Modeling Dose-Response Microarray Data in Early Drug Development Experiments Using R

Brain Quest, America's #1 educational brand with more than 57 million copies in print, is now for babies! My First Brain Quest board books introduce essential early learning concepts and foundational vocabulary using engaging visuals and Brain Quest's signature question and answer format.Give your child the best foundation to their education with this colorful and fun guide to shapes.My First Brain Quest: Shapes helps lay the foundation for pre-math skills, as children identify and describe shapes and their attributes. Questions help children build vocabulary and their understanding about the similarities and differences between shapes. Smart, colorful, grounded in educational principles, and reviewed by a panel of early learning experts, this board book introduces numbers in a fun, engaging way.

Help babies and toddlers master the building blocks of speech with this adorable, fun-to-read rhyming board book, written by an early speech expert!My First Learn-to-Talk Book is a joyful book that encourages speech development in little ones. By using adorable rhythmic rhyming text, simple exclamatory words and sounds, and engaging photographs of babies and toddlers, this book gives parents, grandparents, teachers, and therapists a new tool that does more than just entertain and engage babies and toddlers―it uses proven therapeutic techniques to help little ones think, repeat, react, and babble: the vital skills they need to talk!When I go down a slide, my mouth says "wheeee!"When I want a turn, my mouth says "me!"When I'm acting playful, my mouth says "boo!"When I hug my family, I say "I love you!"

Loved by millions of children, these classic peekaboo books are now gathered together in a boxed set that's ideal for gift giving—and for giving story time an extra dose of fun! Showcasing animals, ve

A tummy-time, fold-out book. This first focus frieze title is aimed at children from 3 months plus. In Counting, the panels are designed to aid babie 3+ months development by using recognisable high c

Sculpted pages that little ones can turn! Finally, early-learning concept books with pages that children can turn all by themselves! Created with the help of child development experts, this unique for

Finally, early learning concept books with pages that little ones can turn all by themselves! Created with the help of child development experts, this unique format is designed to keep the pages from

Finally, early learning concept books with pages that little ones can turn all by themselves! Created with the help of child development experts, this unique format is designed to keep the pages from

This is the way we use the potty. Do you know what to do?Are you ready to take your nappy offand try the potty too?Get ready for your little one's next big step with this adorable slider book you can read together before you start potty-training. This rhyming story is perfect for reading aloud together with toddlers, building familiarity and confidence around using the potty, and introducing some fun ideas for all the family to try.Little ones will love to unroll the toilet paper, slide a nappy down and spin a wheel to change clothes after a little accident. For parents and carers, each page features short practical tips to help you and your child, consulted by Early Years expert Lizzie Noble.

Welcome toMiniTouch: On the Go! A gorgeous, giftable touch-and-feel book for little ones from birth upwards. Introduce vehicles and first words, and boost motor skills with sensory touch-and-feel fabrics.The MiniTouch series for babies aged 0–3 is packed full of developmental benefits. Fresh, stylish and playful with gently rhyming text, each book makes a beautiful addition to your child's playspace or bookshelf,forming an eye-catching collection.The content of each book covers core early learning concepts. There are two layers of learning: the first being topic-themed, such as vehicles, and the second being learning-based, such as first words. Theplayful rhyming text is perfect for engaging your childand will help develop their rhythm and rhyme as well as bringing added context to each new word.Each book in the series features a unique range of touch-and-feel areas, which are ideal for developing your child's motor skills as well as aiding sensory development. Fabrics such as corduroy

Trace the trails for search and find finger fun!Discover finger-tracing fun as you trace the trails and follow the shark through the busy under-the-sea pictures. There are peekaboo windows to peep through, and lots of splashing, snapping and swimming sea creatures to spot, too!Bright illustrations feature lots of detail to spot and words to say out loud, andaid development of first wordsand early reading.Perfect forsensory funandinteractive play.Helps to develop bothmotor and literacy skills.

Trace the trails for search and find finger fun!Discover search-and-find finger-tracing fun as you trace the trails and follow the tractor through the busy farmyard pictures!Each scene is full of lots of neighing, oinking, and baaing farm animals to spot, too!Bright illustrations feature lots of detail to spot and words to say out loud, and aid development of first words and early reading.There are tactile trails to follow, bumpy textures to find and feel, plus peep-through windows lead you through the pages as you follow that tractor and find out where it is going!The tactile trails, bumpy textures and peep-through holes are perfect for sensory fun and interactive play.

