Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Quantitative Methods in Archaeology Using R is the first hands-on guide to using the R statistical computing system written specifically for archaeologists. It shows how to use the system to analyze many types of archaeological data. Part I includes tutorials on R, with applications to real archaeological data showing how to compute descriptive statistics, create tables, and produce a wide variety of charts and graphs. Part II addresses the major multivariate approaches used by archaeologists, including multiple regression (and the generalized linear model); multiple analysis of variance and discriminant analysis; principal components analysis; correspondence analysis; distances and scaling; and cluster analysis. Part III covers specialized topics in archaeology, including intra-site spatial analysis, seriation, and assemblage diversity.

This text introduces the use of R statistical software in finance and economics using RStudio. It explains the RStudio interface; common data types and structures used in statistical analysis using R;

While there are many books available on statistical analysis of data from experiments, there is significantly less available on the design, development, and actual conduct of the experiments. Laborato

How can animal models contribute to the early drug development process, from target validation to lead profiling? Pharmaceutical industry experts discuss the opportunities for novel drug development a

"This book prepares readers to analyze data and interpret statistical results using R more quickly than other texts. R is a challenging program to learn because code must be created to get started. To

Buysse and Peisner-Feinberg (child development, U. of North Carolina at Chapel Hill) offer a 29-chapter handbook on the application of response to intervention (RTI) in early childhood settings. Educa

"This book presents a thorough treatment and unified coverage of Bayesian item response modeling with applications in a variety of disciplines, including education, medicine, psychology, and sociology

Covering the latest advances in CNS drug development, this book will guide all those involved in pre-clinical to early clinical trials. The authors describe how recent innovations can accelerate the d

Early characterization of toxicity and efficacy would significantly impact the overall productivity of pharmaceutical R&D and reduce drug candidate attrition and failure. By describing the available p

A guide to data collection, modeling and inference strategies for biological survey data using Bayesian and classical statistical methods.This book describes a general and flexible framework for model

Using data from a newspaper corpus, this book offers the first empirical study into the development of style in early mass media.>

Drug-Drug Interactions in Pharmaceutical Development comprehensively reviews the relevant science, industrial practice, and regulatory agency positions on drug-drug interactions. It focuses on the eva

This book presents studies of complexity in the context of nonequilibrium phenomena using theory, modeling, simulations, and experiments, both in the laboratory and in nature.

Using data in questionnaire responses from large research and development organizations, Niosi (administration, L'UniversitT de QuTbec s MontrTal) looks at the history and current status of Canadian r

如果有一天變成熊，你會做什麼？在本書中，「我」一早醒來，吃早餐、騎摩托車，還順手拯救被熱氣球帶走的好朋友——這些都是再正常不過的「熊日常」。當然，不可能站在全班面前做一份無聊又詳盡的熊類報告吧？Corey R. Tabor 以第一人稱視角巧妙鋪陳，讓讀者彷彿成了那隻熊，畫面邊緣還能看見熊的手腳晃動，幽默感十足。故事在出其不意的轉折中揭露真正的說話者，也溫柔回應孩子對上台報告的緊張。曾獲 Caldecott Honor 與三座 Geisel Award 的作者，再次帶來兼具創意與笑點的圖畫書。Assignment: Imagine yourself as a bear for the day. What would you do? Caldecott Honor and three-time Geisel Award–winning author and illustrator Corey R. Tabor offers an inspiring—and surprising—answer in this funny picture book for fans of Mo Willems, David Shannon, and Peter Brown.If you were a bear for a day, what would you do? Probably wake up, eat breakfast, go for a motorcycle ride, and rescue your best friend from a rogue hot air balloon. . . . You know, normal bear stuff!You certainly wouldn’t stand in front of the whole class and give a boring, detailed, and informational report about bears.Dynamically illustrated from the bear’s perspective, the Caldecott Honor and three-time Geisel Award–winning Corey R. Tabor delivers an innovati

