Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

In the late 19th and early 20th century, a combination of coastal defence for the homeland and fleet defence for the East Indies became the established naval strategy for the Royal Dutch Navy and set

大數據(Big Data)，爆紅速度僅次於雲端運算。近年來，雲端運算雖然還是很熱門的話題，但更熱門的是Big Data，情況就像幾年前廠商不約而同在談雲端運算一樣。大數據已成為目前全球學術單位、政府機關以及頂級企業必須認真面臨的挑戰，隨著有關大數據的程式語言、運算平台、基礎理論，以及虛擬化、容器化的技術成熟，了解大數據的原理、實作、工具、應用以及未來趨勢，都將會是求學、進修、求職、深造的必備技能。

A coming-of-age story about learning to celebrate yourself -- and teaching the world to recognize you, too -- perfect for fans of R. J. Palacio's Wonder!"This glimpse into the world of a young autisti

THE REESE WITHERSPOON X HELLO SUNSHINE BOOK CLUB PICK FOR NOVEMBER AND USA TODAY BESTSELLER"One of the most twisted and entertaining plots."—Reese Witherspoon"Whiplash-inducing."—New York Times Book R

Build early mathematics skills like counting, number recognition, understanding relative quantity and size, and more with Number Circus!. This large, sturdy lift-the-flap book teems with humorous vign

本書特色■ 以SPSS最新版本SPSS 23～25進行全面編修，更新介面說明，增補新增功能介紹，充分發揮SPSS優勢長項。■ 納入免費軟體R的操作介紹與實例分析，搭配統計原理與SPSS的操作對應，擴展學習視野與分析能力。■ 強化研究上的實務解決方案，充實變異數分析與多元迴歸範例，納入PROCESS模組，擴充調節與中介效果實作技術，符合博碩士生與研究人員需求。量化研究是當代社會與行為科學的強勢典範，

The instant New York Times bestseller, "A must-read for anyone who thinks 'build a wall' is the answer to anything." --EsquireFor Francisco Cantú, the border is in the blood: his mother, a park ranger and daughter of a Mexican immigrant, raised him in the scrublands of the Southwest. Haunted by the landscape of his youth, Cantú joins the Border Patrol. He and his partners are posted to remote regions crisscrossed by drug routes and smuggling corridors, where they learn to track other humans under blistering sun and through frigid nights. They haul in the dead and deliver to detention those they find alive. Cantú tries not to think where the stories go from there.Plagued by nightmares, he abandons the Patrol for civilian life. But when an immigrant friend travels to Mexico to visit his dying mother and does not return, Cantú discovers that the border has migrated with him, and now he must know the whole story. Searing and unforgettable, The Line Becomes a River goes behind the headlines

Funny and totally true childhood biographies and full-color illustrations tell tales from the challenging yet defining growing-up years of Albert Einstein, Jane Goodall, Marie Curie, and 12 other brilliant scientists.Every great scientist started out as a kid. Before their experiments, inventions, and discoveries that changed the world, the world's most celebrated scientists had regular-kid problems just like you.*Stephen Hawking hated school, and preferred to spend his free time building model airplanes, inventing board games, and even building his own computer.*Jane Goodall got in trouble for bringing worms and snails into her house.*And Neil deGrasse Tyson had to start a dog-walking business to save up money to buy a telescope.Readers ages 8 to 12 years old will learn all the stories of a diverse and inclusive group—also including Temple Grandin, Nikola Tesla, Ada Lovelace, Benjamin Franklin, Isaac Newton, Rosalind Franklin, Sally Ride, Rachel Carson, George Washington Carver, and V

Whizzing Through The Woods Deep in the woods where people seldom go live The Butterfly Children. It was early morning and The Butterfly Children were asleep. All of a sudden DC was woken up by a loud

A picture book biography of Ada Lovelace, the woman recognized today as history’s first computer programmer—she imagined them 100 years before they existed!In the early nineteenth century lived Ada By

Margaret Hamilton loved numbers as a young girl. She knew how many miles it was to the moon (and how many back). She loved studying algebra and geometry and calculus and using math to solve problems i

