This collection of cutting-edge techniques for the study of the eukaryotic cell cycle and its key regulatory molecules includes overviews of cell cycle regulatory mechanisms in many major research or
The first collection of methods to study embryonic and fetal hematopoiesis in both invertebrate (fruit flies) and vertebrate (frog, fish, mouse, chick, and human) organisms. These state-of-the-art tec
In this collection, experts review clinical and preclinical genomics and describe changes in gene expression to physiological end points to produce a more holistic approach combining molecular biology
Platelets, the essential element of the body's hemostasis system, are also involved in thrombosis. Their life span is limited and they must be continuously manufactured by their precursor, the megakar
Platelets, the essential element of the body's hemostasis system, are also involved in thrombosis. Their life span is limited and they must be continuously manufactured by their precursor, the megakar
Gu (microbiology, Columbia University) and Rajewsky (The Center for Blood Research, Harvard Medical School) present a collection of protocols that range from the latest inventions and applications to
Public Health Microbiology: Methods and Protocols is focused on microorganisms that can present a hazard to human health in the course of everyday life. There are chapters dealing with organisms that
Pioneering bench researchers describe in detail the cutting-edge techniques they have developed for analyzing the genomes and gene products in a diverse range of protozoan and metazoan parasites. The
Fu (pharmacology, Emory University School of Medicine) provides descriptions of biochemical, biophysical, genetic, and computational techniques for studying protein-protein interactions. The reproduci
Schatten (veterinarian pathobiology, University of Missouri) brings together laboratory investigators to describe techniques for the molecular and genetic analysis of germ cells in a variety of differ
Because tumor necrosis factor-alpha plays a pivotal role in the regulation of homeostasis and inflammatory immune responses, it offers researchers opportunities to develop new drugs for the treatment
A collection of cutting-edge methods for investigating G protein signaling from a variety of perspectives ranging from in vitro biochemistry to whole animal studies. Among the readily reproducible tec
Twenty-four papers describe protocols for gene delivery using a variety of chemical and physical methods, including ultrasound, biolistics, peptides, PNA clamps, liposomes, microinjection, electropora
Highly experienced researchers describe in step-by-step detail methods that have proven most useful in delivering genes to mammalian cells. Volume 2: Viral Gene Transfer Techniques, details procedures
Highly experienced physicians and biologists clearly explain the basic technical knowledge needed to use AFM and demonstrate its multifarious uses in biomedicine and the life sciences. The application
In a volume bridging a "PRC generation gap" even though the field is only some 20 years old, UK scientists introduce the origin and applications of the polymerase chain reaction that is now a keystone
Academy researchers and industry practitioners from the US and Australia, with a few European outliers, offer a detailed guide to some of the most commonly used approaches to investigating plant gene
This outstanding new textbook provides a comprehensive overview of qualitative approaches to educational research. The text draws upon a broad range of real-life examples to describe and illustrate th
A comprehensive compendium of cutting-edge protocols for the generation of molecular diversity. Described in step-by-step detail to ensure experimental success, these protocols include readily reprod
Pioneering researchers describe leading fluorescence in situ hybridization (FISH) techniques in step-by-step fashion and look at molecular technologies beyond FISH now available for diagnostic servi
Presenting statistical methods for the genetic analysis of quantitative traits, 12 contributions review recent methodologies in the areas of human traits underlying disease, experimental organisms as
". . . the writing makes this book interesting to all levels of students. Bobko tackles tough issues in an easy way but provides references for more complex and complete treatment of the subject. . .
Katherine Bushby and Louise Anderson assemble an outstanding collection of key techniques for the analysis of DNA and protein from patients suspected to suffer from muscular dystrophy. Each method is
Researchers, engineers, and technologists explain in detail how to design and construct DNA microarrays, as well as how to hybridize them with biological samples for analysis. They offer step-by-step
John R. Crowther provides todayA-s premier practical guide to the understanding and application of ELISA. Updating and greatly expanding his widely appreciated earlier publication, ELISA Theory and P
Computer-Aided Reasoning: ACL2 Case Studies illustrates how the computer-aided reasoning system ACL2 can be used in productive and innovative ways to design, build, and maintain hardware and software
Research gastroenterologists, immunologists, and other scientists detail laboratory methods for studying the biology and immunopathology of celiac disease, which involves sensitivity to gluten. They i
Object-Z is an object-oriented extension of the formal specification language Z. It adds to Z notions of classes and objects, and inheritance and polymorphism. By extending Z's semantic basis, it e
Looking for a practical introduction to the strategies and methods of qualitative evaluation? Ian Shaw shows how evaluation practice can utilize qualitative approaches to gain an understanding that mo
Leading forensic experts from around the world describe in detail their time-proven methods for identity testing through DNA analysis. Their state-of-the-art collection of easily reproducible methods
A collection of 26 contributions describing the latest experimental methods for herpes virology ranging from the more biological in vivo maneuvers to the purely molecular. Most of the protocols rely
Conducting studies of natural and man-made air contaminants is a specialized research activity that draws upon skills from a variety of disciplines including toxicology, pharmacology, industrial hygie
Electroporation is one of the most widespread techniques used in modem molecular genetics. It is most commonly used to introduce DNA into cells for investigations of gene structure and function, and i
This book provides a systematic introduction to models, methods and applications of event history analysis. Yamaguchi emphasizes 'hands on' information, including the use and misuse of samples, models
Like all writing, biographies are interpretive. They require no less than organizing into text the chaos of human existence. InInterpretive Biography Denzin combines one of the oldest techniques in th
This provocative volume deals with one of the chief criticisms of ethnographic studies, a criticism which centres on their particularism or their insistence on context -- the question is asked: How ca
Kirk and Miller define what is -- and what is not -- qualitative research. They suggest that the use of numbers in the process of recording and analyzing observations is less important than that the r