A gorgeous illustrated edition of the fourth book in the beloved A Song of Ice and Fire series, the inspiration for HBO's Game of Thrones With a special foreword by Joe Abercrombie Here is the fourth book in the landmark series that has redefined imaginative fiction and become a modern masterpiece in the making. This special edition of A Feast for Crows features 24 original color illustrations from artist Jeffrey R. McDonald. A FEAST FOR CROWS After centuries of bitter strife, the seven powers dividing the land have beaten one another into an uneasy truce. But it's not long before the survivors, outlaws, renegades, and carrion eaters of the Seven Kingdoms gather. Now, as the human crows assemble over a banquet of ashes, daring new plots and dangerous new alliances are formed while surprising faces--some familiar, others only just appearing--emerge from an ominous twilight of past struggles and chaos to take up the challenges of the terrible times ahead. Nobles and commoners, soldiers a

Following on from the hugely popular Mesozoic Art, this magnificent new volume showcases 20 amazing artists whose work represents the very best of palaeoart. Our knowledge of how dinosaurs and other extinct species looked is continuously evolving with each new palaeontological discovery, as is the dramatic art that depicts these ancient worlds. Palaeoartists now have access to more information than ever before, allowing them to achieve greater levels of accuracy in their work. Using fossilised material and the latest scientific knowledge, palaeoartists visualise and recreate creatures from the prehistoric world - they put flesh on the bones of long-extinct species and their environments. It is through this imaginative artform that fossils can be brought to life in fresh, breathtaking detail. Mesozoic Art II presents 20 new leading paleoartists who present life in the primordial past through a broad diversity of artistic styles and techniques, from traditional oil painting to cutting-ed

全新登場的《Sonic the Hedgehog Advent Calendar (音速小子降臨曆)》讓聖誕倒數更有趣！Sonic 與夥伴們邀你展開24天節慶挑戰，每天都有新內容——從手作與知識問答，到趣味笑話與節慶故事，帶來滿滿驚喜與歡笑。六大主題活動兼具創意與互動，讓孩子在遊戲中學習、在倒數中體驗節慶樂趣。NEW for 2025, a festive collection of books, activities, crafts and surprises! The perfect gift for kids who are fans of the movies, TV shows and games!Race into the holiday season with Sonic and his super squad!Ready for a festive adventure with Sonic and his friends? Of course you are! Join Team Sonic for 24 days of holiday fun by diving into this 6 in 1 advent calendar! Count down to Christmas with a new surprise every day!*A variety of festive tasks that will keep you entertained throughout December.*Daily dose of laughter with hilarious jokes.*Cool challenges designed for Sonic fans of all ages.*Fun facts about Sonic and his world to enhance your holiday spirit.*Awesome crafts that you can create and share with friends and family.*A special festive story that captures the magic of the holiday season with your favourite characte

Pre-order now to receive the stunning DELUXE LIMITED EDITION— only available on the first printing while supplies last! The collector’s hardcover features stenciled edges, case effects, and illustrated endpapers.Dante’sInfernomeetsSusanna Clarke’sPiranesiin this all-new dark academia fantasyfrom R. F. Kuang, the #1New York Timesbestselling author ofBabel and Yellowface,in which two graduate students must put aside their rivalry and journey to Hell to save their professor’s soul—perhaps at the cost of their own.Katabasis, noun, Ancient Greek:The story of a hero’s descent to the underworldAlice Law has only ever had one goal: to become one of the brightest minds in the field of Magick. She has sacrificed everything to make that a reality: her pride, her health, her love life, and most definitely her sanity. All to work with Professor Jacob Grimes at Cambridge, the greatest magician in the world.That is, until he dies in a magical accident that could possibly be her fault.Grimes is now in

Learning how to read should be a walk in the dog park! Follow four curious canines on letter-replacement adventures in this phonics-based early reader series starter from Theodor Seuss Geisel Medalist Ethan Long.Meet the Letter Setters! When their BONE is GONE, these dynamic dogs—Patrick (an Irish Setter), R.W. (a Red and White Setter), Victoria (an English Setter), and Gordy (a Gordon Setter)—sound the GONG and spring into action to retrieve their tasty treat.In this engaging new early reader series from acclaimed author-illustrator Ethan Long, each story starts out with a four letter word. On the next page, one swapped letter makes a new word—and a new canine caper for little ones learning how to read! As this fresh and fun device propels the pups into silly, slapstick sequences, phonics help readers to discover new words, study how words relate to each other, and observe how text and pictures support one another.Geisel Medalist Ethan Long’s expressive artwork shines in these energet