This early learning play sets consists of a board book with bright photographs and chunky press out puzzle pieces in a plastic pocket. Designed to develop a young child's vocabulary and matching skill

“A brisk historical tour of the marketing and selling of the small principality of Monaco and its famous city…A well-researched, dramatic rags-to-riches urban tale” (Kirkus Reviews) of Monte Carlo’s r

Many books explain what is known about the universe. This book investigates what cannot be known. Rather than exploring the amazing facts that science, mathematics, and r

本書特色 雲端運算是基於網際網路的運算方式，它通過網際網路為個人使用者或企業使用者提供按需即取的服務。隨著電腦技術的發展，資料的存儲量成倍的增長，Data Mining 技術在“資料海洋、知識荒漠”的背景下應運而生的，並且一經出現就得到各個領域的重視。隨著Data Mining 的逐漸成熟，以Data Mining 為核心的Business Intelligence（BI）已經成為了IT 和其他行

Arvid Jansen is a young boy who lives on the outskirts of Oslo. It's the early sixties, his father works in a shoe factory and his Danish mother works as a cleaner. Arvid wets his bed at night and has

When her family is too busy using their electronic gadgets to notice her repeated attempts to greet them, little Lydia ventures outside and bids hello to the rocks, leaves and flowers before returning

The pink elephant herd, along with Elmer's friend Rose, are celebrating Old's one-hundredth birthday. But the celebrations take an unexpected turn when Old becomes stranded on a dangerous cliff top. R

本書將領導視為一種藝術，主張優秀的領導者如同藝術家，以誠意與想像力創造出令人共鳴的作品。書中提出12項關鍵特質，從真誠到創新，幫助讀者重新思考領導的本質。適合每一位渴望精進、發揮影響力的讀者閱讀。Make Every Business Day a Masterpiece“This fascinating book is a must-read for every leader or individual that aspires to become one. It eloquently offers tips, examples, and analogies that help the reader focus effort and attention in that noble attempt to become a better leader.”―Eric Weber, Associate Dean IESE, Business School“Unlike explorations of leadership that too often provide ‘more heat than light,’ O’Malley and Baker offer a refreshing and engaging lens that not only illuminates but inspires the reader.”―Mary C. Gentile, Creator and Director of Giving Voice to Values, and Senior Research Scholar, Babson College“This is not another book on leadership. Its essence is that all great leaders show an intense artistry. O’Malley and Baker give leadership criteria that weave business language with a strong dose of artistic principles. A great read.”―Chuck Royce, Chairman, Royce Funds“Im

本書以《Princess and the Pea》為靈感，翻轉經典童話中「過度敏感」的公主形象，帶來一則幽默又帶點當代氣息的愛情故事。Prince Henrik 一心想找到一位與兄長王妃截然不同的伴侶——不嬌弱、不怕苦，最好熱愛戶外活動。於是，他將傳統的豌豆測試改成更「實際」的方法：把一整包冷凍豌豆塞進露營用的薄墊下，考驗前來求婚的公主們。結果，多數公主紛紛抱怨不適，直到 Henrik 的老朋友 Pippa 意外登場。她自在地搭帳篷、打曲棍球，甚至還能巧妙運用那包冷凍豌豆，展現出截然不同的生活態度。故事在輕快節奏中，傳達對多元氣質與真實自我的欣賞。插畫以拼貼、水粉與鉛筆線條構成，比例誇張、風格俏皮，為故事增添獨立電影般的幽默感。本書適合喜歡顛覆童話、欣賞不一樣公主形象的讀者。*]:pointer-events-auto scroll-mt-[calc(var(--header-height)+min(200px,max(70px,20svh)))]" data-turn="assistant" data-scroll-anchor="true" data-testid="conversation-turn-60" data-turn-id="e03a0c23-03b5-42ec-b40a-1510b5e00568">In this playful, contemporary twist on The Princess and the Pea, Prince Henrik decides that traditional princesses are simply too sensitive for his taste. Determined to find a partner who loves the outdoors and isn’t afraid of a little discomfort, he devises a new test: instead of hiding a single pea beneath layers of mattresses, he slips an entire bag of frozen peas under a flimsy camping mat.Princess after princess arrives—and