Trace the trails for search and find finger fun!Discover search-and-find finger-tracing fun as you trace the trails and follow the truck through the busy pictures!Each scene is full of lots of beeping, chugging and rumbling vehicles to spot, too!Bright illustrations feature lots of detail to spot and words to say out loud, and aid development of first words and early reading.There are tactile trails to follow, bumpy textures to find and feel, plus peep-through windows lead you through the pages as you follow that truck and find out where it is going!The tactile trails, bumpy textures and peep-through holes are perfect for sensory fun and interactive play.

Lively illustrations by well-known artist and illustrator Kaley McKeanSupports science teaching in schoolsFirst in an exciting, bright new series of lift-the-flap books - 'How It Works'An ILLUMINATING introduction to the science of lightLift the flaps to discover what light is, where it comes from and how it works, from rainbows and reflections to lightyears and lasers. Then see light in action for yourself by trying out some simple home experiments.

Brain Quest, America's #1 educational brand with more than 57 million copies in print, is now for babies! My First Brain Quest board books introduce essential early learning concepts and foundational vocabulary using engaging visuals and Brain Quest's signature question and answer format.From the rain in the sky to the grass at their feet, help your child understand the world around them with the guidance of this fun and exciting introduction to science!My First Brain Quest: First Words: Science Around Us introduces babies and toddlers to more than 100 STEM-related vocabulary words in their world—in the backyard, at the doctor's office, at the beach. Each scene features labeled illustrated objects as well as brief captions that help to introduce STEM concepts and help put into context, alongside questions that encourage conversation between reader and child. Children have fun naming, counting, and comparing.

Hello, USA! This delightful board book from Hello, World creator Ashley Evanson pairs early learning concepts with colorful, stylish illustrations of the iconic art, architecture, food, and culture from all 50 US states.In Hello, USA! A Book of Beginner Concepts, readers learn all about the 50 states through five sections of early reading concepts (numbers, months, colors, shapes, and opposites): from the eight iconic stripes on Maine's Acadia Lighthouse to four purple wildflowers in Montana's Glacier National Park to the colorful rectangle houses in South Carolina's Charleston, and more -- all in Ashley Evanson's dynamic Hello, World style.

Have fun and discover letter shapes in this moving-counter play book!Toddlers can start their writing journey without having to grasp a pen ­- just slide the counters around each track and have fun with the rhyming text!This book features curved tracks that mimic early handwriting patterns and with Waves and Wiggles little ones can become familiar with letter shapes: W, M, N, U and V. The five sliding counters in this book have fingerholes to help keep little hands steady and the rhyming narrative and bright illustrations from Ekaterina Trukhan will keep them entertained as they whizz around the tracks!This Learn&Play title:Boosts motor skillsIntroduces letter shapesRecommended for children 2+Look out for the other Ladybird Learn&Play title:Swirls and Squiggles

Have fun and discover letter shapes in this moving-counter play book!Toddlers can start their writing journey without having to grasp a pen ­- just slide the counters around each track and have fun with the rhyming text!This book features curved tracks that mimic early handwriting patterns and with Swirls and Squiggles little ones can become familiar with letter shapes: S, C, Z, E and O. The five sliding counters in this book have fingerholes to help keep little hands steady and the rhyming narrative and bright illustrations from Ekaterina Trukhan will keep them entertained as they whizz around the tracks!This Learn&Play title:Boosts motor skillsIntroduces letter shapesRecommended for children 2+Look out for the other Ladybird Learn&Play title:Waves and Wiggles

It's play time! Can you play on the swings and jump on the trampoline?In this fun new series, little ones learn first words and experiences by using satisfying sliders and sturdy flaps. Each spread in

It's gardening time! Can you rake the soil and plant the seeds?In this fun new series, little ones learn first words and experiences by using satisfying sliders and sturdy flaps. Each spread introduce

Introduce your baby to first colours in this gorgeous pop-up book, illustrated by Nila Aye. Based on the popular tale of Little Red Riding Hood, a simplified story runs through the book for a shared r

