas be able to escape or will project Zorgo prevail once and for all? This original graphic novel is perfect for readers searching for a whirlwind adventure!

Did you know that stars explode? Or that they can be different colors? Have you ever wondered how many stars exist in the universe or how they form? These are just a few of the topics covered through

Did you know the moon is considered a natural satellite? Or that its gravity affects ocean tides on Earth? This book explores the closest celestial body to Earth and the ways in which the moon and Ear

Three boys + a supercool clubhouse + "No sisters allowed!" = tons of adventure!Sam, Matt, and Luke have built the coolest clubhouse ever. But they can't decide what kind of club they should be. Are they space explorers? Dino hunters? Piratecaptains?For three small boys with big ideas, life is one crazy adventure after another in this simple Level 1 reader!

The engaging Explore My World picture books invite kids to take their first big steps toward understanding the world around them and are just the thing for parents and kids to curl up with and read aloud. In Frogs, curious kids learn about the fascinating world of frogs, especially their growth from tadpole to full-grown frog and the relationship between baby frogs and their parents.

A True Book-Physical Science Whether you're an aspiring inventor or an everyday science buff, you've probably created your own experiments to uncover the truth about the forces of physical science. No

Discusses why immigrants came to the United States in the late 19th and early 20th centuries, the difficulties of the journey, the establishment of the Ellis Island Immigration Station and what went o

Moo Dog is a sweet and funny early graphic reader about a bird and a dog who aren't like the other animals.This Level One reader is a follow-up to the sweet and funny Moo Bird in which Bird says "moo" instead of "tweet." In this book, Dog says "moo" instead of "woof!" The other animals laugh at Dog. They don't understand why he is different. Can friends Dog and Bird show the other animals that being different can be fun?With comic speech bubbles and full-color artwork throughout, Geisel Award Honoree David Milgrim's early reader is sure to be a hit with beginning readers!

Racing Ace #1-3 (共3本)Drive It! Fix It!: An Acorn Book (Racing Ace #1)Build It! Jump It!: An Acorn Book (Racing Ace #2)Ride It! Patch It!: An Acorn Book (Racing Ace #3)Ace enters a mountain bike race in this fast-paced, STEM-themed early reader!Pick a book. Grow a Reader!This series is part of Scholastic's early reader line, Acorn, aimed at children who are learning to read. With easy-to-read text, a short-story format, plenty of humor, and full-color artwork on every page, these books will boost reading confidence and fluency. Acorn books plant a love of reading and help readers grow!Ace polishes up her mountain bike and prepares for the big bike race! She oils the chain and tests the brakes. Then the race begins! But Ace's bike chain comes off the sprocket and then she needs to patch a tire! Will she be able to fix her bike and find her way to the finish line?With Larry Dane Brimner's simple text and Kaylani Juanita's full-color artwork on every page, this fast-paced, action-packed bo

The Bad Guys are back in another holiday adventure!This time, Mr. Wolf and the team are taking on the spookiest day of the year... Halloween! Heists, candy, and maybe a few hilarious costumes. Join the Bad Guys in this novelization based on the new Netflix Halloween special, coming your way in Fall 2024. Includes a sheet of stickers.

Welcome to Playtime Co.! Don't mind the toys, they are all harmless.... mostly! This in-world Orientation Notebook to the viral video game Poppy Playtime teaches gamers everything they need to know to be the very best employees. Learn all about Huggy Wuggy, Mommy Long Legs, and all of your favorite toys in Poppy Playtime.The Orientation Notebook even includes exclusive secrets not found in the factory. It may be your first day on the job, but don't worry, this notebook will show you the ropes. Just remember, feel free to explore ...uncover secrets and most importantly, survive. Filled with lore straight from the game's creators, handwritten notes, incident reports and so much more. This in-world notebook is sure to delight fans of the hit horror video game! perfect for budding horror fans learn all the secret lore behind the hit horror game find out more about the grisly truth about your favourite characters

