Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

A concise, brilliant, and trenchant examination of Democratic Nominee Joseph R. Biden Jr.'s lifelong quest for the presidency by National Book Award winner Evan Osnos, adapted from nearly a decade of

2015 Pulitzer Prize for Fiction2015 Andrew Carnegie Medal for Excellence in FictionWinner of the Pulitzer Prize, a New York Times Book Review Top Ten Book, National Book Award finalist, more than two and a half years on the New York Times bestseller listFrom the highly acclaimed, multiple award-winning Anthony Doerr, the stunningly beautiful instant New York Times bestseller about a blind French girl and a German boy whose paths collide in occupied France as both try to survive the devastation of World War II.Marie-Laure lives in Paris near the Museum of Natural History, where her father works. When she is twelve, the Nazis occupy Paris and father and daughter flee to the walled citadel of Saint-Malo, where Marie-Laure’s reclusive great uncle lives in a tall house by the sea. With them they carry what might be the museum’s most valuable and dangerous jewel.In a mining town in Germany, Werner Pfennig, an orphan, grows up with his younger sister, enchanted by a crude radio they find that

When Vincent Saunders -- fresh out of college in the States -- arrives in Taiwan as a Christian volunteer and English teacher, he meets a wealthy Taiwanese businessman who wishes to marry a young woma

You may be surprised to learn that microchips are the new oil—the scarce resource on which the modern world depends. Today, military, economic, and geopolitical power are built on a foundation of computer chips. Virtually everything—from missiles to microwaves—runs on chips, including cars, smartphones, the stock market, even the electric grid. Until recently, America designed and built the fastest chips and maintained its lead as the #1 superpower, but America’s edge is in danger of slipping, undermined by players in Taiwan, Korea, and Europe taking over manufacturing. Now, as Chip War reveals, China, which spends more on chips than any other product, is pouring billions into a chip-building initiative to catch up to the US. At stake is America’s military superiority and economic prosperity.Economic historian Chris Miller explains how the technology works and why it’s so important, recounting the fascinating events that led to the United States perfecting the chip design, and to Ameri

The cell rings twice, and then his old partner in his ear . . . 'I'm at the scene of what appears to be a murder-suicide . . . Come and take a look. Bring your sidekick with you.'Bill Hodges, who now

From #1 New York Times bestselling author Stephen King, the most riveting and unforgettable story of kids confronting evil since It—publishing just as the second part of It, the movie, lands in theate

In the tradition of Michio Kaku’s The Future of the Mind, acclaimed technologist and inventor Amir Husain answers the universal question of how we can live amidst the coming age of sentient mach

In a thrillingly alive, candid new work, award-winning author Mitchell S. Jackson takes us inside the drug-ravaged neighborhood and struggling family of his youth, while examining the cultural forces—

In her extraordinary bestseller, Adrian Nicole LeBlanc immerses readers in the intricacies of the ghetto, revealing the true sagas lurking behind the headlines of gangsta glamour, gold-drenched drug

Tracing the development of American cities and city life from early colonial settlements to the familiar downtowns of today, a sweeping cultural history reveals how our urban spaces have been shaped b

In this debut novel, “a crisp, exciting exploration of love, friendship, and everything in between” (Kirkus Reviews), longtime romantic partners Kathryn and Chris experiment with an open r

The author of the bestselling The Immune System Recovery Plan shares her science-based, drug-free treatment plan for the almost fifty million people who suffer from arthritis: an amazing 3-step guide

From the Pulitzer Prize-winning, bestselling author of The Emperor of All Maladies—a magnificent history of the gene and a response to the defining question of the future: What becomes of being human

Another fabulous Boston-based thriller by Chuck Hogan, this one involving an Iraq war veteran who gets involved with dangerous big-time drug dealers.

Inside the Clark R. Bavin U.S. Fish and Wildlife Service Forensics Laboratory lies a rarely seen world, a CSI for wildlife, where a walk-in freezer contains carcasses and animal parts awaiting necrop

After Alexander Lawson -- a rising star on Northern Ireland's police force at twenty-four -- is assigned to the corruption-ridden drug squad, he becomes addicted to heroin under unusual circumstances

Eminent mystery authors Philip R. Craig and William G. Tapply team up for a richly nuanced new installment in the Brady Coyne/J. W. Jackson series that is a tribute not only to two witty, smart ficti

The restored edition of Hemingway's classic memoir of his early life in Paris.

An entertaining and intelligent history of the development of medicine in America by an award-winning physician.

Another fabulous Boston-based thriller by Chuck Hogan, this one involving an Iraq war veteran who gets involved with dangerous big-time drug dealers.