In Gentle Voices, Bold Strides, Professor Fanny Cheung shares her inspiring journey as a psychologist, academic leader, and champion of gender equality. Growing up in a traditional Hong Kong family, she recognized early injustices against women and dedicated her life to change.Pioneering gender studies in Asia and leading the Equal Opportunities Commission, she fought discrimination, domestic violence, and gender bias in policy and research. Her leadership reshaped academia and public policy through consensus-building and quiet determination, leaving a legacy of empowerment.By blending personal narratives with social history, this memoir serves as a testament to the power of advocacy and the quiet strength of those who strive to make a difference.

這次他們意外離開了熟悉的課桌世界，跌入了未知的戶外。Pencil因一時興奮跌出書包，忠誠的Eraser也跟著前往。兩人得憑藉智慧、默契與些許忍者技巧，闖過校園外的重重阻礙，只為回到原本的位置。Fans of NARWHAL AND JELLY as well as PIZZA AND TACO, prepare to meet your new favorite duo: a pair of best friend school supplies! In the next adventure of this hilarious early-reader graphic novel series, Pencil and Eraser get lost outside the lines!Pencil and Eraser are on their way to their first ever karate class—well, their person Stella is and they are tagging along. When Pencil gets a little too excited practicing her ninja moves, she falls right out of Stella’s backpack and lands on the sidewalk! And naturally, Eraser has no choice but to follow her.Stranded all alone in the big wide world, these two buds will have to use their wits, charm, and of course their impressive ninja moves, to find the dojo and make it safely back into Stella’s backpack before class is over. Between squirrelly obstacles and flashy distractions, will the duo (ahem, Pencil) stay on the straight and narrow lon

A love letter to books, showing how many elements and people contribute to making something beautiful, from Caldecott honoree Elisha Cooper In this poetic and beautifully illustrated ode to creativity and the process of making books, Caldecott honoree Elisha Cooper takes readers on a journey showing how words and art move from one person to another. From writer to reader, and everyone who contributes in between: Here is a book, made with love. An artist's studio overflows with sketches, drafts, a wastebasket, and wonder. A publisher's office hums with computers, layouts, coffee, and teamwork. A printer makes a layout into a book using presses, ink, paper, and time. And that book travels to a school, to a library, to a student, to a home.

In Christianity and Education in Modern China, Wong Man Kong, George Kam Wah Mak, and other contributors demonstrate how Christianity served as a driving force in the development of modern education in China. Each of the chapters offers new insights into Christian involvement in different issues concerning education in modern China. The contributors examine how Christian missionaries and Chinese Christian educators interacted with China’s social, cultural, and political contexts. Also explored are the Christian legacies of higher education in mainland China and Taiwan, as well as how the spirit of Christian higher education in modern China has been carried on in Asia. This volume suggests that Western missionary and Chinese Christian perspectives of higher education were complementary with each other in modern China.

The third book in a laugh-out-loud early graphic novel series perfect for fans of Narwhal and Jelly! Quiet-loving Moose's life is turned upside down by free-wheeling Duck. The two will need to put their differences aside if they're ever going to be neighbors...or friends!It’s time for a best-friends-slash-roommates sleepover! Duck is prepared for everything: he’s got snacks, his karaoke machine, and a stack of movies for Moose and him to watch. But is Duck ready for how early it gets dark now that it’s winter in Denali? Moose sheds some light on the situation and shows Duck that sometimes things aren’t as scary as you imagined.Filled with zany hijinks and slapstick humor, Kirk Reedstrom's Duck and Moose series showcases unlikely friendships and the power of compromise.

Where does history come from, and how do we know what really happened? Find out in this eye-opening book.Every nation tells its own history in its own way. This important book explains what's going on behind the scenes in those tellings - who gets to decide which facts are taught, and which truths are massaged, or even denied. Using a mix of comic strips, diagrams and clear, simple language, this book shows readers how to dig deeper into any story, how to investigate recent and ancient history for themselves, and learn why it's vital to understand how the world has ended up where it is today.This is a History book unlike any other you've read. It doesn't just tell stories from the past, it unpicks details within those stories, explains how and where those stories came from, and why they can change, depending on who is telling them.

