Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

2015 Pulitzer Prize for Fiction2015 Andrew Carnegie Medal for Excellence in FictionWinner of the Pulitzer Prize, a New York Times Book Review Top Ten Book, National Book Award finalist, more than two and a half years on the New York Times bestseller listFrom the highly acclaimed, multiple award-winning Anthony Doerr, the stunningly beautiful instant New York Times bestseller about a blind French girl and a German boy whose paths collide in occupied France as both try to survive the devastation of World War II.Marie-Laure lives in Paris near the Museum of Natural History, where her father works. When she is twelve, the Nazis occupy Paris and father and daughter flee to the walled citadel of Saint-Malo, where Marie-Laure’s reclusive great uncle lives in a tall house by the sea. With them they carry what might be the museum’s most valuable and dangerous jewel.In a mining town in Germany, Werner Pfennig, an orphan, grows up with his younger sister, enchanted by a crude radio they find that

When Vincent Saunders -- fresh out of college in the States -- arrives in Taiwan as a Christian volunteer and English teacher, he meets a wealthy Taiwanese businessman who wishes to marry a young woma

You may be surprised to learn that microchips are the new oil—the scarce resource on which the modern world depends. Today, military, economic, and geopolitical power are built on a foundation of computer chips. Virtually everything—from missiles to microwaves—runs on chips, including cars, smartphones, the stock market, even the electric grid. Until recently, America designed and built the fastest chips and maintained its lead as the #1 superpower, but America’s edge is in danger of slipping, undermined by players in Taiwan, Korea, and Europe taking over manufacturing. Now, as Chip War reveals, China, which spends more on chips than any other product, is pouring billions into a chip-building initiative to catch up to the US. At stake is America’s military superiority and economic prosperity.Economic historian Chris Miller explains how the technology works and why it’s so important, recounting the fascinating events that led to the United States perfecting the chip design, and to Ameri

The cell rings twice, and then his old partner in his ear . . . 'I'm at the scene of what appears to be a murder-suicide . . . Come and take a look. Bring your sidekick with you.'Bill Hodges, who now

In this debut novel, “a crisp, exciting exploration of love, friendship, and everything in between” (Kirkus Reviews), longtime romantic partners Kathryn and Chris experiment with an open r

The restored edition of Hemingway's classic memoir of his early life in Paris.

First published in 1927, Men Without Women represents some of Hemingway's most important and compelling early writing. In these fourteen stories, Hemingway begins to examine the themes that would occu

In the tradition of Silent Spring and The Sixth Extinction, an urgent, "disturbing, empowering, and essential" (Kirkus Reviews, starred review) book about the ways in which chemicals in the modern environment are changing--and endangering--human sexuality and fertility on the grandest scale, from renowned epidemiologist Shanna Swan. In 2017, author Shanna Swan and her team of researchers completed a major study. They found that over the past four decades, sperm levels among men in Western countries have dropped by more than 50 percent. They came to this conclusion after examining 185 studies involving close to 45,000 healthy men. The result sent shockwaves around the globe--but the story didn't end there. It turns out our sexual development is changing in broader ways, for both men and women and even other species, and that the modern world is on pace to become an infertile one. How and why could this happen? What is hijacking our fertility and our health? Count Down unpacks these ques

Like Henry Ford, Sam Walton, or Steve Jobs in the early years of Ford, Walmart, and Apple, Jeff Bezos is the business story of the decade. Bezos, the richest man on the planet, has built one of the mo

The tragic and fascinating history of the first epic struggle between white settlers and Native Americans in the early seventeenth century: “a riveting historical validation of emancipatory impu

From Harold Bloom, one of the greatest Shakespeare scholars of our time comes “a timely reminder of the power and possibility of words [and] the last love letter to the shaping spirit of Bloom&r

With an epilogue on recent Russian spying, a “page-turner of a memoir” (Publishers Weekly) about an American civilian with a dream, who worked as a double agent with the FBI in the early 2

The debut novel from award-winning author Lori Ostlund—“smart, resonant, and imbued with beauty” (Publishers Weekly) that “provides considerable pleasure and emotional power” (TheNew York Times Book R

A desperate man attempts to win a reality TV game where the only objective is to stay alive in this #1 national bestseller from Stephen King, writing as Richard Bachman. “Under any name King mesmerizes the reader” (Chicago Sun-Times).Ben Richards is a desperate man. With no job, no money, no way out, and a young daughter in need of proper medical attention, he must turn to the only possibility of striking it rich in this near-future dystopian America: participating in the ultra-violent TV programming of the government-sanctioned Games Network. Ben soon finds himself selected as a contestant on the biggest and the best that the Games Network has to offer: “The Running Man,” a no-holds-barred thirty-day struggle to stay alive as public enemy number one, relentlessly hunted by an elite strike force bent on killing him as quickly as possible in front of an audience all too eager to see that happen. It means a billion dollars in prize money if he can live for the next month. No one has ever

