Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

NATIONAL BESTSELLER A MOST ANTICIPATED BOOK: Entertainment Weekly, Oprah Daily, Vogue, Los Angeles Times, The Daily Beast, CNN, Harper's Bazaar ';A glorious bookan assured novel that's gorgeously told.' The New York Times Book Review ';An incredibly moving epic about an unforgettable family.' CBS Sunday Morning ';[An] absorbing novelI felt both grateful to have known these people and bereft at the prospect of leaving them behind.' The Washington Post A stunning novel about love, work, and marriage that asks how far one family and one community will go to protect their future.Colleen and Rich Gundersen are raising their young son, Chub, on the rugged California coast. It's 1977, and life in this Pacific Northwest logging town isn't what it used to be. For generations, the community has lived and breathed timber; now that way of life is threatened. Colleen is an amateur midwife. Rich is a tree-topper. It's a dangerous job that requires him to scale trees hundreds of feet talla job t

A darkly humorous and spellbinding real-life detective story that chronicles one Mississippi man's relentless search for an authentic, accurate portrait of William Shakespeare.Following his divorce, down-and-out writer and Mississippi exile Lee Durkee holed himself up in a Vermont fishing shack and fell prey to a decades-long obsession with Shakespearian portraiture. It began with a simple premise: despite the prevalence of popular portraits, no one really knows what Shakespeare looked like. That the Bard of Avon has gotten progressively handsomer in modern depictions seems only to reinforce this point. Stalking Shakespeare is Durkee's fascinating memoir about an obsession gone awry, the 400-year-old myriad portraits attached to the famous playwright, and Durkee's own unrelenting searchvia X-ray and infrared technologiesfor a lost picture of the Bard painted from real life. As Durkee becomes better at beguiling curators into testing their paintings with spectral technologies, we get a

From one of the most celebrated writers of our time, a literary figure with cult status, a ';sibling novel' to her Pulitzer Prize- and NBCC Award-winning A Visit from the Goon Squadan electrifying, deeply moving novel about the quest for authenticity and meaning in a world where memories and identities are no longer private.The Candy House opens with the staggeringly brilliant Bix Bouton, whose company, Mandala, is so successful that he is ';one of those tech demi-gods with whom we're all on a first name basis.' Bix is 40, with four kids, restless, desperate for a new idea, when he stumbles into a conversation group, mostly Columbia professors, one of whom is experimenting with downloading or ';externalizing' memory. It's 2010. Within a decade, Bix's new technology, ';Own Your Unconscious'that allows you access to every memory you've ever had, and to share every memory in exchange for access to the memories of othershas seduced multitudes. But not everyone. In spellbinding interlocking

An evocative and engrossing collection of new stories and a novella about women experiencing life's challenges and beauty from the award-winning writer Megan Mayhew Bergman.A recently separated woman fills a huge terrarium with endangered flowers to establish a small world only she can control in an attempt to heal her broken heart. A competitive swimmer negotiates over which days she will fulfill her wifely duties, and which days she will keep for herself. A peach farmer wonders if her orchard will survive a drought. And generations of a family in South Carolina struggle with fidelity and their cruel past, some clinging to old ways and others painfully carving new paths. In these haunting stories, Megan Mayhew Bergman portrays women who wrestle with problematic inheritances: a modern glass house on a treacherous California cliff, a water-starved ranch, and an abandoned plantation on a river near Charleston. Bergman's provocative prose asks the questions: what are we leaving behind fo

';The Hard Crowd is wild, wide-ranging, and unsparingly intelligent throughout.' Taylor Antrim, Vogue From a writer celebrated for her ';chops, ambition, and killer instinct' (John Powers, Fresh Air), a career-spanning collection of spectacular essays about politics and culture.Rachel Kushner has established herself as ';the most vital and interesting American novelist working today' (The Millions) and as a master of the essay form. In The Hard Crowd, she gathers a selection of her writing from over the course of the last twenty years that addresses the most pressing political, artistic, and cultural issues of our timesand illuminates the themes and real-life experiences that inform her fiction. In nineteen razor-sharp essays, The Hard Crowd spans literary journalism, memoir, cultural criticism, and writing about art and literature, including pieces on Jeff Koons, Denis Johnson, and Marguerite Duras. Kushner takes us on a journey through a Palestinian refugee camp, an illegal motorcyc

From the world's most influential management consulting firm, McKinsey & Company, an insight-packed, revelatory look at how the best CEOs do their jobs based on extensive interviews with today's most successful corporate leaders―including chiefs at Netflix, JPMorgan Chase, General Motors, and Sony. Being a CEO at any of the world's largest companies is among the most challenging roles in business. Billions, and even trillions, are at stake―and the fates of tens of thousands of employees often hang in the balance. Yet, even when ';can't miss' high-achievers win the top job, very few excel. Thirty percent of Fortune 500 CEOs last fewer than three years, and two out of five new CEOs are perceived to be failing within eighteen months. For those who shoulder the burden of being the one on whom everyone counts, a manual for excellence is sorely needed. To identify the 21st century's best CEOs, the authors of CEO Excellence started with a pool of over 2400 public company CEOs. Extensiv

"Tahmima Anam deftly uses humor to explore both start-up culture and the institution of marriage in an utterly charming and genuinely thoughtful way." --Rumaan Alam, author of Leave the World Behind N

The inspiring journey of a girl from Africa whose near-death experience sparked a dream that changed the world.When severe draught hit her village in Zimbabwe, Elizabeth, then eight, had no idea that