Oscar the Grouch meets Frog & Toad in this hilarious illustrated early reader series about a cranky wolf on a quest to be left alone. Wolf has just the right amount of friends: NONE. He loves to be alone. Unfortunately, everywhere he goes, other people are there too. At school, the teacher says if he can't get along with the other students, he has to leave. So he goes to the movies. More people! He tries the beach. No peace there, either. He flees to the remote peak of a mountain, and even there, someone comes along to bother him. Finally, Wolf hatches a plan. All these people arrive for a party at Wolf's house . . . while Wolf makes a quick exit. Move over, Elephant & Piggie! For readers who have had enough of the buddy duos, for kids who'd rather play by themselves--Wolf is the antihero you've been waiting for. Lone Wolf Goes to School is the first in a hilarious early reader series starring the completely lovable, chronically grumpy Wolf, a character who affirms kids who fly

本套《The Collected Poems of J.R.R. Tolkien》為全球首部托爾金詩作全集，跨越近七十年的創作歷程。詩作題材多元，從愛情、友情、信仰，到自然景物與奇幻傳說，既獨立成篇，也與《The Hobbit》與《The Lord of the Rings》緊密相連。收錄作品中，包含一戰期間創作的思鄉之作，以及融合《The Silmarillion》世界觀的史詩詩篇。由 Christina Scull 與 Wayne G. Hammond 編輯與註解，為讀者帶來文學與人生交織的詩歌全景。跨越托爾金一生的重要詩作全收錄揭示詩作背後的創作背景與生平故事兼具文學價值與典藏意義的三卷精裝套書Award-winning world first publication of the collected poems of J.R.R. Tolkien, spanning almost seven decades of the author’s life and presented in an elegant three-volume hardback boxed set. Winner of the 2025 Mythopoeic Scholarship Award in Inkling Studies J.R.R.Tolkien aspired to be a poet in the first instance, and poetry was part of his creative life no less than his prose, his languages, and his art. Although Tolkien’s readers are aware that he wrote poetry, if only from verses in The Hobbit and The Lord of the Rings, its extent is not well known, and its qualities are underappreciated. Within his larger works of fiction, poems help to establish character and place as well as furth

The significance of Fong Chung-Ray’s artistic oeuvre lies in his contribution both to the global art scene and the representation of Chinese artistic traditions in late twentieth- and early twenty-first-century California. As an ambassador for art, he has played a crucial role in fostering cultural exchange between China and the West, and his artworks have introduced richly diverse artistic traditions, techniques and themes to international audiences, promoting a deeper understanding and appreciation of Chinese culture.This anniversary publication presents a careful selection of Fong’s work tracing his artistic career and stylistic development over the last 60 years. It is a testament to the master’s contribution to late-twentieth-century Chinese painting in a global context.藝術家馮鍾睿的創作夙負盛名。二十世紀晚期至二十一世紀初，馮氏以中國傳統為基礎的作品於美國加州藝壇獨樹一幟，其畫風及作畫方式多元豐碩，展現出他對融合中西藝術的永恆追求。馮氏以自身創作於海外積極傳播中華文化，在推動跨文化交流方面扮演了重要的角色，幫助國際社會更深入地理解和欣賞中國藝術。是次富有紀念意義的出版物包括橫跨馮鍾睿整個創作生涯的多幅作品，回顧他過去六十年的藝術成就和風格發展，對這位大師在二十世紀晚期中國畫壇所作出的貢獻予

NEW YORK TIMES BESTSELLER • The apocalypse will be televised! Welcome to the first book in the wildly popular and addictive Dungeon Crawler Carl series—now with bonus material exclusive to this print edition.You know what’s worse than breaking up with your girlfriend? Being stuck with her prize-winning show cat. And you know what’s worse than that? An alien invasion, the destruction of all man-made structures on Earth, and the systematic exploitation of all the survivors for a sadistic intergalactic game show. That’s what.Join Coast Guard vet Carl and his ex-girlfriend’s cat, Princess Donut, as they try to survive the end of the world—or just get to the next level—in a video game–like, trap-filled fantasy dungeon. A dungeon that’s actually the set of a reality television show with countless viewers across the galaxy. Exploding goblins. Magical potions. Deadly, drug-dealing llamas. This ain’t your ordinary game show.Welcome, Crawler. Welcome to the Dungeon. Survival is optional. Keeping

