Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Written by an distinguished mathematician and teacher, this undergraduate text uses a combinatorial approach to accommodate both math majors and liberal arts students. In addition to covering the bas

With an Introduction by Tim Cook. Shakespeare's sonnets have an intensity of both feeling and meaning unmatched in English sonnet form. They divide into two parts; the first 126 sonnets are addressed

She was a beautiful doelike child, with an intense, graceful fragility. In her first year, she picked up words, smiled and laughed, and learned to walk. But then Anne-Marie began to turn inward. And w

With an Introduction and Notes by Dr Sally Minogue. The Professor is Charlotte Brontes first novel, in which she audaciously inhabits the voice and consciousness of a man, William Crimsworth. Like Jan

Widely regarded as one of Edith Wahrton’s greatest achievements, The Age of Innocence is not only subtly satirical, but also a sometimes dark and disturbing comedy of manners in its exploration of the

When the Cuthberts send to an orphanage for a boy to help them at Green Gables, their farm in Canada, they are astonished when a talkative little girl steps off the train. Anne, red-headed, pugnacious

When Ms. Frizzle drives the Magic School Bus full speed ahead into the ocean, the class takes a submarine expedition that's anything but ordinary. With a well-meaning lifeguard in tow, the class takes

“A serious, powerful novel…[Gaines] is a writer of terrific energy.”—The NationThis is the story of Marcus: bonded out of jail where he has been awaiting trial for murder, he is sent to the Hebert plantation to work in the fields. There he encounters conflict with the overseer, Sidney Bonbon, and a tale of revenge, lust and power plays out between Marcus, Bonbon, Bonbon’s mistress Pauline, and Bonbon’s wife Louise.

With an Introduction, Bibliography and Glossary by Michael Irwin, Professor of English Literature University of Kent at Canterbury. Thomas Hardy started composing poetry in the heyday of Tennyson and

Dad, mum and two brothers spend a day at the zoo, looking at the animals in the cages - or is it the animals that are looking at them?

Every time Mr Archimedes has a bath with his friends, the water overflows. Somebody must be putting extra water in the bath. Is it Kangaroo? Or is it Goat or Wombat? Whoever it is, Mr Archimedes is go

With an Introduction, Notes and Bibliography by Dr Bruce Woodcock, Senior Lecturer in English, University of Hull. Shelley's short, prolific life produced some of the most memorable and well-known lyr

In this seminal work Oliver O'Donovan delineates a convincing theological ethics from an evangelical standpoint that illumines such important concepts as freedom, authority, nature, history, and revel

With an Introduction by Paul Wright. 'What the imagination seizes as Beauty must be truth' So wrote the Romantic poet John Keats (1795-1821) in 1817. This collection contains all of his poetry: the ea

With an Introduction by Antonia Till. William Wordsworth (1771-1850) is the foremost of the English Romantic poets. He was much influenced by the events of the French Revolution in his youth, and he d

Robin Hood is the best-loved outlaw of all time. In this edition, Henry Gilbert tells of the adventures of the Merry Men of Sherwood Forest - Robin himself, Little John, Friar Tuck, Will Scarlet, and

Introduction and Notes by R.T. Jones, Honorary Fellow of the University of York. This edition of the poetry of Rudyard Kipling (1865-1936) includes all the poems contained in the Definitive Edition of

Discusses the main types of wolves, where wolves live, wolf packs, communication among wolves, the relationship between wolves and humans, other facts about wolves, and wolves in folklore

"I don't like the dark," said Little Bear."What dark?" said Big Bear."The dark all around us," said Little Bear.In this tender account of a sleepless night in the bear cave, Big Bear sets out with all

Once there was a little island in the ocean. That little island changes as the seasons come and go. The storm and the day and night change it. So do the lobsters and seals and gulls that stop by. Then

With an Introduction and Notes by Dr Pamela Knights, Department of English Studies, Durham University. Lorna Doone, a Romance of Exmoor is an historical novel of high adventure set in the South West o

In these delightful tales, Oscar Wilde employs all his grace, artistry and wit. The Happy Prince tells of the statue of a once pleasure-loving Prince which, with the help of a selfless Swallow helps p

At first dismayed at having to spend the last month of her summer vacation helping out in the household of recently widowed Mrs. Hata, Rinko discovers there are pleasant surprises for her, but then ba

Introduction and Notes by R.T. Jones, Honorary Fellow of the University of York. This novel, based on George Eliot's own experiences of provincial life, is a masterpiece of ambiguity in which moral ch

Set on the outskirts of a small Southern town, The Grass Harp tells the story of three endearing misfits--an orphaned boy and two whimsical old ladies--who one day take up residence in a tree house. A

Since it was first published over fifty years ago, April's Kittens remains a classic cat story and is now made available again in this handsome new edition.Many children understand April's dilemma whe

A frog's-eye view of life in a tiny pond follows a little green frog from springtime, through the warmth of summer, to fall and the coming of winter, as the little frog burrows deep into the mud at th