It's time for bed, but Goat isn't tired. Thankfully, he can get his sillies out during his bedtime routine, leaving him ready for bed in the end. Using light text and funny illustrations, this board b

Oh no! It's raining. Can you help Bear put on his wellington boots and rain mac?In this fun new series, little ones learn first words and experiences by using satisfying sliders and sturdy flaps. Each

This delightful interactive book is a charming introduction to the four seasons, changes in the weather, changes in the natural world and seasonal activities. A fun introduction to a key early learnin

Slide Surprise is a new series using sliding mechanisms to create fun, lively stories in vibrant colors with subjects that children will identify with. Go Wild! uses a jungle setting and includes many

A charming, interactive introduction to space, exploring not just what's in space, but what it would be like to actually visit. Find out what you can hear, see and eat, and what living on Mars would r

Presents the letters of the alphabet with elements from the nineteen-fifties representing each letter, from A for atom and D for drive-in to H for hot rod and R for rock-n-roll.

Little ones will love using their fingers to follow the glittery, bumpy shiny trails in DK's Follow The Trail Trucks. This tactile board book is packed with colourful illustrations to help encourage e

Join Bear as he tries out different forms of transport and has an adventure with each one. Rhyme and repetition support the learning layers of travel and transportation, as Bear travels in a raft, a r

Join in this popular nursery rhyme as you slide and play with this interactive board book!Sing along with your baby as you help Little Bo Peep find her lost sheep with this sturdy book that encourages language development. Use the Stories Aloud QR code to listen to the song and join in the words as you pull the sliders and spin the wheel. The perfect first introduction to this classic nursery rhyme. Other titles in the series: Here We Go Round the Mulberry Bush, Five Little Speckled Frog, Polly Put the Kettle On, Old MacDonald Had a Farm and Twinkle, Twinkle, Little Star, plus many more.

Find out how a submarine works in this interactive book with flaps and holes.Lift flaps and peep through holes to explore with a little sub on a deep-sea dive. Find out how the sub works by opening it up and peeping inside at the cockpit and the ballast tanks, and help the crew collect deep-sea samples using the mechanical arms. There's lots to learn about marine life, too - investigate what an octopus is guarding, meet a hammerhead shark and switch off the sub lights to see all the glowing creatures in the dark.

Join Bluey and Bingo in this push-and-pull book and help them find all the critters! From witchetty grubs to butterflies, this interactive format is perfect for little Bluey fans. Slide the scroll bar, pull the tab and spin the wheel to discover what bugs are hiding in this book!“Hello, itchitty grubs!” Don’t miss these other awesome Bluey books:Bluey: A Big Pop-Up BookBluey: Outdoor Games: A Lift-the-Flap BookBluey: Toys: A Touch-and-Feel playbookBluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK.Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

Join in this popular nursery rhyme as you slide and play with this interactive board book!Sing along with your baby as you do the actions to Pat-a-Cake with this sturdy book that encourages language development. Use the Stories Aloud QR code to listen to the song and join in the words as you pull the sliders and spin the wheel. The perfect first introduction to this classic nursery rhyme. Other titles in the series: Here We Go Round the Mulberry Bush, Five Little Speckled Frog, Polly Put the Kettle On, Old MacDonald Had a Farm and Twinkle, Twinkle, Little Star, plus many more.

A stompingly good novelty book with hilarious animals and fun sliders!With simple rhyming text, things to push pull and spin, and brilliant illustrations from Guilerhem Karsten, children will love to copy the movements of these animals and join in the jungle fun.A fun way to develop a child's physical development and encourage them to explore the way their bodies move.Look out forAnimal Actions: Snap Like a Crabtoo!

Join the unicorns and their fairy friends as they fly over a rainbow, explore and enchanted forest and splash in a magical pond. Move the chunky sliders to reveal lots of little surprises. The eye-catching illustrations are designed for very young children, and the sliders, cut-outs and fingertrails are brilliant for developing essential early learning skills.

