Nanostructures and Nanoconstructions Based on DNA

Evolutionally optimized biomolecules and their complexes present attractive objects in the production of functionalized nanoobjects. Indeed, nucleic acid-based molecules are primary candidates as building blocks for development of nanoscale systems and devices.

Written for chemists, physicists, molecular biologists, and students in related fields, Nanostructures and Nanoconstructions Based on DNA covers specific properties of metallic nanoparticles, and compares their properties with those related to nanoobjects formed by biological molecules. It also discloses details of formation and physicochemical peculiarities of the DNA nanostructures and DNA-based nanoconstructions. Furthermore, the book considers:


The peculiarities of two approaches to structural DNA nanotechnology, i.e. to creation of spatial nanoobjects formed by DNA molecules and their complexes: (i) the hybridization approach and (ii) the liquid-crystalline approach
The physicochemical properties of DNA nanostructures as well as "liquid" and "rigid" DNA-based nanoconstructions
The connection of liquid crystalline phase formation in DNA with possible nanotechnological applications


This timely reference covers more DNA physics and molecular biology than any other published title. The authors discuss how nucleic acid molecules and their complexes with chemical and biologically active compounds are an area of increasing significance in the development of various nanoscale systems and devices of practical importance.

Chemists, physicists, molecular biologists, and other scientists and students of related fields.

Nanoparticles and Biological Molecules Metal Nanoparticles and Their Properties Biological Molecules: A New Background for the Creation of Nanoobjects Organization of Research in Nanotechnology Area The Health Risk of Nanomaterials Nanostructures Formed by Hybridization of Synthetic Single- Stranded DNA Molecules General Concept of the Fundamental Properties of DNA Used in Nanotechnology Hybridization Technique of Creating Nanostructures Based on Synthetic Single-Stranded DNA Molecules (Bottom-Up Approach to the Creation of DNA Nanostructures) Organic Linker Molecules as Rigid "Vertices" in the Tailored Spatial DNA Nanostructures Formed by Hybridization Technique Arrangement of Objects on the Surface of DNA Nanostructures "Liquid" Nanoconstructions Based on Spatially Ordered Double-Stranded DNA MoleculesDouble-Stranded DNA Molecules as Building Blocks for NanotechnologyPhase Exclusion of Double-Stranded DNA Molecules from Polyethylene Glycol SolutionsThe Cholesteric Mode of Nucleic Acid Molecules Packing in Particles of Dispersions Results in an Appearance of Abnormal CD SpectraAccumulation of the "Guest" Molecules in the DNA Molecules Forming CLCD Particles"Rigid" Nanoconstructions Based by Spatially Ordered Double-Stranded DNA Molecules Complexed with Various Compounds and NanoparticlesBackgrounds for Formation of Rigid DNA NanoconstructionsRigid Nanoconstructions Formed as a Result of Formation of Nanobridges between Neighboring DNA Molecules Fixed in Quasinematic LayersThe Magnetometric Evaluation of Cu2+ Ions in the Content of Nanobridges Formed between Spatially Fixed DNA MoleculesVisualization of Rigid DNA Nanoconstructions Linked with Nanobridges and Manipulations with These NanoconstructionsDependence of Optical Properties of DNA Nanoconstructions on TemperatureRigid Nanoconstruction Formed as a Result of Formation of Complexes of DNA Molecules Fixed in Quasinematic Layers with Rare-Earth Metal CationsVisualization of Rigid Particles of Cholesteric Liquid-Crystalline Dispersion of a [DNA-Gd3+] ComplexAu Nanoparticles Can Induce Formation of Rigid DNA NanoconstructionAn Additional Case: Formation of Semi-Rigid Liquid-Crystalline ParticlesViral Particles as "Rigid" Biological Nanoconstructions: Their Creation and Medical Application ProspectsD. Yu. Logunov, B. S. Naroditsky, and A. L. GintsburgA "PEG-Like Situation" in Biological Systems and Peculiarities of Biological NanoconstructionsMethods for Obtaining Recombinant Adenovirus "Rigid" NanostructuresRecombinant Adenovirus Nanostructures with a Modified GenomeReplication-Competent Recombinant Adenovirus NanostructuresReplication-Incompetent Recombinant Adenovirus NanostructuresCapsid-Modified Recombinant Adenovirus NanostructuresPhysicochemical Modifications of Recombinant Adenovirus ParticlesApplication of Recombinant Adenovirus Nanostructures in MedicineApplication of "Liquid" and "Rigid" DNA Nanoconstructions Immobilized in Polymeric Hydrogel as Sensing UnitsIssues of Stabilization of Particles of Liquid-Crystalline DispersionsImmobilization of DNA LCD Particles in a HydrogelFormation and Immobilization of DNA Nanoconstruction in a Hydrogel