Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

The Ancient Roman world is brought to life with carefully researched and meticulously illustrated scenes. Flaps animate the action and reveal fascinating hidden details. Simply turn the pages to visit the Roman Forum, stroll the streets of Ancient Rome, attend a party in a villa, spend a day at the Roman baths, watch gladiators in action at the Colosseum, and so much more.

Celebrate the milestones of a child’s life with this adorable board book about feelings inspired by the many different holiday eras celebrated at Christmastime with a little inspiration from Taylor Swift.Young Swifties will delight in the adorable illustrations of children rejoicing in their favorite “era” of childhood during the holidays. This uniquely Taylor Swift–inspired book of emotions isn’t about being simply happy or sad . . . or even being fearless. Families can gather to explore the season in a playfully fun way by celebrating their “Jolly Era,” “Naughty or Nice Era,” “Evergreen Era,” and more! This lighthearted title helps kids find new and different ways to express their emotions and show their love for their—and their parents—favorite singer at the same time.

This sweet story of the friendship between a child and a bear, which features gender-free pronouns throughout, is a celebration of all the ways we show our love to the important people in our lives. Now in a sturdy board book format for the youngest readers! This sweet story of the friendship between a child and a bear, which features gender-free pronouns throughout, is a celebration of all the ways we show our love to the important people in our lives. A heartfelt gesture that's as simple as a hug, a smile, or a helping hand conveys deep feelings of love and appreciation that words might not be able to show. In this story, a child and a bear are best friends; and even though one is big and the other is small, they find common ground as they play, sing, wish each other good night, and apologize after they have an argument. The little things they do together and for each other make up the meaningful friendship they share. Now in a sturdy board book format for the youngest readers that c

The second book in the Knuffle Bunny series by best-selling author-illustrator Mo Willems, in a board book format perfect for the littlest readers. Trixie can't wait to bring her one-of-a-kind Knuffle Bunny to school and show him off to everyone. But when she gets there, she sees something awful: Sonja has the same bunny. Suddenly, Knuffle Bunny doesn't seem so one-of-a-kind anymore. Chaos ensues until the bunnies are taken away by Ms. Greengrove. After school, Trixie finally gets her beloved bunny back. But in the middle of the night, Trixie realizes something. She has the wrong bunny! Daddy comes to the rescue again as a midnight swap is arranged with the other bunny, the other little girl, and the other daddy. Needless to say, the daddies are not very happy. By the end of the story Trixie has her beloved bunny back, but she has also gained something new: her very first best friend. In the tradition of the Caldecott Honor-winner KNUFFLE BUNNY: A CAUTIONARY TALE, this is another heart

Take care of an adorable kitten in this sweet touchy-feely book.Help take care of an adorably sweet, snuggly kitten in this engaging touchy-feely book. Tickle under its chin when it's feeling lonely, stroke its back when it's had a little fright, rub its paw better after it steps in a cold puddle. Then, when it's safe and warm, tickle its soft, fluffy tummy.Encouraging kindness and empathy, this interactive book will delight babies and toddlers as they look after the heart-meltingly cute kitten.

Use the picture magnets to fill the charming scenes around Apple Tree Farm.Join Poppy and Sam for a day at Apple Tree Farm in this delightful magnet book. From collecting the freshly laid eggs in the morning to taking the animals back to the barn at night, children will love choosing the magnets to finish the charming scenes.- Contains 10 magnets to place in different scenes- Engaging, interactive, shared storytelling experience- Discover more Farmyard Tales Poppy and Sam books, from activity and cookery books, to story collections and stickers

A chunky Halloween board book for babies, with soft flaps to lift on every spread.It's Halloween and Little Ghost can't find her friends anywhere! Are they picking in the pumpkin patch, sitting beneath the starry sky, or even hiding in the haunted house? Lift the felt flaps to help look for them - who will shout BOO?With soft flaps on every spread that are easy for babies to lift and help develop their fine motor skills, this gorgeous book by Axel Scheffler, bestselling illustrator of Room on the Broom, is the perfect Halloween gift for little ones.Also available: In the Jungle: A Push, Pull, Slide Book, Can You Find the Easter Bunny?: A Felt Flaps Book and On the Farm Sticker Activity Book.

