Methods

Microtubules are at the heart of cellular self-organization, and their dynamic nature allows them to explore the intracellular space and mediate the transport of cargoes from the nucleus to the outer

This advanced textbook on modeling, data analysis and numerical techniques for marine science has been developed from a course taught by the authors for many years at the Woods Hole Oceanographic Institute. The first part covers statistics: singular value decomposition, error propagation, least squares regression, principal component analysis, time series analysis and objective interpolation. The second part deals with modeling techniques: finite differences, stability analysis and optimization. The third part describes case studies of actual ocean models of ever increasing dimensionality and complexity, starting with zero-dimensional models and finishing with three-dimensional general circulation models. Throughout the book hands-on computational examples are introduced using the MATLAB programming language and the principles of scientific visualization are emphasised. Ideal as a textbook for advanced students of oceanography on courses in data analysis and numerical modeling, the boo

Immunology has made significant progress in the past decade, driven forward by rapidly advancing technology and a renewed interest in the vast realm of innate immunity. The receptors that mediate thes

A general class of powerful and flexible modeling techniques, spline smoothing has attracted a great deal of research attention in recent years and has been widely used in many application areas, from

Recent years have witnessed growing interest in a series of issues related to migration, including identity formation and change, the role of social capital and social networks, ethnic discrimination,

The TransNav 2011 Symposium held at the Gdynia Maritime University, Poland in June 2011 has brought together a wide range of participants from all over the world. The program has offered a variety of

""The book makes excellent use of questions throughout, both in order to help the reader gain clarity regarding the ontological and epistemological assumptions underpinning different approaches to qua

It is clear that hydraulic research is developing beyond traditional civil engineering to satisfy increasing demands in natural hazards assessment and also environmental research. Our ability to descr

With the advent of approximation algorithms for NP-hard combinatorial optimization problems, several techniques from exact optimization such as the primal-dual method have proven their staying power and versatility. This book describes a simple and powerful method that is iterative in essence and similarly useful in a variety of settings for exact and approximate optimization. The authors highlight the commonality and uses of this method to prove a variety of classical polyhedral results on matchings, trees, matroids and flows. The presentation style is elementary enough to be accessible to anyone with exposure to basic linear algebra and graph theory, making the book suitable for introductory courses in combinatorial optimization at the upper undergraduate and beginning graduate levels. Discussions of advanced applications illustrate their potential for future application in research in approximation algorithms.

With the advent of approximation algorithms for NP-hard combinatorial optimization problems, several techniques from exact optimization such as the primal-dual method have proven their staying power and versatility. This book describes a simple and powerful method that is iterative in essence and similarly useful in a variety of settings for exact and approximate optimization. The authors highlight the commonality and uses of this method to prove a variety of classical polyhedral results on matchings, trees, matroids and flows. The presentation style is elementary enough to be accessible to anyone with exposure to basic linear algebra and graph theory, making the book suitable for introductory courses in combinatorial optimization at the upper undergraduate and beginning graduate levels. Discussions of advanced applications illustrate their potential for future application in research in approximation algorithms.

This volume is centered around the issue of market design and resulting market dynamics. The economic crisis of 2007-2009 has once again highlighted the importance of a proper design of market protoco

Are you an applied researcher or a statistics student? If so, have you ever wondered if there is any rhyme or reason behind the apparent jumble of ad hoc statistical “recipes” that are most commonly

Cytogenetic studies of malignancy have become a central tool in the clinical management of cancer patients. Now in a second, revised edition, this book presents practical cytogenetic and FISH techniqu

A comprehensive overview of Monte Carlo simulation that explores the latest topics, techniques, and real-world applicationsMore and more of today’s numerical problems found in engineering and fi

The past two decades have seen an explosion in the number of research articles relating to both the physiological and pathological responses evoked by nitric oxide generation. Despite this, accurate q

Covering all aspects of business research, from review of the literature to multivariate analysis, this readable text aimed at advanced undergraduate students intends to help aspiring managers make be