Reads L to R (Western style). Arrietty isn’t your ordinary fourteen-year-old girl - she's small enough to make her home under the floorboards of a typical house, “borrowing” what she and her family ne

Schuster, an author and mentor/coach who serves on the faculty for coaching programs at Columbia U. and the Hudson Institute of Santa Barbara, describes a method for using the past as a resource to ma

A collection of 365 environmentally friendly activities using paper, card and all manner of materials to be found around the house.

Using toolboxes, ambulances, and other ingenious measures, Irena Sendler defied the Nazis and risked her own life by saving and then hiding Jewish children. Her secret list of the children's real iden

Most business books on social media have focused exclusively on using it as a marketing tool. Many employers see it as simply a workplace distraction. But social media has the potential to revolutioni

In prose possessed of the radically stripped-down beauty and ferocious wit that characterize his work, this early novel by Nobel Prize winner Samuel Beckett recounts the grotesque and improbable adven

Elizabeth Cady Stanton stood up and fought for what she believed in. From an early age, she knew that women were not given rights equal to men. But rather than accept her lesser status, Elizabeth went

Brimming with advice and techniques, this essential reference for book- and songwriters clearly explains the fundamentals of the three crafts of a musical?book, music, and lyrics. Using copious exampl

It’s Little Frog’s birthday, and Mama Frog gets a big surprise when the guests show up for his party－all he animals are the wrong color! Little Frog tells her she’s not looking long enough, and he’s r

Rod Campbell, the creator of the preschool lift-the-flap classic Dear Zoo, has been a trusted name in early learning for over thirty-five years. In My Presents, toddlers can lift the flaps to find out what's inside all the birthday presents. Then open the very last one and look inside the basket to find the best present of all! With bright, bold artwork, an engaging story and lots of presents to open, My Presents is the perfect birthday gift for fans of Dear Zoo and Dear Santa – and the thick card pages, sturdy flaps and chunky cased cover make it great for small hands.

From the wild imagination of Rowboat Watkins, author of Rude Cakes and Go-Go Guys, comes a riotous read-aloud about every kind of mustache imaginable!Hip, hip, HOORAY-stache! It's your lucky day-stache!Join Mouse and Moose in a mustache-mania world packed with silly rhymes and playful illustrations--perfect for building early reading skills, nurturing a love of language, and keeping readers laughing along the way.Sit down and stay-stache! And read this book right AWAY-stache! SUPER-FUN READ-ALOUD: Rowboat Watkins's uniquely funny children's books make for read-aloud and read-along fun, for both family and classroom reading time. The pure silliness of the words and pictures will delight young readers.READING & LANGUAGE SKILLS: The creative vocabulary and rhythmic text are great for helping kids develop an understanding and love of language. The illustrations and hilarious story are perfect for engaging new and emerging readers.ACCLAIMED CREATOR: Rowboat is known for such favorites a

本書可做為短期或一學期的機率學教科書，適合主修數學、物理、工程、統計、精算、商管、財務金融、作業研究和電腦科學的學生，也適合修過基礎微積分的學生。本書以自然的方式介紹機率，透過有趣且具啟發性的範例、習題與測驗題，激發相關理論、定義、定理與方法論的學習。精心設計的範例、習題與測驗題，旨在喚起學生的好奇心，鼓勵學生積極深入學習基礎機率學。本版新增 R 軟體程式進行模擬，說明模擬技術如何取得複雜機率問題的近似解。