Discover your favourite animals in the city with The Very Hungry Caterpillar in this bright and bold lift-the-flap book!Join The Very Hungry Caterpillar in this interactive lift-and-learn board book filled with beautiful nature and city scenes to explore and hidden animals to discover. Perfect for little ones who love the outdoors, animals, bugs and all things you can find in the city!Discover more interactive stories with The Very Hungry Caterpillar:The Very Hungry Caterpillar’s Lift-and-Learn: FarmThe Very Hungry Caterpillar's Bug HuntThe Very Hungry Caterpillar's Magnet BookThe Very Hungry Caterpillar's Finger Puppet BookThe Very Hungry Caterpillar's Nature Sticker and Colouring

Peppa loves adventures with unicorns! Press out and make FIVE huge jigsaw puzzles to find out where she’ll go! Meet all her amazing unicorn friends at the wildflower meadow, in the enchanted woods and even at bedtime!Join Peppa in her magical jigsaw adventure!Peppa loves jigsaw puzzle books. EVERYBODY loves jigsaws!Don't miss these other brilliant Peppa books:Peppa Pig: Peppa’s Jigsaw Puzzle BookPeppa Pig: Fun at the Zoo Jigsaw Puzzle BookPeppa Pig: Peppa the UnicornPeppa Pig is a 4-time BAFTA award-winning preschool animation shown in the UK daily on Channel Five’s Milkshake and Nick Jnr. Peppa is a loveable, cheeky little piggy whose days are filled with action packed activities.Along with her family and friends, Peppa learns and plays and has lots of fun. Join Peppa and her family on their funny, action-packed, everyday adventures in this collection of activity, story and novelty books.

Be wowed and terrified by the world's wildest places in flap-book formThe wildest, most extraordinary places on Earth await you. But, do you dare to enter the Bwindi Impenetrable Forest? Visit the serpent-infested Snake Island? Dip your toes in the deadly waters of the glittering Lake Natron? Meet savage creatures and amazing ones too, as you discover some of the most thrilling parts of our diverse and beautiful world.

Discover a zoo full of amazing animals from around the world in this lively flap book.Little Butterfly is flying all around the zoo looking for her friend. Can you help him find her? With lots of flaps for curious hands to lift and plenty of amazing animals to meet. From hippos wallowing in the mud to slippery snakes in the reptile house, visit all the incredible enclosures and learn new words as you search. Endearing illustrations and sturdy flaps will make this a treasured book to revisit again and again.

Join Bizzy Bear and his friends at the local swimming pool this summer!Bizzy Bear is always busy and today he’s come to the local lido but he needs YOUR help to get in the pool! With sturdy mechanisms on every spread that put the reader at the heart of the action, can you get Bizzy Bear into his swimming costume and into the pool?Bizzy Bear’s adventure is told with rhyming text that children will love to join in with and guess the rhyming words. With more than thirty titles in the series, there’s a Bizzy Bear book for every occasion!Other titles to collect include:Camping TripDeepsea DiverDinosaur SafariPirate AdventureKnights CastleZoo RangerFarmyard Fun

A raucous read-aloud rhyme for toddlers, part of Julia Donaldson's Toddler Club range and illustrated by bestselling Nick Sharratt.Little ones will love learning to get dressed with help from this colourful, funny board book from Julia Donaldson.There's chaos in the clothes shop when the animals go on a glorious shopping spree. Zebra's zip is stuck and Toad's tracksuit is far too big, but Flamingo finds a stylish bag, and Caterpillar's shoes are really cool. Even the smallest toddler will enjoy the wonderfully silly animal antics in this book, so join in the fun – you've never seen a fashion show like it!Nick Sharratt's mischievous and funny illustrations in a sturdy board book format make this playful book a sure winner. Plus you can scan the QR code on the back cover to listen along to Julia Donaldson reading the book too.Look out for for more Toddler Time books: Animal Music, Chocolate Mousse For Greedy Goose, and Goat Goes to Nursery.

