Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

“Data-Driven Modeling: Using MATLABR in Water Resources and Environmental Engineering” provides a systematic account of major concepts and methodologies for data-driven models and presents a unified f

Economic Modeling Using Artificial Intelligence Methods examines the application of artificial intelligence methods to model economic data. Traditionally, economic modeling has been modeled in the lin

Assuming no prior knowledge of R, Spatial Data Analysis in Ecology and Agriculture Using R provides practical instruction on the use of the R programming language to analyze spatial data arising from

The focus of early drug development has been the submission of an Investigational New Drug application to regulatory agencies. Early Drug Development: Strategies and Routes to First-in-Human Trials gu

While the utilization of microarrays for gene expression studies has been widely published, Microarray Methods for Drug Discovery describes the use of this technology for a multitude of other vital ap

A valuable guide to understanding the problem of quantifying uncertainty in dose response relations for toxic substances In today's scientific research, there exists the need to address the topic of

In this new volume, renowned authors contribute fascinating, cutting-edge insights into microarray data analysis. Information on an array of topics is included in this innovative book including in-dep

This reference provides a concise overview of the key principles in dose selection and optimization and demonstrates applicability to recent successful new drug applications. Compiling key issues and

A multi-discipline, hands-on guide to microarray analysis of biological processes Analyzing Microarray Gene Expression Data provides a comprehensive review of available methodologies for the analysis

★ 40個「看起來像魔法」的科學實驗，讓孩子在家變身小小巫師！★ 《Ology》暢銷系列創作者 A.J. Wood 打造的奇幻科學實驗書★ 翻頁機關＋小冊子設計，每一頁都藏著驚喜探索★ 用廚房材料做出彩色藥水、結晶糖果與神奇冰淇淋結合奇幻魔法與真實科學，收錄40個簡單又充滿驚喜的實驗，讓孩子在家就能探索化學與自然的奧秘。透過翻頁機關、小冊子與互動活動，小小讀者將在魔法學院的故事情境中動手實驗，從水、空氣到能量與結晶，一步步發現科學的神奇魅力，最後獲得屬於自己的見習巫師證書。The Wizard's Guides to Magical Experimentssparks wonder and curiosity with 40 engaging real-life science experiments for wizards-in-training to try at home.The Wizard's Guides to Magical Experimentssparks wonder and curiosity with 40 engaging real-life science experiments for wizards-in-training to try at home.Welcome to the Touchwood Academy of Magical Thinking, where magical abilities are a must.Kids will discover the thrill ofthe real-life magic ofchemistry with hands-on experiments from the creator of the bestselling Ology books, A.J. Wood. As a "First Class Wizard," Wood guides wizards-in-training through dozens of magic tricks and spells that are actually wow-inducing age-appropriate science experiments.Mini-booklets and fold-out activities on e

This book introduces a new approach to embedded development, grounded in modern, industry-standard JavaScript. Using the same language that powers web browsers and Node.js, the Moddable SDK empowers IoT developers to apply many of the same tools and techniques used to build sophisticated websites and mobile apps. The Moddable SDK enables you to unlock the full potential of inexpensive microcontrollers like the ESP32 and ESP8266.Coding for these microcontrollers in C or C++ with the ESP-IDF and Arduino SDKs works for building basic products but doesn't scale to handle the increasingly complex IoT products that customers expect. The Moddable SDK adds the lightweight XS JavaScript engine to those traditional environments, accelerating development with JavaScript while keeping the performance benefits of a native SDK. Building user interfaces and communicating over the network are two areas where JavaScript really shines.IoT Development for ESP32 and ESP8266 with JavaScript shows you how t

A valuable new edition of a standard referenceThe use of statistical methods for categorical data has increased dramatically, particularly for applications in the biomedical and social sciences. An In

The first volume in this Early Childhood Education and Care in the 21st Century: International Teaching, Family and Policy Perspectives miniseries provides a snapshot of early childhood education and

Pro Spring Boot is your authoritative hands-on practical guide for increasing your Spring Framework-based enterprise Java and cloud application productivity while decreasing development time using the

