Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Who's that singing on the savannah? It's the top-five ugly animals in Africa! The wildebeest, warthog, vulture, hyena and marabou stork swagger proudly across the savannah, rejoicing in their ugliness

Duck just wants to play with his best friend Bear... the final story in the hilarious Duck and Bear series from an award-winning team!Duck wants to play in the snow.But Bear thinks it's waaaaay too co

The Thea Sisters are on a magical adventure!The Thea Sisters were are needed in Starlight Kingdomthe Kingdom of Starlight. All of the stars in the sky of the kingdom's sky have been losing their shine

A celebration of love and connection for young readersSusan Verde and Peter H. Reynolds continue their collaboration with the fourth book in their bestselling wellness series. A celebration of love in

Mark Janssen is a master in creating worlds where everything is possible. Previously we joined two brothers on a dinosaur hunt in a magical forest in Dinos Don’t Exist and travelled the oceans on the

Spend the holidays with your favorite blue cat in this in paper-over-board edition of Pete the Cat Saves Christmas!Now available in paper-over-board, Pete the Cat Saves Christmas is a perfect gift for all Pete fans at this great value price.Twas the day before Christmas and Santa was ill.In the cold winter wind he had caught a bad chill.Will Christmas be cancelled? Will it come to that?“Never!” cried Santa. “Let’s call Pete the Cat!”In this rockin’ new spin on the traditional fable The Night Before Christmas, Pete the Cat proves that giving your all in the spirit of Christmas is the totally groovy thing to do.Harperchildrens · Pete the Cat Saves Christmas

Set in rural Nebraska, Willa Cather’s My Ántonia is both the story of an enduring friendship and a brilliant portrayal of the lives of rural pioneers in the late-nineteenth century. Part of the Macmil

Meet RORY BRANAGAN – he eats bad guys for breakfast. Well, not ACTUALLY. But he IS the best detective in town. Fifth in a hilarious comedy-crime series for readers of 8+.Hello. I am Rory Branagan. I a

There are three simple nine-piece jigsaws and a beautifully illustrated board book in this box. Little children can enjoy a selection of detailed jungle scenes in the book, and then use the jigsaws to recreate three scenes from the book.3款9大片拼圖+1本小書拼圖完成後尺寸為17*17公分

Up, down . . . in, out . . . happy, sad. Lift the flaps to learn the opposites with Peppa!It's a lovely sunny day, and Peppa and her family are going on a picnic in the countryside. So off they go on

The Upside-Down Magic kids are back in another topsy-turvy adventure in the next installment of this New York Times bestselling series!When Marigold's magic makes her shrink, it turns into a BIG probl

Mr Gum is back in this second hilarious book and he's as nasty as ever! In fact, he's absolutely grimsters. But this book's not just about him. Meet a gingerbread man named Alan Taylor who

Best Friends is the vividly honest follow-up to the runaway bestselling graphic memoir Real Friends.Sixth grade is supposed to be perfect. Shannon's got a sure spot in the in-crowd called The Group, a

Sitting cat, spitting cat, tangled-in-your-knitting cat, paw cat, claw cat ruining your chair!New cat, shoo cat! Living in the zoo cat, swing cat, cling cat . . . HANG IN THERE!This laugh-out-loud pic

The story of Greta Thunberg, the schoolgirl who inspired a worldwide climate change movement.It’s 20 August 2018, late summer in Stockholm, and it feels incredibly hot in the city. The TV news reports

WINNER OF THE NOBEL PRIZE IN LITERATUREWINNER OF THE MAN BOOKER INTERNATIONAL PRIZENATIONAL BOOK AWARD FINALIST FOR TRANSLATED LITERATUREA visionary work of fiction by "A writer on the level of W. G. Sebald" (Annie Proulx)"A magnificent writer." — Svetlana Alexievich, Nobel Prize-winning author of Secondhand Time"A beautifully fragmented look at man's longing for permanence.... Ambitious and complex." — Washington PostFrom the incomparably original Polish writer Olga Tokarczuk, Flights interweaves reflections on travel with an in-depth exploration of the human body, broaching life, death, motion, and migration. Chopin's heart is carried back to Warsaw in secret by his adoring sister. A woman must return to her native Poland in order to poison her terminally ill high school sweetheart, and a young man slowly descends into madness when his wife and child mysteriously vanish during a vacation and just as suddenly reappear. Through these brilliantly imagined characters and stories, interwo

his gorgeous Benji Davies title is now available in board book format!At the bottom of Syd’s garden, through the gate and past the tree, is Grandad’s house. Syd can let himself in any time he likes. B