Learn the alphabet with Brown Bear and Friends in this sweet forest adventure!In the forest, looking for a treat! What will Brown Bear find to eat? Apple, Berries, Cherries, Deee-licious!Explore everything there is to see, taste, and discover in the forest as Brown Bear delights in each letter from A to Z in this charming alphabet book. With rhythmic, rhyming, read-aloud text, and Eric Carle's bright, distinctive artwork, each letter introduces foods, animals, sounds, and so much more. Expand your Eric Carle library: Brown Bear, Brown Bear, What Do You See?Baby Bear's Busy DayThe Very Hungry Caterpillar

Watch as farm animals appear and disappear as you move the sliders in this delightful board book.Babies will love looking at the bright pictures in this delightful book and seeing what appears when they move the sliders. The simple sliding panels reveal a chick hatching in a hen house, baby goats peeping out of a barn, a busy tractor and cows being milked. As well as the sliders, there are finger trails to follow too.

A BRAND NEW You Choose board book series that's perfect for toddlers!A brand new interactive board book mini-adventure in the BESTSELLING seriesMake up your very own bedtime routine where YOU CHOOSE what happens - what toys will you play with in the bath? What will you choose to wear to bed? What kind of bed would you like to snuggle up in?The perfect book for toddlers to choose before they snooze - with an ingenious lift-the-flap ending. With satisfying rhyming text from Pippa Goodhart and vivid illustrations from Nick Sharratt, this is a joyful and accessible introduction to You Choose for younger readers.Discover these bigger You Choose picture book adventures:You ChooseYou Choose Your DreamsYou Choose in SpaceYou Choose Fairy TalesYou Choose Christmas

Explore the A, B, Cs of SpongeBob SquarePants in this fun and interactive title in the popular Abrams Block Book series Like other books in this hugely popular series, SpongeBob SquarePants Alphablock features die-cut shapes on every spread and has durable, interactive gatefolds, perfect for curious hands. Sponge! Friend! Fry cook! For 25 years, SpongeBob SquarePants has been delivering laughs to fans both young and old. Now get ready to see him as you've never seen him before. Masterfully interpreted by Peski Studios, this Alphablock book brings a fresh, artistic approach to the places and faces of Bikini Bottom. From the Goo Lagoon and King Neptune, to ukuleles and imaginaaaation, this Block Book is the perfect gift for both kids and collectors alike. It's nautical nonsense from A to Z! Other favorites in this series: Alphablock * Countablock * Dinoblock * Cityblock * Buildablock * Farmblock * Loveblock * Sharkblock * Spaceblock * Bugblock

A book, toy, and decoration all in one, Space Train shares simple facts about our solar system from the sun to the Kuiper BeltAll aboard the Space Train! Put on your space suit and strap in for an interstellar adventure. Starting at the sun and learning facts about each planet along the way, this adorable two-in-one, sturdy, die-cut board book unfolds into a 56'' train (perfect for playtime or room decor!). Printed on both sides with boldly colored illustrations, the book includes a handy velcro clasp to keep everything snuggly shut when reading time is over. A perfect interactive primer for teaching our solar system to kids, Space Train provides that colorful, educational, and toylike experience that makes learning fun.

Spend a day on the road with The Very Hungry Caterpillar!Let’s take a ride with The Very Hungry Caterpillar! What will you find? From planes high in the sky to big trucks on the ground, discover all kinds of ways to travel in this tabbed board book with easy-to-flip tabs, easy-to-read text, and easy-to-love Eric Carle art featuring The Very Hungry Caterpillar.

There are probably twenty quadrillion ants in the world - that's a lot! But most people have no idea about the tiny creatures scuttling, flying, wriggling or burrowing around us. This beautifully illustrated flap book gives the reader a glimpse into the fascinating world of bugs - brilliant butterflies, bugs that live in water, tropical bugs high up in rainforest trees, ones that burrow deep underground and even those that only come out at night.

Join Bizzy Bear at the dinosaur park for a ROARSOME adventure in this chunky new board book with five sliding counters! /b>Bizzy Bear is searching for dinosaurs today, and he needs your help! Jump in the jeep and follow the dino tracks by pushing the sliding counters through the story to discover a Triceratops, Stegosaurus, T.Rex and more with the five easy-to-move counters.Learn dinosaur vocabulary with simple first words and helpful text prompts to encourage talking – perfect for babies and toddlers who love dinosaurs and love being in control of the story!Explore, discover and learn with more Bizzy Bear books:Bizzy Bear: Find and Follow: In SpaceBizzy Bear: Find and Follow: On the FarmBizzy Bear: Find and Follow: Under the SeaBizzy Bear: Dinosaur SafariBizzy Bear: My First Sticker Book: Amazing Adventures

