Carbohydrate-Based Drug Discovery 2V Set

This handbook presents the latest knowledge on carbohydrate chemistry and biochemistry so as to exploit the full potential of this diverse compound class for the development of novel active substances. While it is unique in covering the entire field, particular emphasis is placed on carbohydrates with pharmaceutical potential. Topics include the following:

• Chemical synthesis of carbohydrates
• Carbohydrate biosynthesis and metabolism
• Carbohydrate analysis
• Cellular functions of carbohydrates
• Development of carbohydrate-based drugs

A premier resource for carbohydrate chemists and drug developers, this comprehensive two-volume work contains contributions by more than 50 of the world's leading carbohydrate chemists.

Professor Chi-Huey Wong received his B.S. and M.S. degrees from National Taiwan University, and Ph.D. in Chemistry (with George Whitesides) from Massachusetts Institute of Technology in 1982. He started his independent career as Assistant Professor of Chemistry at Texas A&M University in 1983, where he became Full Professor in 1987. He has been Professor and Ernest W. Hahn Chair in Chemistry at the Scripps Research Institute since 1989 and is also a member of the Skaggs Institute for Chemical Biology since 1996.
Professor Wong is a member of the U.S. National Academy of Sciences and the American Academy of Arts and Sciences. He is a recipient of The Searle Scholar Award in Biomedical Sciences (1985), the Presidential Young Investigator Award in Chemistry (1986), the American Chemical Society A.C. Cope Scholar Award (1993), the Roy Whistler Award of the International Carbohydrate Organization (1994), the American Chemical Society Harrison Howe Award in Chemistry (1998) and the Claude S. Hudson Award in Carbohydrate Chemistry (1999), the International Enzyme Engineering Award (1999) and the Presidential Green Chemistry Challenge Award (2000). He is a member of Academia Sinica, Taipei (1994), the American Academy of Arts and Sciences (1996) and the US National Academy of Sciences (2002). He serves as editor-in-chief of Bioorganic and Medicinal Chemistry and is an executive board member of the Tetrahedron Publications. He was head of the Frontier Research Program on Glycotechnology at RIKEN (Institute of Physical and Chemical Research, Japan) (1991-1999) and is currently a scientific advisor of the Max-Planck Institute, a board member of the U.S. National Research Council on Chemical Sciences and Technology, and is a founding scientist of Optimer Pharmaceuticals, Inc. He is author and co-author of over 450 publications, 60 patents and several books.
His current interests are in the areas of bioorganic and synthetic chemistry and biocatalysis, including development of new synthetic chemistry based on enzymatic and chemo-enzymatic reactions, synthetic approach to carbohydrate-mediated biological recognition, design and synthesis of mechanism-based inhibitors of enzymes, RNA and carbohydrate receptors, development of oligosaccharide and aminoglycoside microarrays for high-throughput screening and the study of reaction mechanisms.

VOLUME 1.

Preface.

List of Contributors.

1. Synthetic Methodologies (C. Saotome and O. Kanie).

2. Complex Carbohydrate Syntyhesis (M. Kiso, et al.).

3. The Chemistry of Sialic Acid (G. Boons and A. Demchenko).

4. Solid-Phase Oligosaccharide Synthesis (P. Seeberger).

5. Solution and Ploymer-Supported Synthesis of Carbohydrates (S. Nishimura).

6. Enzymatic Synthesis of Oligosaccharides (J. Zhang, et al.).

7. Glycopeptides and Glycoproteins: Synthesis Chemistry and Biology (O. Seitz).

8. Synthesis of Complex Carbohydrates: Everninomicin 13,384-1 (K. Nicolaou, et al.).

9. Chemical Synthesis of Asparagine-Linked Glycoprotein Oligosaccharides: Recent Examples (Y. Ito and I. Matsuo).

10. Chemistry and Biochemistry of Asparagine-Linked Protein Glycosylation (B. Imperiali and V. Tai).

11. Conformational Analysis of C-Glycosides and Related Compounds: Programming Conformational Profiles of C- and O-Glycosides (P. Goekjian, et al.).

12. Synthesis Lipid A Antagonists for Sepsis Treatment (W. Christ, et al.).

13. Polysialic Acid Vaccines (H. Jennings).

14. Synthesis Carbohydrate-Based Vaccines (S. Keding and S. Danishefsky).

15. Chemistry, Biochemistry, and Pharmaceutial Potentials of Glycosaminoglycans and Related Saccharides (T. Islam and R. Linhardt).

16. A New Generation of Antithrombotics Based on Synthetic Oligosaccharides (M. Petitou and J. Herbert).

VOLUME 2.

17. Sequencing of Oligosaccharides and Glycoproteins (S. Haslam, et al.).

18. Preparation of Heterocyclic 2-Deoxystreptamine Aminoglycoside Analogues and Characterization of their Interaction with RNAs by Use of Electrospray Ionization Mass Spectrometry (R. Griffey, et al.).

19. Glycosylation Aanalysis of a Recombinant P-Selectin Antagonist by High-pH Anion-Exchange Chromatography with Pulsed Electrochemical Detection (HPAEC/PED) (M. Hardy and R. Cornell).

20. Analytical Techniques for jthe Characterization and Sequencing of Glycosaminoglycans (R. Sasisekharan, et al.).

21. Thermodynamic Models of the Multivalency Effect (P. Kitov and D. Bundle).

22. Synthetic Multivalent Carbohydrate Ligands as Effectors or Inhibitors of Biological Processes (L. Kiessling, et al.).

23. Glycosyltransferase Inhibitors (K. Jung and R. Schmidt).

24. RNA-Aminoglycoside Interactions (H. Weizman and Y. Tor).

25. Glycosylated Natural Products (J. Thorson and T. Vogt).

26. Novel Enzymatic Mechanisms in the Biosynthesis of Unusual Sugars (A. Wong, et al.).

27. Neoglycolipids: Identification of Functional Carbohydrate Epitopes (T. Feizi, et al.).

28. A Preamble to Aglycone Reconstruction for Membrane-Presented Glycolipid Mimics (M. Mylvaganam and C. Lingwood).

29. Small Molecule Inhibitors of the Sulfotransferases (D. Verdugo, et al.).

30. Carbohydrate-Based Treatment of Cancer Metastasis (R. Kannagi).

31. N-Acetylneuraminic Acid Derivatives and Mimetics as Anti-Influenza Agents (R. Thomson and M. von Itzstein).

32. Modified and Modifying Sugars as a New Tools for the Development of Therapeutic Agents - The Biochemically Engineered N-Acyl Side Chain of Sialic Acid: Biological Implications and Possible Uses in Medicine (R. Horstkorte, et al.).

33. Modified and Modifying Sugars as a New Tools for the Development of Therapeutic Agents - Glycosidated Phospholipids as a New Type of Antiproliferative Agents (K. Danker, et al.).

34. Glycoside Primers and Inhibitors of Glycosylation (J. Brown, et al.).

35. Carbohydrate-Based Drug Discovery in the Battle Against Bacterial Infections: New Opportunities Arising from Programmable One-Pot Oligosaccharide Synthesis (T. Ritter and C. Wong).

Subject Index.