由 Adam Kay 與 Henry Paker 攜手打造，本書延續暢銷作 Kay’s Anatomy 的精神，化身為一本兼具知識與惡趣味的活動書。全書包含超過 500 種活動：從破解暗號、動手實驗到怪異食譜應有盡有，更收錄 144 道全新「True or Poo」真假問答題，讓人一邊學習人體知識，一邊笑到停不下來。讀者將在輕鬆中分辨出膝蓋骨與西班牙燉飯的差別，甚至學到如何用假石膏請假不上學。這本活動書充滿荒誕卻真實的知識點，既能啟發孩子對人體的好奇，也能成為親子共享的趣味讀物。From creative duo Adam Kay and Henry Paker comes a hilarious and fact-filled activity book based on the record-setting bestseller Kay's AnatomyContains over 500 hilarious, disgusting activities - codes to crack, experiments, recipes and more, including 144 all-new \"True or Poo\" quiz questions!Do you know your patella from your paella?Have you ever tasted phlegm soup?Want to learn how to bunk off school with a fake plaster cast?From the record-breaking, Number One bestselling author of KAY'S ANATOMY comes the funniest, most fact-filled and most disgusting activity book about the body ever written. Guaranteed to challenge, entertain and revolt readers aged 7 to 739.

本書為 David Walliams 首部聖誕主題故事，充滿幽默與動作場面，講述一場發生在平安夜的驚險冒險。全球最知名的玩具店遭遇竊賊突襲，店內的聖誕老人與他的兒子意外被困其中，兩人必須善用身邊各式玩具，展開機智反擊。從彈簧鞋到臭氣彈，從遙控直升機到泡泡槍，每樣玩具都成為對抗壞蛋的奇招武器。Walliams 以其一貫誇張風趣的筆法，為聖誕故事注入快節奏與家庭溫情，是一本能讓讀者邊笑邊翻頁的節慶讀物。From number one king of comedy David Walliams comes his first Christmas caper - packed full of hilarious toy-shop action!?The perfect Christmas gift for kids of all ages?Hilarious seasonal adventure from king of comedy David Walliams?A fun, funny and heartwarming story for the whole familyIt's the night of Christmas Eve.In the most famous toy shop in the world, a robbery is underway.The shop's Santa and his son are locked inside with the baddies.Can our heroes stop them using just the toys in the shop as weapons?Pogo sticks! Bouncy balls! Remote-controlled helicopters! Bubble guns! Slime! Slinkies! Stink bombs!Santa & Son is a hilarious action adventure, and sure to become a Christmas classic.

用自己的水瓶、關燈、重複利用舊衣服——原來保護地球可以這麼簡單！《10 Things I Can Do to Help My World》以互動翻頁設計，介紹10個孩子每天都能做到的小行動。插圖鮮明大方，語言簡單親切，不僅鼓勵幼兒主動參與環保，也為親子共讀帶來溫暖啟發。這是一本讓行動從閱讀開始的環保入門繪本。Sometimes it's the little things that make a difference--like filling up your reusable water bottle, upcycling old clothes, or any of the other clever suggestions in this eco-picture book with fun die-cut pages and flaps. Do you bring leftovers for lunch? Or shop for fresh, unpackaged produce at the farmers' market? Perhaps you opt for a bamboo toothbrush over a plastic one, or take public transportation when you go out? Creativity plays a part, too--in crafty projects like using an eggshell as a little container to grow watercress, or making a wildlife shelter in your backyard. With ten doable suggestions, bright illustrations, and short explanations of how the actions help to protect the earth, Melanie Walsh shows even the youngest eco-warriors several easy ways to weave green choices into their everyday lives.

Virginia Woolf's first fully realized work of fiction--published in its final, revised form for the first time A beguiling trio of fantastical and farcical anti-fairy tales about a giantess who builds a magical "cottage of one's own," battles a silver-scaled sea monster, and defies governesses and gravity alike In 1907, eight years before she published her first novel, a twenty-five-year-old Virginia Woolf drafted three interconnected comic stories chronicling the adventures of a giantess named Violet--a teasing tribute to Woolf's friend Mary Violet Dickinson. But it was only in 2022 that Woolf scholar Urmila Seshagiri discovered a final, revised typescript of the stories. The typescript revealed that Woolf had finished this mock-biography, making it her first fully realized literary experiment and a work that anticipates her later masterpieces. Published here for the first time in its final form, The Life of Violet blends fantasy, fairy tale, and satire as it transports readers into a