Join Bizzy Bear in his submarine for an underwater adventure in this chunky new board book with sliding counters!Bizzy Bear is searching for treasure today, and he needs your help! Climb inside his submarine and explore the ocean by pushing the sliding counters through the story to discover a sea turtle, orca, friendly seal and more with the five easy-to-move counters.Learn underwater vocabulary with simple first words and helpful text prompts to encourage talking – perfect for babies and toddlers who love the ocean and love being in control of the story!Explore, discover and learn with more Bizzy Bear books:Bizzy Bear: Find and Follow: In SpaceBizzy Bear: Find and Follow: At the Dinosaur ParkBizzy Bear: Deepsea DiverBizzy Bear: Dress-Up FunBizzy Bear: My First Sticker Activity Book: Amazing Adventures

Tap, slide and jiggle the pages to take a cheeky little puppy on a walk in this interactive novelty board book from bestselling children's author Tom Fletcher.A brand-new series of novelty board books from bestselling author Tom Fletcher!WOOF WOOF! Oh look - a hungry little Puppy is in your book!Shall we get her something to eat?Tap, slide, and jiggle the pages to follow mischievous Puppy on her adventure, as she digs up the garden in search of a treat and turns into a mucky pup! Can you help her get clean again?Toddlers will love this interactive board book, full of fun novelties that encourage curiosity and exploration and a gentle narrative that is perfect to read aloud.More Who's in Your Book interactive board books:There's a Little Chick in Your BookThere's a Little Snowman in Your BookFor readers up to five, discover the exciting world of Who's in Your Book:There's a Monster in Your BookThere's a Dragon in Your BookThere's an Alien in Your BookThere's an Elf in Your BookThere's a

Discover all your favorite vehicles in this shaped board book.Each uniquely shaped page reveals a new vehicle alongside a playful sound to join in with. Little ones will love to BEEP, TOOT, and WEE-WOO along as they meet a car, tractor, train, boat, and even a helicopter!Packed with bright art from Matthew Scott, the toylike pages are sure to hold the attention of babies and toddlers.

Discover all your favorite dinosaurs in this shaped board book.Each uniquely shaped page reveals a new dinosaur alongside a playful sound to join in with. Little ones will love to ROAR, STOMP, and SCREECH along as they meet dinosaurs big and small, from a stomping T. rex to a soaring pterodactyl.Packed with bright art from Matthew Scott, the toylike pages are sure to hold the attention of babies and toddlers.

For young kids learning their basics and exploring the world around them, this creatively formatted book teaches kids how to count from 1 to 10 and then in reverse, from 10 to 1.Read this book forwards and backwards! For young kids learning their basics and exploring the world around them, this board book teaches how to count from 1 to 10-and back again, from 10 to 1.This board book has two spines-one on each side-so that the book opens outward left and right. Plus, each page is shaped like a number from 1 to 10! As new stars appear in the darkening night sky, count them along with the rhyming text:Just ONE star in the sky.TWO stars now in the blink of an eye.Twinkle, twinkle number THREE.Then FOUR stars for us to see....Then, in order to close the book correctly, count backward while the sun rises again:The stars have aligned and there are TEN.A necklace of NINE glisten like gems.A shower of EIGHT put on a show.See the SEVEN sparklers glow....With wonderfully layered design, illustrat

A lift-the-flap non-fiction series that reveals all the secrets of the farm.Join us for a walk around the farm. See the lambs being fed, the chicks hatching and the corn being harvested in this lift-the-flap non-fiction book.Filled with bite-sized nature facts and over 40 flaps to lift, young explorers can enjoy a colourful and interactive introduction to the busy life of a working farm.Follow the family as they walk through the six farmyard themed scenes, from the farmhouse to the paddock, to green pastures and through to the barn.Reveal hidden facts and learn more about the world around you and the animals who share it with you.Also available:A Walk in SpringA Walk in SummerA Walk in AutumnA Walk in WinterComing soon:A Walk in the Rainforest

Welcome to Acorn Wood. Join Hare and her friends at a party in this brand new preschool lift-the-flap book from the creators of The Gruffalo.Lift the flaps to join in the fun with Hare's New Dress, a brand new rhyming story in the bestselling Tales from Acorn Wood preschool series by Julia Donaldson and Axel Scheffler, creators of The Gruffalo.It's time for a dance in Acorn Wood! But Hare needs a new dress first . . . Lift the flaps to join in the excitement as Hare hunts for something to wear, then heads to Acorn Hall for a party with her friends.With sturdy flaps on every spread and a rhyming story that is a joy to read aloud, Hare's New Dress joins the bestselling Tales from Acorn Wood series which has been delighting parents and children for over twenty-five years.Enjoy more lift-the-flap adventures from Acorn Wood: Cat's Cookbook, Squirrel's Snowman, Badger's Band, Dormouse Has a Cold, Frog's Day Out and Mole's Spectacles.

