Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

FROM THE AUTHOR OF GREAT ADVENTURERS - WINNER OF THE EDWARD STANFORD CHILDREN'S TRAVEL BOOK OF THE YEAR 2019. Sometimes adventure, like life, doesn't work out as you want it to. Even determined explorers make mistakes.Many of the greatest adventurers of all time have failed along the way... Hand-picked by adventurer Alastair Humphreys, this compilation retells the extraordinary journeys undertaken by explorers who have tried, failed and succeeded against the odds. It features adventurers whose expeditions went desperately wrong, turning into struggles for survival.And adventurers who had to fight for their right to succeed in the face of discrimination or setbacks that threatened to squash their dreams. These are stories of self-belief, resilience, friendship, courage, determination and hope - against the odds. Featuring explorers modern and ancient, from Zheng He to Joe Simpson, Jeanne Baret to Matthew Henson, these men and women ventured into space, oceans, deserts and jungles, and m

Celebrate 20 incredible years of Ology with this special edition of Dragonology - the journal of dragonologist Dr Ernest Drake. Do you believe in dragons? Said to originate from the library of eminent Victorian dragonologist Ernest Drake, this book imparts to readers the secrets of the ancient science of dragonology, bridging the gap between dragon legend and fact. The meticulous Dr.Drake assigns Latin names to various dragon species, ruminates on why dragons are able to speak, speculates on how they could fly, and explains the true purpose of their notorious hoarding habits. It includes a host of novelties, such as old letters, magic dust and dragon scales. In his afterword, Dr.Drake reveals that one of the crucial goals of dragonologists is to preserve and protect the magnificent creatures of their study wherever possible - a goal this lavishly illustrated volume most affectionately achieves. An incomparable gift for secret dragonologists everywhere! For true believers only. Don't le

A brand-new novelty series all about things that go!All aboard the baby train, We're going on a ride today. All aboard the baby trainThe whistle PEEPS - we're on our way!Climb aboard the train in this brand-new novelty series, perfect for babies and pre-schoolers. With tabs to slide and wheels to spin, little ones will love to make the train move on every page.Seb Braun (illustrator of Spinderella by Julia Donaldson, the Daddy Grizzle books by Mark Sperring and author-illustrator of Raj and the Best Day) creates friendly, action-packed scenes, full of detail and warmth. Bursting with adorable animal characters on a special day trip, this bright and busy book will provide hours of entertainment. Also in the series: Baby on Board: Car (2023), Tractor (2024), Aeroplane (2024)

Princess Katie and her kittens are back in:BELLA AT THE BALL - SUKI IN THE SNOW - POPPY AND THE PRINCE - RUBY AND THE ROYAL BABY

A Caribbean celebration of family and food - with a spicy twist!There is not a better smell in the world than Ajee's Cook-up rice. The kitchen fills with the smell of coconut, garlic and spices. Faruq loves his grandmother Ajee, and he loves her cooking.In fact, Faruq would like to cook too - he wants to be a chef, but Ajee says he has to be a doctor like his father. But one day when Ajee is too ill to make the family feast, with the help of his neighbour Mrs Joseph, Faruq picks some hot wiri wiri chilli peppers and cooks up a banquet. Preparing food for his family fills Faruq's heart with love - and sets a different course for his future.This sumptuous story celebrates Caribbean culture and food through Sophia Payne's distinct voice that is reflective of her Indo-Guyanese heritage and is brought to life by Sandhya Prabhat's beautiful artwork. It also includes a recipe for Guyanese Lime cookies for you to try at home!

A vibrant, lift-the-flap story about a girl with a big imagination!A fantastic new edition of this joyful and vibrant story about a girl with a big imagination - now packed with lift-the-flap fun!Poppy lives in an ordinary house with ordinary parents but Poppy is EXTRAORDINARY. You see, her imagination comes ALIVE . . . and sometimes it gets her into a bit of a pickle. Poppy's room is soon packed with wonderful creatures, which might sound fun, until it starts to go very, VERY wrong! Poppy needs to get rid of all these creatures FAST - but how?This EXTRAORDINARY new edition is perfect for sharing and reading together - with flaps both big and small for little hands to lift. Ideal for fans of Emma's other titles, such as Dragon Post; Orion and the Dark; Sidney, Stella and the Moon and the Nibbles the Book Monster series.

