"The skin is a continually renewing organ that acts as a protective barrier isolating us from the external environment. This book examines the cells that make up the skin and their functions, as well
Academic scientists may find it hard to negotiate consulting agreements with biotechnology or pharmaceutical companies. The fine print is daunting, anxieties abound on both sides, and there are pitfa
During endocytosis, extracellular molecules and plasma membrane components are selectively internalized by cells. This fundamental process of "cellular ingestion" is required for diverse activities su
Genome Science is a textbook and laboratory manual for advanced secondary and post-secondary education. It combines approachable narrative with extensively tested lab exercises that illustrate key con
The transplantation of organs such as the heart, kidney, and lungs is an important means of replacing seriously damaged or diseased body parts. However, a transplanted organ may fail if the recipient'
Specialists from specific fields explain how the genetics of the past decade or two has changed the understanding of human history, diversity, and race. They also explore what that new understanding m
Bacterial pathogens cause numerous human diseases. This collection from Cold Spring Harbor Perspectives in Medicine surveys the spectrum of bacterial pathogens from Salmonella and Shigella to Heliobac
The MYC gene is frequently activated in cancer. It encodes a transcription factor that controls gene expression programs regulating numerous aspects of cellular behavior, including cell proliferation,
Cell culture systems for specific neural cell types are essential for studies of their development and function.This laboratory manual provides step-by-step protocols for isolating specific cell popul
Cell culture systems for specific neural cell types are essential for studies of their development and function.This laboratory manual provides step-by-step protocols for isolating specific cell popul
Mitochondria are intracellular organelles that power the cell by metabolizing glucose and other energy sources to generate ATP. They are also critical in programmed cell death, and dysfunction of mito
Cells must respond to a wide variety of signals. These include hormones, growth factors, morphogens, and environmental stress, as well as signals from internal regulators and checkpoints. A complex ne
This 4th edition of the "Mouse Manual"-Manipulating the Mouse Embryo-appears 28 years after the first edition and once again is the definitive reference source on mouse development, transgenesis techn
Signaling by calcium ions is an important regulator of muscle contraction, nerve impulses, fertilization, and numerous other cellular processes. This book explores the experimental techniques used to
Receptor tyrosine kinases are cell-surface receptors that respond to numerous hormones and growth factors, including insulin, insulin-like growth factors, epidermal growth factor, and nerve growth fac
Signaling by calcium ions is an important regulator of muscle contraction, nerve impulses, fertilization, and numerous other cellular processes. This book explores the experimental techniques used to
London's Imperial Cancer Research Fund laboratories at Lincoln's Inn Fields and Clare Hall (renamed The London Research Institute in 2002) were world-famous for a century. This book, published with th
This second edition of the now-classic lab manual Antibodies, by Harlow and Lane, has been revised, extended, and updated by Edward Greenfield of the Dana-Farber Cancer Center, with contributions from
Lab Math: A Handbook of Measurements, Calculations, and Other Quantitative Skills for Use at the Bench, 2nd edition, collects in one place the numbers and equations you rely on for your experiments an
During the last decade, research in developmental biology has undergone a dramatic change brought about by the availability of whole genome sequences from diverse organisms, the availability of transc
Hemoglobin is an iron-containing protein in red blood cells that transports oxygen to tissues throughout the body. The abundance, stability, and oxygen-carrying properties of hemoglobin can be altered
Plants are integral to human wellbeing, and many species have been domesticated for over ten thousand years. Evidence of plant scientific investigation and classification can be found in ancient texts
Plants are integral to human wellbeing, and many species have been domesticated for over ten thousand years. Evidence of plant scientific investigation and classification can be found in ancient texts
Cystic fibrosis is caused by mutations in the CFTR gene, which encodes a protein channel that regulates salt movement across the epithelial membranes of the lungs, pancreas, and other organs. In cysti
Immune tolerance ensures that the immune system generates T-cell and B-cell populations that react to foreign antigens rather than endogenous molecules.
DNA replication is essential for the propagation of life on Earth. Cells in living organisms must be able to synthesize a complete copy of their DNA with extraordinary precision, so that they can pass
In Russia, the initial euphoria of the Bolshevik leaders for a new socialist society, combined with a commitment to a truly universal health care system, gave a huge boost to the emergence of both the
One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operat
The endoplasmic reticulum (ER) is an extensive network of membranes that folds, modifies, and transports proteins in eukaryotic cells. It also manufactures lipids and interacts extensively with other
One of the foundations of molecular biology is how the interactions of proteins with DNA control many aspects of gene expression. Since the mid-20th century discoveries of the lac repressor and operat
Nineteen chapters review the process and regulation of protein synthesis as understood through recent research. Among the topics are new insights and challenges in the mechanism of eukaryotic translat
Twenty three chapters were selected to provide a bench-to-bedside understanding of the adult-onset neurodegenerative condition, bridging the gap between clinical concerns and the basic science. Among
Signaling by the Wnt family of secreted proteins is recognized as one of the most fundamental and conserved regulatory systems in animals, controlling many critical aspects of development and adult ti
The anthology updates scientists and clinicians on all aspects of the autoimmune disease that manifests as uncontrolled high blood sugar levels because of pancreatic beta-cell loss and dysfunction. Am
This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding
This volume is based on presentations by world-renowned investigators who gathered at the 76th Cold Spring Harbor Symposium on Quantitative Biology. It reviews the latest advances in our understanding
Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years. No other manual has been so popular, or so influential. Molecular Cloning, Fourth Edition, by the
Molecular Cloning has served as the foundation of technical expertise in labs worldwide for 30 years. No other manual has been so popular, or so influential. Molecular Cloning, Fourth Edition, by the
Alzheimer disease causes the gradual deterioration of cognitive function, including severe memory loss and impairments in abstraction and reasoning. Understanding the complex changes that occur in the