在地球最深的海域中，會發現什麼驚奇？本書帶領讀者隨兩位科學家乘坐潛水器，下潛至數千公尺深的太平洋海底。沿途可見發光的生物、奇特的海底火山與罕見的生態現象，並揭開深海研究的實際過程。由於環境極端，這裡的生命形式展現了驚人的適應能力。本書以漫畫形式搭配海洋專家審訂，讓深奧的科學知識變得易於理解且充滿探索樂趣。A bright, entertaining exploration of what scientists study in the deepest oceans, told in comic book style.Join two scientists as they climb inside a hi-tech submersible and descend into the darkest depths of the Pacific Ocean.Meet strange-looking creatures thousands of miles below the surface and explore alien landscapes. Discover how experiments are performed at the bottom of the ocean, what happens after a whale dies, and what makes extremophiles so extreme.- Told in lively comic book style- Written with expert advice from marine biologist Dr. Diva Amon- Perfect for school projects- Discover more books in the 24 hours in... series

An indispensable reference to the development of the Chinese economy—past, present, and future.—DALE W. JORGENSON, Samuel W. Morris University Professor, Harvard University Since China undertook economic reform and opened its economy to the world in the late 1970s, its economy has been growing at an average annual rate of over 9 percent for more than four decades. No other economy in recorded history has grown at such a high rate and for such a long period as China has done. The questions that naturally arise are: Was the Chinese economy a miracle? Or was it a mere bubble? Will the Chinese economy begin to stagnate like the Japanese economy did in the 1990s, and perhaps decline? Will it be able to escape the “middle-income trap”? If it is not a miracle, can the Chinese development experience be replicated elsewhere? This book provides a comprehensive and detailed discussion of the remarkable growth of the Chinese economy over the past decades, by scrutinising the sources of e

Ursula finds confidence in seeing the world her own way in another innovative, flipped-format picture book from Caldecott Honoree and Geisel Award winner Corey R. Tabor.Ursula is a happy catfish, swimming through a shimmering river with weeds waving above and a sky full of scrumptious bugs below.Then one question turns her world upside down.Is left right? Is right wrong? Which way even is up?From the Caldecott Honor–winning creator of Mel Fell comes another innovative, flipped-format picture book that encourages children to find confidence in their individuality.

Join Peppa Pig and friends in a fun story from Read It Yourself - a structured programme to support children from first phonics to fluent readingBased on the award-winning children's series!Featuring everyone's favourite little piggy, Peppa! Peppa and George must be on their best behaviour so they can play on the computer once Mummy Pig finishes working. Can Daddy Pig come to the rescue when the computer breaks?Peppa Pig: The Family Computer is from Early Reader Level 1 and is perfect for children aged from 4+ who are taking their first steps beyond phonics.Each book has been carefully checked by educational and subject consultants and includes comprehension puzzles, book band information, and tips for helping children with their reading.With five levels to take children from first phonics to fluent reading and a wide range of different stories and topics for every interest, Read It Yourself helps children build their confidence and begin reading for pleasure.

Join Peppa Pig and friends in a fun story from Read It Yourself - a structured programme to support children from first phonics to fluent readingBased on the award-winning children's series!Featuring everyone's favourite little piggy, Peppa! Grandpa Pig's garden is full of vegetables, flowers, and lots of fascinating little creatures! Join Peppa and George as they discover the wonders that live in the garden.Peppa Pig: Little Creatures is from Early Reader Level 1 and is perfect for children aged from 4+ who are taking their first steps beyond phonics.Each book has been carefully checked by educational and subject consultants and includes comprehension puzzles, book band information, and tips for helping children with their reading.With five levels to take children from first phonics to fluent reading and a wide range of different stories and topics for every interest, Read It Yourself helps children build their confidence and begin reading for pleasure.