Five little penguins went out one dayOver the hills and far away. Mamma Penguin said "Hurry back to me!"How many penguins can you see? Join the adorable penguins on a lift-the-flap walk through a winter wonderland. There's so much to see as Mamma Penguin and her chicks waddle through a frosty forest, skate down an icy river and toboggan down snowy slopes.Along the way, they meet all kinds of festive animals playing in the snow. But wait - the chicks are disappearing one by one... Whatever are they up to? Lift the flaps to find the chicks and discover a fantastic surprise ending.Based on the nursery rhyme 'Five Little Ducks', the second title in an all-new lift-the-flap series is perfect for sharing at Christmas.

A brilliantly funny take on growing families and introducing new siblings.Everyone knows sharing is difficult, but a new sibling can be a particularly tricky challenge for lots of children. This story is a brilliantly funny take on growing families and introducing new siblings. The determined heroine of I Really Want to Share faces this conundrum - with mixed results! A hilarious story with an important message at its heart, from the author of I Really Want the Cake (shortlisted for the Waterstones Children's Book Prize), I Really Want to Win and I Really Want to Shout .One morning, as I lazed in bed,my parents, smiling, came and said,"Come snuggle up with us instead. We've news we want to share."That's when I learned that we, a three,a perfect little family,would soon be four, Mum telling me,"You'll have to learn to share."

The perfect board book for any parent working from home. Working from home with a young child around can be tricky: toddlers love to burst in on a video call, and Mummy would love to play, but has to finish his work first. On the upside, there can be a kiss between calls, and a sticky cuddle at lunchtime.When Mummy Works From Home explores and celebrates some of these moments in a nurturing, heartwarming manner. Following the success of When Mummy Goes to Work and When Daddy Goes to Work, this is the ideal gift book for anyone returning to work after parental leave, or adjusting to the new normal of home-working. Also available: When Daddy Works From Home.

What happens when the famous fixer of broken things finds a problem that she can't solve?Bea is a fixer. She is the finest fixer, far and wide, and people bring her everything - from tiny sprockets to enormous rockets - because they know she'll have them working again in no time. One day, Bea finds a broken thing.It's very small and very sad, and try as hard as she might, she cannot fix it. Bea soon realises that not every problem has to be solved alone, and that talking to her friends is the answer she has been looking for. This heartwarming story sensitively discusses big feelings like sadness, and acts as a reminder for readers young and old that we don't have to face things alone and can find support in those around us.The perfect companion for readers of Tom Percival's Big Bright Feelings series, The Way Home for Wolf and books by Oliver Jeffers.

Little ones will love saying 'hello' to a whole host of friendly jungle animals in this delightful lift-the-flap book. Sam Boughton's vibrant illustrations bring facts to life with deft humour and mem

Picture book series from Jane FosterThere's so much to discover together in the museum!Follow Brown Bear and his friends as they explore all of the different rooms - from the transport section to the art gallery.With vibrant artwork and charming animal characters, this new picture book series from Jane Foster introduces little ones to everyday adventures and the spirit of friendship.

Picture book series from Jane FosterThere's so much to discover together in London!Follow Brown Bear and his friends as they explore the big city - from Tower Bridge to Buckingham Palace.With vibrant artwork and charming animal characters, this new picture book series from Jane Foster introduces little ones to everyday adventures and the spirit of friendship.

A camping trip with his Scout troop leads Lewis straight to a strange, old grave and a mysterious, magical silver whistle. When Lewis discovers that this whistle has the power to stop the boys in his

Grandmother's Garden is tangled with weeds, "Wildflowers, says grandma, food for the bees." A little girl visits her grandmother in summer and winter, and together they explore the wonders of Grandmot

This beautifully illustrated collection tells the awe-inspiring stories of 50 women who have pushed the boundaries of human excellence and endeavour. Standing out for their achievements in sport, scie

Little ones will love saying 'hello' to a whole host of friendly undersea animals in this delightful lift-the-flap book. Sam Boughton's vibrant illustrations bring facts to life with deft humour and m

Little ones will love saying 'hello' to a whole host of friendly woodland creatures in this delightful lift-the-flap book. Sam Boughton's vibrant illustrations bring facts to life with deft humour and

Anna Llenas's popular Colour Monster is back, and this time he's heading off to school! But what exactly is school? A spooky castle filled with terrifying animals? A place in the sky, amongst the rain

Little ones will love saying 'hello' to a whole host of friendly savannah creatures in this delightful lift-the-flap book. Sam Boughton's vibrant illustrations bring facts to life with deft humour and

Little ones will love saying 'hello' to a whole host of friendly dinosaurs in this delightful lift-the-flap book. Sam Boughton's vibrant illustrations bring facts to life with deft humour and memorabl