Use real data, and become a pro at using Excel for statistical analysis! Designed for users already familiar with Excel and basic computer operations, this Second Edition of Neil J. Salkind’s Excel St

Within this text, the contributors provide a historical perspective on the development of anthropology and sociology since their introduction to Chinese thought and education in the early twentieth ce

Understand the role of mathematics in biology with MODELING THE DYNAMCICS OF LIFE: CALCULUS AND PROBABILTY FOR LIFE SCIENTISTS, 3E, International Edition! Designed to demonstrate the importance of mat

Essential Skills--Made Easy!Create dynamic Web pages complete with special effects using today's leading Web development language. JavaScript: A Beginner's Guide, Third Edition gives you step-by-step

Learn data science by doing data science! Data Science Using Python and R will get you plugged into the world’s two most widespread open-source platforms for data science: Python and R.Data scien

This book introduces the main theoretical findings related to copulas and shows how statistical modeling of multivariate continuous distributions using copulas can be carried out in the R statistical

Panel Data Econometrics with R provides a tutorial for using R in the field of panel data econometrics. Illustrated throughout with examples in econometrics, political science, agriculture and epidemi

The only how-to guide offering a unified, systemic approach to acquiring, cleaning, and managing data in R Every experienced practitioner knows that preparing data for modeling is a painstaking, time-

For readers who may not be statisticians or data analysts, Sarmento and Costa explain how to analyze data using the Python and R languages. They have particularly in mind, students and researchers

This book is a comprehensive introduction to financial modeling that teaches advanced undergraduate and graduate students in finance and economics how to use R to analyze financial data and implement

This volume covers a large area, from the description of methodologies for data analysis to the real application. Chapters focus on methodologies for preprocessing of microarray data, a survey of miRN

The Oracle Press Guide to Big Data Analytics using RCowritten by members of the Big Data team at Oracle, this Oracle Press book focuses on analyzing data with R while making it scalable using Oracle’s

The only Oracle Press guide to MySQL Workbench explains how to design and model MySQL databases. MySQL Workbench Data Modeling and Development helps developers learn how to effectively use this power

A reference guide for applications of SEM using MplusStructural Equation Modeling: Applications Using Mplus is intended as both a teaching resource and a reference guide. Written in non-mathematical terms, this book focuses on the conceptual and practical aspects of Structural Equation Modeling (SEM). Basic concepts and examples of various SEM models are demonstrated along with recently developed advanced methods, such as mixture modeling and model-based power analysis and sample size estimate for SEM. The statistical modeling program, Mplus, is also featured and provides researchers with a flexible tool to analyze their data with an easy-to-use interface and graphical displays of data and analysis results.Key features:Presents a useful reference guide for applications of SEM whilst systematically demonstrating various advanced SEM models, such as multi-group and mixture models using Mplus.Discusses and demonstrates various SEM models using both cross-sectional and longitudinal data wi

As clinicians begin to realize the important role of dose-finding in the drug development process, there is an increasing openness to "novel" methods proposed in the past two decades. In particular, t

Support vector machines (SVMs) are used in a range of applications, including drug design, food quality control, metabolic fingerprint analysis, and microarray data-based cancer classification. While

Using R for Data Management, Statistical Analysis, and Graphics presents an easy way to learn how to perform an analytical task in R, without having to navigate through the extensive, idiosyncratic,

Leading experts illustrate how sophisticated computational data mining techniques can impact contemporary drug discovery and development In the era of post-genomic drug development, extracting and ap

Data Analysis Using Stata provides a comprehensive introduction to Stata with an emphasis on data management, linear regression, logistic modeling, and using programs to automate repetitive tasks. Thr

Multilevel and Longitudinal Modeling Using Stata, Second Edition discusses regression modeling of clustered or hierarchical data, such as data on students nested in schools, patients in hospitals, or

Collecting and presenting the latest research and development results from the leading researchers in the field of industrial database modeling, Database Modeling for Industrial Data Management: Emerg