“Hoffman certainly knows how to enchant” (The New York Times Book Review) in this breathtaking conclusion to the Practical Magic series―a spellbinding and bewitching novel that asks how far will you go to change your fate?For over three-hundred years a curse has kept the Owens family from love―but all of that is about to change. The novel begins in a library, the best place for a story to be conjured, when beloved aunt Jet Owens hears the deathwatch beetle and knows she has only seven days to live. Jet is not the only one in danger―the curse is already at work.A frantic attempt to save a young man’s life spurs three generations of the Owens women, and one long-lost brother, to use their unusual gifts to break the curse as they travel from Paris to London to the English countryside where their ancestor Maria Owens first practiced the Unnamed Art. The younger generation discovers secrets that have been hidden from them in matters of both magic and love by Sally, their fiercely protective

A New York Times bestseller, this extraordinary memoir from Huma Abedin―Hillary Clinton’s famously private top aide and longtime advisor―offers “a gripping testament to the power of a woman finding her voice, owning her ambition, and sharing her truth” (Glennon Doyle).Abedin’s stunning memoir garnered an extraordinary amount of media coverage, with appearances on CBS Sunday Morning, the Today show, The Late Show with Stephen Colbert, The View, Late Night with Seth Meyers, Christiane Amanpour, and coverage in many other outlets, including The Washington Post, The New York Times, and NPR.The daughter of Indian and Pakistani intellectuals and advocates, Abedin grew up in the United States and Saudi Arabia and traveled widely. Both/And grapples with family, legacy, identity, faith, marriage, motherhood―and work―with wisdom, sophistication, grace, and clarity.Abedin launched full steam into a college internship in the office of the First Lady in 1996, never imagining that her work at the Wh

A New York Times Notable Book, Critic’s Top Pick, and Top Ten Book of Historical FictionNamed a Best Book of the Year by The Washington Post, NPR, Vogue, The Wall Street Journal, and Bloomberg Businessweek​From one of today’s most brilliant and beloved novelists, a dazzling, epic family saga set across a half-century spanning World War I, the rise of Hitler, World War II, and the Cold War that is “a feat of literary sorcery in its own right” (Oprah Daily).The Magician opens in a provincial German city at the turn of the twentieth century, where the boy, Thomas Mann, grows up with a conservative father, bound by propriety, and a Brazilian mother, alluring and unpredictable. Young Mann hides his artistic aspirations from his father and his homosexual desires from everyone. He is infatuated with one of the richest, most cultured Jewish families in Munich, and marries the daughter Katia. They have six children. On a holiday in Italy, he longs for a boy he sees on a beach and writes the sto

The ';grippingphenomenalgorgeous' (USA TODAY) #1 New York Times bestselling novella collection from master storyteller Stephen King!Readers adore Stephen King's novels, and his novellas are their own dark treat, briefer but just as impactful and enduring as his longer fiction. Many of his novellas have been made into iconic films, including ';The Body' (Stand by Me) and ';Rita Hayworth and Shawshank Redemption' (Shawshank Redemption). The four brilliant tales in If It Bleeds prove as iconic as their predecessors. In the title story, reader favorite Holly Gibney (from the Mr. Mercedes trilogy and The Outsider) must face her fears, and possibly another outsiderthis time on her own. In ';Mr. Harrigan's Phone' an intergenerational friendship has a disturbing afterlife. ';The Life of Chuck' explores, beautifully, how each of us contains multitudes. And in ';Rat,' a struggling writer must contend with the darker side of ambition. If these novellas show King's range, they also prove that cert

From the bestselling author of Good Girl, Bad Girl and When You Are Mine comes a gripping thriller featuring the brilliant forensic psychologist Cyrus Haven as he becomes embroiled in an explosive murder case with disturbing origins.Criminal psychologist Cyrus Haven and Evie Cormac return in this ';powerhouse of a novel' (Booklist, starred review) from internationally bestselling author Michael Robotham, a writer Stephen King calls ';an absolute master...with heart and soul.' Who is Evie, the girl with no past, running from? She was discovered hiding in a secret room in the aftermath of a terrible crime. Her ability to tell when someone is lying helped Cyrus crack an impenetrable case in Good Girl, Bad Girl. Now, the closer Cyrus gets to uncovering answers about Evie's dark history, the more he exposes Evie to danger, giving her no choice but to run. Ultimately, both will have to decide if some secrets are better left buried and some monsters should never be named...

