Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

It’s a rainy day in the month of May and Sam spots a rainbow, and then a puddle. A perfect spring puddle. His mother warns, No! No jumping in puddles! You must keep clean today!” but Sam can’t stop hi

An audacious jewel heist. A murdered actress. A killer case for NYPD Red. In a city where crime never sleeps, NYPD Red is the elite task force called in only when a case involves the rich, famous, an

Stina, who lives in Iceland, does not like the cold. In fact, she will go to any length to avoid it. Even in summer she never goes out without tights and socks. When winter comes, she hides inside, kn

Into the Snow is an immediate depiction of a child playing, experiencing the sensory joys of winter and independence.Into the Snow is an exuberant story told in the child's own voice. Celebrating immediacy and exploration, along with the tender bond between mother and child, this is a story that feels good, the way all real things do.Masamitsu Saito was born in 1958 in Japan. He studied graphic design at Tama Art University. His work can be found in magazines, on chocolate packages, and inside wonderful books.Yuki Kaneko is an artist, naturalist, translator, and author. She grew up in Japan, and now lives in Brooklyn with her husband and daughter.

根據國際知名諮詢公司麥肯錫的報告顯示：在大數據應用綜合價值潛力方面，資訊技術、金融保險、政府及批發貿易四大行業潛力最高。具體到行業內每家公司的數據量來看，資訊、金融保險、計算機及電子設備、公用事業四類的數據量最大。而以中國為例，金融業大數據的投資規模為第三名，占據了17.5%，由此可看出，無論企業的規模大小及歷史長短，大數據已全面性地走入了各行各業。而根據研究機構國際數據資訊（Internatio

DescriptionThe Workplace Success series prepares students for working in an English-speaking job environment. All four English skills-reading, listening, speaking and writing-are included in each unit

The global expansion of judicial powers makes no exception to Asia. Most noticeable is the judicial expansion in tandem with unprecedented political and legal reforms that have occurred in the two Asi

“I devoured Finding Jake. The tension is almost unbearable in this thriller-cum-character study as layer after layer of a father’s soul are revealed as reflected in the character of his missing son. Utterly engrossing.”—Alice LaPlante, New York Times bestselling author of Circle of Wives and Turn of MindA heart-wrenching but redemptive story of psychological suspense told from the point of view of the father of a boy who is unaccounted for during a school shooting, in the vein of Reconstructing Amelia and Defending Jacob.While his successful wife goes off to her law office each day, Simon Connolly takes care of their kids, Jake and Laney. Now that they are in high school, the angst-ridden father should feel more relaxed, but he doesn?t. He’s seen the statistics, read the headlines. And now, his darkest fear is coming true. There has been a shooting at school.Simon races to the rendezvous point, where he’s forced to wait. Do they know who did it? How many victims were there? Why did thi

Bill Bryson’s first travel book opened with the immortal line, ‘I come from Des Moines. Somebody had to.’ In this deeply funny and personal memoir, he travels back in time to explore the ordinary kid

Mr. and Mrs. Eiffel are a happy couple enjoying living in the most romantic city in the world, Paris. Until one day, Mrs. Eiffel begins to feel desperately unwell. The experts are unanimous: the only

In 1996, poet Leah Lakshmi Piepzna-Samarasinha ran away from America with two backpacks and ended up in Canada, where she discovered queer anarchopunk love and revolution, yet remained haunted by the

A vibrant and playful seek-and-find picture book by the acclaimed Swedish artist and designer Laura Ljungkvist, in which the reader uncovers animals hidden in a dazzling array of patterns and colors.

Class is back in session....Sophronia continues her second year at finishing school in style--with a steel-bladed fan secreted in the folds of her ball gown, of course. Such a fashionable choice of we

Join Florence the hedgehog and she sets out on a winter adventure in this beautifully illustrated picture book.Winter is approaching, and Florence the hedgehog wants to go outside and play in the wood

There are a lot of things to be afraid of in this world: spiders, the dark, being alone. In this simple, beautifully-crafted picture book, acclaimed author/illustrator Laura Vaccaro Seeger shows that

I'm just as good as bloody Pierrepoint.In his small pub in Oldham, Harry is something of a local celebrity. But what's the second-best hangman in England to do on the day they've abolished hanging? Am

Sitting in the sun in a small Tuscan town, her boyfriend beside her and a drink in her hand, Ella Hatto’s life seems beautiful and calm. But someone is watching her. Something unimaginable is about to

Literary legend James Bond returns to his 1950s heyday in this exhilarating thriller by Sunday Times bestselling author Anthony Horowitz. It's 1957 and James Bond (agent 007) has only just survived his showdown with Auric Goldfinger at Fort Knox. By his side is Pussy Galore, who was with him at the end.Unknown to either of them, the USSR and the West are in a deadly struggle for technological superiority. And SMERSH is back. The Soviet counter-intelligence agency plans to sabotage a Grand Prix race at the most dangerous track in Europe.But it's Bond who finds himself in the driving seat and events take an unexpected turn when he observes a suspicious meeting between SMERSH's driver and a sinister Korean millionaire, Jai Seong Sin. Soon Bond is pitched into an entirely different race with implications that could change the world. Thrown together with American agent, Jeopardy Lane, Bond uncovers a plan that will bring the West to its knees in a heart-stopping climax.Welcoming back famili

