BIOLOGY OF DEPRESSION - FROM NOVEL INSIGHTS TO THERAPEUTIC STRATEGIES 2V SET

Reported by the WHO and the World Bank to be the fourth cause of disability worldwide, depression can best be explained from a genetic perspective as a complex disorder of gene-environment interactions.
This is the first major reference to cover the clinical aspects of this common and complex disorder of unknown cause. Readers will also learn about our current understanding of the psychosocial, environmental, biological, and genetic aspects of depression. The authors are internationally recognized experts from leading academic and industrial environments, and they present the features, advantages, and limitations of animal models while reviewing candidate biological systems and genetic approaches. In addition, the book covers the important topic of the medical consequences of depression, as clinicians and investigators increasingly appreciate how it negatively impacts on cardiovascular function and bone mineral density. Finally, a separate section is devoted to the biochemical and molecular basis for existing treatments, along with strategies for the use of genomic tools to discover new targets for antidepressants and to predict therapeutic outcomes.

Professor Ma-Li Wong, Co-Director of the Center for Pharmacogenomics & Clinical Pharmacology, UCLA Neuropsychiatric Institute, was trained in neurology at the University of S?o Paulo, Brazil and psychiatry at the Albert Einstein College of Medicine, New York, and at Yale University. She joined the National Institute of Mental Health (Bethesda, MD) in 1993 as Head of the Molecular Neuroendocrinology Unit, Clinical Neuroendocrinology Branch. In 1999 she took up a professorship at the UCLA Department of Psychiatry & Biobehavioral Sciences, later becoming Director of its Neuroendocrine Core, and has been Director of the General Clinical Research Center Core Laboratory since 2002. Her current research focuses on the genomics and genetics of antidepressant treatment. Professor Wong is Associate Editor of Molecular Psychiatry.

Professor Julio Licinio, Co-Director of the Center for Pharmacogenomics & Clinical Pharmacology, UCLA Neuropsychiatric Institute, was trained in medicine at the University of S?o Paulo, Brazil, endocrinology at the University of Chicago, and psychiatry at Cornell University and Yale University and joined the National Institute of Mental Health (Bethesda, MD) in 1993 as Head of the Clinical Research Unit, Clinical Neuroendocrinology Branch. In 1999 he came to UCLA as Professor of Psychiatry & Biobehavioral Sciences and Medicine/Endocrinology. He is Founding President of the International Society of Pharmacogenomics and one of the principal investigators in the NIH Pharmacogenetics and Pharmacogenomics Research Network. His main research interests include the role of leptin in neuroendocrine-immune interactions and pharmacogenomics of antidepressants. Professor Licinio is Editor of The Pharmacogenomics Journal and Molecular Psychiatry.

Preface.

List of Contributors.

Abbreviations.

1 Classification of Depression: Research and Diagnostic Criteria: DSM-IV and ICD-10 (Alan M. Gruenberg, Reed D. Goldstein and Harold Alan Pincus).

2 Psychosocial and Environmental Formulations of Depression (Gordon Parker and Kay Parker).

3 The Economic Burden of Depression: Societal and Patient Perspectives (Paul E. Greenberg and Howard G. Birnbaum).

4 The Depressive Spectrum: Reconceptualizing the Relationship between Dysthymic, Subthreshold and Major Depressions (Hagop S. Akiskal and Lewis L. Judd).

5 The Monoamine Hypothesis of Depression (Leslie Iversen).

6 Monoaminergic-based Pharmacotherapy for Depression (George I. Papakostas and Maurizio Fava).

7 Psychobiology of Electroshock (Max Fink).

8 Current Prognosis of Depression (H. Brent Solvason and Alan Schatzberg).

9 Treatment of Depression in Medical Illness (Charles L. Raison, David C. Purselle, Lucile Capuron and Andrew H. Miller).

10 Depression and Suicidality in Children and Adolescents (Cynthia R. Pfeffer).

11 The Biology and Genetics of Suicidality (Gustavo Turecki and Aleksandra Lalovic).

12 Geriatric Depression (Bindu Shanmugham and George Alexopoulos).

13 Comorbidity of Depression and Substance Abuse (Edward V. Nunes and Wilfred N. Raby).

14 Depression in the Context of Cancer (Elliot J. Coups, Jeremy Winell and Jimmie C. Holland).

15 Treatment of Refractory Depression (Michael Gitlin).

16 Clinical Pharmacology of New Classes of Antidepressant Drugs (Justine M. Kent).

17 Neuroimaging and Neuropathological Studies of Mood Disorders (Wayne C. Drevets and Joseph L. Price).

18 Dysregulation of Circadian Rhythms in Mood Disorders: Molecular Mechanisms (Blynn G. Bunney, Steven G. Potkin and William E. Bunney).

19 Neuropeptidergic Dysfunction in Depression (Garth Bissette).

20 Depression, Mania, and Thyroid Function: A Story of Intimate Relationships (Peter C. Whybrow and Michael Bauer).

21 Stress System Dysregulation in Depression: From Molecular Biology to New Treatment Opportunities (P. W. Gold).

22 Neuroimmune Mediators: Are Cytokines Mediators of Depression? (Renaud de Beaurepaire, Artur H. Swiergiel and Adrian J. Dunn).

23 Borna Disease Virus: Impact on Mood and Cognition (Liv Bode, Detlef E. Dietrich and Hanns Ludwig).

24 Depression and Heart Disease (Robert M. Carney and Kenneth E. Freedland).

25 Genetic Substrates Shared by Depression and Cardiovascular Disease (Brigitta Bondy).

26 History and Epidemiology of Depression (Ma-Li Wong).

27 Major Depression and Animals Models (Ma-Li Wong).

28 Loss and Deprivation: From Animal Models to Clinical Presentation (Kristin M. Penza, Christine Heim and Charles B. Nemeroff).

29 Neurogenomics of depression (Klaus Peter Lesch).

30 Genetic Approaches to Depression: Linkage Studies (Francis M. Mondimore and James B. Potash).

31 Genetic Approaches to Depression: Association Studies (Kopal Tandon and Katherine J. Aitchison).

32 Molecular Effects of Antidepressant Treatments (Pierre Sokoloff).

33 The Role of Transcription Factors in the Biology of Depression (Robert D. Beech and Ronald S. Duman).

34 Pharmacogenetics and Pharmacogenomics of Antidepressant Drug Action (Ma-Li Wong).

35 Pharmacogenetics of Antidepressant Drug Metabolism and Its Clinical Implications (Adrián Llerena).

36 Bioinformatics Approaches for Identifying Allelic Variants in Candidate Pathways underlying Major Depression and Antidepressant Treatment Response (Kristopher J. L. Irizarry).

37 Emerging Treatments for Depression: Beyond the Monoamine Hypothesis (Julio Licinio).

38 Antidepressants and Suicide: Clinical Considerations (Julio Licinio).

39 Depression in Developing Countries (Maurício Silva de Lima and Bernardo Garcia de Oliveira Soares).

40 Complementary and Alternative Medical Treatment for Depression (Peter B. Bongiorno).

41 The Experience of Depression (Susan Blauner, Catherine Bond, Philip J. Burguieres, Ma-Li Wong, Julio Licinio, and Deborah L. Flores).

Subject Index.