Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Loki's fourth doodle-packed diary in the number one best-selling series. Loki has made a fair few enemies during his time in Asgard. Too many to count and certainly too many to remember.When the elf, Vinir beams Loki aboard his chariot and challenges him to a magical duel, Loki hasn't got a clue why. Sweet talking his way out of a fight by pointing out there's little honour in duelling someone who can't remember how they wronged you, and even less in picking on a child, Loki is returned safely to school. That is until Vinir shows up in child form, as resolute as ever about seeking that duel...and vengeance.

Join Bizzy Bear as he zooms into space in this chunky new board book with sliding counters.Bizzy Bear is an astronaut today. He’s zooming in his rocket off on a space adventure and he needs your help! Board the spaceship, fly into space, grab a snack in zero gravity and meet the aliens on a nearby planet with four easy-to-use moving counters.Learn space vocabulary with simple first words and helpful text prompts to encourage talking. Then push Bizzy Bear along 4 different tracks with a moving counter on every spread, plus an extra one on the cover! The perfect book for children who love space and love being in control of the story!Other titles in the series include: On the Building Site, At the Zoo and On the Farm.

當 Pencil 發現自己的筆尖鈍了，陷入了「我是不是沒有用了？」的危機時，她決定展開冒險，尋找一個削筆器。旅程驚險又爆笑，她的最佳夥伴 Eraser 雖然不太願意，也只好一路陪伴。Pencil 活潑外向、充滿點子，Eraser 謹慎內向、凡事小心翼翼，兩者個性迥異卻意外合拍。故事中穿插許多教室中小物的巧妙變身，既富創意也貼近孩子日常生活經驗，Narwhal and Jelly 或 Pizza and Taco 粉絲不可錯過。Fans of Narwhal and Jelly & Pizza and Taco, prepare to meet your new favorite duo! This hilarious new early-reader graphic novel series follows the adventures of two best friend school supplies: Pencil and Eraser!Pencil is a joyous adventure seeker and Eraser is a cautious curmudgeon. And when their human person Stella isn’t watching, these two unlikely friends go on all sorts of adventures!It's the start of a new school year, and Pencil and Eraser are ready for anything. Except when Pencil notices her point has dulled. That's never happened before and she feels...pointless. Stella can't write with a dull pencil. So what can Pencil do? The only answer is to leave the comfort of their desk behind and venture out to find a sharpener. But if Pencil is going on an adventure,

SUPER HAPPY MAGIC FOREST ADVENTURES NOW IN COLOUR! A Super Happy Magic Forest chapter book packed with illustrations and plenty of humour-this is the perfect read for fans of Dog Man and Captain Underpants (6+). Fun-filled frolics from award-winnig author Matty Long. The Super Happy Magic Forest is the friendliest, most frolic-filled place in all the world, but very occasionally something comes along and disturbs the peace.That's when our five brave heroes step up to save the day-there's Blossom the unicorn, Twinkle the pixie, Herbert the gnome, Hoofius the faun, and a plucky little mushroom called Trevor. In Super Happy Magic Forest and the Deep Trouble, the five heroes go diving for Candy Coral in Lake Sparkle and find more than they bargained for-a fishy-looking creature called Foam. It's the start of a brand-new seafaring quest! Time for the gang to find their sea-legs and set sail on an adventure to the underwater city of Fishopolis!For more laugh-out-loud adventures with the Supe

SUPER HAPPY MAGIC FOREST ADVENTURES NOW IN COLOUR! A Super Happy Magic Forest chapter book packed with illustrations and plenty of humour-this is the perfect read for fans of Dog Man and Captain Underpants (6+). Fun-filled frolics from award-winning author Matty Long. The Super Happy Magic Forest is a place of happiness, frolicking, and picnics.Well, most of the time it is, but something is threatening to disrupt the peace. In Super Happy Magic Forest and the Portals of Panic, a mysterious portal opens up above the forest and a small and very hungry gargoyle-like creature flies out determined to eat everything in its path. It even tries to take a bite out of Trevor the mushroom! Thank goodness for our five brave heroes: Hoofius the faun, Trevor the mushroom, Twinkle the pixie, Herbert the gnome, and Blossom the unicorn, who set off to Wizard City for answers.Can they figure out which wizard is responsible in time to save the day, or will they be distracted by a busy sightseeing schedul