For the first time ever some of the most famous names in music, sport and show business have got together for a game of consequences to raise money for the BBC Children in Need Appeal. Each participat

The commentary translated in these pages is unusual and rare. But if the commentary is a rarity, its subject matter—the seven-line invocation of Padmasambhava—is one of the best-known prayers in the T

In this fourth and final book in Karel Haye's acclaimed Visitors series, the beloved family of bears gets in another round of adventures as they experience the full enjoyment of a New England autumn,

Real kids make a real difference in their communities in this vibrantly photographed chronicle by George Ancona.George Ancona celebrates the joy of kids giving back. In one after-school program, middl

Gavin Sasaki was a promising young journalist in New York City until the day he was fired for plagiarism. The last thing he wants is to sell foreclosed real estate for his sister Eilo’s company in the

For fans of The Hunger Games, Divergent, and Red Rising comes a gripping sci-fi adventure in which a group of teenagers wake up in a mysterious corridor with no knowledge of who they are or how they g

Provides an understanding of statistics in the social sciences. This best-selling introduction to statistical analysis in the social sciences provides the right balance of conceptual understandin

Max and Bob are old friends. Max helps out in Bob's shop, and in the evenings they go fishing together. Until one summer, when everything changes ...From the winner of the 2013 Crichton Award for Aust

This multi-award winning collection, the first from Ted Hughes, has at its heart the mixture of beauty and violence in the natural world. Dedicated to Sylvia Plath, Hawk in the Rain is a stunning collection of poems on the themes of competition and the struggle for survival. Hughes would go on to become Britain's Poet Laureate in 1984 until his death in 1998.Including many of Hughes' best-known poems, such as 'The Jaguar', 'The Thought-Fox' and 'Wind' - now stapes of British poetry anthologies - Hawk in the Rain is the foundation of Hughes' reputation as one of the twentieth-century's greatest poets.

Newly elected Prime Minister Francis Urquhart takes on the new King, in the controversial No 1 bestselling second volume in the Francis Urquhart trilogy - now reissued in a new cover. After scheming h

Set in the same world as The Promise of Amazing, this smart, surprising, and romantic follow-up to Robin Constantine's debut novel follows two New Jersey teens as they become friends and fall in love.

*Long-awaited new book from best-selling illustrator and designer*Highly detailed illustrations will absorb readers of all ages*Cut-out windows and gatefolds transform the book into a house to be exploredOften, after school, a little girl goes to her grandmother’s house, where everything is always the same but, then again, different. One day, she puts her coat on the hook in the hall, pours a glass of milk for herself in the kitchen, and tries to reach the cookie jar on the highest shelf in the pantry. But where is Grandma?Children will love exploring the rooms in Grandma’s House, peering through its cutout pages from one room to the next and journeying high up into the foldout attic in search of Grandma. Highly detailed and intricately illustrated in Alice Melvin’s trademark style, Grandma’s House is another winner from one of today’s shining stars of illustration.商品除瑕疵品外，恕不接受退換貨因拍攝略有色差，圖片僅供參考，顏色請以實際收到商品為準

Don't miss a beat with the fourth and final novel in the New York Times and USA Today bestselling Stage Dive series from Kylie Scott.One by one, the members of Stage Dive are falling in love. David, M

With an introduction by Rory Stewart In 1994, the Rwandan government orchestrated a campaign of extermination, in which everyone in the Hutu majority was called upon to murder everyone in the Tutsi mi

The story of Livy and M's passionate love affair comes to a stunning conclusion in the final book in the One Night trilogy!Book 1--ONE NIGHT: PROMISEDBook 2--ONE NIGHT: DENIED

Discover the inspiring true story of Isatou Ceesay, an African woman who started a recycling movement to combat the pollution caused by plastic bags in her community.For years, plastic bags were a cheap and convenient option for carrying goods in Njau, Gambia. However, when these bags broke or were no longer needed, they were carelessly discarded, leading to an unsightly accumulation of plastic waste alongside roads. The stagnant water in the bags provided a breeding ground for mosquitoes and diseases, while the burning of bags left behind a foul smell. The bags also strangled gardens, killed livestock, and polluted the environment.Isatou Ceesay decided to take action, and she began to collect the plastic bags and recycle them into something new. Her efforts not only helped to clean up the environment, but also provided income for women in her community who had been struggling to make ends meet.This powerful and moving book showcases the impact of one person's determination and ingenui

Return to the past with Geronimo Stilton in this fabumouse special edition!Imagine my surprise when I, Geronimo Stilton, was offered the chance to travel back in time again! Professor Paws von Volt en

The world is filled with ten thousand things in confusion:Never overtax your literary thought.The Literary Mind and the Carving of Dragons is the first comprehensive work of literary criticism in Chin

In this funny historical picture book, a family of misbehaving children get George Washington to finally smile—just in time for his portrait!Charlotte, James, and baby John have promised to be on thei

From the Nordic noir duo who brought you The New York Times bestseller The Boy in the Suitcase comes a chilling new thriller with a mystery seventy-years in the making.Nina. Natasha. Olga. Three women

Born into one of the leading Mob families in Chicago, Aria Scuderi struggles to find her own path in a world where no choices are given. Aria was only fifteen when her parents betrothed her to Luca –

In Trouble in Paradise, Slavoj Zizek, one of our most famous, most combative philosophers, explains how by drawing on the ideas of communism, we can find a way out of the crisis of capitalism. There i