My Very First Britannica Encyclopedia 是一本為學齡前孩子設計的第一本百科全書。從地球到音樂、數字到食物，以最貼近孩子視角的方式，呈現世界的多樣與驚奇。語言簡潔、節奏感強，適合朗讀，圖像溫暖生動，幫助幼兒建立語彙與認知概念，是親子共讀、日常探索的最佳起點。The first-ever Britannica Encyclopedia for children under three, in a beautifully illustrated, large-format board book.My Very First Britannica Encyclopedia explores big ideas through a little one’s eyes. This huge board book covers an enthralling spectrum of topics: Earth, Animals, Plants, Food, Machines, Art, Music, Numbers and Shapes. The simple, clear and lyrical text includes plenty of sound words for an enjoyable reading-aloud experience, and is paired with gorgeous illustrations by Hanako Clulow. Reviewed by early-years specialist Dr Amanda Gummer, as well as a host of Britannica subject experts, this is the perfect book to inspire little brainiacs!Quotes/Reviews"Rocket fuel for cognitive development."-Wall Street JournalSelected for Waterstones Best Children's Books in October 2022 List"Just the right amount of information is included

Follow Little Bee as she buzzes from garden to greenhouse to desert, visiting all kinds of different blooms, each one as beautiful and fascinating as the next.Little Bee leaves her hive and flies out to discover the many beautiful and strange plants and flowers that bring color to the world. Buzz by dazzling tulips and floating water lilies but watch out for the snapping Venus flytraps!Packed with bright illustrations and creative wordplay, this chunky board book is designed to instill a love of nature from an early age, great for reading aloud yet perfect for bedtime, finishing with a peaceful nighttime scene. Written by an expert baby-book writer, using sound effects and simple phrases to engage babies with the pictures on the page, this series of board books has broad appeal to both Zommer fans and gift givers alike.

Find your baby’s face in this delightful new lift-the-flap book with a mirror on every page!One thing is for sure – babies love mirrors! This series of board books aims to enhance early mirror play as very young children will enjoy finding their own face on every page. Featuring large card flaps with friendly animals which are easy for even the littlest hands to grab, babies will enjoy reaching for these books again and again.Scan the QR code on the back cover to join in with the playful rhyming song based on the classic ‘Finger Family’ rhyme!Other books in the series include: Little Bear, Little Dog, Little Owl, Little Tiger, Little Lamb, Little Lion and Little Mouse

Sing along with Bluey and Bingo!Bluey and Bingo love to sing! They even make up fun songs for their games. Join them and sing along to The Wheels on the Bus, Ten Green Bottles and Poor Little Bug on the Wall, and other Bluey and Bingo tunes.Follow the tabs in this musical board book and start singing!More Bluey fun:Bluey: Love From BlueyBluey: PerfectBluey: What Games Should We Play?Bluey is an Emmy award-winning Australian children's television programme following the adventures of a loveable six-year-old Blue Heeler Puppy, Bluey and her family. It’s currently showing on Disney+, BBC iPlayer and CBeebies in the UK. Bluey enjoys exploring the world and using her imagination to turn everyday life into an amazing adventure. Join Bluey in this fun collection of story, activity and novelty books that celebrate play.

Find your baby's face in this delightful new lift-the-flap book with a mirror on every page! One thing is for sure - babies love mirrors! This series of board books aims to enhance early mirror play as very young children will enjoy finding their own face on every page. Featuring large card flaps with friendly animals which are easy for even the littlest hands to grab, babies will enjoy reaching for these books again and again. Scan the QR code on the back cover to join in with the playful rhyming song based on the classic 'Finger Family' rhyme! Other books in the series include: Little Bear, Little Dog, Little Owl, Little Tiger, Little Lamb and Little Lion

An exciting new collection of board books for early years fun!A new collection of board books introducing early concepts and the world of Dr. Seuss, perfect for babies and toddlers!Flip the flap – what can you see? Full of Dr. Seuss’s craziest characters and wittiest rhymes, this collection of eight lift-the-flap board books is perfect for introducing early concepts to young readers.Bright, vibrant and with interactive flaps throughout, these books are brilliantly designed for babies and toddlers and offer a perfect first step into the wonderfully wacky world of Dr. Seuss.Includes:Silly OppositesAmazing AnimalsWacky WeatherDizzy DaysSpecial ShapesSuper SensesCrazy ColoursNutty Numbers