A monster has broken into Jack's garden and stolen his favourite yellow underpants. The cheek! Jack sees his chance to flex his new fairy skills and embark on his first ever solo mission. Unfortunately, in chasing the creature across town and leaving a trail of chaos in his wake, Jack breaks every rule in the fairy rule book (you must keep the magical kingdom a secret from humans, no one can know you are really a fairy, and you must NEVER EVER cause a lorry to crash into a take-out restaurant shop, creating a ketchup spillage across the high street whilst in pursuit of a magical creature who has your pants).Will Jack get his wand back, track down the monster, and make everything right again before he's kicked out of the magical kingdom for good?

A delightful, funny story about making friends and learning to communicate from award-winning and bestselling author–illustrator, Emma Yarlett.The lion is King and everyone in his kingdom is happy. Everyone, that is, except King Lion himself. The king feels lonely and decides he needs a friend. He tries everything: roaring “hello”, waving his paws, flashing a smile and even cracking a joke. But everyone just runs away. Then, feeling lonelier than ever, the king climbs up the tallest tower in his kingdom and roars and roars and ROARS! Now no one in the kingdom is happy. Until a little girl sees the king and comes up with a very brave plan to help him.A joyful, touching and vibrantly illustrated story.

Adèle迎來人生轉變：第一次月經讓她獲得與幽靈溝通的能力，也揭開家族中不為人知的祕密。她本想平靜度過假期，卻因此展開一段穿越城市、認識幽靈、也重新看見自己的旅程。本書幽默之中帶著真誠，探索青春、文化與身分，是一部感性與奇幻交織的圖像小說。A Little Maverick Graphic Novel Reading List SelectionIn this hilarious and heartwarming graphic novel, a young girl's first period brings an unexpected gift: the ability to see ghosts! As she meets these spectral visitors, she uncovers her family's secret lineage of mediums, while learning about the power of compassion and community.Adèle just wants to spend her winter break at the library, cozied up with her favorite books, and completely forgetting abut her friends who are all traveling to warmer climates. Unfortunately, life has other plans...not only does Adèle get her first period...but she learns she comes from a long line of mediums!And if seeing ghosts wasn't enough of a surprise, Adèle learns that not only can she interact with them, but apparently, they've been using her sister's car to get around the city for years! When the ghosts won't leave her alone Ad

INCLUDES A NEW MAX SHORT STORY!NEW YORK TIMES BESTSELLING SERIES • The clock is ticking on Max's final adventure as she races to uncover family secrets. From the creator of the Big Nat series, now an Emmy-nominated animated TV show on Paramount+ and Nickelodeon"An epic finish to an epic tale!" -Jeff Kinney, New York Times bestselling author of the Diary of a Wimpy Kid seriesEveryone's favorite knight-in-training is back...to back! Max's twin is public enemy number one, and it's up to the Midknights to find her before time runs out! But dangers loom, including bloodthirsty trolls, murderous pirates, and even a ruthless king--or two. Can Max and her band of loyal friends unlock the mystery of her past? Lincoln Peirce pens another epic quest in The Tower of Time, book three in the New York Times bestselling Max & the Midknights series.Series Overview: Third and concluding book in the Max and the Midknights series.One Max paperback conversion per season, beginning in Spring '24.

Award-winning creators Mac Barnett and Shawn Harris are back with the second volume in the bestselling The First Cat in Space graphic novel series! Secret tales of woe, hilarious new characters, and dangerous plans of sabotage will keep readers delighted and laughing until the thrilling climax. Perfect for fans of Dog Man and InvestiGators. The Moon Queen has been poisoned--by SOUP. With few she can trust in her own royal court, she and First Cat will have to journey alone to find the antidote. If only LOZ 4000 were still with them . . . But our once-heroic toenail clipping robot is on the run, looking for new purpose in this vast universe. Unbeknownst to our trio, secret forces are working against them. In a world of villainous cowboys, high-speed chases, and falling pianos, can our iconic trio find their way back to one another and save the Moon Queen before it's too late? And who would want to poison her? Is Captain Babybeard, the adorable baby pirate, in this one? Praise for The Fi