With an Introduction and Notes by Keith Wren, University of Kent at Canterbury. Set in 1482, Victor Hugo's powerful novel of 'imagination, caprice and fantasy' is a meditation on love, fate, architect

With an Introduction and Notes by Dr Claire Seymour, University of Kent at Canterbury. The Turn of the Screw is the classic ghost story for which James is most remembered. Set in a country house, it i

The Russian T-72 Ural tank is the most widely-deployed main battle tank of the current generation. Used by the armies of the former Warsaw pact and Soviet Union, it has also been exported in large num

★ 諾貝爾文學獎得主約翰．史坦貝克代表作★ 大蕭條時代最動人的友情與夢想寓言★ 短篇篇幅，卻擁有震撼人心的情感力量★ 殘酷現實與溫柔人性交織的經典之作在經濟大蕭條的荒蕪年代，流浪工人喬治與雷尼相依為命，穿梭於加州塵土飛揚的農場之間。他們一無所有，卻懷抱著同一個簡單而遙遠的夢——擁有一小塊土地、一間屬於自己的小屋，不再為生存奔波。喬治精明謹慎，雷尼力大無窮卻心智單純，如同孩子般依賴著喬治。這對看似不可能的組合，在孤獨與艱困之中成為彼此唯一的依靠。當他們終於在一座牧場找到工作，夢想似乎近在眼前，命運卻悄然逼近。一次無法預料的意外，將所有希望推向無法挽回的結局。《人鼠之間》以簡潔而深刻的筆觸，描繪友情、孤獨與人性，在殘酷世界中閃現的微光與無奈。A controversial tale of friendship and tragedy during the Great Depression"A thriller, a gripping tale . . . that you will not set down until it is finished. Steinbeck has touched the quick." —The New York TimesJohn Steinbeck's classic novella follows an unlikely pair: George is "small and quick and dark of face"; Lennie, a man of tremendous size, has the mind of a young child. Yet together they have formed a family, clinging to each other in the face of loneliness, and alienation, and hardship.Laborers in California's dusty vegetable fields, they hustle work when they can, living a hand-to-mouth existence. For George and Lennie have a plan: to own an acre of land and

This edition contains Alice's Adventures in Wonderland and its sequel Through the Looking Glass. It is illustrated throughout by Sir John Tenniel, whose drawings for the books add so much to the enjoy

Set in a diner where the food isn't very good and the ambience veers between heaven and hell, this bestselling novel from the author of Mama Day and The Women of Brewster Place is a feast for the sens

A classic Amelia Bedelia story is now an I Can Read Book, and in full color too! With new illustrations based on the original art of Fritz Siebel, this laugh-out-loud favorite comes to life as the lov

Little Women is one of the best-loved children's stories of all time, based on the author's own youthful experiences. It describes the family life of the four March sisters living in a small New Engla

Jason is riding the bus when a dog sits down right in the middle of the road. He will not get out of the way! A lady tries to move him and a policeman tries, too. But only Jason knows how to get that

With an Introduction and Notes by Dr Tim Middleton, Head of English Studies, University of Ripon and York. In seeking to discover his inner self, the brilliant Dr Jekyll discovers a monster. First pub

In this selection of tales by the master folklorist Andrew Lang, the reader is taken into the romantic world of the gallant Knights of the Round Table and their courageous and chivalrous deeds, fair m

Anatole Broyard，長年擔任《紐約時報》書評人、書評版編輯與隨筆作家，渴望被記住——而他確實做到了。這本隨筆集收錄多篇不羈、幽默又犀利的文章，書寫生命與死亡的種種考驗，其中許多篇章完成於他與癌症對抗、並於 1990 年辭世之前的歲月。本書收錄他晚年完成的隨筆，文字優雅、清醒而不煽情，被譽為直面生命極限的經典之作，是一部關於如何活著、也如何告別的深刻書寫。獲《紐約時報》年度注目好書Anatole Broyard, long-time book critic, book review editor, and essayist for the New York Times, wants to be remembered. He will be, with this collection of irreverent, humorous essays he wrote concerning the ordeals of life and death—many of which were written during the battle with cancer that led to his death in 1990. A New York Times Notable Book of the Year “A heartbreakingly eloquent and unsentimental meditation on mortality . . . Some writing is so rich and well-spoken that commentary is superfluous, even presumptuous. . . . Read this book, and celebrate a cultured spirit made fine, it seems, by the coldest of touches.”—Los Angeles Times“Succeeds brilliantly . . . Anatole Broyard has joined his father but not before leaving behind a legacy rich in wisdom about the written word and the

A record of buddhistic kingdoms, being an account by the Chinese monk fa-hien of his travels in india and ceylon(A. D. 399－414) 法顯傳，又稱高僧法顯傳、佛國記、歷遊天竺記傳、高僧傳，乃東晉高僧法顯西域至印度諸國求法過程的記錄，為我國僧侶遊行印度記傳中現存最古典籍。本傳與唐