Nanotechnology Cancer Therapy

While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance for Nanotechnology in Cancer in 2004 and pledged $144.3 million in funding over the next five years. Edited by one of the most dynamic pioneers in the field, Nanotechnology for Cancer Therapy focuses on those nanoscientific and nanotechnological strategies that are evolving as the most promising for the imaging and treatment of cancer. Among the various approaches considered, nanotechnology offers great possibilities for the targeted delivery of drugs and genes to tumor sites and the ultimate replacement of those chemotherapeutic agents so compromised by side effects.Within this volume, the expertise of world-renowned academic and industrial researchers is brought together to provide a comprehensive treatise. Composed of 38 chapters, the book is divided into 7 sections that cover -Fundamentals of targeting strategies, nanotechnology characterization for cancer therapy, and USFDA guidelines on approval of nanotechnology productsPolymeric conjugates used for tumor-targeted imaging and delivery, including imaging to evaluate therapeutic efficacy Polymeric nanoparticle systems that emphasize biodegradable, long-circulating nanoparticles for passive and active targetingPolymeric micellar assemblies, where sophisticated chemistry is leading to novel nanosystems that can provide efficient delivery to tumors Dendritic nanostructures used for cancer imaging and therapy Liposome-based delivery systems -- the oldest nanotechnology method employed in cancer therapy Other lipid nanosystems used for targeted delivery, including those that can cross biological barriers, as well as mitochondria-specific delivery

SECTION 1 NANOTECHNOLOGY AND CANCERIntroduction and Rationale for Nanotechnology in Cancer Therapy; Fredika M. Robertson and Mauro FerrariPassive Targeting of Solid Tumors: Pathophysiological Principles and Physicochemical Aspects of Delivery Systems; S. M. MoghimiActive Targeting Strategies in Cancer with a Focus on Potential Nanotechnology Applications; Randall J. MrsnyPharmacokinetics of Nanocarrier-Mediated Drug and Gene Delivery; Yuriko Higuchi, Shigeru Kawakami, and Mitsuru HashidaMultifunctional Nanoparticles for Cancer Therapy; Todd J. Harris, Geoffrey von Maltzahn, and Sangeeta N. BhatiaNeutron Capture Therapy of Cancer: Nanoparticles and High Molecular Weight Boron Delivery Agents; Gong Wu, Rolf F. Barth, Weilian Yang, Robert J. Lee, Werner Tjarks, Marina V. Backer, and Joseph M. BackerPreclinical Characterization of Engineered Nanoparticles Intended for Cancer Therapeutics; Anil K. Patri, Marina A. Dobrovolskaia, Stephan T. Stern, and Scott E. McNeilNanotechnology: Regulatory Perspective for Drug Development in Cancer Therapeutics; N. Sadrieh and T. J. MillerSECTION 2 POLYMER CONJUGATESPolymeric Conjugates for Angiogenesis Targeted Tumor Imaging and Therapy; Amitava Mitra, Anjan Nan, Bruce R. Line, and Hamidreza GhandehariPoly (L-Glutamic Acid): Efficient Carrier of Cancer Therapeutics and Diagnostics; Guodong Zhang, Edward F. Jackson, Sidney Wallace, and Chun LiNoninvasive Visualization of In Vivo Drug Delivery of Paramagnetic Polymer Conjugates with MRI; Zheng-Rong Lu, Yanli Wang, Furong Ye, Anagha Vaidya, and Eun-Kee JeongSECTION 3 POLYMERIC NANOPARTICLESPolymeric Nanoparticles for Tumor-Targeted Drug Delivery; Tania Betancourt, Amber Doiron, and Lisa Brannon-PeppasLong-Circulating Polymeric Nanoparticles for Drug and Gene Delivery to Tumors; Sushma Kommareddy, Dinesh B. Shenoy, and Mansoor M. AmijiBiodegradable PLGA/PLA Nanoparticles for Anticancer Therapy; Sanjeeb K. Sahoo and Vinod LabhasetwarPoly (alkyl cyanoacrylate) Nanoparticles for Delivery of Anticancer Drugs; R. S. R. Murthy and L. Harivardhan ReddyAptamers and Cancer Nanotechnology; Omid C. Farokhzad, Sangyong Jon, and Robert LangerSECTION 4 POLYMERIC MICELLESPolymeric Micelles for Formulation of Anticancer Drugs; Helen Lee, Patrick Lim Soo, Jubo Liu, Maok Butler, and Christine AllenPEO-Modified Poly (L-Amino Acid) Micelles for Drug Delivery; Afsaneh Lavasanifar, Xiuo-Bing Xiong, and Hamidreza Montazeri AliabadiHydrotropic Polymer Micelles for Cancer Therapeutics; Sang Cheon Lee, Kang Moo Huh, Tooru Ooy, and Kinam ParkTumor-Targeted Delivery of Sparingly-Soluble Anti-Cancer Drugs with Polymeric Lipid-Core Immunomicelles; Vladimir P. TorchilinCombined Cancer Therapy by Micellar-Encapsulated Drug and Ultrasound; Natalya RapoportPolymeric Micelles Targeting Tumor pH3; Eun Seong Lee and You Han BaecRGD-Encoded, MRI-Visible Polymeric Micelles for Tumor-Targeted Drug Delivery; Jinming Gao, Norased Nasongkla, and Chalermchai KhemtongTargeted Antisense Oligonucleotide Micellar Delivery Systems; Ji Hoon Jeong, Sun Hwa Kim, and Tae Gwan ParkSECTION 5 DENDRITIC NANOCARRIERSDendrimers as Drug and Gene Delivery Systems; Tae-Il Kim and Jong-Sang ParkDendritic Nanostructures for Cancer Therapy; Ashootosh V. Ambade, Elamprakash N. Savariar, and S. Thai ThayumanavanPEGylated Dendritic Nanoparticulate Carriers of Anti-Cancer Drug; D. Bhadra, S. Bhadra, and N. K. JainDendrimer Nanocomposites for Cancer Therapy; Lajos P. Balogh and Mohamed K. KhanSECTION 6 LIPOSOMESApplications of Liposomal Drug Delivery Systems to Cancer Therapy; Alberto A. GabizonPositively-Charged Liposomes for Targeting Tumor Vasculature; Robert B. CampbellCell Penetrating Peptide (CPP)-Modified Liposomal Nanocarriers for Intracellular Drug and Gene Delivery; Vladimir P. TorchilinRGD-Modified Liposomes for Tumor Targeting; S. P. VyasFolate Receptor-Targeted Liposomes for Cancer Therapy; Xiaobin B. Zhao, Natarajan Muthusamy, John C. Byrd, and Robert J. LeeNanoscale Drug Delivery Vehicles for Solid Tumors: A New Paradigm for Localized Drug Delivery Using Temperature Sensitive Liposomes; David Needham and Ana PonceSECTION 7 OTHER LIPID NANOSTRUCTURESNanoemulsions Formulations for Tumor-Targeted Delivery; Sandip B. Tiwari and Mansoor M. AmijiSolid Lipid Nanoparticles for Antitumor Drug Delivery; Ho Lun Wong, Yongqiang Li, Reina Bendayan, Mike Andrew Rauth, and Xiao Yu WuLipoprotein Nanoparticles as Delivery Vehicles for Anti-Cancer Agents; Andras G. Lacko, Maya Nair, and Watter J. McConathyDQAsomes as Mitochondria-Targeted Nano-Carriers for Anticancer Drugs; Shing-Ming Cheng, Sarathi V. Boddapati, Gerard G. M. D'Souza, and Volkmar Weissig