商品簡介
Developing better therapies for neurological conditions such as Parkinson’s and Alzheimer’s diseases remains an enduring problem for 21st century medicine. The testing of novel therapies will continue to require a robust experimental animal model. The marmoset is an ideal animal model for modern neurological research because of the species’ convenient body size, ease of handling, and the fundamental similarity of its neuroanatomy to the human brain.
The Stereotaxic and Chemoarchitectural Atlas of the Brain of the Common Marmoset (Callithrix jacchus) is the most detailed atlas of the marmoset brain available. An essential tool for researchers developing more effective therapies for disabling and debilitating neurological disorders, the book contains:
Fully delineated, high-quality (400x magnification) images of Nissl-stained, acetylcholinesterase histochemically-stained and parvalbumin, calbindin and neurofilament immunohistochemically-stained coronal and sagittal sections, as well as structural magnetic resonance images (MRI) for direct comparisons
Line diagrams with delineations of all cortical and subcortical structures, with grid overlays so the precise position of each structure can be located stereotaxically relative to the interaural line and infraorbital margin
Quantitative data regarding volume and cell number of many of the structures delineated in the atlas, regularly updated on an accompanying website
Standard nomenclature widely used in the Paxinos group of atlases, allowing users to compare and contrast homologous nuclei in different species using the major available atlases
The book combines modern imaging (MRI) with an accurate stereotaxic and chemoarchitectonic section atlas, making the fullest use of available technologies. The companion DVD includes all the images in full color. Designed by publishing neuroanatomists, this book/DVD will be a cornerstone in marmoset brain research for years to come.
作者簡介
Dr. Craig Hardman is a Lecturer within the Department of Anatomy, School of Medical Sciences at the University of New South Wales, Australia.
Professor Ken WS Ashwell is a Professor within the Department of Anatomy, School of Medical Sciences at the University of New South Wales, Australia.
目次
IntroductionEcology, Behavior and Evolution of the Common MarmosetThe Marmoset in Neuroscience ResearchKey Features of this BookAnimals and Ethical ConsiderationsMethods: MRI, Perfusion and Tissue ProcessingImaging, Principles of Delineation and AbbreviationQuantitation of Volumes and Neuronal Populations of Motor NucleiBases for Delineation of Specific Regions and NucleiReferencesNamed structures and abbreviationsIndex of atlas platesAtlas plates
