Statistics at the Bench in R is a convenient bench-side handbook for biologists, designed as a handy reference guide for elementary and intermediate statistical analyses using the free/public software
Orphan is about the struggle to save the lives of children who, because of an unlucky roll of the genetic dice, are born with any one of several thousand rare genetic disorders. Many are burdened with
Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine reviews our understanding of the molecular mechanisms involved in conception, pregnancy, la
Size is a primary feature of living things. From egg to adult, the various organs, tissues, cells, and subcellular structures that make up an organism grow to appropriate sizes so that they effectivel
The Proceedings of the 79th Symposium capture many of the tremendous discoveries currently being made by neuroscientists and psychologists working on cognitive processes at scales varying from the mol
The Proceedings of the 79th Symposium capture many of the tremendous discoveries currently being made by neuroscientists and psychologists working on cognitive processes at scales varying from the mol
Bacteria have been the dominant forms of life on Earth for the past 3.5 billion years. They rapidly evolve, constantly changing their genetic architecture through horizontal DNA transfer and other mec
Despite the availability of an effective vaccine for hepatitis B, hundreds of millions of people worldwide are infected with the hepatitis B virus (HBV). This virus can cause serious liver damage and
Our brains learn and remember information by modifying synaptic connections in neuronal networks. These changes occur in different circuits and regions of the brain, depending on the occasion. The und
In this book, the distinguished geneticist David Botstein offers help and advice to scientists and physicians daunted by the arcane technical terms that flourish in his discipline. As knowledge of gen
Members of the transforming growth factor b (TGFb) family, which include activins and bone morphogenetic proteins (BMPs), are essential intercellular signaling molecules that control of cell prolifera
Prevail Through Knowledge: A History of Cold Spring Harbor Laboratory is published to mark the Laboratory's 125th anniversary. Written by historian Jan Witkowski, Executive Director of the Laboratory'
Virtually every cell in a living organism contains an identical set of chromosomes thanks to mitosis, a complex process involving hundreds of proteins and regulatory steps that ensures duplicated chro
Regulated cell death, which is involved in nearly every aspect of animal development and physiology, can be challenging to study in the laboratory. There are multiple types of cell death, several inte
Regulated cell death, which is involved in nearly every aspect of animal development and physiology, can be challenging to study in the laboratory. There are multiple types of cell death, several inte
Next-generation DNA sequencing (NGS) technology has revolutionized biomedical research, making genome and RNA sequencing an affordable and frequently used tool for a wide variety of research applicati
The heart is the first organ to form in a developing embryo, and all subsequent life processes depend on its proper function. But a range of genetic and environmental factors can lead to its failure.
"Fungal infections affect millions of individuals worldwide. They a particular danger to immunocompromised individuals, such as those with HIV/AIDS, and invasive infections often have a mortality rate
Tuberculosis (TB) is a serious infectious disease of the lungs that is usually caused by the bacterium Mycobacterium tuberculosis. Nearly one-third of the world's population is currently infected with
"Metabolic pathways used to be "road maps" most biologists learned as undergraduates and then promptly forgot. Recent work has revealed how changes in metabolism are closely linked to many aspects of
"Glia are cells that serve to nourish and support the neuronal cells that relay electrical signals through the nervous system. They also play critical roles in development and synapse formation, helpi
The regulation of gene expression in many biological processes involves epigenetic mechanisms. In this new volume, 36 chapters written by experts in the field discuss epigenetic effects from many per
Eukaryotic cells are remarkably complex structures, containing a vast repertoire of macromolecules, organelles, and other compartments that orchestrate the tasks required for life. For in-depth studie
This laboratory manual presents 18 chapters that outline step-by-step protocols (both traditional and innovative) for the extraction of subcellular components from animal tissues, yeasts, plants, and
The innate immune system is rapidly activated in response to infection and injury. It is a generic rather than pathogen-specific response that recruits immune cells, promotes inflammation, and mobiliz
Patents are an important way of protecting inventions in the pharmaceutical and biotechnology industries. However, intellectual property law reforms have not kept pace with the rapid advances in genom
Recombination mechanisms allow cells to break and reattach DNA sequences. They are important for repair of damaged DNA. They also help generate additional genetic diversity in sperm and eggs cells by
Perhaps one of the most important drivers of evolution, sexual conflict results from the differing genetic interests of males and females of a single species during sexual reproduction. This collectio
A wide variety of powerful molecular techniques have been applied to biology in recent decades, ranging from recombinant DNA technologies to state-of-the-art imaging methods. But the plethora of techn
Molecular genetics has revolutionized many fields of biology, including neuroscience, through the application of new techniques like recombinant DNA studies and new imaging options. This guide offers
Since the appearance of modern humans in Africa around 200,000 years ago, we have migrated around the globe and accumulated genetic variations that affect various traits, including our appearance, ski
The retina is a layer of neural tissue that lines the inner eye and captures visual stimuli. Hereditary, physiologic, or environmental factors can lead to various retinal disorders and may cause blind
"Experimental Design for Biologists is a unique and successful handbook on the theory and practice of effective design of scientific experiments, based on a well-received course by the author. This se
"The first time I went to the United States was in 1953...to the Cold Spring Harbor symposium where Jim Watson described in detail his model of double helix. All these symposia were extremely importan
"The first time I went to the United States was in 1953...to the Cold Spring Harbor symposium where Jim Watson described in detail his model of double helix. All these symposia were extremely importan
"This book is an introductory course in molecular biology for mathematicians, physicists, and engineers. It covers the basic features of DNA, proteins, and cells but in the context of recent technolog
Universities are granting ever more PhDs in biomedical fields, but the number of tenured teaching and academic research positions--traditional destinations for PhD students--is not growing at the same
Informatics can vastly assist progress in research and development in cell and molecular biology and biomedicine. However, many investigators are either unaware of the ways in which informatics can im
All protists, fungi, animals, and plants on Earth are eukaryotes. Their cells possess membrane-bound organelles including a nucleus and mitochondria, distinct cytoskeletal features, and a unique chrom
Many of us wonder how our heritage has influenced who we are and what we have become. The renowned scientist and author James D. Watson has more to reflect upon than most. A Radio Quiz Kid at 12 and a
