Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Fresh from his recent acclaim as a Good Morning America Bookclub choice, Philip R. Craig casts his observant eye on the fine line between tragedy and comedy on Martha's Vineyard.Just look at the Viney

Our lives, our half-century.Nick Shay and Klara Sax knew each other once, intimately, and they meet again in the American desert. He is trying to outdistance the crucial events of his early life, hau

ONE OF THE ECONOMIST'S BEST BOOKS OF THE YEAR AND A WINNER OF THE WASHINGTON MONTHLY'S ANNUAL POLITICAL BOOK AWARDPolitical experts John B. Judis and Ruy Teixeira convincingly use hard data -- demogr

Set at a boys' school in New England during the early years of World War II, A Separate Peace is a harrowing and luminous parable of the dark side of adolescence. Gene is a lonely, introverted intell

Until that fateful moment when she was shot and left for dead, Regina Harris was living la vida loca with pimps and hustlers and using whatever money she had to get high and forget that she was livin

It is Ireland in the early 1990s. Helen, her mother, Lily, and her grandmother, Dora have come together to tend to Helen's brother, Declan, who is dying of AIDS. With Declan's two friends, the six of

Set at a boys’ boarding school in New England during the early years of World War II, A Separate Peace is a harrowing and luminous parable of the dark side of adolescence. Gene is a lonely, introverte

The remarkable untold story of a Jewish orphan who fled Nazi Germany for London, only to be arrested there by the British government and sent to an internment camp for suspected foreign agents on the Isle of Man, alongside a renowned group of refugee musicians, intellectuals, artists, and―possibly―genuine spies.Following the events of Kristallnacht in 1938, Peter Fleischmann evaded the Gestapo’s midnight roundups in Berlin by way of a perilous journey to England via the Kindertransport train. But he could not escape the British police, who came for him in the early hours and shipped him off to Hutchinson Camp on the Isle of Man, under suspicion of being a spy for the very regime he had fled.Peter’s story was no isolated incident. During Hitler’s rise to power in the 1930s, tens of thousands of German and Austrian Jews escaped and found refuge in Britain. Once war broke out in 1939, the nation turned against them, fearing that Nazis had planted spies posing as refugees. Innocent asylum

This lyrical debut novel is at once a passionate coming-of-age story, a meditation on illness and death, and a kaleidoscopic journey through one woman's lifetold in part by the malevolent voice of her disease.Lia, her husband Harry, and their beloved daughter, Iris, are a precisely balanced family of three. With Iris struggling to navigate the social tightrope of early adolescence, their tender home is a much-needed refuge. But when a sudden diagnosis threatens to derail each of their lives, the secrets of Lia's past come rushing into the present, and the world around them begins to transform. Deftly guided through time, we discover the people who shaped Lia's youth; from her deeply religious mother to her troubled first love. In turn, each will take their place in the shifting landscape of Lia's body; at the center of which dances a gleeful narrator, learning her life from the inside, growing more emboldened by the day. Pivoting between the domestic and the epic, the comic and the hea

Futureproof your body and relieve chronic pain resulting from sitting, slouching, and other bad lifestyle habits with this easy-to-perform set of daily stretching and exercise routinesfrom an innovative physical therapist and social media star who coaches dozens of celebrity clients.What if we could easily acquire long-lasting protection for our bodies and escape the chronic pain caused by our sit-all-the-time, slouch-too-much lifestyles? Vinh Pham is a world-class physical therapista member of a new breed that dissects how people really move. He has worked with a broad range of clients, from Olympians to NBA stars to MMA fighters to Golden Globe and Grammy Awardwinning artists. Early in his career, he discovered a disappointing truth: most of his patients came to him already in pain. They had poor, deeply ingrained lifestyle habits that misaligned their joints and tightened their muscles. And the recent epidemic of prolonged sittingwhich represents an all-day assault on the body has

Temple Grandin's Animals in Translation speaks in the clear voice of a woman who emerged from the other side of autism, bringing with her an extraordinary message about how animals think and feel.Tem

During the early years of her career, while struggling to "keep body and soul apart" (as she ruefully put it later), Dorothy Parker wrote more than three hundred poems and verses for a variety of pop

THE STUNNINGLY ORIGINAL, ICONOCLASTIC, AWARD-WINNING AUTHOR OF THE BUDDHA OF SUBURBIA RETURNS WITH HIS FINEST, MOST EXUBERANT NOVEL.In the early 1980s Hanif Kureishi emerged as one of the most compel

Told with urgency and sharp political insight, Nixonland recaptures America's turbulent 1960s and early 1970s and reveals how Richard Nixon rose from the political grave to seize and hold the preside

