Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

From the peerless Jon Klassen comes a board book for young readers who relish things that go bump in the night—while feeling safely tucked into their own house, with plenty of somebodies around.Here are all the things in this house: a chair, a clock on the wall, a stool, a lamp. And more. What’s missing from this house? Somebody. This is the house with nobody in it. Well, there might be something . . . Designed as an oversize board book, this story takes young ones through a recognizable, cozy house, while die cuts introduce just a hint of precarity. This is the house with nobody in it—or is it? Ideal for children whose older siblings are fans of Jon Klassen’s The Skull—readers who aren’t quite ready for “creepy” but are totally on board with being gently spooked—this is classic Klassen, revealing a bit of mystery out there before bringing us back into the familiar . . . shifty eyes and all.

Join Poppy and Sam for a noisy day on Apple Tree Farm in this irresistible touchy-feely sound book. Each time you press one of the soft patches, you'll hear one of Poppy and Sam's animal friends... and of course there's a little yellow duck to find in every picture too.

Bring the world of the jungle to life with the three different jigsaws and simple story in this enchanting book. The jigsaws have nine pieces each and are perfect for young children, who will also enjoy reading about the magic of the jungle in the atmospheric story.

This beautifully illustrated flap book transports the reader back in time to the amazing world of the dinosaurs. From fearsome meat-eaters to giant herbivores, readers can lift the different flaps to discover the very different world these big beasts lived in. Discover the strange, feathery dinosaurs who lived in deserts, what a T.Rex had for lunch, the massive reptiles who soared in the sky and swam in the sea, before finding out why dinosaurs no longer live with us. Or do they...?

Help the baby sea animals find their way home in this fun sliding counter board book series!Meet baby turtle, baby dolphin, baby clownfish and baby whale - four adorable animals who are lost in the waves!With easy-to-use moving parts and four unique tracks to develop hand-eye coordination and concentration, babies and toddlers will enjoy taking the baby animals home in this robust board book.Includes a FREE Nosy Crow Stories Aloud® audiobook! Scan the code, hear the story.Other titles in the Let's Go Home series include:*Baby Tiger*Baby Shark*Baby T-Rex*Let's Go Home, Baby Panda

Explore the big outdoors in these action-packed animal board books with sliders on every page.This series of board books will inspire a love of nature in even the littlest of animal lovers. With vibrant artwork printed on white board, robust easy-to-use mechanisms for tiny hands and a rhyming text with friendly animal facts, these are the perfect books to captivate curious little explorers time and time again.In this first minibeasts book, there are earthworms tunnelling underground, spiders spinning webs, butterflies flitting around and many more bugs to discover and bring to life with the moving parts.Includes a FREE Nosy Crow Stories Aloud® audiobook! Scan the code, hear the story.Other titles in the series include:*Countryside*Seaside*Woods*Farm*River*Snow*Jungle*Safari*Birds

Stunning, large-format board book with flaps on every page and lots of dinosaurs to meet!A brand-new title in this best-selling gift format from award-winning illustrator and homeware and stationery designer, Edward Underwood.The perfect gift book for dinosaur fans of all ages, with bold colours and big flaps that will catch a child's attention on every page as they learn all about dinosaurs with over 100 words and pictures to spot. This book will help develop vocabulary, encourage speech and promote book confidence in an interactive way, as well as introduce first words from the world of dinosaurs.Other books in the 100 First Words series include: First Words, First Words: City, First Words Nature, My First ABC and My First 123

This delightfully illustrated sound book features five songs for little children to join in with. It includes some of the best-loved nursery rhymes and songs, such as "If You're Happy and You Know it", "Mary Had a Little Lamb", and "Hey Diddle Diddle", all sung in a beautiful, gentle voice - perfect for children to sing along with.

Read and learn about feelings with Pip and Posy in this chunky, lift-the-flap book!With multiple flaps to lift, engaging scenes and beautiful images, this book has lots to name, discover and talk about. Every page has a thumb-tab to make turning the pages easy and the chunky pages are designed to withstand even the most enthusiastic of toddlers. Each page explores a different feeling, offering examples from Pip and Posy's world, as well as a question to encourage readers to think about when they felt that emotion too. This helps show that these feelings are normal, healthy and important to us all.Includes a FREE Nosy Crow Stories Aloud® audiobook! Scan the code, hear the story.Look out for other titles in the Pip and Posy series, including Pip and Posy Felt Flaps: In the Garden, At the Seaside, At Christmas, In the Park and At the Party.