'There's something very important that I need you to remember. When I say Ooh, you say Aah. Let's try it.' Ooh the donkey has lost his pants. Readers must help him find them! In this picture book, you

Get creative with this amazing geometric colouring book that gives colour and copy a modern twist. Instead of squares to colour, Geo Art enables you to colour geometric shapes to create amazing 3D pictures that look like hybrids of pixels and 3D images. A must-have for fans of colouring, fans of detailed pictures and fans of animation.The book is divided into four sections to help you build your Geo Art skills:- In section one, the geometric shapes are larger and the pictures are simpler. Some of the pictures are partially coloured, so you just have to follow the mini finished picture and fill in the colour to complete each picture. - Then in section two, the geometric shapes are smaller, and the pictures have more detail to colour.You must complete the picture with only the outline and the finished picture to help you bring your Geo Art picture to life. - Section three is more challenging but fun! There's a finished picture to follow, but no outline to help you. Each picture is hidden

I'M A NAUGHTY NAUGHTY MONSTER! ARE YOU READY? HERE I COME! I AM HUNGRY FOR MY DINNER AND I WANT YOU IN MY TUM! The Naughty Naughty Monster is looking for for a tasty meal to fill his monstrous belly. He rampages through woodland, farm and town, scaring all of the happy little animals that he thinks could make a good snack, but he runs into a fairy who is NOT happy with him at all! Will Naughty Naughty Monster learn his lesson and change his naughty ways? Kaye Umansky has written over 130 books for children and her work ranges from picture books to novels. She is best known for the Pongwiffy series. Greg Abbott is a talented new illustrator. Naughty, Naughty Monster is his first picture book. 商品除瑕疵品外，恕不接受退換貨因拍攝略有色差，圖片僅供參考，顏色請以實際收到商品為準

A new title in the Pictura Puzzles series, Wild Wonders explores the world's wildest habitats and the extraordiary animals that live there. Journey around the seven continents of the world and discove

I can splash the middle of a puddle! I can hit the last leaf on a tree! I even splattered a great white shark, when it stuck its head out of the sea. WHAT A NAUGHTY BIRD! In this rhyming romp, a naugh

Textile artist, Jane Foster, makes toys and prints that appear throughout the world in iconic design publications and stores. Her retro-inspired designs have a strong Scandinavian influence and are se

Textile artist, Jane Foster, makes toys and prints that appear throughout the world in iconic design publications and stores. Her retro-inspired designs have a strong Scandinavian influence and are se

In this book, collage artist Ellen Giggenbach has brought together twenty of her favourite Christmas papercraft projects, including baubles, wall decorations and 3-D models, for you to make during the

This visual feast from acclaimed illustrator Alison Jay is the perfect festive gift. On Christmas Eve, a man buys presents for the woman he loves, beginning with a partridge in a pear tree. The couple

Mechanical Marvels is the second title in the Record Breakers series and combines amazing facts with funky design, attractive artwork and flaps to lift throughout. It's filled to the brim with the wor

Pictura is a stunning range of black-and-white artworks to collect and colour, for ages 9 to 90. In Hedgerow Year, the beautiful seasons of the English countryside are witnessed by one ever-changing h

Join pirate family the Jolley-Rogers as they move to Dull-on-Sea and get neighbourhood tongues wagging in Jonny Duddle's award-winning tale. Sound buttons and page-prompts mean even the youngest reade

On Christmas Eve the young animals gather in Mrs Owl's bookshop to hear the story of the Silver Fox, who grants the Christmas wish of every good boy and girl. We see five Christmas wishes granted, and then the final one bringing the Silver Fox himself to the Christmas feast! Caroline Anstey's joyful illustrations make this a Christmas treat sure to be treasured by all who receive it.

A ring-tailed lemur is stowed away on a boat from Madagascar, and eventually ends up in the home of an eccentric but dysfunctional family. His night-time antics cause confusion, as he nibbles on the f

In this wonderfully funny picture book we meet Lily. One day she looks out of her window and see's a doggy! This is no oridinary doggy, this is an enormous bear escaped from a zoo. Follow Lily's adven

Looks at a day in the life of Bob. Find out what he does on the moon: cleaning and tidying, welcoming vistors, performing tricks for tourists and much more. He knows almost everything there is to know

This exciting lift-the-flap novelty book is packed with simple science experiments for kids to try at home. Covering elements from Key Stage 2 and 3 of the school science curriculum in a fun and acces

Sorcery and mystery with a dose of horror and history

It's gardening time! Can you rake the soil and plant the seeds?In this fun new series, little ones learn first words and experiences by using satisfying sliders and sturdy flaps. Each spread introduce