In the trenches of a typical day, every parent encounters a child afflicted with ingratitude and entitlement. In a world where material abundance abounds, parents want so badly to raise self-discipli

Very early on, Kerrie-Ann begins to dream of the world beyond the rough council estate where she lives. Her father is nowhere to be found, her mother is a junkie, and she is left to care for her litt

Temple Grandin's Animals in Translation speaks in the clear voice of a woman who emerged from the other side of autism, bringing with her an extraordinary message about how animals think and feel.Tem

To a small child, the world is an exciting but sometimes frightening and unstable place. In The Magic Years, Selma Fraiberg takes the reader into the mind of the child, showing how he confronts the w

Here, in his own words, are the fascinating first thirty years in the life of one of the most provocative and compelling leaders of the twentieth centuryWinston ChurchillAs a visionary, statesman, an

A desperate man attempts to win a reality TV game where the only objective is to stay alive in this #1 national bestseller from Stephen King, writing as Richard Bachman. “Under any name King mesmerizes the reader” (Chicago Sun-Times).Ben Richards is a desperate man. With no job, no money, no way out, and a young daughter in need of proper medical attention, he must turn to the only possibility of striking it rich in this near-future dystopian America: participating in the ultra-violent TV programming of the government-sanctioned Games Network. Ben soon finds himself selected as a contestant on the biggest and the best that the Games Network has to offer: “The Running Man,” a no-holds-barred thirty-day struggle to stay alive as public enemy number one, relentlessly hunted by an elite strike force bent on killing him as quickly as possible in front of an audience all too eager to see that happen. It means a billion dollars in prize money if he can live for the next month. No one has ever

A beautifully designed, full-color collection of paper dolls created by Zelda Fitzgerald, lovingly compiled by her granddaughter, Eleanor Lanahan.Born in Montgomery, Alabama, Zelda Sayre Fitzgerald has long been an American cultural icon. A Southern belle turned flapper, Zelda was talented in dance, painting, and writing but lived in the shadow of her writer husband F. Scott Fitzgerald’s success.The golden couple of the Jazz Age, Zelda and her husband moved around―from hotels to rented villas to apartments in Paris―and Zelda always brought along her paints. Few people know she painted at all, and fewer still know she made paper dolls. But throughout her life, Zelda created dolls, whenever she could, in private. By design, paper dolls are delicate, fragile, and destined for destruction at the hands of children. Zelda’s dolls began as playthings for her daughter, Scottie, born in 1921. Fortunately, Zelda continued to make figures after Scottie outgrew them, first of their family and then

“Hoffman certainly knows how to enchant” (The New York Times Book Review) in this breathtaking conclusion to the Practical Magic series―a spellbinding and bewitching novel that asks how far will you go to change your fate?For over three-hundred years a curse has kept the Owens family from love―but all of that is about to change. The novel begins in a library, the best place for a story to be conjured, when beloved aunt Jet Owens hears the deathwatch beetle and knows she has only seven days to live. Jet is not the only one in danger―the curse is already at work.A frantic attempt to save a young man’s life spurs three generations of the Owens women, and one long-lost brother, to use their unusual gifts to break the curse as they travel from Paris to London to the English countryside where their ancestor Maria Owens first practiced the Unnamed Art. The younger generation discovers secrets that have been hidden from them in matters of both magic and love by Sally, their fiercely protective

A New York Times bestseller, this extraordinary memoir from Huma Abedin―Hillary Clinton’s famously private top aide and longtime advisor―offers “a gripping testament to the power of a woman finding her voice, owning her ambition, and sharing her truth” (Glennon Doyle).Abedin’s stunning memoir garnered an extraordinary amount of media coverage, with appearances on CBS Sunday Morning, the Today show, The Late Show with Stephen Colbert, The View, Late Night with Seth Meyers, Christiane Amanpour, and coverage in many other outlets, including The Washington Post, The New York Times, and NPR.The daughter of Indian and Pakistani intellectuals and advocates, Abedin grew up in the United States and Saudi Arabia and traveled widely. Both/And grapples with family, legacy, identity, faith, marriage, motherhood―and work―with wisdom, sophistication, grace, and clarity.Abedin launched full steam into a college internship in the office of the First Lady in 1996, never imagining that her work at the Wh