After breaking a “curse” on the imperial heirs, a palace servant with training in herbal medicine is promoted up the ranks to food taster...and right into the thick of palace intrigue in this lushly illustrated historical mystery series!Strong-armed into getting out more, Maomao attends a spooky soiree where court ladies share spine-tingling tales of terror as a diversion from their daily toil. While there are plenty of chills to go around, the thrills are perhaps few for the skeptical Maomao...until the evening takes an eerie turn! And still more thrills await when Jinshi requests Maomao’s presence on a hunting trip. All is not as it seems when court intrigue and subterfuge are in play however, and master and servant find themselves in a very tight spot and uncomfortably close quarters when a break from a banquet on the hunt goes awry...

The Princess in Black may know how to handle all kinds of monsters, but a kitten set on destruction? Me-OW! Duchess Wigtower had heard that pets are fun, but all her kitten has gotten her is nine lives' worth of problems. Eeeeek! It's time for someone else to deal with this catastrophe. Princess Magnolia is thrilled when a kitten lands on her doorstep, but just as she's about to play with Plumpkins (or should it be Hugmaster Floof?) the monster alarm goes off. When Princess Magnolia returns to her castle, her furry companion has carved up the wallpaper! In fact, each time Princess Magnolia leaves to help the Goat Avenger fight a very grouchy monster, her feline friend wreaks havoc. Has the Princess in Black finally met her match? Ten years after she first donned her cape, the Princess in Black returns for a purrfectly hilarious entry to the New York Times best-selling series.

Eight monstrous mammals battle it out in this exciting bind-up featuring four Who Would Win? books in this action-packed animal series!Which dangerous animals would win in a fight? Find out in this awesome bind-up of four books in the popular Who Would Win? series. The collection features a range of mammal battles to satisfy all kinds of animal fans, including Coyote vs. Dingo, Lion vs. Tiger, Rhino vs. Hippo, and Walrus vs. Elephant Seal. Kids will learn about each animal's anatomy, behavior, and more alongside photos, charts, illustrations, and amazing facts.

A 2023 National Book Award Finalist!A resourceful teenager in rural Vermont struggles to hold on to the family home while his mom recovers from addiction in this striking debut novel. Ian Gray isn't supposed to have a dog, but a lot of things that shouldn't happen end up happening anyway. And Gather, Ian's adopted pup, is good company now that Ian has to quit the basketball team, find a job, and take care of his mom as she tries to overcome her opioid addiction. Despite the obstacles thrown their way, Ian is determined to keep his family afloat no matter what it takes. And for a little while, things are looking up: Ian makes friends, and his fondness for the outdoors and for fixing things lands him work helping neighbors. But an unforeseen tragedy results in Ian and his dog taking off on the run, trying to evade a future that would mean leaving their house and their land. Even if the community comes together to help him, would Ian and Gather have a home to return to? Told in a wry, cau

各章節主題如下：第一章至第三章：全球環境困境、永續發展議題之緣起、願景與脈絡，以及永續發展目標。第四章至第六章：永續發展之環境議題（氣候議題、生態保育與環境污染及生產與消費）。第七章至第九章：永續發展之社會議題（貧窮、飢餓與教育、健康醫療、性別平等與多元共融）。第十章至第十二章：永續發展之經濟議題（就業與經濟、工業與創新、能資源使用）。第十三章至第十四章：永續發展之治理議題（和平與正義、全球夥伴關係）。第十五章：結論──挑戰與展望。本書特色自工業革命以來，由於社會發展所導致的全球暖化及氣候變遷問題，已成為人類存續的關鍵議題。為面對全球性的氣候危機與永續浪潮，聯合國提出了「永續發展目標」(Sustainable Development Goals, SDGs)，訂定世界各國推動全球永續發展的努力目標。我國亦根據國內現況及需求，配合提出「2050淨零排放」，宣示推動永續發展的決心，希望藉由政府、企業、民眾團結合作，共同努力翻轉目前的困境。台灣永續能源基金會多年來關注聯合國永續發展目標之氣候變遷、永續能源、生物多樣性等核心議題，期望藉由本書能強化國內產業針對永續能源相關議題之關切，使大專院校學生增進認識能源永續發展的概念，共同為推動永續能源研究之發展貢獻心力。