Psychosis and Schizophrenia in Hong Kong covers some of the most serious mental health conditions that top the global disease burden and affect 3 per cent of the general population. However, most research on psychotic disorders is undertaken in the West, and few studies have been systematically carried out in Asia despite global interest in regional differences. This work offers a unique and coherent account of these disorders and their treatment in Hong Kong over the last thirty years.Chen and his research programme’s pioneering work has ranged from the impact of early intervention on outcomes and relapse prevention, to the renaming of psychosis to reduce stigma. The studies have contributed to wider international debates on the optimal management of the condition. Their investigations in semantics and cognition, as well as cognition-enhancing exercise interventions, have provided novel insights into deficits encountered in psychotic disorders and how they might be ameliorated. The re

"Max in the House of Spies is everything you could hope for in a book," -R. J. Palacio, #1 New York Times bestselling author of Wonder, White Bird, and Pony "Espionage! Secrets! Suspense! If you've ever dreamed of being a spy, this book is for you." -Alan Gratz, #1 New York Times bestselling author of Refugee and Projekt 1065 Max Bretzfeld doesn't want to move to London. Leaving home is hard and Max is alone for the first time in his life. But not for long. Max is surprised to discover that he's been joined by two unexpected traveling companions, one on each shoulder, a kobold and a dybbuk named Berg and Stein. Germany is becoming more and more dangerous for Jewish families, but Max is determined to find a way back home, and back to his parents. He has a plan to return to Berlin. It merely involves accomplishing the impossible: becoming a British spy. Thought-provoking historical fiction with a dash of magic, Max in the House of Spies is a World War II story as only acclaimed storytell

Mo Willems, #1 New York Times bestselling, award-winning author-illustrator, tackles a BIG concept in this hilarious nonfiction picture book about the relationship between size and scale. Are YOU big? A simple question sends readers to the far reaches of the universe. From an average-size kid . . . to a hot air balloon . . . to a storm cloud . . . to the M100 Galaxy, size is a matter of perspective. Bold text, expressive art, and real-world science come together in this original Mo Willems STEAM-based, early-learning concept book.

In Rosie Young: A Lifetime of Selfless Service, Moira Chan-Yeung presents a brief history of Professor Young’s remarkable career in medical education and administration at the University of Hong Kong (HKU) and her wide-ranging public service to the community over many decades. As the first female dean of HKU’s Faculty of Medicine, her career was deeply intertwined with the socio-economic development of Hong Kong. After her retirement from HKU, she continued to serve HKU and the community up to the present. This book illustrates her many contributions to the development of medical education in Hong Kong and to the university administration at HKU. Professor Young’s extensive public service in the field of medicine also helped improve primary care, hospital care, and public health in Hong Kong. In short, this book provides a valuable record of a female giant in Hong Kong’s medical history and documents her selfless and enduring service to the HKU community and Hong Kong society.

列文森（Joseph R. Levenson） 舒扶瀾（Franz Schurmann）加州伯克利中國通史講義殘稿，首次中譯 並非歷史信息與細節的疊加 「我們試圖讓歷史學習成為深化思想複雜性的過程」 麻省理工學院教授、列文森之子托馬斯．列文森（Thomas Levenson） 作序葉文心、歐立德（Mark C. Elliott）、董玥、黃樂嫣（Gloria Davies）、齊慕實（Timothy Cheek）、白傑明（Geremie R. Barmé） 聯合撰寫長篇導讀 1960年代，約瑟夫．列文森（Joseph R. Levenson, 1920–1969）與舒扶瀾（Franz Schurmann, 1926–2010）在加州大學伯克利分校開設中國歷史課程，其講義中關於「早期中國」的部分在列文森身後出版，即本書《詮釋中國史：從源起到漢亡》。 與一般中國通史不同，本書在敘述史實之外，逐章引入對思想史中關鍵概念和框架的辨析，進而對歷史書寫和研究作出深刻的反思。在列文森看來，中國歷史不僅是某種基於朝代更迭、簡單遞進的連續過程，而是「極度的多樣性，一次又一次地將中國重構成統一的整體」。