#1 New York Times bestselling author Kathy Reichs takes forensic anthropologist Temperance Brennan behind the scenes of a major commercial airliner crash in this pulse-pounding thriller.';Buckle up and take this voyage,' says People. The journey begins with Temperance Brennan hearing shocking news on her car radio. An Air TransSouth flight has gone down in the mountains of western North Carolina, taking with it eighty-eight passengers and crew. As a forensic anthropologist and a member of the regional DMORT team, Tempe rushes to the scene to assist in body recovery and identification. As bomb theories abound, Tempe soon discovers a jarring piece of evidence that raises dangerous questionsand gets her thrown from the DMORT team. Relentless in her pursuit of its significance, Tempe uncovers a shocking, multilayered tale of deceit and depravity as she probes her way into frightening territorywhere someone wants her stopped in her tracks.

The next call you take could be your last in this terrifying #1 New York Times bestseller by master storyteller Stephen King!On October 1, God is in His heaven, the stock market stands at 10,140, most of the planes are on time, and graphic artist Clayton Riddell is visiting Boston, having just landed a deal that might finally enable him to make art instead of teaching it. But all those good feelings about the future change in a moment thanks to a devastating phenomenon that will come to be known as The Pulse. The delivery method is a cell phoneeveryone's cell phone. Now Clay and the few desperate survivors who join him suddenly find themselves in the pitch-black night of civilization's darkest age, surrounded by chaos, carnage, and a relentless human horde that has been reduced to its basest nature...and then begins to evolve. There's really no escaping this nightmare. But for Clay, an arrow points the way home to his family in Maine, and as he and his fellow refugees make their harrow

Now in one stunning collection, four of Stephen King's most well-loved horror stories: The Mist, Apt Pupil, The Body, and The Sun Dog. Each standalone story is a riveting master class in short fiction

From a brilliant Brookings Institute writer, a vivid, timely, and insightful examination of the critical role that oceans currently play in the struggle for global power, in the bestselling tradition

Named a Best Book of the Year by The New York Times Nominated for the 2021 Edgar Allan Poe Award From a Pulitzer Prizewinning investigative reporter at the Charleston Gazette-Mail, a ';powerful,' (The

*Featured on Best of Lists in Vogue, People, Entertainment Weekly, Real Simple, Southern Living, and more* In this ';wicked slow burn' (Entertainment Weekly) of psychological suspense, a woman becomes

In the tradition of Barbara Ehrenreich’s classic Nickel and Dimed, a talented young journalist goes undercover as a casino labor-union organizer in this rare inside look at the ongoing struggle of hou

In the tradition of In Cold Blood and The Executioner’s Song, this haunting, insightful, and surprisingly intimate portrait of Saddam Hussein provides “a brief, but powerful, meditation on

Set in the fictional town of Castle Rock, MaineFrom #1 New York Times bestselling author Stephen King, a powerful tale of grief, of love's enduring bonds, and the haunting secrets of the past.Set in t

In this “riveting read, meshing memoir with scientific explication” (Nature), a world-renowned neuroscientist reveals how he learned to communicate with patients in vegetative or “gr

The New York Times bestselling author of In Harm’s Way and Horse Soldiers shares the powerful account of an American army platoon fighting for survival during the Vietnam War in “an import

When bombs explode at the Islamic Cooperation Council’s headquarters in Oslo, detective Hanne Wilhelmsen is on the case in the ninth installment of the award-winning series from Norway’s bestselling c

A young college grad buys a house in Detroit for $500 and attempts to restore it—and his new neighborhood—to its original glory in this “deeply felt, sharply observed personal quest

In the tradition of Christmas memoirs such as A Child's Christmas in Wales and A Christmas Memory, The Hired Man's Christmas is the story of how the events of two Christmas Eves brought George Givens

In her “keenly observed” (Minneapolis Star-Tribune) debut, Rachel Louise Snyder chronicles the twenty-four hours following a mass burglary in a Chicago suburb and the suspicions, secrets,

A brave survivor in a postapocalypse society broken by nuclear war and disease practices hunting skills in the snowy Canadian Yukon before being compelled into a role she never imagined by an enigmati

An intriguing blend of colorful characters, fascinating history, and winemaking detail come together in Ellen Crosby’s “sprightly” (Publishers Weekly) tale of suspense—the fourth in her Wine Country m

An award-winning poet offers a multi-generational portrait of an American family—weaving together the lives of his ancestors, his parents, and his own coming of age in the 60s and 70s in the wake of h

In this “inventive, beautiful, and deceptively morally complex novel” (The Miami Herald), a prideful electrician in 1920s rural Alabama struggles to overcome past sins, find peace, and rescue his marr

The country’s new female prime minister has been shot dead and the gun can’t be found in Anne Holt’s fourth mystery in the award-winning, internationally bestselling Hanne Wilhelmsen books that are “a

Fascinating and groundbreaking—a talented young journalist goes undercover to work as a casino labor-union organizer in Florida in this rare, smart look at the ongoing struggle between the haves and t