Join in and help the busy zookeeper in this playful, interactive flap book!Can you help the busy zookeeper to look after the animals? Join in and use the flaps to feed the chimpanzees, clean the elephant house, and feed the baby aardvark. With interactive action-flaps, you can do it, too!Each clever flap provides an action or scene-change to encourage children to actively engage and explore. The playful flaps are perfect for little hands to develop fine motor skills and hand-eye coordination.Original concept and illustration by Dan GreenThe Busy Day series:Introduces the worldBoosts motor skillsRecommended for children aged 2+Also available in the Busy Day series:AstronautAthleteBuilderChefDoctorFarmerFather ChristmasFirefighterFootballerMechanicPolice OfficerTeacherTrain DriverVet

Come and explore with the Moomins in this brand-new story in a book shaped like the Moominhouse. Moomintroll is searching the Moominhouse for a string for his kite. He spots a red string .. . but where does it lead? Join Moomintroll as he follows the string past Snufkin playing a tune, Snorkmaiden swinging on a trapeze and Little My sliding down the stairs.Along the way, lift the flaps to explore rooms, peek into cupboards and peer behind doors. There are all kinds of wonderful things to find!With simple text, things to spot and flaps to lift on every page, In the Moominhouse is the perfect introduction for little ones to Tove Jansson's world of Moominvalley. If you like this book, join Moomintroll as he tiptoes through rooms in In the Lighthouse, the next lift-the-flap shaped board book in this series!

Come and explore with the Moomins in this brand-new story in a book shaped like the Moomin Lighthouse. Moomintroll has found a trail of mysterious footprints in the Lighthouse . .. but where do they end? Join Moomintroll as he follows the footprints through dark rooms and spooky corridors, past Sniff, Snufkin and even a group of fizzing Hattifatteners. Along the way, lift the flaps to explore rooms, peek into cupboards and peer behind doors.There are all kinds of amazing things to find!With simple text, things to spot and flaps to lift on every page, In the Lighthouse is the perfect introduction for little ones to Tove Jansson's world of Moominvalley. If you like this book, don't forget to join Moomintroll in In the Moominhouse, the first lift-the-flap board book in this series!

An action-packed comedy about a fake family that includes a spy, an assassin and a telepath! Master spy Twilight is unparalleled when it comes to going undercover on dangerous missions for the betterment of the world. But when he receives the ultimate assignment--to get married and have a kid--he may finally be in over his head! Anya's friendship scheme seems to be taking a turn for the better in the aftermath of the failed hijacking. Meanwhile, Operation Strix and Loid's true identity are in danger--a mole has been uncovered, but not before they went underground!

It's bathtime in the bear household... but the little bears aren't quite ready for a wash! Behind each fluffy flap in this cute book you'll find a mischievous bear cub making a great big mess... before all the bears are revealed together in the bath on the last page. With adorable illustrations and lots of fun surprises, this is a perfect book to share with babies and toddlers.

本書深入教育工作者最關注的兩項議題：評量方法與有效學習，徹底研究多元評量、揭示差異化教學如何精進不同年段與領域的學習過程。 作者Carol Ann Tomlinson和Tonya R. Moon先將差異化做一概述，再著重其理論如何應用於各種形式的評量，如：前測、形成性評量、總結性評量及成績單等。閱讀此書後，對於差異化評量方法的斬獲：․提升學生興趣及動機；․澄清教師教學的重心；․強化師生習得之信念；․幫助教師了解個別學生異同，促進有效教學。 Tomlinson和Moon強調教與學的五個要素（課程、引導、評量、學習環境和課堂領導/管理）間的相互關聯，以及無論學生學習起點為何，保持學生對於所學知識、理解和技能一以貫之的重要性。書中所示之詳細情境，說明如何以差異化的三個變項（學習準備度、興趣和學習風格）設計評量，及如何提升評量的效度。 本書奠基研究基礎，結合作者課堂教學實務，深入淺出，為探索、奮力發揮真實潛能的教師與學生，勾勒出兼具理論與實務的學習樣貌。

