Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Never Let Me Go meets Black Mirror in this thrilling dystopian debut about a tech company that deletes unwanted memories, the consequences for those forced to contend with what they tried to forget, and the dissenting doctor who seeks to protect her patients from further harm.What if you once had a painful memory removed? And what if you were offered the chance to get it back? Tell Me an Ending follows four characters grappling with the question of what to rememberand what they hoped to forget forever. Finn, an Irish architect living in the Arizona desert, begins to suspect his charming wife of having an affair. Mei, a troubled grad school drop-out in Kuala Lumpur, wonders why she remembers a city she's never visited. William, a former police inspector in England, struggles with PTSD, the breakdown of his marriage, and his own secret family history. Oscar, a handsome young man with almost no memories at all, travels the world in a constant state of fear. Into these characters lives co

Now in one stunning collection, four of Stephen King's most well-loved horror stories: The Mist, Apt Pupil, The Body, and The Sun Dog. Each standalone story is a riveting master class in short fiction

From a brilliant Brookings Institute writer, a vivid, timely, and insightful examination of the critical role that oceans currently play in the struggle for global power, in the bestselling tradition

From a brilliant Brookings Institute writer, a vivid, timely, and insightful examination of the critical role that oceans currently play in the struggle for global power, in the bestselling tradition

Named a Best Book of the Year by The New York Times Nominated for the 2021 Edgar Allan Poe Award From a Pulitzer Prizewinning investigative reporter at the Charleston Gazette-Mail, a ';powerful,' (The

*Featured on Best of Lists in Vogue, People, Entertainment Weekly, Real Simple, Southern Living, and more* In this ';wicked slow burn' (Entertainment Weekly) of psychological suspense, a woman becomes

In the tradition of Silent Spring and The Sixth Extinction, an urgent, meticulously researched, and groundbreaking book about the ways in which chemicals in the modern environment are changing-and end

An illuminating, authoritative, and in-depth examination of the fascinating science behind pain and the complexities of its treatment—from one of the internationally leading doctors in pain management

In the bestselling tradition of Hampton Sides’s In the Kingdom of Ice, a riveting and cinematic tale of Dutch polar explorer William Barents and his three harrowing Arctic expeditions—the last of whic

F. Scott Fitzgerald''s second novel, written at a pivotal moment in his career, is now available in a beautifully designed special collector''s edition.

Now available in a beautifully designed collector’s edition, this modern classic set in the South of France after World War I is the story of a brilliant psychiatrist and the bewitching, wealthy, and

In the tradition of The Boys in the Boat and Seabiscuit, a fascinating portrait of a groundbreaking but forgotten figure—the remarkable Major Taylor, the black man who broke racial barriers by b

The award-winning, internationally bestselling novel—“the French Brokeback Mountain” (Elle)—about a love affair between two teenage boys in a provincial high school in 1984 Fra

From legendary writer Amy Hempel, one of the most celebrated and original voices in American short fiction: a ravishing, sometimes heartbreaking new story collection—her first in over a decade.Amy Hem

In the tradition of Barbara Ehrenreich’s classic Nickel and Dimed, a talented young journalist goes undercover as a casino labor-union organizer in this rare inside look at the ongoing struggle of hou

From the author of the bestselling National Book Award finalist The Big House comes a story in the tradition of The Boys in the Boat about an unforgettable group of young athletes who battled in the l

In the tradition of In Cold Blood and The Executioner’s Song, this haunting, insightful, and surprisingly intimate portrait of Saddam Hussein provides “a brief, but powerful, meditation on

Set in the fictional town of Castle Rock, MaineFrom #1 New York Times bestselling author Stephen King, a powerful tale of grief, of love's enduring bonds, and the haunting secrets of the past.Set in t

The shocking true story of international intrigue involving the 1993 murder of CIA officer Freddie Woodruff by KGB agents and the extensive cover-up that followed in Washington and in Moscow.On August

In this “riveting read, meshing memoir with scientific explication” (Nature), a world-renowned neuroscientist reveals how he learned to communicate with patients in vegetative or “gr

A sweeping, romantic, and profoundly moving novel, set in Europe in the aftermath of World War I and Los Angeles in the 1950s, about a lonely young man, a beautiful widow, and the amnesiac soldier who

Miranda July meets Mary Karr in this brilliant debut novel from Jen Beagin, Whiting Award winner and “one of the freshest voices I've read in years—funny, wise, whip-smart and compassionat

The New York Times bestselling author of In Harm’s Way and Horse Soldiers shares the powerful account of an American army platoon fighting for survival during the Vietnam War in “an import

When bombs explode at the Islamic Cooperation Council’s headquarters in Oslo, detective Hanne Wilhelmsen is on the case in the ninth installment of the award-winning series from Norway’s bestselling c

The final nail-biting installment in the ten-part, award-winning Hanne Wilhelmsen series—bestselling in Norway and throughout Europe—from Scandinavia’s most celebrated female crime w

A young college grad buys a house in Detroit for $500 and attempts to restore it—and his new neighborhood—to its original glory in this “deeply felt, sharply observed personal quest

In the tradition of Christmas memoirs such as A Child's Christmas in Wales and A Christmas Memory, The Hired Man's Christmas is the story of how the events of two Christmas Eves brought George Givens

In her “keenly observed” (Minneapolis Star-Tribune) debut, Rachel Louise Snyder chronicles the twenty-four hours following a mass burglary in a Chicago suburb and the suspicions, secrets,

A brave survivor in a postapocalypse society broken by nuclear war and disease practices hunting skills in the snowy Canadian Yukon before being compelled into a role she never imagined by an enigmati

In this spectacular father/son collaboration, Stephen King and Owen King tell the highest of high-stakes stories: what might happen if women disappeared from the world of men?In a future so real and n

An intriguing blend of colorful characters, fascinating history, and winemaking detail come together in Ellen Crosby’s “sprightly” (Publishers Weekly) tale of suspense—the fourth in her Wine Country m

In the bestselling tradition of The Girl on the Train and In a Dark, Dark Wood, from the internationally bestselling author whom Stephen King called “an absolute master” of the psychological thriller,

An award-winning poet offers a multi-generational portrait of an American family—weaving together the lives of his ancestors, his parents, and his own coming of age in the 60s and 70s in the wake of h

A young writer’s sincere search (with his dog) for an authentic life—buying a ruined house in Detroit for $500, fixing it up nail by nail, and, in the process, participating in the grassroots rebirth

In this “inventive, beautiful, and deceptively morally complex novel” (The Miami Herald), a prideful electrician in 1920s rural Alabama struggles to overcome past sins, find peace, and rescue his marr

The country’s new female prime minister has been shot dead and the gun can’t be found in Anne Holt’s fourth mystery in the award-winning, internationally bestselling Hanne Wilhelmsen books that are “a

Fascinating and groundbreaking—a talented young journalist goes undercover to work as a casino labor-union organizer in Florida in this rare, smart look at the ongoing struggle between the haves and t

From internationally bestselling and award-winning author Anne Holt—hailed as “the godmother of Norwegian crime fiction” by Jo Nesbo—the exciting seventh installment in the Hanne Wilhelmsen series in

In his New York Times bestselling The Wind Through the Keyhole, Stephen King returns to the spectacular territory of the Dark Tower fantasy saga to tell a story about gunslinger Roland Deschain in his

“WWII scholar John Kelly triumphs again” (Vanity Fair) in this remarkably vivid account of a key moment in Western history: The critical six months in 1940 when Winston Churchill debated whether Engla