Jump in the driver's seat for an unforgettable holiday in this non-fiction novelty book for toddlers!With five sliding counters to move across adventure-packed pages, this is the perfect book for preschoolers who love to be in control of the story. They can help drive the ice cream van in the park, steer the cruise ship, take the campervan through the mountains and push the rollercoaster trolley round and round at the theme park. Look at all the different labels for the equipment needed on each page, then push the counter around the tracks. Other titles to collect in the series include: Cars, Trains, Boats, In the Sky, Emergency, Building Site, Farm and Trucks.

Make tummy time extra fun for your baby with this fold-out concertina board book. It comes with a surprise mirror ending, too!Say hello to the ocean animals in this engaging tummy time book for babies. There is a busy underwater scene on one side of the concertina and friendly sea creatures and a mirror for babies to see themselves in on the other side.This dazzling board book is designed with tummy time in mind - a gentle exercise where a baby lies on their front to help strengthen their muscles and improve their head control.The fold-out concertina allows the book to be spread out in-front of your baby, while the bold colours stimulate their developing eyesight.The captivating, bright artwork from Louise Lockhart (the illustrator behind The Printed Peanut) creates a series of books that will enchant baby at reading time.Tummy Time: Ocean also includes a FREE Nosy Crow Stories Aloud® audiobook! Scan the code, hear the story.Also available in the series:Tummy Time: FarmTummy Time: Safa

Join in with the fun of the 2026 World Cup with this sporty new title in our original, award-winning Felt Flap series - perfect for babies and toddlers!Each title in this stylish series has five spreads with friendly characters to find behind colourful felt flaps. Lift the final flap and there's a surprise mirror - always a hit with the little ones.In Where's Mr Footballer?, you can find Mrs Goalkeeper, Mr Referee, Mrs Coach and Mr Footballer himself!Parents adore these books because they are beautiful but tough enough to withstand even the most enthusiastic of young readers. And children love them because they are just so much fun!

Join Peggy in her garden adventures in a charming story about curiosity, determination, and the joys of everyday life.Join Peggy and her mother on a delightful day in the garden! Determined to help with every task, Peggy eagerly exclaims, "I'll do it, I'll do it!" as she plants beans, waters seedlings, removes weeds and tastes raspberries. Though the results aren't always perfect, Peggy's cheerful spirit never waivers.This charming book celebrates the small joys of everyday life paired with heart-warming illustrations and endearing messages of persistence and determination.

Guess who's hiding under the sea in this lushly illustrated, rhyming read-aloud guessing game, then lift the sturdy cardboard flaps to meet the ocean 's most amazing creatures - both familiar and wonderfully weird!There are six sea creatures hiding in the book: can you guess who's hiding under the surface?This playful lift-the-flap book takes toddlers on an underwater adventure, introducing them to the wonderfully weird creatures of the ocean - and shows how their unique features are what make them amazing. On each spread, a hidden sea creature is described with a lively read-aloud rhyme, while peek-through details give extra clues to the animal's identity. Little hands can lift a satisfying, sturdy flap to reveal who's hiding under the sea.For example: Who carries mama's eggs in his belly? (Lift the flap - it's the seahorse!)Who's covered in slime so they don't feel stings? (Peek under - it's the clownfish!)The answer is revealed under the flap through a stunning, vibrant illustration

A board edition of the book described by the Daily Telegraph as ‘an utter gem’.Written in a gentle rhyme that reflects the slow pace of Mouse’s rambling journey, and illustrated in the inimitable style of Alice Melvin, Mouse’s Wood is a heart-warming celebration of slow living in nature.The story follows Mouse, who first ventures out in wintry January to visit his friend Squirrel. Mouse moves on to wake up Hedgehog for the arrival of spring and as he continues along the path in the wood, Mouse’s journey from friend to friend maps out the changes in seasons from January through to December, from picnicking among the bluebells with Mole in May and picking berries with Dormouse in June, to taking refuge in Fox’s cozy caravan as winter draws in.

The original, award-winning Felt Flap series - perfect for babies and toddlers!Each title in this stylish series has five spreads with friendly characters to find behind each colourful felt flap.In Where's Mrs Fish?, you're on the look out for Mr Dolphin, Mrs Crab, Mr Lobster and Mrs Fish herself! Lift the final flap and there's a surprise mirror for little ones to find themselves in - something that is always a hit!Parents adore these books because they are beautiful but tough enough to withstand even the most enthusiastic of young readers. And children love them because they are just so much fun!Other titles in the series include:Felt Flaps Where's Mr Narwhal?Felt Flaps Where's Mr Unicorn?Felt Flaps Where's Mrs Ladybird?Felt Flaps Where's Mrs Car?Felt Flaps Where's Mr Lion? won Sainsbury's Children's Book of the Year 2017"The felt flaps in this sturdy board book are perfect for little ones to turn and tug, which means you can get even the tiniest tot into books and finding the activi