Press the soft patches to hear the skeleton and its friends come to life in this hilarious Halloween treat.You'd better not tickle the skeleton... because it might just rattle if you do!Babies and toddlers just won't be able to resist tickling the touchy-feely patches to hear each creature make a sound in this hilarious novelty book. At the end, readers will find all the characters gathered together for a spooktastic Halloween dance. An exciting series for babies and toddlers, from the creators of That's not my...Withover 20 books to discover in this award-winning series, there is a book to excite every baby and toddler; including dinosaurs, bears, tigers, unicorns and lots more - giggles are guaranteed!Every DON'T TICKLE book supports sensory development with:- Engaging characters to encourage playfulness- Furry patches for developing motor skills- Playful music to inspire movement- Holes to peep through, sparking curiosity- Rhythmic text for developing language

Get ready for bed in this big board format with three games to play on every page!Pip and Posy are going to bed. They need to have a snack, brush their teeth and have a wash before it's time to read a bedtime story. This chunky board book is the perfect way to make the bedtime routine fun, with 36 sliders and three games to play but none of the mess of a card game!Designed to aid a chil'd's memory and language development, with simple labels to build vocabulary and lots of things to spot.Other titles to collect: The Super Seasons

Playful, interactive, and full of whimsy, Sean Taylor's collection of poems invites little ones to get their fingers, hands, and wiggles ready. One little friendin the playground . . . sliding.Two little friends playing chase and . . . hiding.What better way to get little ones excited about poems than to make them part of the delivery? In the hallowed tradition of nursery rhymes and songs like "Itsy Bitsy Spider," this imaginative collection entices children to use their fingers, hands, and sometimes whole bodies to bring a variety of verses to life. Whether the subject is sailing ships or stomping dinosaurs, falling snow or popping bubbles, jumping onto waterslides or riding a crowded elevator, Sean Taylor's rhythmic read-aloud verses pair with Fiona Woodcock's fresh, colorful illustrations, offering clues to the finger actions kids can follow--unless they're happily acting things out already, using shapes and movements all their own.

全方位智慧流通與永續管理探討：本書共分為兩大篇：第一篇為理論與技術篇，主要將智慧流通相關理論、技術與應用，包含：大數據與人工智慧概論、物聯網技術、機器學習與深度學習等內容，進行系統性的說明與介紹；第二篇為產業應用篇，詳述物聯網（IoT）、大數據（Big Data）與人工智慧（AI）技術，在生產、零售與物流等產業的應用與發展趨勢，以及流通業因應減碳與淨零轉型，實現永續管理與發展目標，使讀者瞭解資料科學（Data Science）與智慧聯網技術（AIoT），在現代化流通與永續管理以及商業模式的運作中發揮的功能、優勢與價值。中華食品安全管制系統發展協會認證指定教材：中華食品安全管制系統發展協會﹙Chinese HACCP﹚審核通過，指定成為協會在學界與產業界，推動「HACCP智慧流通與永續管理師」與「HACCP智慧食品供應鏈與永續管理師」認證培訓課程的指定教材。同時本會與「英國皇家物流與運輸協會台灣分會(The Chartered Institute of Logistics and Transport in Taiwan, CILT Taiwan)」建立兩會合作與策略聯盟，成立「智慧流通與永續管理認證中心」，共同推動兩會相關智慧流通與永續管理認證課程。學界教學用書：本書將複雜的作業流程及營運模式，以生動活潑、易於明瞭的流程圖，搭配系統文字說明與呈現，給予讀者最佳的學習效果，有助於讀者瞭解智慧流通與永續管理的運作、價值與產業應用。適合食品餐飲業、商業、工業、農業與資訊等相關科系課程之大專院校及研究所師生，做為教學與產業研究的教科書。業界參考書：本書內容涵蓋流通產業在生產、零售、物流與永續管理等領域，從事生產、銷售與營運管理或決策工作，相關資料科學（Data Science）與資通訊技術（ICT）的知識與觀念，適合從事食品、餐飲、生產、零售、物流及資訊等相關產業界人士，充實專業知識及內部教育訓練之參考用書。