MOLECULAR STRUCTURE & ENERGETICS V10 - ENVIRONMENTAL INFLUENCES & RECOGNITION IN ENZYME CHEMISTRY

Nine chapters by leading researchers from a variety of disciplines examine the structure/activity of enzymes that depend on their surrounding, including other proteins, cofactors, substrates, the reaction medium, and even themselves. The modern techniques discussed, both experimental and calculational, range from the systematic use of crystal structures to the mathematics of fractals to the design of antibodies that behave as enzymes.

Vitamin B_12 and Its Coenzymes: Structures and Reactivities.

Influences of Solvent Water on Transition State Stabilization.

Structure of Hydration Shells Around Hyrophobic Molecules.

Proximate Charge Effects.

Protein Folding.

Fractal Surfaces of Proteins.

Artificial Allosteric Molecules -
Especially Focusing Upon Allosteric O_2 Bindign Molecules of the Hemoglobin Type.

Progress in Molecular Recognition.

Computational Analysis of Molecular Recognition by Artificial Enzymes.

Specificity and Mechanism of the Chemical Nuclease Activity of 1,10 -
Phenantroline-Copper Ion.

Catalytic Antibodies: Generation and Characterization.