Written for biologists and medical researchers who don't have any special training in data analysis and statistics, Guide to Analysis of DNA Microarray Data, Second Edition begins where DNA array equi

A novel dialogue between Buddhism and Western psychology, grounded in original Pali texts. As mindfulness and meditation become mainstream therapeutic tools, their deep Buddhist roots are often stripped away and limit their effectiveness for clients from Buddhist cultural backgrounds. Early Buddhist Teachings: A Theoretical Foundation for Counseling restores these practices to their original context, offering a culturally congruent counseling model grounded in Pali scriptures and core Buddhist principles. This informative volume explores key Buddhist concepts including dependent co-arising, non-self, and impermanence, and places them in conversation with Western psychological theories. Supplemented with practical assessment tools and intervention techniques, this work provides mental health professionals with a new framework for integrating Buddhist teachings into counseling. For therapists, students, and counselors seeking to expand their approach, Early Buddhist Teachings offers a vi

A unique illustrated exploration of the development of finance that combines data from every part of the world and covers five thousand years of history “The book is a lot of fun. Data-fixated readers will enjoy unpicking its main content: a series of elegantly produced maps, graphs and other visualisations. These are eclectic in scope and ambitious in intent.”—Jonathan Guthrie, Financial Times From the emergence of money in the ancient world to today’s interconnected landscape of high-frequency trading and cryptocurrency, the story of finance has always taken place on an international stage.Finance is one of the most globalized and networked of human activities, and one of the most important social technologies ever invented. This volume, the first visually based book dedicated to finance, uses graphics and maps to bring the complex and abstract world of finance down to earth, showing how geography is fundamental for understanding finance, and vice versa. It illuminates the people—inc

適合程式設計新手，迅速進入資料科學領域。資料匯入、整理、變換、視覺化與模型建立。使用R和RStudio進行資料科學研究，利用tidyverse套件使工作更高效、流暢。這一版介紹Tidyverse的最新功能和最佳實務做法，並新增章節介紹從不同來源獲取資料，進一步實踐所學。「這本書更新了世界首屈一指的R資料科學實務指南，優秀程度令人驚歎，凡是與資料打交道的人都應該閱讀此書！」—Emma RandUniversity of York, UK運用R將資料轉化為洞察力、知識和理解。透過這本實用的書籍，有志於成為資料科學家的讀者將學會如何使用R和RStudio進行資料科學研究，並利用tidyverse這組專為協同工作而設計的套件，讓資料科學實務變得更快速、流暢且有趣。即使沒有程式設計的經驗，本書最新版也能幫助你迅速進入資料科學的領域。你將學會如何匯入、變換和視覺化資料，並傳達結果。你還將獲得資料科學流程的整體理解，以及管理細節所需的基本工具。這一版針對最新的tidyverse功能和最佳實務做法進行了更新，有新的章節示範如何從試算表、資料庫和網站獲取資料。其中的習題也將幫助你實踐所學。你將學到如何：‧視覺化：為資料探索和結果的交流創建圖表‧變換：找出變數型別及處理它們的工具‧匯入：將資料匯入R並轉換為方便分析的形式‧程式設計：學習R語言的工具，以更清晰的方式輕鬆解決資料問題‧溝通：使用Quarto整合說明、程式碼和分析結果

ONE OF THE MOST SPOKEN DIALECTS in China, Southeast Asia, and globally, Cantonese was nevertheless deemed a local dialect enjoying little prestige among the intellectuals. Not much was recorded in official documents or gazetteers about the early history of Hong Kong. The Cantonese language and its origin remained much of a mystery until the mid-20th century when scholars started to accord it with increasing attention. Thanks to dedicated efforts of early missionaries, pedagogues, and linguists, we can now trace back the evolution of modern Cantonese since the 19th century— how differences in sounds, words, and grammar distinguish the old from contemporary speech today. In this book, Hung-nin Samuel Cheung, an acclaimed scholar on the study of Cantonese, offers profound insights to various firsthand century-old materials including language manuals, Bible translations, and maps of Hong Kong, with findings that will be useful for ongoing efforts to study the development of