Discover the magical world of Moomins in this chunky lift-the-flap book with a surprise pop-up ending!It's time for a very special picnic in Moominvalley. But where is Moomintroll? Join Little My, Moominmappa and more marvellous Moomin characters as they join in the hunt to find Moomin!Based on Tove Jansson's original characters and artwork, this interactive board book is perfect for little readers and the youngest Moomin fans!Discover more magical Moomin books:Moomin's First 100 WordsMoomin: The Very BIG Moominhouse Lift-the-Flap BookMoomin's Peekaboo Night Night: A Lift-and-Find BookMy First Moomin: Best FriendsMy First Moomin: Goodnight MoominMy First Moomin: Be Brave, MoominMoomin's Pancake Picnic Peep-Inside

Travel through time as you explore the famous period rooms at The Metropolitan Museum of Art, and craft your own doll’s house with the press-out paper dolls and objects.Immerse yourself in five opulent historical spaces with this chic, illustrated doll’s house book that brings to life the period rooms at The Metropolitan Museum of Art. Perfect for doll’s house fans and crafting hobbyists of all ages, The Met Paper Doll’s House is the ideal way to recreate the magic of The Met’s beloved period rooms and build your own dream historical spaces.Press out and craft your own period-inspired doll’s houses:*The latest book in The Met Dress Up Paper Dolls series*Learn about how people lived throughout history in a format perfect for youngsters and crafting enthusiasts alike*The ideal gift for kids who enjoy doll’s houses, as well as fans of period-themed museum exhibitsShelter under the pagoda in a Chinese-inspired garden while admiring exotic plants, explore an 18th-century parlour, and admire

Make your own 3D decorations with this brilliant board book of press-out ancient Egyptian decorations from the British Museum!From sarcophaguses to scarab beetles and canopic jars to crocodiles, this book features more than 30 unique, intricately foiled designs that can be slotted together and to create 3D ornaments, hung up or threaded together to make an amazing amulet garland.Each page is covered in gold foil, with foiled pieces which can be pressed out and coloured in to make a fun collection of ancient Egyptian decorations.Over 30 different designs to press out, colour and display.Shiny gold foil on every page.Sturdy board pages allow you to repeatedly press pieces in and out of the book.Updated format with hardback spine.Press out the pieces, get creative with colour, then display your decorations!This book was developed in consultation with experts at the British Museum.

A raucous read-aloud rhyme for toddlers, part of Julia Donaldson's Toddler Club range and illustrated by bestselling Nick Sharratt.Join in with Julia Donaldson’s Toddler Club! This funny read-aloud rhyme is perfect for sharing with the youngest readers.All the animals are busy lending a hand in the garden in this lively numbers book! The parrots are pulling up carrots, the bears are picking pears and a swarm of bees are pruning the trees with their miniature shears. Even the smallest toddler will enjoy the wonderfully silly animal antics in this book, so join in the fun – you've never seen a garden like it!Nick Sharratt's mischievous and funny illustrations in a sturdy board book format make this playful book a sure winner.Toddlers can have more fun with Julia Donaldson's Toddler Club, in: Hippo Has a Hat, Animal Music, Toddle Waddle, Goat Goes to Playgroup, and Chocolate Mousse for Greedy Goose.

It's a busy day at the building site. Let's get to work! Use the interactive felt flaps to join in, help out and have fun!It's a busy day at the building site! Let's get to work!Can you help shovel the dirt with digger? And lift a heavy load with the crane?Use the bright and durable felt flaps to help the animals in this interactive and exciting board book, ideal for imaginative play!For fans of Maisy and Uh Oh, Niko, this series is perfect for those busy toddlers who always want to help out!Looking for more fun? Check out the other books in the series:Play Pals to the RescuePlay Pals at the ParkPlay Pals at the Hospital