Join little bear Niko for a fun-filled day on the farm in this interactive board book, packed with push-and-pull sliders and flaps.Feed the chickens. What a crowd!Uh-oh, Niko.That’s so loud!Help little Niko feed the animals, ride a tractor and waddle with the ducklings in this sturdy, interactive board book packed with push-and-pull sliders and flaps.Uh-Oh Niko is a little bear who sometimes gets things a little wrong. Whatever happens, he always tries again and learns new skills along the way.For fans of Maisy and Tales of Acorn Wood, this colourful, illustrated series is the perfect way to help toddlers with their daily routines. This board book is made with durable pages and interactive elements for helping little ones develop their fine motor skills.Children will love joining in with the fun-filled rhyming text and playing along with the story..Want more fun with Niko? Check out the other books in the series:Uh-Oh, Niko: BathtimeUh-Oh, Niko: BedtimeUh-Oh, Niko: The ParkUh-Oh, Niko:

Take care of a sweet fluffy lamb in this adorable touch-and-feel book.Stroke the little lamb's velvet nose better after it sniffs a prickly plant, pat its woolly head and rub its soft ears. Babies and toddlers will love being able to make it all better after this gorgeous animal character has everyday mishaps. A snuggly, cosy book to encourage empathy and kindness in little children.Discover more books in the There There Little... series:- There There Little Puppy- There There Little Bear- There There Little Kitten- There There Little Reindeer- There There Little Bunny

What makes bees dance? How do moths and other nocturnal bugs find their way at night? Which tiny bugs can build nests taller than a person? Just how big is the world's biggest butterfly? Lift the flaps to find out the answers and many more bug facts in this fascinating introduction to the world of insects.Chapters in this book include:- Buzzy bees- Butterflies...- Watery bugs- In the undergrowth...- As it gets dark...- Bug homes- Bug facts- Please help the bugs!

An eye-catching nature novelty series for babies that love spotting wildlife!Even babies can be wildlife explorers!In fact, babies love noticing all kinds of animals out and about and this fantastic new board book builds on that enjoyment with easy-to-lift card flaps and a stimulating question-and-answer text.Where do cows live? What colour are hen eggs? What are baby sheep called? Little ones will love joining in with the answers, while recognising five different farm animals and lifting the flaps to find more hiding in the scenes.Featuring playful artwork packed with personality and tactile embossed covers, this series of My Very First Spotter's Guides from the National Trust is perfect for little nature lovers.Includes a free Nosy Crow Stories Aloud® audiobook! Scan the code, hear the story.Also available in this series:I Spot a DuckI Spot a SnailI Spot a RabbitI Spot a Fish

Ruff! Ruff! Meet Ruffles, the playful puppy who faces all the tricksy troubles of preschool life in these bright, sturdy refreshed board books from bestselling author and illustrator David Melling.Praise for Ruffles and the Red, Red Coat:"Guaranteed to strike a chord with your own mischievous pups!" - Lancashire PostJust like every preschooler, Ruffles the puppy experiences all the ups and downs of daily life as he learns about the world around him. There are LOTS of things he likes and LOTS of things he doesn't . . . and he doesn't always get things quite right!.Ruffles LOVES scratching, digging and chewing but he does NOT like wearing his coat on rainy days. No, no, no, no, NO! But when Ruffles wants to splash in puddles with his best friend, Ruby, he soon learns that some things are definitely worth wearing your coat for!Dog-lovers won't be able to resist the adorable Ruffles in this preschool series from the creator of Hugless Douglas (over 5 million copies sold worldwide). Now in

Duck kicks the ball but it flies over the net--where's it gone? BOOM into the tree, SPLAT in the puddle, DOOGA DOOGA under the bench. Duck runs, Owl runs, Spider runs, Dog runs--they all run after the ball. Until KERSPLASH it lands in the pool. Uh-oh, there's a crocodile in the water. It's too late to stop the ball! Or is it?Susanne Strasser's snowballing animal stories that children love are bestsellers in multiple languages. This funny, energetic game takes an unexpected turn after the ball lands in the pool--and ends with a goal, of course.