**The 5* escape of the summer!**‘So many twists and turns’ ⭐⭐⭐⭐⭐‘Full of such charm! ⭐⭐⭐⭐⭐'Had me gripped from the beginning' ⭐⭐⭐⭐⭐DO NOT DISTURB. WHODUNNIT IN PROGRESS…Molly the maid sees everything at The Regency Grand Hotel.So when a renowned guest drops very dead on the tearoom floor, sullying the hotel’s five-star reputation, it falls to Molly to sweep up the clues.An unfortunate accident? Or a murderous mess?The answers to the mystery lie behind one guest’s door – and only the maid holds the key…_________________________________________________________________Over a million readers have been swept away by Nita Prose's delightful mysteries:‘Excellent and totally entertaining … the most interesting (and endearing) main character in a long time’ STEPHEN KING‘This is phenomenal thriller. Maid or murderer or victim? Find out in the book’ READER REVIEW ⭐⭐⭐⭐⭐‘Gripping, deftly written, and led by a truly unforgettable protagonist in Molly. I'm recommending it to everyone I know' EMMA STO

AI助攻！搭配ChatGPT學習效率加倍！ ★提供用書教師相關的教學資源★ 【資料結構】(Data Structures)是資訊科學領域中的基礎課程，多數資訊相關科系的研究所入學考試會將之列入考科，而諸如高考三級、地方特考、司法特考、鐵路考試中的資訊類別考試亦會將之列入考科，因此選擇一本觀念正確、條理清晰且掌握命題趨勢的書籍是很重要的。 本書以實例演練為導向，漸進式的學習架構，詳盡解說各種資料結構，期能帶領讀者了解其中的精髓，進而具備開發大型程式的功力。此外，為了因應未來報考資訊相關科系的研究所或準備國家考試，本書精選題型多元的考題，並融入相關章節、隨堂練習與學習評量，建議讀者勤加練習。 AI助攻 *使用【ChatGPT】輔助學習資料結構，例如查詢理論與實作、上傳圖片解題、出題練習、撰寫程式、優化與除錯、與其它程式語言互相轉換等，這些技巧大多不限定於ChatGPT，也可以靈活運用在【Microsoft Copilot】、【Google Gemini】等AI助理。 *本書是以C語言進行實作，讀者可以自行使用ChatGPT轉換成Python、C++、C#、Java等程式語言。 *ChatGPT相關內容統一放在本書最後一章，希望讀者以學會資料結構為主，而使用ChatGPT為輔，同時不會干擾到學習或上課的節奏。 考題觀摩 收錄研究所入學考試與資訊類別國家考試的精選考題，增加實例演練經驗，提升即戰力。

In award-winning author/illustrator Mike Maihack's action-packed and hilarious third graphic novel in the Mighty Marvel Team-Up series, Spider-Man is thrust into space and must team up with the rebellious Guardians of the Galaxy! Spider-Man has ventured into space to return Silver Surfer's surfboard to the space-faring hero. But what starts as a simple mission quickly evolves into a new mystery involving a collection of rare talismans that can give the owner great and potentially dangerous cosmic power. Before he can return home, Spider-Man must discover where all the talismans are and just what their purpose is in order to ensure they don't fall into the wrong hands. Good thing Spidey has joined forces with the perfect Super Hero team--the Guardians of the Galaxy--to see this mission through! With the help of Groot, Rocket Raccoon, Star-Lord, Gamora, and Drax, can Spider-Man save the day and secure his way home? Or is he fated to be lost in space forever? A Mighty Marvel Team-Up serie

Explore the enchanting animal kingdom with a twist in this magical book. Children will discover lots of fun facts about fascinating animals in this interactive book. Simply spin the wheel on each right-hand side page and reveal the cutest animal families. A great first introduction to the animal world!

Explore the enchanting animal kingdom with a twist in this magical book. Children will discover lots of fun facts about fascinating animals in this interactive book. Simply spin the wheel on each right-hand side page and reveal the cutest animal families. A great first introduction to the animal world!

Jamie Smart's number-one bestselling series continues! Bunny, Monkey and the gang are delivering more bonkers hilarity than ever before, in this glorious cornucopia of chuckles!The Woods are in uproar!Pig has vanished! What could have happened to him?And who is that familiar-looking bearded figure sitting on a cloud?Could they be connected?