Ellen Sandbeck is an organic landscaper, worm wrangler, writer, and graphic artist who lives with (and experiments on) her husband and an assortment of younger creatures -- which includes two mostly

Hauntingly beautiful and heartbreaking, Colm Toibin's sixth novel, Brooklyn, is set in Brooklyn and Ireland in the early 1950s, when one young woman crosses the ocean to make a new life for herself.E

Inside the Clark R. Bavin U.S. Fish and Wildlife Service Forensics Laboratory lies a rarely seen world, a CSI for wildlife, where a walk-in freezer contains carcasses and animal parts awaiting necrop

Based on the true story of Matt Bondurant's grandfather and two granduncles, The Wettest County in the World is a tale of brotherhood, greed, and murder. The Bondurant Boys were a notorious gang of r

When Witold Rybczynski first heard about New Daleville, it was only a developer's idea, attached to ninety acres of cornfield an hour and a half west of Philadelphia. Over the course of five years, R

Early in 2004, two writers and Red Sox fans, Stewart O'Nan and Stephen King, decided to chronicle the upcoming season, one of the most hotly anticipated in baseball history. They would sit together a

Two physicians unveil a revolutionary, accessible, science-based, patient-centered program for living an active, age-defying, disease-free life.Healthcare is pulled and shaped by many forces, by drug

First published in 1927, Men Without Women represents some of Hemingway's most important and compelling early writing. In these fourteen stories, Hemingway begins to examine the themes that would occu

The Mind/Body ConnectionMillions of readers are familiar with the work of Dr. Herbert Benson and the Mind/Body Medical Institute from the mega-bestselling book The Relaxation Response. With over thre

From New York Times bestselling author of The Gentle Art of Swedish Death Cleaning, a book of humorous and charming advice for embracing life and aging joyfully.Margareta Magnusson shared with the world her practical Swedish tradition of dstdning, or ';death cleaning'clearing out unnecessary belongings before others must do it for youin her international bestseller The Gentle Art of Swedish Death Cleaning. Now, unburdened by baggage (emotional and actual) she is able to focus on what makes each day worth living, and reveals her discoveries about growing oldersome difficult to accept, many rather wondrous. She reflects on her early days growing up in Sweden and raising her family around the world, offering tips and wisdom on how to age gracefully, such as: don't be afraid to wear stripes, don't resist new technology, let go of what doesn't matter, and much more. As with death-cleaning, it's never too early to begin and The Swedish Art of Aging Well shows us how to prepare for and unders

In the tradition of Silent Spring and The Sixth Extinction, an urgent, "disturbing, empowering, and essential" (Kirkus Reviews, starred review) book about the ways in which chemicals in the modern environment are changing--and endangering--human sexuality and fertility on the grandest scale, from renowned epidemiologist Shanna Swan. In 2017, author Shanna Swan and her team of researchers completed a major study. They found that over the past four decades, sperm levels among men in Western countries have dropped by more than 50 percent. They came to this conclusion after examining 185 studies involving close to 45,000 healthy men. The result sent shockwaves around the globe--but the story didn't end there. It turns out our sexual development is changing in broader ways, for both men and women and even other species, and that the modern world is on pace to become an infertile one. How and why could this happen? What is hijacking our fertility and our health? Count Down unpacks these ques

From the most successful mystery writers in the business, an invaluable guide to crafting mysteries-from character development and plot to procedurals and thrillers-a must-have for every aspiring myst

Like Henry Ford, Sam Walton, or Steve Jobs in the early years of Ford, Walmart, and Apple, Jeff Bezos is the business story of the decade. Bezos, the richest man on the planet, has built one of the mo

The tragic and fascinating history of the first epic struggle between white settlers and Native Americans in the early seventeenth century: “a riveting historical validation of emancipatory impu

From Harold Bloom, one of the greatest Shakespeare scholars of our time comes “a timely reminder of the power and possibility of words [and] the last love letter to the shaping spirit of Bloom&r

With an epilogue on recent Russian spying, a “page-turner of a memoir” (Publishers Weekly) about an American civilian with a dream, who worked as a double agent with the FBI in the early 2

Using unprecedented, dramatically compelling sleuthing techniques, legendary statistician and baseball writer Bill James applies his analytical acumen to crack an unsolved century-old mystery surround

The debut novel from award-winning author Lori Ostlund—“smart, resonant, and imbued with beauty” (Publishers Weekly) that “provides considerable pleasure and emotional power” (TheNew York Times Book R

In the early 1990s, Stone Temple Pilots—not U2, not Nirvana, not Pearl Jam— was the hottest band in the world. STP toppled such mega-bands as Aerosmith and Guns N’ Roses on MTV and

Her Last Death begins as the phone rings early one morning in the Montana house where Susanna Sonnenberg lives with her husband and two young sons. Her aunt is calling to tell Susanna her mother is i