From finding awe in the world, to understanding and embracing big feelings, the awesome activities in this book have been expertly designed to help children discover the wonder of themselves. Build co

SOON TO BE A MAJOR MOTION PICTURE. A charming memoir about the impact of Bruce Springsteen's music on a Pakistani boy growing up in 1970s Britain.Sarfraz Manzoor was two years old when, in 1974, he em

Get whisked away through time in the magic tree house with Jack and Annie in the #1 bestselling series—and meet famous Founding Father and inventor Ben Franklin!Jack and Annie know all about Ben Frank

In 1969 history was made when the first humans stepped on the moon. Back on earth, one woman was running the numbers that ensured they got there and back in one piece. As a child, Katherine Johnson lo

New in the critically acclaimed Little People, BIG DREAMS series, discover the life of Mohandas Gandhi, the father of India. As a young teenager in India, Gandhi led a rebellious life and went agains

Shorlisted for the Women's Prize for Fiction and the Costa Novel Award Booker-winning novelist Pat Barker imagines the untold story of the women at the heart of history's greatest epic'Magnificent... You are in the hands of a writer at the height of her powers' Evening Standard'Chilling, powerful, audacious... A searing twist on The Iliad. Amid the recent slew of rewritings of the great Greek myths and classics, Barker's stands out for its forcefulness of purpose and earthy compassion' The Times'A stunning return to form' ObserverWhen the Greek Queen Helen is kidnapped by Trojans, the Greeks sail in pursuit, besieging the city of Troy. Trapped in the Greek soldiers' camp is another captured queen, Briseis. Condemned to be bed-slave to Achilles, the man who butchered her family, she becomes a pawn in a menacing game between bored and frustrated warriors. In the centuries after this most famous war, history will write her off, a footnote in a bloody story scripted by vengeful men - but B

THE SUNDAY TIMES BESTSELLERLONGLISTED FOR THE MAN BOOKER PRIZE 2018 Connell and Marianne grow up in the same small town in rural Ireland. The similarities end there; they are from very different world

A haunting, heartbreaking tale of female friendship and intimacy that reads like The Handmaid's Tale meets The RoadDiscover the haunting, heartbreaking post-apocalyptic tale of female friendship and intimacy set in a deserted world.Deep underground, thirty-nine women are kept in isolation in a cage. Above ground, a world awaits. Has it been abandoned? Devastated by a virus?Watched over by guards, the women have no memory of how they got there, no notion of time, and only vague recollection of their lives before. But, as the burn of electric light merges day into night and numberless years pass, a young girl - the fortieth prisoner - sits alone and outcast in the corner.Soon she will show herself to be the key to the others' escape and survival in the strange world that awaits them above ground. The woman who will never know men.WITH A NEW INTRODUCTION BY SOPHIE MACKINTOSH, MAN BOOKER PRIZE-LONGLISTED AUTHOR OF THE WATER CURE

Meet Harriet, a lovable monster who is just sick at the thought of giving a report in front of her class! Her heart pounds, her chest gets tight, and her stomach twists in painful knots. She can't eve

Now in paperback, children will love to recognise the feelings in Keith Negley's bold illustrations which accompany a fun-to-read aloud narrative. Parents can enjoy and engage with children in a light

Anne Frank was an ordinary girl living in extraordinary times. Forced to go into hiding to escape the Nazis’ persecution of Jews in World War II, Anne kept a diary that would become one of the most fa

It’s no peas please for Nancy, in this second title in the Dinosaur Juniors series from picture book genius Rob Biddulph! The second creatively cretaceous story from the bestselling Rob Biddulph in hi

The fourteenth title in the bestselling series, from the brilliantly talented Liz Pichon. This book is VERY important because it contains BISCUITS, BANDS and all my (doodled) plans to make DogZombies the BEST band in the world. MY VERY BIG PLAN: 1.Write more songs about VERY important things like...... biscuits 2. Make sure there's a good supply of SNACKS for our band practice 3.Avoid Delia at ALL COSTS, she thinks I've been SNOOPING in her room. (I have.) 4. DOODLE as much as possible, especially if Marcus is watching ABOUT THE SERIES: Written in diary form Full of Tom's doodles and pictures & his amazing sense of humour The Brilliant World of Tom Gates, was the winner of the Roald Dahl Funny Prize! Perfect gifts for boys & girls who love to laugh themselves silly The first series of The Brilliant World of Tom Gates won the Scottish BAFTA for Entertainment! Love Tom Gates? Don't miss Liz Pichon's spectacular Shoe Wars, a laugh-out-loud, gadget-packed adventure!