From Rex Ogle and Dave Valeza, the creators of Four Eyes, comes the second book in this humorous and heartfelt middle-school memoir trilogy.Just can't face it!On the first day of seventh grade, Rex encounters a bump in the road -- a big angry pimple right in the center of his forehead. And this is only the beginning of his problems. What follows is a frustrating battle with stubborn acne, body odor, and other embarrassments of puberty. Still struggling with a home life edging on the poverty line, Rex can't afford to buy the acne medication or deodorant he needs, and bullies are noticing Rex's awkward transformation. On top of it all, things have gotten weird with his friends, making Rex feel like he can't do or say anything right. So far, seventh grade stinks!

The third book in the irresistible series about chosen family, high stakes thievery, and what it really means to do good. Perfect for fans of M.G. Leonard and Anthony Horowitz.It’s Gabriel’s third year at Crookhaven School for Thieves. Along with the usual Break-In challenge – this year to Reclamation island – and difficult new classes like Signs & Signals, Gabriel and his friends have another goal: taking down the Nameless.The Nameless are the very worst type of criminals – they steal, trick and kidnap for their own benefit, rather than to do good in the world. Each member of Gabriel’s crew has a very personal reason for wanting to take the Nameless down – but what can a group of underage school children do compared to the most powerful crew of the underworld?Luckily, there might be something hidden at Crookhaven that could help them. But first they have to find it…The third book in the ‘criminally good’ Crookhaven series, the secret school where students are taught to do wrong, s

Help the baby dinosaurs find their way home in this fun sliding counter series!Meet T-rex, stegosaurus, pterodactyl and triceratops - four adorable baby dinosaurs who are lost in the wild! With easy-to-use moving parts and four unique tracks to develop hand-eye coordination and concentration, babies and toddlers will enjoy taking the baby dinosaurs home in this robust, satisfying board book. Scan the Stories Aloud QR code on the back cover to read along with the story!Other titles in the series include: Let's Go Home, Baby Rabbit, Let's Go Home, Baby Tiger, Let's Go Home, Baby Shark and Let's Go Home, Baby Lion

Can in-game friendship level-up to something more in real life? The second volume of the award-winning manga that inspired the anime My Love Story with Yamada-kun at Lv999.After college student Akane was dumped by her boyfriend, she met Yamada, a handsome high school boy and pro gamer, while playing an online RPG. In-game, he brushed her off, but in the real world, Yamada helped Akane escape an embarrassing encounter with her ex.When Akane’s guild master invites her to an in-person meet-up with other members of their guild—including Yamada—she eagerly accepts. But things get tense when she meets Runa, a player who didn’t want to include Akane—or any new members—in their guild activities.Meanwhile, Akane’s feelings for Yamada continue to grow but she’s conflicted about those emotions. Could Yamada like her too?Volume 2 includes Chapters 10-19.Story Locale:Japan, online game world

本書讀者獨享專屬紀念NFT掌握比特幣爆發式上漲！！！2030年預估會有十億人參與加密貨幣的投資。部分分析師預測2024年比特幣的價格也有望突破十五萬美元。不過依過去的發展史來看，加密貨幣的價格總是在波動中成長！那趨動它價格的動力是什麼？2011年以來，比特幣面臨四次多頭及一次空頭。價格在暴跌之後，總是價暴漲，一次又一次的漲破前高。推動它上漲的原因，在於一群死忠支持者：程式開發人員、礦工、交易員、外部投資人。不停的創造足以推升價格的環境或機制。如馬斯克不停的在社群媒體行銷狗狗幣，造成它的大漲。而當利多出盡，或是出現利空消息（經常是詐欺案），則造成價格大跌。本書說明歷來重要加密巨鱷，如何改進交易機制、積極行銷，以促進價格及市場成長的歷程。你可以透過本書成為他們的一分子，進而掌握價格的波動。2011年6月1日，媒體網站Gawker 登載了阿德里安・陳（Adrian Chen）的一篇題為《可以買到你能想像得到的所有毒品的地下暗網》（The Underground Website Where You Can Buy Any Drug Imaginable）的文章，向讀者介紹了絲路暗網及其唯一的支付方式，比特幣，以及可以買到比特幣的網站，Mt. Gox exchange。文章閱讀量達三百萬人，美國緝毒局（Drug Enforcement Administration，即DEA）開始展開對絲路的調查。幾天後的6 月5 日，美國參議員查爾斯・舒默（Charles Schumer）要求聯邦當局關閉絲路網站 。隨著媒體的曝光，絲路的用戶從幾百人增加到了萬餘人。在舒默發表言論後不久，比特幣價格從9 美元攀升至29 美元。2013年比特幣的價格暴漲，則是起因於中國的需求。因為資本管制、大型比特幣礦場建設對資金的需求、中國人的投機心態以及政府官員、媒體的報導等因素。中國的比特幣交易量在全球的占有率從2012年夏季的1.5％一路漲至2013年的10.8％ 和2014年的70.8％。這讓比特幣由不到200美元，漲至1,147美元。2017年發生的第三次加密貨幣牛市，有一大部分受到一項新事物的推動，那便是「首次代幣發行」 （ICO）。首次代幣發行是一種基於區塊鏈的集資方式，旨在資助初始協定的開發活動。在首次代幣發行期間，投資者購買加密貨幣平台發行的數位代幣（不是加密貨幣本身），以獲取投票權或從協定