A New York Times Notable Book, Critic’s Top Pick, and Top Ten Book of Historical FictionNamed a Best Book of the Year by The Washington Post, NPR, Vogue, The Wall Street Journal, and Bloomberg Businessweek​From one of today’s most brilliant and beloved novelists, a dazzling, epic family saga set across a half-century spanning World War I, the rise of Hitler, World War II, and the Cold War that is “a feat of literary sorcery in its own right” (Oprah Daily).The Magician opens in a provincial German city at the turn of the twentieth century, where the boy, Thomas Mann, grows up with a conservative father, bound by propriety, and a Brazilian mother, alluring and unpredictable. Young Mann hides his artistic aspirations from his father and his homosexual desires from everyone. He is infatuated with one of the richest, most cultured Jewish families in Munich, and marries the daughter Katia. They have six children. On a holiday in Italy, he longs for a boy he sees on a beach and writes the sto

Set in a Harlem high rise, a stunning debut about a tight-knit cast of characters grappling with their own personal challenges while the forces of gentrification threaten to upend life as they know it.Like Gloria Naylor's The Women of Brewster Place and Lin Manuel Miranda's In the Heights, Sidik Fofana's electrifying collection of eight interconnected stories showcases the strengths, struggles, and hopes of one residential community in a powerful storytelling experience. Each short story follows a tenant in the Banneker Homes, a low-income high rise in Harlem where gentrification weighs on everyone's mind. There is Swan in apartment 6B, whose excitement about his friend's release from prison jeopardizes the life he's been trying to lead. Mimi, in apartment 14D, who hustles to raise the child she had with Swan, waitressing at Roscoe's and doing hair on the side. And Quanneisha B. Miles, a former gymnast with a good education who wishes she could leave Banneker for good, but can't seem

From the bestselling author of The Trouble with Goats and Sheep and Three Things About Elsie, a delightfully sinister novel about a married woman living a nice, quiet suburban lifebut things aren't always what they seemLinda has lived in a quiet neighborhood since fleeing the dark events of her childhood in Wales. Now she sits in her kitchen, wondering if this is all there is: pushing the vacuum around and cooking fish sticks for dinner, a far cry from the glamorous lifestyle she sees in the glossy magazines coming through the mail slot addressed to the previous occupant, Rebecca. Linda's husband Terry isn't perfecthe picks his teeth, tracks dirt through the house, and spends most of his time in front of the TV. But that seems fairly standarduntil he starts keeping odd hours at work, at around the same time young women in the town start to go missing. If only Linda could track down and befriend Rebecca, maybe some of that enviable lifestyle would rub off on her and she wouldn't have to

The ';grippingphenomenalgorgeous' (USA TODAY) #1 New York Times bestselling novella collection from master storyteller Stephen King!Readers adore Stephen King's novels, and his novellas are their own dark treat, briefer but just as impactful and enduring as his longer fiction. Many of his novellas have been made into iconic films, including ';The Body' (Stand by Me) and ';Rita Hayworth and Shawshank Redemption' (Shawshank Redemption). The four brilliant tales in If It Bleeds prove as iconic as their predecessors. In the title story, reader favorite Holly Gibney (from the Mr. Mercedes trilogy and The Outsider) must face her fears, and possibly another outsiderthis time on her own. In ';Mr. Harrigan's Phone' an intergenerational friendship has a disturbing afterlife. ';The Life of Chuck' explores, beautifully, how each of us contains multitudes. And in ';Rat,' a struggling writer must contend with the darker side of ambition. If these novellas show King's range, they also prove that cert

An unforgettable debut novel from an award-winning writer: a lively, daring ghost story about a teenage ghost who falls in love with a writer who doesn't know she exists.In 1473, fourteen-year-old Blanca dies in a hilltop monastery in Mallorca. Nearly four hundred years later, when George Sand, her two children, and her lover Frederic Chopin arrive in the village, Blanca is still there: a spirited, funny, righteous ghost, she's been hanging around the monastery since her accidental death, spying on the monks and the townspeople and keeping track of her descendants. Blanca is enchanted the moment she sees George, and the magical novel unfolds as a story of deeply felt, unrequited longingthe impossible love of a teenage ghost for a woman who can't see her and doesn't know she exists. As George and Chopin, who wear their unconventionality, in George's case, literally on their sleeves, find themselves in deepening trouble with the provincial, 19th-century villagers, Blanca watches helpless

The masterful story of a lifelong friendship between two very different women with shared histories and buried secrets, tested in the twilight of their lives, set across the arc of the 20th century.Celebrated children's book author Agnes Lee is determined to secure her legacyto complete what she knows will be the final volume of her pseudonymously written Franklin Square novels; and even more consuming, to permanently protect the peninsula of majestic coast in Maine known as Fellowship Point. To donate the land to a trust, Agnes must convince shareholders to dissolve a generations-old partnership. And one of those shareholders is her best friend, Polly. Polly Wister has led a different kind of life than Agnes: that of a well-off married woman with children, defined by her devotion to her husband, and philosophy professor with an inflated sense of stature. She exalts in creating beauty and harmony in her home, in her friendships, and in her family. Polly soon finds her loyalties torn be