*A New York Times Book Review Editors' Choice* From celebrated Yale professor Valerie Hansen, a ';vivid' and ';astonishingly comprehensive account [that] casts world history in a brilliant new light'

The ';compelling [and] vivid' (The New York Times Book Review) true story of a man who claimed to be a survivor of a 1919 British massacre in India, his elaborate twenty-year plan for revenge, and the

From the intimate perspective of three friends and neighbors in mid-nineteenth century Auburn, New York-the "agitators" of the title-acclaimed author Dorothy Wickenden tells the fascinating and crucia

A vivid and incisive account of a mostly unknown yet critical chapter in the life of Eleanor Rooseveltwhen she moved to New York's Greenwich Village, shed her high-born conformity, and became the prog

From National Book Award–nominated writer Andrea Lee, an epic, gorgeously evocative novel about love and identity, following two decades in the marriage between an African American professor and her w

A new collection showcasing the best of Ernest Hemingway's short stories including his well-known classics, as featured in the magnificent three-part, six-hour PBS documentary by Ken Burns and Lynn No

New York Times bestselling author Carol Edgarian delivers an astonishing feat of imagination, a grand adventure set in 1906 San Franciscoa city leveled by quake and firefeaturing an indomitable heroin

#1 New York Times bestselling author Kathy Reichs “roars back with a Temperance Brennan mystery unlike any that have come before” (Booklist, starred review) in which the forensic anthropologist must u

SummaryH is for Hawk meets The Duke of Deception in this wry, moving story of a young man who, as his estranged father is dying, saves a baby magpie only to find that caring for the mischievous bird h

A revised collection with thirteen essays, including six new to this edition and seven from the original edition, by the “star in the American literary firmament, with a voice that is courageous, hone

In this astonishing story that “reads like a thriller and is so, so timely” (BuzzFeed) Ariana Neumann dives into the secrets of her father’s past: “Like Anne Frank’s diary, it offers a story that need

“A rare triumph” (The New York Times Book Review), this powerful memoir about the divergent paths taken by two brothers is a classic work from one of the greatest figures in American literature: a ref

In this groundbreaking and “poignant” (Los Angeles Times) book, David Kessler―praised for his work by Maria Shriver, Marianne Williamson, and Mother Teresa―journeys beyond the classic five stages to d

From one of the most dynamic rising stars in astrophysics, an accessible and eye-opening look at five ways the universe could end, and the mind-blowing lessons each scenario reveals about the most imp

A heartwarming, poignant, and charming debut novel for fans of Nick Hornby and The Rosie Project, about a father and son overcoming their grief in surprisingly inventive ways.Danny’s life is falling a

From the bestselling author of The Secrets She Keeps and Good Girl, Bad Girl comes a new thriller featuring the brilliant forensic psychologist Cyrus Haven as he becomes embroiled in an explosive murd

A vivid, deeply researched work of history that explores the life of an unconventional woman during the first half of the 19th century in Edo―the city that would become Tokyo―and a portrait of a great

F. Scott Fitzgerald''s romantic and witty first novel is now available in a beautifully designed special collector''s edition.

A gorgeously illustrated, first-ever graphic novel adaptation of F. Scott Fitzgerald’s beloved American classic.First published in 1925, The Great Gatsby has been acclaimed by generations of readers a

F. Scott Fitzgerald’s poignant final work is now available in a beautifully designed collector’s edition.Fitzgerald’s final novel portrays the glittering excess of 1930s Hollywood. This edition, autho

F. Scott Fitzgerald’s beloved classic, now available in a stunningly designed collector’s edition.The Great Gatsby, F. Scott Fitzgerald’s third book, stands as the supreme achievement of his career an

The first standalone novel in Stephen King's Bill Hodges trilogy (Mr Mercedes, Finders Keepers, End of Watch) - and the basis of Mr Mercedes, an AT&T Audience Original Series starring Brendon Glee

The second standalone novel in Stephen King's Bill Hodges trilogy (Mr Mercedes, Finders Keepers, End of Watch) - and the basis of the third season of Mr Mercedes, an AT&T Audience Original Series (10

In this spectacular New York Times bestselling father/son collaboration that "barrels along like a freight train" (Publishers Weekly), Stephen King and Owen King tell the highest of high-stakes storie

An epic war between good and evil, a gory, glorious story that will thrill the millions of hyper-devoted readers of The Shining and wildly satisfy anyone new to the territory of this icon in the King

An in-depth, revelatory, and unbiased look at Amazon’s world-dominating business model, the current competitors either imitating or trying to outfox Amazon, and the ways Bezonomics is shaping the life

An entertaining, deeply informative explanation of how high-level financial crimes work, written by an industry insider who's an expert in the field.The way most white-collar crime works is by manipul

From legendary master storyteller Stephen King, a riveting story about “an ordinary man in an extraordinary condition rising above hatred” (The Washington Post) and bringing the fictional town of Cast

From the Academy Award-winning cowriter of Birdman, a wonderfully eccentric, suspenseful debut in the tradition of Misery and Kiss of the Spiderwoman about a screenwriter kidnapped by a world-famous d

ONE OF NPR'S BEST BOOKS OF 2019';Engrossing, beautiful, and deeply imaginative, Out of Darkness, Shining Light is a novel that lends voice to those who appeared only as footnotes in history, yet whose

A Kirkus Reviews Best Book of the Year The witty and exuberant New York Times bestselling author Ken Jennings relays the history of humor in “lively, insightful, and crawling with goofy factling

A warm and stylish Southern cookbook, from the owners of the beloved Nashville-based The Peach Truck, celebrating all things peach in 100 fresh and flavorful recipes.When Stephen and Jessica Rose sett