Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Throughout his long life, William Butler Yeats -- Irish writer and premier lyric poet in English in this century -- produced important works in every literary genre, works of astonishing range, energ

John le Carre's classic novels deftly navigate readers through the intricate shadow worlds of international espionage with unsurpassed skill and knowledge, and have earned him unprecedented worldwide acclaim.A man is missing. Harting, refugee background, a Junior Something in the British Embassy in Bonn. Gone with him are forty-three files, all of them Confidential or above. It is vital that the Germans do not learn that Harting is missing, nor that there's been a leak. With radical students and neo-Nazis rioting and critical negotiations under way in Brussels, the timing could not be worse -- and that's probably not an accident. Alan Turner, London's security officer, is sent to Bonn to find the missing man and files as Germany's past, present, and future threaten to collide in a nightmare of violence.

Isabel Allende is one of the world's most beloved authors. In 1988, she introduced the world to Eva Luna in a novel of the same name that recounted the adventurous life of a young Latin American woman

Interviews describe ghetto life in Chicago.

This astonishing, devastating debut novel, riven through with mystery and magic, tells the story of a lonely girl living in a small African town and her struggle to free herself from her mercurial, charming mother.Ayosa is a wandering spiritjoyous, exuberant, filled to the brim with longing. Her only companions in her grandmother's crumbling house are as lonely as Ayosa herself: the ghostly Fatumas, whose eyes are the size of bay windows, who teach her to dance and wail at the death news; the Jolly-Annas, cruel birds who cover their solitude with spiteful laughter; the milkman, who never greets Ayosa and whose milk tastes of mud; and Sindano, the kind owner of a caf no one ever visits. Unexpectedly, miraculously, one day Ayosa finds a friend. Yet she is always fixed on her beautiful mama, Nabumbo Promise: a mysterious and aloof photographer, she comes and goes as she pleases, with no apology or warning. Set at the intersection of the spirit world and the human one, Things They Lost is

From #1 New York Times bestselling author Stephen King, the most riveting and unforgettable story of kids confronting evil since It―publishing just as the second part of It, the movie, lands in theate

A post-apocalyptic debut novel in a tradition that includes The Hunger Games and Station Eleven, this vision of a possible future shows humanity pushed beyond its breaking point, the forging of vital

An alarming message from an award-winning journalist with unprecedented access to the highest naval officers in America and China and their ships and weapons, this is a chilling look at the “war

Soon to be a major motion picture—Stephen King’s terrifying, classic #1 New York Times bestseller, “a landmark in American literature” (Chicago Sun-Times)—about seven adults who return to their hometo

In this stunning debut collection, Curtis Dawkins, an MFA graduate and convicted murderer serving life without parole, takes us inside prison life with stories that dazzle with their humor and insight

In this captivating new memoir, award-winning writer Jessica B. Harris recalls a lost era—the vibrant New York City of her youth, where her social circle included Maya Angelou, James Baldwin, and othe

From Aravind Adiga, the bestselling, Booker Prize­–winning author of The White Tiger, a dazzling new novel about two brothers in a Mumbai slum who are raised by their obsessive father to become cricke

New York Times bestselling, award-winning historian S.C. Gwynne tells the incredible story of how Hal Mumme and Mike Leach—two unknown coaches who revolutionized American football in the 1980s, 1990s

Published in time for the 75th anniversary, a gripping and definitive account ofthe event that changed twentieth-century America—Pearl Harbor—based on years of research and new information uncovered b

“The most trusted opinion in rock music” (Billy Corgan, The Smashing Pumpkins), Matt Pinfield offers the ultimate music fan’s memoir, a chronicle of the songs and artists that inspired his improbable

An ambitious, stunning debut novel by an original young writer blurs the lines between life and art with the story of a film director’s unthinkable experiment in the Amazon—a place that holds deep, da

In 2014, a former hedge fund trader’s New York Times Sunday Review front page article about wealth addicition instantly went viral. This is his unflinching memoir about coming of age on Wall Street, f

The Night Swimmer, Matt Bondurant’s utterly riveting modern gothic novel of marriage and belonging, confirms his gift for storytelling that transports and enthralls. In a small town on the southern co

The daughter of Sophie's Choice author William Styron discusses what it was like growing up in the same house as a moody literary giant, whose life spiraled out of control when he sank into a deep dep

This brilliantly reported, unforgettable true story reveals how one of the most monstrous sexual criminals in the history of the Mormon church preyed on his victims even as he was protected by the ch

A smart and entertaining crime series debut set in the underbelly of Los Angeles, with a cast of characters that runs the gamut from saints to sinners.In the City of Angels, not everyone plays by the