From the New York Times bestselling author of The Good House, the story of two friends, raised in the same orphanage, whose loyalty is put to the ultimate test when they meet years later at a controversial institutionone as an employee; the other, an inmate.It's 1927 and eighteen-year-old Mary Engle is hired to work as a secretary at a remote but scenic institution for mentally disabled women called the Nettleton State Village for Feebleminded Women of Childbearing Age. She's immediately in awe of her employerbrilliant, genteel Dr. Agnes Vogel. Dr. Vogel had been the only woman in her class in medical school. As a young psychiatrist she was an outspoken crusader for women's suffrage. Now, at age forty, Dr. Vogel runs one of the largest and most self-sufficient public asylums for women in the country. Mary deeply admires how dedicated the doctor is to the poor and vulnerable women under her care. Soon after she's hired, Mary learns that a girl from her childhood orphanage is one of th

Set over the course of one summer, this perfect beach read follows a mother and her two daughters as they grapple with heartbreak, young love, and the weight of family secrets.Brian and Margot Dunne live year-round in Seaside, just steps away from the bustling boardwalk, with their daughters Liz and Evy. The Dunnes run a real estate company, making their living by quickly turning over rental houses for tourists. But the family's future becomes even more precarious when Brian develops a brain tumor, transforming into a bizarre, erratic version of himself. Amidst the chaos and new caretaking responsibilities, Liz still seeks out summer adventure and flirting with a guy she should know better than to pursue. Her younger sister Evy works in a candy shop, falls in love with her friend Olivia, and secretly adopts the persona of a middle-aged mom in an online support group, where she discovers her own mother's most vulnerable confessions. Meanwhile, Margot faces an impossible choice driven by

Set in London now, Love Marriage marks the magnificent return of Monica Ali, the Booker Prize shortlisted, ';splendid, daring, brilliant, refreshing' novelist (The New Republic) ';with an inborn generosity that cannot be learned' (The New York Times Book Review).Yasmin Ghorami in twenty-six, in training to be a doctor (like her Indian-born father), and engaged to the charismatic, upper-class Joe Sangster, whose formidable mother, Harriet, is a famous feminist. The gulf between families is vast. So, too, is the gulf in sexual experience between Yasmin and Joe. As the wedding day draws near, misunderstandings, infidelities, and long-held secrets upend both Yasmin's relationship and that of her parents, a ';love marriage,' according to the family lore that Yasmin has believed all her life. A gloriously acute observer of class, sexual mores, and the mysteries of the human heart, Monica Ali has written a captivating social comedy and a profoundly moving, revelatory story of two cultures, tw

A riveting, decades-in-the-writing memoir from the determined young prosecutor who, in two of America's most celebrated trials, managed to convict famed mob boss John Gottiand subsequently took down the Mafia altogether.John Gotti was without a doubt the flashiest and most feared Mafioso in American history. He became the boss of the Gambino Crime Family in spectacular fashionwith the brazen and very public murder of Paul Castellano in front of Sparks Steakhouse in midtown Manhattan in 1985. Not one to stay below law enforcement's radar, Gotti instead became the first celebrity crime boss. His penchant for eye-catching apparel earned him the nickname ';The Dapper Don;' his ability to beat criminal charges led to another: ';The Teflon Don.' This is the captivating story of Gotti's meteoric rise to power and his equally dramatic downfall. Every step of the way, Gotti's legal adversaryJohn Gleeson, an Assistant US Attorney in Brooklynwas watching. When Gotti finally faced two federal rac

From the bestselling author of Good Girl, Bad Girl and When You Are Mine comes a gripping thriller featuring the brilliant forensic psychologist Cyrus Haven as he becomes embroiled in an explosive murder case with disturbing origins.Criminal psychologist Cyrus Haven and Evie Cormac return in this ';powerhouse of a novel' (Booklist, starred review) from internationally bestselling author Michael Robotham, a writer Stephen King calls ';an absolute master...with heart and soul.' Who is Evie, the girl with no past, running from? She was discovered hiding in a secret room in the aftermath of a terrible crime. Her ability to tell when someone is lying helped Cyrus crack an impenetrable case in Good Girl, Bad Girl. Now, the closer Cyrus gets to uncovering answers about Evie's dark history, the more he exposes Evie to danger, giving her no choice but to run. Ultimately, both will have to decide if some secrets are better left buried and some monsters should never be named...