※創新管理重要知識+企業創新成功個案，理論與實務兼具。※超圖解式圖文搭配，易於閱讀，一看即懂。※強化「創新領域」必備知識及最新趨勢概念。※企業內部教育訓練、讀書會及大專授課教材的最佳知識用書。創新是不斷學習、試誤、累積，最後成功的過程。※「顧客」在公司創新戰略扮演什麼角色，如何搜集顧客對創新的意見？※ 如何做好「品牌年輕化」創新？※ 如何加快研發創新速度，以保持技術領先暨創造新商機？※ 台積電「全球研發中心」（R&D Center）成立簡介及分析。※ 全台第一大電商momo，如何制定營運發展策略、布局規劃與願景目標？上班族必懂創新管理最新重要知識，非讀不可企業內部各級主管及負責創新人員必讀專書「創新」方面的企業實戰及本土化專書 作者觀察國內各中大型企業近一、二十年來的創新領域及成果，再加上日本各大型上市公司「統合報告書」中的創新描述內容，總結出創新最重要6大內容。 書中所談到的各種創新戰略實戰知識，都是作者過去30多年來在企業上班、大學授課，以及閱讀很多財經、商管、企業經營等資料，長期學習累積而來，是很難得的寶貴知識價值與經驗價值。 公司員工閱讀本書後，將可大幅提升每家公司的整體競爭力及公司組織能力，因為，每位員工的「創新意志」與「創新能力」，將是每家公司競爭力及組織能力來源的最大核心關鍵點。而一位有能力的各級領導主管，更須具備完整的創新架構與全方位創新知識，才能對公司最終的競爭力及經營績效做出最好的貢獻。

How do you solve a murder? Follow the lessons of the master--Agatha Christie! Iris and Alice find themselves in the middle of another Castle Cove mystery in the sequel to New York Times bestseller The Agathas, by powerhouse authors Kathleen Glasgow and Liz Lawson. A PEOPLE MAGAZINE BEST BOOK OF SUMMERA READ WITH JENNA JR. SELECTION Last October, Alice Ogilvie's ex-best friend, Brooke Donovan, was killed--and if it weren't for Alice's unlikely alliance with her tutor, Iris Adams, and her library of the complete works of Agatha Christie, the wrong person would almost certainly be sitting in prison for the crime. The Castle Cove police aren't exactly great at solving crimes. In fact, they're notorious for not solving crimes. Which is why, on the night of Castle Cove High's annual Sadie Hawkins dance, Alice takes the opportunity to explore Levy Castle--the site of one of Castle Cove's most infamous deaths. Mona Moody--­the classic film star--died there almost a century ago, and Alice i

The GNH ideology of Bhutan acts as a catalyst for happiness, challenging the dominant paradigm of economic development as the sole metric of progress and prompting individuals to reassess the true essence of happiness in life. It calls upon governments to integrate happiness into policy planning. We believe that Bhutan's Gross National Happiness concept is not only relevant to Bhutan but also serves as an important reference for every country and the entire world to pursue happiness and well-being.Moving ahead, there is anticipation that alongside national happiness indices, a collective "Gross Earth Happiness" index could emerge, enhancing the overall well-being of humanity and nurturing a more harmonious cosmic civilization within the galaxy!不丹的GNH思想，宛如幸福的火種，改變人類以經濟為發展單一量尺的價值觀，啟發人們重新省思生命的幸福，促使政府將幸福納入政策規劃。我們認為不丹的國家幸福力思想，不只針對不丹，更能作為世界上的每一個國家及全體地球創發幸福的重要參考。期待在未來，除了各國的幸福力，更能成全地球加總的「地球幸福力」，形成整體文明的幸福指數，在銀河中創造更美好的宇宙文明！