If you like Mo Willems'' Pigeon, you''ll love Sam Wedelich's Chicken Little! Hop along as she races the infamous Hare in this perfect springtime read.A CBC Children's and Young Adult Favorite"A successful third hit for the ''real'' Chicken Little." — Kirkus Reviews Chicken Little dislikes competition. So when a marathon—featuring local-record holder, Hare!—is announced in the barnyard, she doesn''t understand all the fuss. Until she watches her brood fall beak over claw for the gamey Hare and ditch their training in favor of his smoothies, sweatbands, and sneakers! Can Chicken Little prove this frontrunner''s methods are phony or will she have to wing it and join the very long race?The plucky star of Chicken Little: The Real and Totally True Tale and Chicken Little and the Big, Bad Wolf will have young readers laughing and cheering all the way to the finish line in this fresh and funny reimagining of a timeless favorite spun with sly wisdom.

An inspiring graphic memoir from celebrated athlete and activist Colin Kaepernick.High school star athlete Colin Kaepernick is at a crossroads in life. Heavily scouted by colleges and Major League Baseball (MLB) as a baseball pitcher, he has a bright future ahead of him. Everyone from his parents to his teachers and coaches are in agreement on his future.Colin feels differently.Colin isn't excited about baseball. In the words of five-time all-star MLB player Adam Jones, 'Baseball is a white man's game.' Colin looks up to athletes like Allen Iverson: talented, hyper-competitive, unapologetically Black, and dominating their sports while staying true to themselves.College football looks a lot more fun than sleeping on hotel room floors in the minor leagues of baseball. But Colin doesn't have a single offer to play football. Yet.Explores the story of how a young change-maker learned to find himself and never compromiseFull-colour illustration throughoutA graphic novel memoir for readers 12

Explains what hydrology is, shows the impact of water on human history, and looks at water's role in climate, the water cycle, and the role of hydrology in the contemporary world.

- Clean new design for easy readability and comprehension- Updated text presented in a lively, continuous narrative- New center-spread "sidebar" feature presenting material in a fun, creative way- Exc

Reinforce must-know phonics concepts with this cutting-edge series of nonfiction books! Each title features simple decodable text paired with clear, colorful photos to maximize learning and fun. From birds to birthdays, fast cars to big sharks—all kids’ favorite topics are here. A super way to motivate every child to become a confident, phonics-wise reader!

A vividly rendered graphic novel adaptation of Lauren Tarshis's bestselling I Survived the Bombing of Pearl Harbor, 1941 with text adapted by Georgia Ball and art by Peter Wartman.A day no one will ever forget... Danny Crane and his mom moved from New York City to Pearl City, Hawaii two months ago. Every day since, Danny has been making a plan to get back to NYC. He's not afraid of the crime or dark alleys there. And he’s not afraid to stow away on the next ship out of Pearl Harbor.But that morning, the skies fill with fighter planes. Bombs pound the harbor. Bullets rain down on the beaches. Danny is shocked -- and, for the first time, truly afraid. He’s a tough city kid. But can Danny survive the day that will live in infamy?Lauren Tarshis's New York Times bestselling I Survived series comes to vivid life in this pulse-pounding graphic novel edition. Perfect for readers who prefer the graphic novel format, or for existing fans of the I Survived chapter book series, these graphic novel

Now in paperback from the bestselling creators of Room on the Broom and The Snail and the Whale -- a very fishy story about very fishy stories!The little fish Tiddler comes late to school every day, but always with an elaborate excuse that charms his classmates -- and annoys his teacher! One day, as he's thinking up his next story, a net sweeps him up and hauls him far away. How will Tiddler find his way home? All he has to do is follow the trail of his biggest, fishiest story yet!For every parent or teacher who knows the boundless creativity of a perpetually late child, this book is sure to become the next read-aloud favorite from the bestselling author-illustrator team behind The Gruffalo, Room on the Broom, and The Baddies.