The 1619 Project illuminated the ways in which every aspect of life in the United States was and is shaped by the existence of slavery. Black Ghost of Empire focuses on emancipation and how this opportunity to make right further codified the racial caste systeminstead of obliterating it.To understand why the shadow of slavery still haunts society today, we must not only look at what slavery was, but also the unfinished way it ended. One may think of ';emancipation' as a finale, leading to a new age of human rights and universal freedoms. But in reality, emancipations everywhere were incomplete. In Black Ghost of Empire, acclaimed historian and professor Kris Manjapra identifies five types of emancipationexplaining them in chronological orderalong with the lasting impact these transitions had on formerly enslaved groups around the Atlantic. Beginning in 1770s and concluding in 1880s, different kinds of emancipation processes took place across the Atlantic world. These included the Gradu

In this examination of landscape and memory, four sites of American history are revealed as places where historical truth was written over by oppressive fictionwith profound repercussions for politics past and present.Popular narratives of American history conceal as much as they reveal. They present a national identity based on harvesting the treasures that lay in wait for European colonization. In Whose Ruins tells another story: winding through the US landscape, from Native American earthworks in West Virginia to the Manhattan Project in New Mexico, this history is a tour of sites that were mined for an empire's power. Showing the hidden costs of ruthless economic growth, particularly to Indigenous people and ways of understanding, this book illuminates the myth-making intimately tied to place. From the ground up, the project of settlement, expansion, and extraction became entwined with the spiritual values of those who hoped to gain from it. Every nation tells some stories and supp

#1 New York Times bestselling author Kathy Reichs takes forensic anthropologist Temperance Brennan behind the scenes of a major commercial airliner crash in this pulse-pounding thriller.';Buckle up and take this voyage,' says People. The journey begins with Temperance Brennan hearing shocking news on her car radio. An Air TransSouth flight has gone down in the mountains of western North Carolina, taking with it eighty-eight passengers and crew. As a forensic anthropologist and a member of the regional DMORT team, Tempe rushes to the scene to assist in body recovery and identification. As bomb theories abound, Tempe soon discovers a jarring piece of evidence that raises dangerous questionsand gets her thrown from the DMORT team. Relentless in her pursuit of its significance, Tempe uncovers a shocking, multilayered tale of deceit and depravity as she probes her way into frightening territorywhere someone wants her stopped in her tracks.

A transformative and compassionate memoir by a leading pioneer in medically assisted dying who began her career in the maternity ward and now helps patients who are suffering explore and then fulfill their end of life choices.Dr. Stefanie Green has been forging new paths in the field of medical assistance in dying since 2016. In her landmark memoir, Dr. Green reveals the reasons a patient might seek an assisted death, how the process works, what the event itself can look like, the reactions of those involved, and what it feels like to oversee proceedings and administer medications that hasten death. She describes the extraordinary people she meets and the unusual circumstances she encounters as she navigates the intricacy, intensity, and utter humanity of these powerful interactions. Deeply authentic and powerfully emotional, This Is Assisted Dying contextualizes the myriad personal, professional, and practical issues surrounding assisted dying by bringing readers into the room with D

The next call you take could be your last in this terrifying #1 New York Times bestseller by master storyteller Stephen King!On October 1, God is in His heaven, the stock market stands at 10,140, most of the planes are on time, and graphic artist Clayton Riddell is visiting Boston, having just landed a deal that might finally enable him to make art instead of teaching it. But all those good feelings about the future change in a moment thanks to a devastating phenomenon that will come to be known as The Pulse. The delivery method is a cell phoneeveryone's cell phone. Now Clay and the few desperate survivors who join him suddenly find themselves in the pitch-black night of civilization's darkest age, surrounded by chaos, carnage, and a relentless human horde that has been reduced to its basest nature...and then begins to evolve. There's really no escaping this nightmare. But for Clay, an arrow points the way home to his family in Maine, and as he and his fellow refugees make their harrow

From a renowned surgeon and historian with five decades of experience comes a remarkable history of surgery's developmentspanning the Stone Age to the present dayblending meticulous medical studies with lively and skillful storytelling.There are not many events in life that can be as simultaneously life-frightening and life-saving as a surgical operation. Yet, in America, tens-of-millions of major surgical procedures are performed annually but few of us pause to consider the magnitude of these figures because we have such inherent confidence in surgeons. And, despite passionate debates about healthcare and the endless fascination with surgical procedures, most of us have no idea how surgeons came to be because the story of surgery has never been fully told. Now, Empire of the Scalpel elegantly reveals the fascinating history of surgery's evolution from its earliest roots in Europe through its rise to scientific and social dominance in the United States. From the 16th-century saga of An