Genomic Structural Variants

The completion of a consensus draft sequence for the human genome was the starting point for more thorough investigations of individual genome variation. The development of array-based strategies mad

A grand summary and synthesis of the tremendous amount of data now available in the post genomic era on the structural features, architecture, and evolution of the human genome. The authors demonstrat

During the last decade, research in Uncertainty Quantification (UC) has received a tremendous boost, in fluid engineering and coupled structural-fluids systems. New algorithms and adaptive variants ha

Classical field theory, which concerns the generation and interaction of fields, is a logical precursor to quantum field theory, and can be used to describe phenomena such as gravity and electromagnetism. Written for advanced undergraduates, and appropriate for graduate level classes, this book provides a comprehensive introduction to field theories, with a focus on their relativistic structural elements. Such structural notions enable a deeper understanding of Maxwell's equations, which lie at the heart of electromagnetism, and can also be applied to modern variants such as Chern–Simons and Born–Infeld. The structure of field theories and their physical predictions are illustrated with compelling examples, making this book perfect as a text in a dedicated field theory course, for self-study, or as a reference for those interested in classical field theory, advanced electromagnetism, or general relativity. Demonstrating a modern approach to model building, this text is also ideal for s

This volume presents a list of cutting-edge protocols for the study of CRISPR-Cas defense systems and their applications at the genomic, genetic, biochemical and structural levels. CRISPR: Methods and

This volume presents a list of cutting-edge protocols for the study of CRISPR-Cas defense systems and their applications at the genomic, genetic, biochemical and structural levels.CRISPR: Methods and

The ‘epi-(Greek for ‘over’, ‘above’)genome’, with its rich cache of highly regulated, structural modifications-including DNA methylation, histone modifications and histone variants-defines the molding

This book reviews various aspects of papaya genomics, including existing genetic and genomic resources, recent progress on structural and functional genomics, and their applications in papaya improvem

The sequencing of the human genome and the identification of associations between specific genetic variants and diseases have led to an explosion of genomic-based diagnostic tests. These tests have th

Collaborative working is an established feature of the public, business and third sector environments, but its effectiveness can be hampered by complex structural and personal variants. This original

Collaborative working is an established feature of the public, business and third sector environments, but its effectiveness can be hampered by complex structural and personal variants. This original

Focussing on the work of Sir John Kingman, one of the world's leading researchers in probability and mathematical genetics, this book touches on the important areas of these subjects in the last 50 years. Leading authorities give a unique insight into a wide range of currently topical problems. Papers in probability concentrate on combinatorial and structural aspects, in particular exchangeability and regeneration. The Kingman coalescent links probability with mathematical genetics and is fundamental to the study of the latter. This has implications across the whole of genomic modelling including the Human Genome Project. Other papers in mathematical population genetics range from statistical aspects including heterogeneous clustering, to the assessment of molecular variability in cancer genomes. Further papers in statistics are concerned with empirical deconvolution, perfect simulation, and wavelets. This book will be warmly received by established experts as well as their students an

Parasitic infections are the most prevalent of human diseases, and researchers continue to face the challenge of designing drugs to successfully counteract them. Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies with which to identify effective antiparasitic agents. An introduction to the early development of parasite chemotherapy is followed by an overview of biophysical techniques and genomic and proteomic analysis. Several chapters are devoted to specific types of chemotherapeutic agents and their targets in malaria, trypanosomes, leishmania and amitochondrial protists. Chapters on helminths include metabolic, neuromuscular, microtubular and tegumental targets. Emphasized throughout is the design of more selective and less toxic drugs than in the past. This book will be especially relevant to medical and clinical researchers and to graduate students in

Parasitic infections are the most prevalent of human diseases, and researchers continue to face the challenge of designing drugs to successfully counteract them. Chemotherapeutic Targets in Parasites analyzes the critical metabolic reactions and structural features essential for parasite survival, and advocates the latest molecular strategies with which to identify effective antiparasitic agents. An introduction to the early development of parasite chemotherapy is followed by an overview of biophysical techniques and genomic and proteomic analysis. Several chapters are devoted to specific types of chemotherapeutic agents and their targets in malaria, trypanosomes, leishmania and amitochondrial protists. Chapters on helminths include metabolic, neuromuscular, microtubular and tegumental targets. Emphasized throughout is the design of more selective and less toxic drugs than in the past. This book will be especially relevant to medical and clinical researchers and to graduate students in

International relations theorists are increasingly turning to historical sociology as a means both of broadening and refining their discipline, and critiquing mainstream thinking. Nevertheless, there is still only a rudimentary understanding of what historical sociology is and what it can offer the subject. This 2001 book acts as a manifesto for historical sociology, considering a range of issues, including accounts of the major variants of historical sociology; how they can be applied to international relations; why international relations theorists should engage with these approaches; and how historical sociological insight can enhance and reconfigure the study of international relations. In addition to describing the seven major approaches - neo-Weberianism, constructivisim, critical historical materialism, critical theory, postmodernism, structural realism and World Systems theory - the volume's introductory and concluding chapters set out in detail an approach and research agenda

International relations theorists are increasingly turning to historical sociology as a means both of broadening and refining their discipline, and critiquing mainstream thinking. Nevertheless, there is still only a rudimentary understanding of what historical sociology is and what it can offer the subject. This 2001 book acts as a manifesto for historical sociology, considering a range of issues, including accounts of the major variants of historical sociology; how they can be applied to international relations; why international relations theorists should engage with these approaches; and how historical sociological insight can enhance and reconfigure the study of international relations. In addition to describing the seven major approaches - neo-Weberianism, constructivisim, critical historical materialism, critical theory, postmodernism, structural realism and World Systems theory - the volume's introductory and concluding chapters set out in detail an approach and research agenda