A new edition of a successful, well-established book that provides the reader with a text focused on practical rather than theoretical aspects of financial modellingIncludes a new chapter devoted to v

This book aims to assist research scientists in choosing the most applicable database or bioinformatics tools to aid and promote their research in plant biotechnology. Chapters include practical examp

As evidenced by the anthrax attacks in 2001, the SARS outbreak in 2003, and the H1N1 influenza pandemic in 2009, a pathogen does not recognize geographic or national boundaries, often leading to devas

Over the past two decades, spectacular advances have been made in our understanding of the molecular genetics of cancer, leading to the pursuit of identifying genes that, when mutated, result in an in

The generation of genetically modified mice is absolutely crucial to gene function studies today, primarily because mice are genetically similar to man and because gene function studies in mice are in

Computational photography refers broadly to imaging techniques that enhance or extend the capabilities of digital photography. This new and rapidly developing research field has evolved from computer

Biomedical, pharmaceutical and medical personnel are interested in studying aspects of arrhythmias at a basic, translational and applied level. The overall understanding of the molecular basis of dis

The importance of chiral interactions for both preparative and analytical separations, particularly for pharmaceutical applications, is underlined by numerous publications in this field. Here, for the

Immunoelectron microscopy is a key technique that bridges the information gap between biochemistry, molecular biology, and ultrastructural studies placing macromolecular functions within a cellular c

Today's tissue microarray (TMA) method presents as a modern high-tech technology, one which allows for the linking of clinical data to the tissues that are combined on one slide. In Tissue Microarray

For new and experienced public safety instructors, McClincy, an EMT, public safety trainer and educator, and director of an EMS council, provides principles, practices, and procedures for quality emer

The purpose of this volume is to provide examples of the multiplicity of tools that have been developed to study protein sorting, membrane targeting, transmembrane crossing and secretion across multi

Human induced biodiversity loss is greater now than at any time in human history, with extinctions occurring at rates hundreds of times higher than background extinction levels. The field of biodiversity economics analyses the socio-economic causes of and solutions to biodiversity loss by combining the disciplines of economics, ecology and biology. This field has shown a remarkable degree of transformation over the past four decades and now incorporates the analysis of the entire diversity of biological resources within the living world. Biodiversity Economics presents a series of papers that show how bio-economic analysis can be applied to the examination and evaluation of the problem of various forms of biodiversity loss. Containing insightful bio-economic research by some of prominent practitioners in the field, this volume will be an essential research tool to those working on biodiversity issues in the academic, policy and private sectors.

"In combination with EEG and MR-based cortical reconstruction, MEG has considerably improved in the past ten years to become very close to the brain imager's long-awaited ideal---a non-invasive method

The technical development of optical tweezers, along with their application in the biological and physical sciences, has progressed significantly since the demonstration of an optical trap for micron-

In many physical problems several scales present either in space or in time, caused by either inhomogeneity of the medium or complexity of the mechanical process. A fundamental approach is to first co

During the past decade, the mathematics of superconductivity has been the subject of intense activity. This book examines in detail the nonlinear Ginzburg-Landau functional, the model most commonly u

This book offers a new, fairly efficient, and robust alternative to analyzing multivariate data. The analysis of data based on multivariate spatial signs and ranks proceeds very much as does a tradit

The action of antimicrobial peptides (AMPs), ranging from direct killing of invading pathogens to immune response modulation and other complex biological responses, has stimulated research and clinic

Biological interactions of visible light with photosensitizers have been studied for over a century while controlled clinical applications of light and photosensitizers to treat solid tumors, known a

Spanning from discoveries in fundamental immunology to industrial and commercial concerns, the study of vaccine adjuvants has developed into an exciting area of work with great, vital potential in inn

The ability to culture cells is fundamental for mass propagation and as a baseline for the genetic manipulation of plant nuclei and organelles. The introduction to Plant Cell Culture: Essential Method

The development of powerful computing environment and the geographical information system (GIS) in recent decades has thrust the analysis of geo-referenced disease incidence data into the mainstream o