From the bestselling author of HOW TO TRAIN YOUR DRAGON comes book 2 in an out-of-this-world new series packed with epic adventure, thrilling space travel and forbidden Magic - perfect for gifting. There is no Magic here on Earth. At least, that's what you've been told...But in an ordinary-looking house in an ordinary-looking village, live a group of children who have just uncovered a secret. A tiny and helpless Magical Creature lost far from home leads the O'Hero-Smith children on another Starcrossing adventure through the Which Ways and across the galaxy. The children have a plan to get little Bug back to the fiery-ice planet where it belongs, and to prove to their parents that they can be trusted with Magic along the way...But a witch's curse, venomous snowsnakes and a gang of fighter robots are waiting for them through the Which Ways. The fate of the galaxy is once again in their hands - they better not mess it up!A family with a Magical secret ... A child with a powerful Gift ...A

A stunning new edition of the fourth novel in the bestselling Bone Season series with gorgeous new cover artwork and updated text, by the bestselling author of The Priory of the Orange Tree.Paige Mahoney has eluded death again. Snatched from the jaws of captivity and sent to a safe house in the Scion Citadel of Paris, she finds herself caught between factions that seek Scion's downfall and those who would kill to protect the puppet empire.The mysterious Domino Programme has plans for Paige, but she has ambitions of her own in this new citadel. With Arcturus Mesarthim at her side, she embarks on an adventure that will lead her from the catacombs of Paris to the glittering hallways of Versailles.As Scion widens its bounds and the free world trembles in its shadow, Paige strives to understand her bond with Arcturus, which grows stronger by the day. But just as the revolution began with them – it could end with them too...

A stunning new edition of the second novel in the bestselling Bone Season series with gorgeous new cover artwork and updated text, by the bestselling author of The Priory of the Orange Tree.Paige Mahoney has escaped the secret prison city of Oxford. Now a fugitive in London, she nurtures a new taste for revolution.Oxford may be behind her, but the Republic of Scion is undefeated. As Scion turns its all-seeing eye on Paige, she is forced to return to Jaxon Hall, her charismatic and brutal employer, to keep her foothold in the underworld.But Paige will bow to only one now, and not even Jaxon will stop her exposing the corruption in the syndicate. As she plots to with the fabled Rose Crown, both sides of an ancient conflict seek her talents for themselves.

A stunning new edition of the third novel in the bestselling Bone Season series with gorgeous new cover artwork and updated text, by the bestselling author of The Priory of the Orange Tree.Following a fierce battle for the Rose Crown, Paige Mahoney has risen to the dangerous position of Underqueen, ruling over the clairvoyant syndicate of London. But with vengeful enemies still at large, the task of stabilising the fractured underworld has never seemed so challenging. As Paige rallies her army of criminals, she continues to meet in secret with her former enemy, Arcturus Mesarthim. Should they be discovered, the fragile alliance with the Ranthen will fail. But all bets are off when Scion introduces Senshield, a deadly technology that spells doom for clairvoyants. Now Paige must race against the clock to stop her reign from ending in blood.

See the world through Paul Cézanne's eyes and be inspired to produce your own masterpieces.Have you ever wondered exactly what artists were looking at to make them draw, sculpt, or paint the way they did? In this charming illustrated series of books created in full collaboration with The Metropolitan Museum of Art, you can see what they saw, and be inspired to create your own artworks, too. In What the Artist Saw: Paul Cézanne meet the famous French painter.Follow the artists' stories and find intriguing facts about their environments and key masterpieces. Then see what you can see and make your own art. Every book in this series is one to treasure and keep - perfect for budding young artists to explore exhibitions with, then continue their own artistic journeys.© The Metropolitan Museum of Art, New York