Prepare yourself for a journey through the world of Patton Oswalt, one of the most creative, insightful, and hysterical voices on the entertain­ment scene today. Widely known for his roles in the

Colm T=ibin's exquisitely written new stories, set in present-day Ireland, 1970's Spain and nineteenth-century England, are about people linked by love, loneliness and desire. T=ibin is a master at p

IN 2008, as he attempted to enter Canada to film a television series, Harry Hamlin—the former star of L.A. Law and once People magazine’s Sexiest Man Alive—was detained at the borde

From a distinguished clinician, pioneer in working with behaviorally challenging kids, and author of the acclaimed The Explosive Child comes a groundbreaking approach for understanding and helping th

From the award-winning reporter and go-to source on Cuban-Miami politics Ann Louise Bardach comes a riveting, eye-opening account of the last chapter in the life of Fidel Castro: his near death and m

Coinciding with the twentieth anniversary of his inauguration and the commission of the USS George H.W. Bush, a collection of the forty-first president’s speeches. Here, in his own words, is the reco

Full of juicy details about what really goes on behind the bedroom door, The Education of a Very Young Madam is a provocative exposé of the newest developments in the world's oldest profession.A

Returning to the territory of "Brokeback Mountain" (in her first volume of Wyoming Stories) and Bad Dirt (her second), National Book Award and Pulitzer Prize winner Annie Proulx delivers a stunning an

In a future world racked by violence and environmental catastrophes, George Orr wakes up one day to discover that his dreams have the ability to alter reality. He seeks help from Dr. William Haber, a

Elisabeth Kübler-Ross's On Death and Dying changed the way we talk about the end of life. Before her own death in 2004, she and David Kessler completed On Grief and Grieving, which looks at the

Billy Collins, one of our most beloved poets, has chosen poems of wit, humor, imagination, and surprise, in a range of styles and forms, for The Best American Poetry 2006. The result is a celebration

No wonder it's so hard to lose weight -- our bodies are designed to keep weight on at all costs; it's a matter of survival. It's embedded in our DNA. Our diet has changed dramatically over the past te

Shortly before her death in 2004, Elisabeth Kübler-Ross and David Kessler, her collaborator, completed the manuscript for this, her final book. On Grief and Grieving is a fitting completion to h

Set in a world of extraordinary circumstances, filled with stunning visual imagery and unforgettable characters, the Dark Tower series is unlike anything you have ever read. Here is the fifth installm

It is an April day in the year 2000 and an era is about to end. The booming times of market optimism -- when the culture boiled with money and corporations seemed more vital and influential than gove

The Japanese-American culture is brought to life in a collection of short stories depicting the aftermath of World War II and its effects on women and children attempting to reconcile personal demons

John le Carré has earned worldwide acclaim with extraordinary spy novels, including The Russia House, an unequivocal classic. Navigating readers through the shadow worlds of international espionage with critical knowledge culled from his years in British Intelligence, le Carré tracks the dark and devastating trail of a document that could profoundly alter the course of world events.In Moscow, a sheaf of military secrets changes hands. If it arrives at its destination, and if its import is understood, the consequences could be cataclysmic. Along the way it has an explosive impact on the lives of three people: a Soviet physicist burdened with secrets; a beautiful young Russian woman to whom the papers are entrusted; and Barley Blair, a bewildered English publisher pressed into service by British Intelligence to ferret out the document's source. A magnificent story of love, betrayal, and courage, The Russia House catches history in the act. For as the Iron Curtain begins to rust and crumb

John le Carré has earned worldwide acclaim with novels that navigate the shadow worlds of espionage. In The Little Drummer Girl, one of his most enduring works, le Carré took leave of the Circus, George Smiley, and all his people, and presented instead an original canvas that remains, two decades later, stunningly fresh and topical. It was then, and is now, a thrilling, moving, and courageous novel of Middle Eastern intrigue.Charlie is a promiscuous, unsuccessful, English actress in her twenties. Vacationing on the Greek island of Mykonos with friends, she longs for commitment. But to what? To whom? Intrigued by a handsome, solitary bather, Charlie finds herself lured into the "theatre of the real." For the mysterious man is Kurtz, an embattled Israeli intelligence officer out to stop the bombing of Jews in Europe. Forced to play her most challenging role, Charlie is plunged into a deceptive and delicate trap set to ensnare an elusive Palestinian terrorist...and soon proves herself a d

Barbara Bush endures as one of America's most popular First Ladies. She has won worldwide acclaim for her wit, compassion, and candor as both a presidential wife and mother. In this #1 New York Times