There are lots of animals at the seaside. Where are they hiding and what are they doing? In this innovative lift-the-flap book, little ones can pore over the beautiful collaged pages and explore under rocks, shells and seaweed to find out interesting facts about seaside wildlife. This is the perfect introduction to the outdoors.Other titles in the series include: Woods, Farm, River, Jungle, Safari

There are lots of animals in the woods. Where are they hiding and what are they doing? In this innovative lift-the-flap book, little ones can pore over the beautiful collaged pages and explore under l

"Applaud for KLAWDE. Two paws up!"--Dav Pilkey, creator of the Dog Man series.Klawde is not your average cat. He's an emperor from another planet, exiled to Earth. He's cruel. He's cunning. He's brilliant... and he's about to become Raj Banerjee's best friend. Whether he likes it or not.Klawde had everything. Sharp claws. Fine fur. And, being the High Commander of the planet Lyttyrboks, an entire world of warlike cats at his command. But when he is stripped of his feline throne, he is sentenced to the worst possible punishment: exile to a small planet in a quiet corner of the universe... named Earth. Raj had everything. A cool apartment in Brooklyn. Three friends who lived in his building. And pizza and comics within walking distance. But when his mom gets a job in Elba, Oregon, and he is forced to move, all of that changes. It's now the beginning of summer, he has no friends, and because of his mother's urgings, he has joined a nature camp.It's only when his doorbell rings and he meet

繼承姑婆留下的老舊旅館後，小女孩安娜決心讓「Hotel Flamingo火鶴飯店」重現光彩。這裡的員工和客人全是動物！無論是企鵝、河馬還是火鶴，安娜都熱情接待。在熊門房、電梯鼠和狐猴櫃檯員的幫助下，她展開一連串溫馨又爆笑的旅館冒險！An enchanting new series for fans of OTTOLINE, CLAUDE and VIOLET AND THE PEARL OF THE ORIENT'Truly heartwarming and uplifting. I'd love to book a room there myself' Philip Ardagh'Hotel Flamingo is bursting with charm, friendship and fabulous characters!' Laura Ellen Anderson'Five stars for Hotel Flamingo!' Harriet Whitehorn'A delightfully sunny new series' Polly Faber'Crammed full of characterful animal illustrations with accents of zinging pink, this flamboyant early chapter book is a splendid, unpreachy testament to the power of hard work' Guardian When young Anna inherits a dilapidated once-grand hotel from her Great Aunt Mathilde, she's determined to restore it to its former glory. But this is no ordinary hotel - all of her staff and guests are animals! Anna soon rises to the challenge. Whether it's a flamingo, a penguin or a hippo knocking at the door, Anna is ready

The first book in a hilarious new series perfect for fans of David Walliams, Kid Normal and Tom Gates. Charlie McGuffin tries to be an optimist, but in reality he's a bit of a worrier. Some of the thi

Make your mark as mayor, design your home, and style your characters in this Nintendo Animal Crossing full-color activity book--plus stickers!Something is always happening in the world of Animal Cross

For fans of Smile and Real Friends comes a debut graphic novel about friendship and finding where you "click" in middle school.Olive wants to get in on the act . . .. . . Any act!Olive “clicks” w

Do you have what it takes to live in one of the harshest places in the world? What if you had just a couple years to gain the knowledge you'll need to survive on your own? Join two curious polar bear

The Crown Jewels are in danger... again! When the jewels go missing from inside a locked room, Mac's spy skills are put to the test. How did the thief break in? Where did the jewels go? And will Mac b

An instant bestseller!By #1 New York Times bestselling author Holly Black, the first book in a stunning new series about a mortal girl who finds herself caught in a web of royal faerie intrigue.Of cou