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The anthology updates scientists and clinicians on all aspects of the autoimmune disease that manifests as uncontrolled high blood sugar levels because of pancreatic beta-cell loss and dysfunction. Among the topics are the breakdown in peripheral tolerance in type 1 diabetes (T1D) in mice and humans, humoral autoimmunity immunologic and metabolic biomarkers of beta-cell destruction in the diagnosis of T1D, the hygiene hypothesis to explain the increasing frequency of insulin-dependent diabetes, advancing animal models of human T1D by grafting functional human tissues in immunodeficient mice, and clinical immunologic interventions. Annotation c2013 Book News, Inc., Portland, OR (booknews.com)
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