An adorable novelty slider series all about things that go!All aboard the baby sub. See it floating in the bay. All aboard the baby sub.We'll go beneath the waves today. A fun rhyming text, perfect for reading aloud, and full of sounds for little ones to join in with! Climb aboard the submarine in this brand-new novelty series for babies and pre-schoolers. With tabs to slide and wheels to spin, little ones will love to make the sub move on every page.Seb Braun (illustrator of Spinderella by Julia Donaldson, the Daddy Grizzle books by Mark Sperring and author-illustrator of Raj and the Best Day) creates friendly, action-packed scenes, full of detail and warmth. Bursting with adorable animal characters exploring under the sea, this bright and busy book will provide hours of entertainment. Also in the series: Baby on Board: Train (2023), Car (2023), Tractor (2024), Aeroplane(2024), Bus (2025), Boat (2025)

A dinky shaped board book packed with things that go.Discover all your favourite construction vehicles in this adorable shaped board book. Each uniquely-shaped page reveals a new vehicle, alongside a simple fact and aplayful sound to join in with. Little ones will love to DIG, BEEP and HEAVE alongas they meet diggers, bulldozers, cranes and dumper trucks.Packed with bright colours and friendly faces from Matthew Scott, the toy-like pagesare sure to hold the attention of the youngest babies while the simple facts areperfect for toddlers. Also in the series: I'm a Dinosaur (2025), I'm a Car (2025), I'm a Lion (2026), I'm a Bunny (2026)

Little children can experience the magic of a moonlit night and meet owls, foxes and bats with the beautifully illustrated jigsaws and simple story in this atmospheric book. There are three 9-piece jigsaws, each featuring an enchanting night-time scene, which can be taken out of the book to complete and, once finished, slotted snugly back in for safekeeping.

Stretch your wings--and your knowledge--with this bird-themed addition to the bestselling Abrams Block Book series From the tiny bee hummingbird to the giant condor and every-wing in between, no fowl is left behind in this fabulous addition to the acclaimed Abrams Block Book series! In this small but sturdy block-shaped board book, young readers are introduced to an incredible array of birds. Follow our young protagonists and their avian-expert grandfather as they explore what makes birds amazing--from the nests of bald eagles to the swift running speed of an ostrich. Around 96 million people in the United States--more than a third of the population--are avid birdwatchers. This book will be a hit with the youngest readers who have jumped on the birding bandwagon! Like other books in the Block Book series, Birdblock features die-cut pages to peek through as well as durable, interactive gatefolds perfect for curious hands. Illustrated in Peski Studio's bright, graphic style, this is a mu

Enjoy this festive board book full of soft felt flaps and sweet illustrations with the jolly kids in your life! Everyone is in a jolly mood for the holidays! But who is the jolliest? This board book features festive characters like a bunny going ice skating and a polar bear sledding in the snow, each uncovered by lifting a soft felt flap. But wait until the end to see the merriest person ever in the mirror included in the back of the book! The whole family can read this interactive playful story with sweet illustrations. It is the perfect gift to celebrate the holidays!

In this board book edition of the third book in theNew York Timesbestselling series, Rainbow Fish brings his signature shine to the idea of peace in community.When a big blue whale comes to live near their reef, there is a terrible misunderstanding between him and Rainbow Fish and his friends. The fish friends are left very unhappy and hungry! To save everyone from disaster, Rainbow Fish must find all his bravery and make peace with the big blue whale.

Hop along with Maisy as she discovers fascinating facts about frogs and toads in this eighth Maisy's Planet adventure. Frogs are fantastic! Every toddler who has been up close and personal with one of these big-eyed amphibians--as well as those not so sure about the bumpy green guys--will be intrigued by this fun introduction to frogs and toads with Maisy leading the way. Young children can find out about everything from tadpoles to lily-pad-leapfrogging in a gentle learning experience, then open out the final inviting scene as Maisy and friends make a frog-friendly pond in her backyard.

Delight in New York at Christmas time in this highly treasurable lift-the-flap Christmas book. Join Kit and Olivia for a day out in New York as they journey through the city, taking in some of its most famous sites. This atmospheric picture book celebrates the joy of sharing traditions with loved ones at Christmas time. With festive flaps to open on each page, a gentle narrative text and details to spot in each illustration, this is a charming festive book that families will return to each year.

Meet Baby Evie in this colourful board book!Peppa has a new baby sister, Evie. She is little, but lots of fun! Join Peppa and her family in this brilliant board book to spend time with Evie!Don't miss these other brilliant Peppa Pig books:Peppa Pig: Peppa's New Baby SisterPeppa Pig: Mummy Pig's Perfect Day Peppa Pig: Daddy Pig's Favourite ThingsPeppa Pig is a 4-time BAFTA award-winning preschool animation shown in the UK daily on Channel Five’s Milkshake and Nick Jnr. Peppa is a loveable, cheeky little piggy whose days are filled with action packed activities.Along with her family and friends, Peppa learns and plays and has lots of fun. Join Peppa and her family on their funny, action-packed, everyday adventures in this collection of activity, story and novelty books.